theophylline has been researched along with Acute Liver Injury, Drug-Induced in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Theophylline is a useful drug for the treatment of asthma." | 7.73 | A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. ( Adachi, M; Fukuda, T; Kihara, N; Makino, S; Miyamoto, T; Nakajima, S; Nishima, S; Ohta, K, 2006) |
| "Theophylline is a useful drug for the treatment of asthma." | 3.73 | A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. ( Adachi, M; Fukuda, T; Kihara, N; Makino, S; Miyamoto, T; Nakajima, S; Nishima, S; Ohta, K, 2006) |
| "Theophylline treated rats exhibited a significant decrease in hepatic vacuolation, apoptosis, leucocyte infiltration, and accumulation of collagen fibers in comparison to the Con A group." | 1.42 | Theophylline, an old drug with multi-faceted effects: Its potential benefits in immunological liver injury in rats. ( Elsirafy, OM; Hamam, GG; Hasanin, AH; Hussein, RM; Kawy, HS; Wahba, YS, 2015) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "6-Mercaptopurine was identified in all tissues by gas chromatography/mass spectrometry." | 1.26 | A Purinethol (6-mercaptopurine) fatality in a case of prescription negligence: a gas chromatographic determination of 6-mercaptopurine. ( Lin, RL; Schaffer, MI; Stein, RJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Hussein, RM | 1 |
| Elsirafy, OM | 1 |
| Wahba, YS | 1 |
| Kawy, HS | 1 |
| Hasanin, AH | 1 |
| Hamam, GG | 1 |
| FISCHER, A | 1 |
| TAKACS, L | 1 |
| VARGA, I | 1 |
| Ming, Z | 1 |
| Fan, YJ | 1 |
| Yang, X | 1 |
| Lautt, WW | 1 |
| Makino, S | 1 |
| Adachi, M | 1 |
| Ohta, K | 1 |
| Kihara, N | 1 |
| Nakajima, S | 1 |
| Nishima, S | 1 |
| Fukuda, T | 1 |
| Miyamoto, T | 1 |
| Lin, RL | 1 |
| Stein, RJ | 1 |
| Schaffer, MI | 1 |
| Shedlofsky, SI | 1 |
| Israel, BC | 1 |
| McClain, CJ | 1 |
| Hill, DB | 1 |
| Blouin, RA | 1 |
| Drent, M | 1 |
| Kuks, PF | 1 |
| van den Bosch, JM | 1 |
| Brandt, KH | 1 |
| Schulz, FH | 1 |
| Brenner, G | 1 |
| Trautmann, H | 1 |
1 review available for theophylline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
16 other studies available for theophylline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Theophylline, an old drug with multi-faceted effects: Its potential benefits in immunological liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caspase 3; Chemical and Drug Induced Liv | 2015 |
[STUDY OF THE INTERMEDIATE METABOLISM OF DRUGS USING PARTIAL HEPATECTOMY].
Topics: Barbiturates; Caffeine; Chemical and Drug Induced Liver Injury; Chloralose; Hepatectomy; Hepatitis; | 1963 |
Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Chemical and Drug Ind | 2006 |
A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Anti-Asthmatic Agents; Asthma; Bronchiti | 2006 |
A Purinethol (6-mercaptopurine) fatality in a case of prescription negligence: a gas chromatographic determination of 6-mercaptopurine.
Topics: Chemical and Drug Induced Liver Injury; Chromatography, Gas; Drug Prescriptions; Female; Gas Chromat | 1982 |
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
Topics: Administration, Oral; Adult; Antipyrine; C-Reactive Protein; Chemical and Drug Induced Liver Injury; | 1994 |
[Psychiatric symptoms due to theophylline overdose; the necessity of blood level monitoring].
Topics: Adult; Akathisia, Drug-Induced; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 1993 |
[Some problems of practical geriatrics].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Analgesics; Cardiovascular Diseases; Chemical and Dr | 1974 |
[Effect of xanthinol-nicotinate on detoxification processes in liver. Experimental studies on the model of hexobarbital-narcosis in rat].
Topics: Anesthesia, General; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dru | 1969 |