Page last updated: 2024-11-05

theobromine and Intermittent Claudication

theobromine has been researched along with Intermittent Claudication in 59 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.

Research Excerpts

ExcerptRelevanceReference
"The efficacy and safety of pentoxifylline (400 mg tid orally) and acenocoumarol, administered singly or in combination, in the treatment of intermittent claudication associated with chronic occlusive arterial disease were evaluated in a multi-center, randomized, factorial, blind clinical trial involving 146 patients."9.06Acenocoumarol and pentoxifylline in intermittent claudication. A controlled clinical study. The APIC Study Group. ( Basevi, P; Dettori, AG; Di Lecce, C; Manotti, C; Moratti, A; Paolicelli, M; Pini, M; Quintavalla, R, 1989)
"The effects of pentoxifylline on intermittent claudication were evaluated at a dose of 1200 mg/day in an open-label twelve-week study on geriatric patients with chronic occlusive arterial disease (COAD)."9.06Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication. ( Cobert, BL; Cohn, JB; Crowder, JE; Hryniewicki, SW; Morgan, DL; Piccirillo, RT; Savitsky, JP; Slywka, J; Wilcox, CS, 1989)
"Pentoxifylline has been shown to improve treadmill walking distances under blinded, controlled conditions in patients with intermittent claudication."9.06Effects of pentoxifylline on severe intermittent claudication. ( Gillings, D; Reich, T, 1987)
"Ten patients with Stage II chronic arterial occlusive disease (intermittent claudication) took part in a randomized, intraindividual crossover study involving acute intravenous administration of 200 mg pentoxifylline or physiological saline solution (placebo)."9.06Influence of pentoxifylline on muscle tissue oxygen tension (pO2) of patients with intermittent claudication before and after pedal ergometer exercise. ( Ehrly, AM; Saeger-Lorenz, K, 1987)
"Pentoxifylline, a methyl xanthine analogue was evaluated for treatment of intermittent claudication in a double-blind placebo controlled parallel group study in seven centers in the United States."9.05Pentoxifylline in the treatment of intermittent claudication of the lower limbs. ( Cutler, BC; Lee, BY; Porter, JM; Reich, T; Reichle, FA; Scogin, JT; Strandness, DE, 1984)
"The influence of the xanthine derivative pentoxifylline ('Trental' or BL191; Hoechst-Roussel) on exercise tolerance was measured in 38 subjects with stable, severe to moderately severe, intermittent claudication who completed a randomised, double-blind, placebo controlled, cross-over clinical trial."9.05Intermittent claudication: a double-blind crossover trial of pentoxifylline. ( Alderman, M; Chivers, D; Dupont, P; Gallus, AS; Gleadow, F; Morley, AA; Walsh, J; Wenzel, A, 1985)
"Pentoxifylline is approved by the Food and Drug Administration for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs."8.77Pentoxifylline: a new agent for intermittent claudication. ( Baker, DE; Campbell, RK, 1985)
"We have previously shown that pentoxifylline, a drug used in intermittent claudication, causes depolymerization of actin in leukocytes in vitro."7.68Effects of pentoxifylline administration on blood viscosity and leukocyte cytoskeletal function in patients with intermittent claudication. ( Cohen, HJ; Crawford, J; Currie, MS; Rao, KM; Simel, DL, 1990)
"All patients who had intermittent claudication (IC) over an 18-month period were given prescriptions for pentoxifylline (PTFX) 400 mg, three times daily."7.67The effects of pentoxifylline on patients with intermittent claudication. ( Green, RM; McNamara, J, 1988)
"Porter et al have reported that pentoxifylline shows statistically significant superiority over placebo in a seven-center, double-blind, parallel group, randomized trial of outpatients with intermittent claudication secondary to chronic occlusive arterial disease."7.67Another look at the pentoxifylline efficacy data for intermittent claudication. ( Gillings, D; Koch, G; Reich, T; Stager, WJ, 1987)
" The positive results derived from pentoxifylline treatment are significant because, for the first time, treadmill testing can prove the effectiveness of a hemorheologic drug, such as pentoxifylline, in the treatment of patients with intermittent claudication."7.66Peripheral vasodilators versus pentoxifylline for the treatment of intermittent claudication. ( Aviado, DM, 1983)
" The dosage was 3 tablets of either formulation t."6.65Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication. ( Di Perri, T; Guerrini, M, 1983)
"To review the evidence for efficacy of three contemporary treatments for intermittent claudication: pentoxifylline, exercise programs, and smoking cessation."6.16Conservative management of intermittent claudication. ( Radack, K; Wyderski, RJ, 1990)
"The efficacy and safety of pentoxifylline (400 mg tid orally) and acenocoumarol, administered singly or in combination, in the treatment of intermittent claudication associated with chronic occlusive arterial disease were evaluated in a multi-center, randomized, factorial, blind clinical trial involving 146 patients."5.06Acenocoumarol and pentoxifylline in intermittent claudication. A controlled clinical study. The APIC Study Group. ( Basevi, P; Dettori, AG; Di Lecce, C; Manotti, C; Moratti, A; Paolicelli, M; Pini, M; Quintavalla, R, 1989)
