theobromine has been researched along with Liver Cirrhosis in 6 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Apparent pharmacokinetic parameters of caffeine elimination from the circulation were determined in 27 patients with histologically confirmed liver cirrhosis, 8 patients with miscellaneous liver disease, and 8 patients with other than liver disease." | 7.67 | Correlation of caffeine elimination and Child's classification in liver cirrhosis. ( Gerok, W; Haag, K; Holstege, A; Staiger, M, 1989) |
| " These findings suggest that CA pharmacokinetic parameters can be estimated using a simplified three-point blood sampling procedure following a single oral load and that the serum PX/CA or (PX + TB + TP)/CA ratio in a single blood sample taken 2 or 4 h after dosing provides a useful indicator for the assessment of hepatic drug-oxidizing capacity, N-demethylation, in decompensated liver cirrhosis." | 5.28 | A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites. ( Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Osada, A; Tanaka, E; Tsuji, K; Yamamoto, Y, 1992) |
| "Apparent pharmacokinetic parameters of caffeine elimination from the circulation were determined in 27 patients with histologically confirmed liver cirrhosis, 8 patients with miscellaneous liver disease, and 8 patients with other than liver disease." | 3.67 | Correlation of caffeine elimination and Child's classification in liver cirrhosis. ( Gerok, W; Haag, K; Holstege, A; Staiger, M, 1989) |
| "Subjects with liver cirrhosis and chronic hepatitis, as well as healthy volunteers, were given the oral dose of 300 mg caffeine." | 2.71 | Serum metabolite/caffeine ratios as a test for liver function. ( Flieger, J; Jodynis-Liebert, J; Juszczyk, J; Matuszewska, A, 2004) |
| " These findings suggest that CA pharmacokinetic parameters can be estimated using a simplified three-point blood sampling procedure following a single oral load and that the serum PX/CA or (PX + TB + TP)/CA ratio in a single blood sample taken 2 or 4 h after dosing provides a useful indicator for the assessment of hepatic drug-oxidizing capacity, N-demethylation, in decompensated liver cirrhosis." | 1.28 | A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites. ( Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Osada, A; Tanaka, E; Tsuji, K; Yamamoto, Y, 1992) |
| "001) and no significant differences were observed in the pharmacokinetic data derived from the respective concentration-time curves." | 1.28 | The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease. ( Chakraborty, J; Marks, V; Morgan, MY; Scott, NR; Stambuk, D, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jodynis-Liebert, J | 1 |
| Flieger, J | 1 |
| Matuszewska, A | 1 |
| Juszczyk, J | 1 |
| Holstege, A | 2 |
| Kurz, M | 1 |
| Weinbeck, M | 1 |
| Gerok, W | 2 |
| Koppenhagen, K | 1 |
| Wenig, HG | 1 |
| Tanaka, E | 1 |
| Ishikawa, A | 1 |
| Yamamoto, Y | 1 |
| Osada, A | 1 |
| Tsuji, K | 1 |
| Fukao, K | 1 |
| Misawa, S | 1 |
| Iwasaki, Y | 1 |
| Scott, NR | 1 |
| Stambuk, D | 1 |
| Chakraborty, J | 1 |
| Marks, V | 1 |
| Morgan, MY | 1 |
| Staiger, M | 1 |
| Haag, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of a Breath Test for Monitoring Liver Metabolic Function in Patients With Chronic Liver Disease and Cirrhosis[NCT00244569] | Phase 3 | 120 participants (Anticipated) | Interventional | 2005-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for theobromine and Liver Cirrhosis
| Article | Year |
|---|---|
Serum metabolite/caffeine ratios as a test for liver function.
Topics: Adult; Caffeine; Female; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Liver Function Tests; M | 2004 |
[The effect of pentoxifylline on liver perfusion: a comparative study in patients with liver diseases and in normal subjects, using 198Au-colloid-scintigraphy (author's transl)].
Topics: Adult; Aged; Chronic Disease; Female; Hepatitis; Humans; Liver; Liver Circulation; Liver Cirrhosis; | 1979 |
4 other studies available for theobromine and Liver Cirrhosis
| Article | Year |
|---|---|
Excretion of caffeine and its primary degradation products into bile.
Topics: Adult; Aged; Bile; Bilirubin; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Liver | 1993 |
A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites.
Topics: Adult; Caffeine; Evaluation Studies as Topic; Female; Humans; Liver; Liver Cirrhosis; Male; Methods; | 1992 |
The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease.
Topics: Adult; Aged; Caffeine; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middl | 1989 |
Correlation of caffeine elimination and Child's classification in liver cirrhosis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Caffeine; Chromatography, High Pressure Liquid | 1989 |