theobromine has been researched along with Urinary Bladder Neoplasms in 4 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cytotoxicity of thiotepa or doxorubicin hydrochloride in human bladder cancer cells was investigated alone and in combination with methylxanthines." | 7.67 | Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa. ( Fingert, HJ; Kindy, RL; Pardee, AB, 1984) |
| "Cytotoxicity of thiotepa or doxorubicin hydrochloride in human bladder cancer cells was investigated alone and in combination with methylxanthines." | 3.67 | Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa. ( Fingert, HJ; Kindy, RL; Pardee, AB, 1984) |
| " With human bladder cancer cells in culture, cytotoxicity of thiotepa was increased up to 10-fold (P less than 0." | 3.67 | In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa. ( Alley, MC; Chen, ZY; Fingert, HJ; Googe, PB; Pardee, AB; Pu, AT, 1988) |
| " However, the effects of the four agents on the clonal survival of irradiated cells failed to correlate with the extent of override, both in terms of the relative effects of the four agents and the dose-response relationships; at a concentration of 1 mM only caffeine was found to potentiate cell killing as well as causing block override, whilst at higher concentrations all the agents had a significant effect on survival but little or no further influence on the degree of block override." | 1.28 | Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. ( Musk, SR; Steel, GG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fingert, HJ | 3 |
| Kindy, RL | 1 |
| Pardee, AB | 3 |
| Musk, SR | 1 |
| Steel, GG | 1 |
| Chang, JD | 1 |
| Pu, AT | 1 |
| Chen, ZY | 1 |
| Googe, PB | 1 |
| Alley, MC | 1 |
4 other studies available for theobromine and Urinary Bladder Neoplasms
| Article | Year |
|---|---|
Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa.
Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Carcinoma, Transitional Cell; Cell Divisio | 1984 |
Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity.
Topics: Caffeine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Ra | 1990 |
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.
Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosom | 1986 |
In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cells, Cultured; Drug Synergis | 1988 |