"The effects of pentoxifylline on intermittent claudication were evaluated at a dose of 1200 mg/day in an open-label twelve-week study on geriatric patients with chronic occlusive arterial disease (COAD)."5.06Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication. ( Cobert, BL; Cohn, JB; Crowder, JE; Hryniewicki, SW; Morgan, DL; Piccirillo, RT; Savitsky, JP; Slywka, J; Wilcox, CS, 1989)
"The efficacy of Trental (pentoxifylline) in the treatment of intermittent claudication was evaluated in 14 double-blind randomized studies, involving 475 patients with chronic occlusive vascular disease."5.06On the assessment of the efficacy of pentoxifylline (Trental). ( Müller, R; Rössner, M, 1987)
"Pentoxifylline has been shown to improve treadmill walking distances under blinded, controlled conditions in patients with intermittent claudication."5.06Effects of pentoxifylline on severe intermittent claudication. ( Gillings, D; Reich, T, 1987)
"Ten patients with Stage II chronic arterial occlusive disease (intermittent claudication) took part in a randomized, intraindividual crossover study involving acute intravenous administration of 200 mg pentoxifylline or physiological saline solution (placebo)."5.06Influence of pentoxifylline on muscle tissue oxygen tension (pO2) of patients with intermittent claudication before and after pedal ergometer exercise. ( Ehrly, AM; Saeger-Lorenz, K, 1987)
"Pentoxifylline, a methyl xanthine analogue was evaluated for treatment of intermittent claudication in a double-blind placebo controlled parallel group study in seven centers in the United States."5.05Pentoxifylline in the treatment of intermittent claudication of the lower limbs. ( Cutler, BC; Lee, BY; Porter, JM; Reich, T; Reichle, FA; Scogin, JT; Strandness, DE, 1984)
"Twenty-six patients with severe short-distance claudication underwent a 24-week, randomized, double-blind, parallel-group evaluation of the efficacy of pentoxifylline in the treatment of intermittent claudication."5.05Pharmacologic treatment of intermittent claudication. ( Bauer, GM; Porter, JM, 1982)
"The influence of the xanthine derivative pentoxifylline ('Trental' or BL191; Hoechst-Roussel) on exercise tolerance was measured in 38 subjects with stable, severe to moderately severe, intermittent claudication who completed a randomised, double-blind, placebo controlled, cross-over clinical trial."5.05Intermittent claudication: a double-blind crossover trial of pentoxifylline. ( Alderman, M; Chivers, D; Dupont, P; Gallus, AS; Gleadow, F; Morley, AA; Walsh, J; Wenzel, A, 1985)
"Pentoxifylline is approved by the Food and Drug Administration for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs."4.77Pentoxifylline: a new agent for intermittent claudication. ( Baker, DE; Campbell, RK, 1985)
"Pentoxifylline was significantly more effective than the placebo in increasing both the initial and absolute claudication distance (ICD and ACD) in patients with peripheral chronic occlusive arterial disease (COAD)."3.76Pentoxifylline (Trental)--a new drug for the treatment of peripheral chronic occlusive arterial disease. ( Aggarwal, KK; Chopra, HK; Chopra, KL; Parashar, SK, 1988)
"We have previously shown that pentoxifylline, a drug used in intermittent claudication, causes depolymerization of actin in leukocytes in vitro."3.68Effects of pentoxifylline administration on blood viscosity and leukocyte cytoskeletal function in patients with intermittent claudication. ( Cohen, HJ; Crawford, J; Currie, MS; Rao, KM; Simel, DL, 1990)
"All patients who had intermittent claudication (IC) over an 18-month period were given prescriptions for pentoxifylline (PTFX) 400 mg, three times daily."3.67The effects of pentoxifylline on patients with intermittent claudication. ( Green, RM; McNamara, J, 1988)
"Porter et al have reported that pentoxifylline shows statistically significant superiority over placebo in a seven-center, double-blind, parallel group, randomized trial of outpatients with intermittent claudication secondary to chronic occlusive arterial disease."3.67Another look at the pentoxifylline efficacy data for intermittent claudication. ( Gillings, D; Koch, G; Reich, T; Stager, WJ, 1987)
" The positive results derived from pentoxifylline treatment are significant because, for the first time, treadmill testing can prove the effectiveness of a hemorheologic drug, such as pentoxifylline, in the treatment of patients with intermittent claudication."3.66Peripheral vasodilators versus pentoxifylline for the treatment of intermittent claudication. ( Aviado, DM, 1983)
"In an open clinical trial 14 patients with intermittent claudication caused by an obliteration of the femoral artery received 400 mg pentoxifylline 3 times daily over a period of 6 months."3.66[The influence of chronic pentroxifylline medication on ergometric and hemodynamic parameters in intermittent claudication (author's transl)]. ( Brock, FE; Nobbe, F; Rudofsky, G; Ulrich, M, 1979)
" The dosage was 3 tablets of either formulation t."2.65Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication. ( Di Perri, T; Guerrini, M, 1983)

