Page last updated: 2024-11-05

theobromine and Lung Neoplasms

theobromine has been researched along with Lung Neoplasms in 9 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)."3.67Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986)
"Pentoxifylline (Trental), a phosphodiesterase inhibitor with platelet aggregation inhibitory effect, was shown to decrease spontaneous metastases in a Wilms' tumor model in Furth-Wistar rats and in neuroblastoma C1300 in A/J mice."3.66Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis. ( Ambrus, JL; Cohen, H; Gastpar, H; Gordon, S; Murphy, GP; Sciandra, J; Williams, P; Witul, M, 1979)
"Theophylline- and caffeine-treated B16-F10 cells exhibited low adhesion to laminin/collagen type IV and reduced invasion through Matrigel in an in vitro assay."1.30Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation. ( Abbruzzese, A; Autuori-Pezzoli, V; Beninati, S; Cardinali, M; Kleinman, HK; Lentini, A; Mattioli, P; Nicolini, L; Pietrini, A, 1998)
" In the present experiment pentoxifylline appears to be a highly effective platelet aggregation inhibitor: a dose-response curve is apparent in monkey between 6 and 24 mg/kg i."1.26Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis. ( Ambrus, CM; Ambrus, JL; Gastpar, H, 1981)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's4 (44.44)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Elkaeed, EB1
Yousef, RG1
Elkady, H1
Alsfouk, AA1
Husein, DZ1
Ibrahim, IM1
Metwaly, AM1
Eissa, IH1
Ambrus, JL2
Ambrus, CM1
Gastpar, H2
Nomura, T1
Gil, M1
Skopińska-Rózewska, E2
Radomska, D1
Demkow, U2
Skurzak, H1
Rochowska, M1
Beuth, J1
Roszkowski, K1
Sommer, E1
Chorostowska-Wynimko, J1
Bałan, B1
Rózycka, B1
Barcz, E1
Filewska, M1
Mlekodaj, S1
Rudziński, P1
Seweryniak, W1
Caban, P1
Kupis, W1
Bogdan, J1
Usiekniewicz, P1
Gatarek, J1
Langfort, R1
Lentini, A1
Kleinman, HK1
Mattioli, P1
Autuori-Pezzoli, V1
Nicolini, L1
Pietrini, A1
Abbruzzese, A1
Cardinali, M1
Beninati, S1
Gordon, S1
Witul, M1
Cohen, H1
Sciandra, J1
Williams, P1
Murphy, GP1
Dezube, BJ1
Fridovich-Keil, JL1
Bouvard, I1
Lange, RF1
Pardee, AB1
Mamytbeková, A1
Rezábek, K1
Kacerovská, H1
Grimová, J1
Svobodová, J1

Other Studies

9 other studies available for theobromine and Lung Neoplasms

ArticleYear
New Anticancer Theobromine Derivative Targeting EGFR
    Molecules (Basel, Switzerland), 2022, Sep-09, Volume: 27, Issue:18

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB

2022
Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis.
    La Ricerca in clinica e in laboratorio, 1981, Volume: 11 Suppl 1

    Topics: Adenocarcinoma; Adenosine Diphosphate; Animals; Carcinoma, Ehrlich Tumor; Female; Head and Neck Neop

1981
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M

1983
Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice.
    Folia biologica, 1993, Volume: 39, Issue:2

    Topics: Animals; Carcinoma; Injections, Subcutaneous; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neopl

1993
Screening of angiogenesis inhibitors by modified tumor-induced angiogenesis (TIA) test in lung cancer.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1997, Volume: 42 Suppl 1

    Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Drug Scr

1997
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
    Melanoma research, 1998, Volume: 8, Issue:2

    Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins;

1998
Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis.
    Journal of medicine, 1979, Volume: 10, Issue:6

    Topics: Adenocarcinoma; Animals; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm M

1979
Pentoxifylline and wellbeing in patients with cancer.
    Lancet (London, England), 1990, Mar-17, Volume: 335, Issue:8690

    Topics: Adult; Breast Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplas

1990
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
    Neoplasma, 1986, Volume: 33, Issue:4

    Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred

1986