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theobromine and Urinary Bladder Neoplasms

theobromine has been researched along with Urinary Bladder Neoplasms in 4 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.

Research Excerpts

ExcerptRelevanceReference
"Cytotoxicity of thiotepa or doxorubicin hydrochloride in human bladder cancer cells was investigated alone and in combination with methylxanthines."7.67Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa. ( Fingert, HJ; Kindy, RL; Pardee, AB, 1984)
"Cytotoxicity of thiotepa or doxorubicin hydrochloride in human bladder cancer cells was investigated alone and in combination with methylxanthines."3.67Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa. ( Fingert, HJ; Kindy, RL; Pardee, AB, 1984)
" With human bladder cancer cells in culture, cytotoxicity of thiotepa was increased up to 10-fold (P less than 0."3.67In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa. ( Alley, MC; Chen, ZY; Fingert, HJ; Googe, PB; Pardee, AB; Pu, AT, 1988)
" However, the effects of the four agents on the clonal survival of irradiated cells failed to correlate with the extent of override, both in terms of the relative effects of the four agents and the dose-response relationships; at a concentration of 1 mM only caffeine was found to potentiate cell killing as well as causing block override, whilst at higher concentrations all the agents had a significant effect on survival but little or no further influence on the degree of block override."1.28Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. ( Musk, SR; Steel, GG, 1990)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fingert, HJ3
Kindy, RL1
Pardee, AB3
Musk, SR1
Steel, GG1
Chang, JD1
Pu, AT1
Chen, ZY1
Googe, PB1
Alley, MC1

Other Studies

4 other studies available for theobromine and Urinary Bladder Neoplasms

ArticleYear
Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa.
    The Journal of urology, 1984, Volume: 132, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Carcinoma, Transitional Cell; Cell Divisio

1984
Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity.
    International journal of radiation biology, 1990, Volume: 57, Issue:6

    Topics: Caffeine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Ra

1990
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosom

1986
In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa.
    Cancer research, 1988, Aug-01, Volume: 48, Issue:15

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cells, Cultured; Drug Synergis

1988