theobromine has been researched along with Seizures in 5 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Caffeine as well as the antiasthmatic drug theophylline can cause seizures when administered to humans or animals in excessive doses." | 7.68 | Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "We determined tonic-clonic seizure duration in rats given ECS with caffeine (0-175 mg/kg, IP) after a course of one or six daily ECS." | 5.29 | Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures. ( Fochtmann, L; Francis, A, 1995) |
| "Caffeine as well as the antiasthmatic drug theophylline can cause seizures when administered to humans or animals in excessive doses." | 3.68 | Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "We determined tonic-clonic seizure duration in rats given ECS with caffeine (0-175 mg/kg, IP) after a course of one or six daily ECS." | 1.29 | Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures. ( Fochtmann, L; Francis, A, 1995) |
| "potentiated seizures induced by the selective adenosine A1 receptor antagonist 8-[4-[[[[(2-aminoethyl)amino]carbonyl]methyl]oxy]-phenyl]- 1,3-dipropylxanthine (XAC)." | 1.29 | Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models. ( Klitgaard, H; Knutsen, LJ; Thomsen, C, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Francis, A | 1 |
| Fochtmann, L | 1 |
| Klitgaard, H | 1 |
| Knutsen, LJ | 1 |
| Thomsen, C | 1 |
| Kockler, DR | 1 |
| McCarthy, MW | 1 |
| Lawson, CL | 1 |
| Zhi, JG | 1 |
| Levy, G | 2 |
| Yasuhara, M | 1 |
5 other studies available for theobromine and Seizures
| Article | Year |
|---|---|
Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Dose-Response Relationship, Drug; | 1995 |
Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Glutamates; Glutamic Acid; Male; Mice | 1993 |
Seizure activity and unresponsiveness after hydroxycut ingestion.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Citrates; Drug Combinations; Drugs, Chinese Herb | 2001 |
Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats.
Topics: Animals; Caffeine; Drug Interactions; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizur | 1990 |
Rapid development of functional tolerance to caffeine-induced seizures in rats.
Topics: Animals; Brain; Caffeine; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobrom | 1988 |