theobromine has been researched along with Leukemia L5178 in 2 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Leukemia L5178: An experimental lymphocytic leukemia of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Theobromine was not mutagenic in the Ames assay up to a maximum concentration of 5000 micrograms/plate either with or without S9 activation." | 1.27 | Genotoxicity of theobromine in a series of short-term assays. ( Brusick, D; Galloway, S; Jagannath, DR; Myhr, B; Rundell, J; Tarka, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ueno, AM | 1 |
| Tanaka, O | 1 |
| Matsudaira, H | 1 |
| Brusick, D | 1 |
| Myhr, B | 1 |
| Galloway, S | 1 |
| Rundell, J | 1 |
| Jagannath, DR | 1 |
| Tarka, S | 1 |
2 other studies available for theobromine and Leukemia L5178
| Article | Year |
|---|---|
Inhibition of gamma-ray dose-rate effects by D2O and inhibitors of poly(ADP-ribose) synthetase in cultured mammalian L5178Y cells.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cobalt Radioisotopes; Deuterium; Deuterium Oxid | 1984 |
Genotoxicity of theobromine in a series of short-term assays.
Topics: Animals; Biotransformation; Caffeine; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Fem | 1986 |