theobromine has been researched along with Leg Ulcer in 9 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months." | 7.68 | Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990) |
| " We describe a patient with bilateral ischemic leg ulcers treated preoperatively with pentoxifylline." | 7.68 | Treatment of ischemic leg ulcers with pentoxifylline: a case report and theoretical considerations. ( Fahey, MJ; Velanovich, V, 1990) |
| "A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months." | 3.68 | Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990) |
| " We describe a patient with bilateral ischemic leg ulcers treated preoperatively with pentoxifylline." | 3.68 | Treatment of ischemic leg ulcers with pentoxifylline: a case report and theoretical considerations. ( Fahey, MJ; Velanovich, V, 1990) |
| "In an open field study, 70 patients with leg ulcers, some existing already for a long time, were treated with Pentoxifylline in addition to the hitherto applied local therapy." | 3.66 | [Trental forte in leg ulcer therapy. Result of a field study]. ( Schmidt-Modrow, G; Weitgasser, H, 1982) |
| "Pentoxifylline (Trental) has multiple mechanisms of action, including stimulation of prostacyclin synthesis, decreased aggregation of platelets, increased deformability of red blood cells, increased mobility of neutrophils, and increased fibrinolysis." | 1.27 | Therapy of livedo vasculitis with pentoxifylline. ( Bard, JW; Ely, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weitgasser, H | 1 |
| Schmidt-Modrow, G | 1 |
| Pemler, K | 1 |
| Penth, B | 1 |
| Adams, HJ | 1 |
| Mund-Hoym, WD | 1 |
| Frost, ML | 1 |
| Treadwell, P | 1 |
| Bittiner, SB | 1 |
| Velanovich, V | 1 |
| Fahey, MJ | 1 |
| Jarcusková, D | 1 |
| Uhrík, J | 1 |
| Ely, H | 1 |
| Bard, JW | 1 |
| Brenner, MA | 1 |
9 other studies available for theobromine and Leg Ulcer
| Article | Year |
|---|---|
[Trental forte in leg ulcer therapy. Result of a field study].
Topics: Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Leg Ulcer; Male; Middle | 1982 |
[Pentoxifylline medication within the scope of leg-ulcer therapy. Results of a field study using Trental 400].
Topics: Administration, Oral; Aged; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Leg Ulcer; Ma | 1979 |
[The treatment of chronic arterial bloodcirculation interference (author's transl)].
Topics: Adult; Aged; Arterial Occlusive Diseases; Cholesterol; Drug Evaluation; Female; Humans; Leg; Leg Ulc | 1978 |
Treatment of sickle cell leg ulcers with pentoxifylline.
Topics: Anemia, Sickle Cell; Chronic Disease; Humans; Leg Ulcer; Male; Middle Aged; Pentoxifylline; Recurren | 1990 |
Oxpentifylline treatment of venous leg ulcers.
Topics: Humans; Leg Ulcer; Obesity; Pentoxifylline; Theobromine | 1990 |
Treatment of ischemic leg ulcers with pentoxifylline: a case report and theoretical considerations.
Topics: Aged; Aged, 80 and over; Female; Humans; Leg Ulcer; Pentoxifylline; Preoperative Care; Skin Transpla | 1990 |
[Evaluation of thermal conductivity and skin temperature in the treatment of leg ulcers].
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Diabetic Angiopathies; Female; Humans; Leg; Leg Ul | 1988 |
Therapy of livedo vasculitis with pentoxifylline.
Topics: Adult; Atrophy; Female; Humans; Leg Ulcer; Middle Aged; Pentoxifylline; Skin; Theobromine; Wound Hea | 1988 |
Nonhealing venous stasis ulcers. Pentoxifylline as adjunctive therapy.
Topics: Aged; Humans; Leg Ulcer; Male; Pentoxifylline; Theobromine; Venous Insufficiency | 1987 |