theobromine has been researched along with Lung Neoplasms in 9 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)." | 3.67 | Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986) |
| "Pentoxifylline (Trental), a phosphodiesterase inhibitor with platelet aggregation inhibitory effect, was shown to decrease spontaneous metastases in a Wilms' tumor model in Furth-Wistar rats and in neuroblastoma C1300 in A/J mice." | 3.66 | Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis. ( Ambrus, JL; Cohen, H; Gastpar, H; Gordon, S; Murphy, GP; Sciandra, J; Williams, P; Witul, M, 1979) |
| "Theophylline- and caffeine-treated B16-F10 cells exhibited low adhesion to laminin/collagen type IV and reduced invasion through Matrigel in an in vitro assay." | 1.30 | Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation. ( Abbruzzese, A; Autuori-Pezzoli, V; Beninati, S; Cardinali, M; Kleinman, HK; Lentini, A; Mattioli, P; Nicolini, L; Pietrini, A, 1998) |
| " In the present experiment pentoxifylline appears to be a highly effective platelet aggregation inhibitor: a dose-response curve is apparent in monkey between 6 and 24 mg/kg i." | 1.26 | Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis. ( Ambrus, CM; Ambrus, JL; Gastpar, H, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Elkaeed, EB | 1 |
| Yousef, RG | 1 |
| Elkady, H | 1 |
| Alsfouk, AA | 1 |
| Husein, DZ | 1 |
| Ibrahim, IM | 1 |
| Metwaly, AM | 1 |
| Eissa, IH | 1 |
| Ambrus, JL | 2 |
| Ambrus, CM | 1 |
| Gastpar, H | 2 |
| Nomura, T | 1 |
| Gil, M | 1 |
| Skopińska-Rózewska, E | 2 |
| Radomska, D | 1 |
| Demkow, U | 2 |
| Skurzak, H | 1 |
| Rochowska, M | 1 |
| Beuth, J | 1 |
| Roszkowski, K | 1 |
| Sommer, E | 1 |
| Chorostowska-Wynimko, J | 1 |
| Bałan, B | 1 |
| Rózycka, B | 1 |
| Barcz, E | 1 |
| Filewska, M | 1 |
| Mlekodaj, S | 1 |
| Rudziński, P | 1 |
| Seweryniak, W | 1 |
| Caban, P | 1 |
| Kupis, W | 1 |
| Bogdan, J | 1 |
| Usiekniewicz, P | 1 |
| Gatarek, J | 1 |
| Langfort, R | 1 |
| Lentini, A | 1 |
| Kleinman, HK | 1 |
| Mattioli, P | 1 |
| Autuori-Pezzoli, V | 1 |
| Nicolini, L | 1 |
| Pietrini, A | 1 |
| Abbruzzese, A | 1 |
| Cardinali, M | 1 |
| Beninati, S | 1 |
| Gordon, S | 1 |
| Witul, M | 1 |
| Cohen, H | 1 |
| Sciandra, J | 1 |
| Williams, P | 1 |
| Murphy, GP | 1 |
| Dezube, BJ | 1 |
| Fridovich-Keil, JL | 1 |
| Bouvard, I | 1 |
| Lange, RF | 1 |
| Pardee, AB | 1 |
| Mamytbeková, A | 1 |
| Rezábek, K | 1 |
| Kacerovská, H | 1 |
| Grimová, J | 1 |
| Svobodová, J | 1 |
9 other studies available for theobromine and Lung Neoplasms
| Article | Year |
|---|---|
New Anticancer Theobromine Derivative Targeting EGFR
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB | 2022 |
Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis.
Topics: Adenocarcinoma; Adenosine Diphosphate; Animals; Carcinoma, Ehrlich Tumor; Female; Head and Neck Neop | 1981 |
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M | 1983 |
Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice.
Topics: Animals; Carcinoma; Injections, Subcutaneous; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neopl | 1993 |
Screening of angiogenesis inhibitors by modified tumor-induced angiogenesis (TIA) test in lung cancer.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Drug Scr | 1997 |
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins; | 1998 |
Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis.
Topics: Adenocarcinoma; Animals; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm M | 1979 |
Pentoxifylline and wellbeing in patients with cancer.
Topics: Adult; Breast Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplas | 1990 |
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred | 1986 |