Page last updated: 2024-11-05

theobromine and Substance Withdrawal Syndrome

theobromine has been researched along with Substance Withdrawal Syndrome in 8 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
" Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence."3.75Functional interaction between purinergic system and opioid withdrawal: in vitro evidence. ( Capasso, A; Gallo, C, 2009)
"Effects of different doses of adenosine receptor agonists and antagonists on naloxone-induced jumping and diarrhea in morphine-dependent mice were studied."3.70Effects of adenosine receptor agents on the expression of morphine withdrawal in mice. ( Naghipour, B; Roushan-zamir, F; Shafaghi, B; Zarrindast, MR, 1999)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Capasso, A2
Gallo, C1
Collier, HO2
Cuthbert, NJ2
Francis, DL2
Zarrindast, MR1
Naghipour, B1
Roushan-zamir, F1
Shafaghi, B1
Baldo, BA1
Koob, GF1
Markou, A1
Coupar, IM1
Tran, BL1
Butt, NM1
Saeed, SA1
Greden, JF1

Other Studies

8 other studies available for theobromine and Substance Withdrawal Syndrome

ArticleYear
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
    Current drug safety, 2009, Volume: 4, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor

2009
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
    Federation proceedings, 1981, Volume: 40, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Huma

1981
Effects of adenosine receptor agents on the expression of morphine withdrawal in mice.
    European journal of pharmacology, 1999, Mar-12, Volume: 369, Issue:1

    Topics: Adenosine; Analysis of Variance; Animals; Behavior, Animal; Diarrhea; Male; Mice; Mice, Inbred Strai

1999
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-15, Volume: 19, Issue:24

    Topics: Adenosine; Animals; Brain; Caffeine; Cocaine; Differential Threshold; Dopamine Uptake Inhibitors; Dr

1999
Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence.
    Life sciences, 2000, Volume: 66, Issue:10

    Topics: Adenosine; Animals; Caffeine; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone;

2000
Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine.
    Life sciences, 2001, Jul-06, Volume: 69, Issue:7

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Female; Injections, Subcuta

2001
Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.
    European journal of pharmacology, 1979, Feb-01, Volume: 53, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Humans;

1979
Anxiety or caffeinism: a diagnostic dilemma.
    The American journal of psychiatry, 1974, Volume: 131, Issue:10

    Topics: Adult; Anxiety Disorders; Cacao; Caffeine; Carbonated Beverages; Coffee; Diagnosis, Differential; Do

1974