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-199055 (93.22)18.7374
1990's4 (6.78)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aviado, DM2
Skovborg, F1
Bonde-Petersen, F1
Bloch, I1
Christensen, E1
Donaldson, DR1
Hall, TJ1
Kester, RC1
Ramsden, CW1
Wiggins, PA1
Perhoniemi, V1
Salmenkivi, K1
Sundberg, S1
Johnsson, R1
Gordin, A1
Reich, T4
Cutler, BC1
Lee, BY3
Porter, JM4
Reichle, FA2
Scogin, JT2
Strandness, DE2
Roekaerts, F1
Deleers, L1
Dettelbach, HR1
Strano, A1
Davi, G1
Avellone, G1
Novo, S1
Pinto, A1
Petruzzi, E1
Bucalossi, A1
Corri, S1
Marsilii, A1
Di Noto, C1
Di Perri, T2
Guerrini, M1
Cutler, BS1
Bauer, GM1
Nobbe, F2
Rudofsky, G2
Brock, FE1
Ulrich, M1
Völker, D1
Radack, K1
Wyderski, RJ1
Ambrus, JL1
Stadler, S1
Bannerman, R1
Rao, KM1
Simel, DL1
Cohen, HJ1
Crawford, J1
Currie, MS1
AbuRahma, AF1
Woodruff, BA1
Weinholdt, T1
Schwartz, RW1
Logan, NM1
Johnson, PJ1
Strodel, WE1
Fine, JG1
Kazmers, A1
Hyde, GL1
Dettori, AG1
Pini, M1
Moratti, A1
Paolicelli, M1
Basevi, P1
Quintavalla, R1
Manotti, C1
Di Lecce, C1
Haussler, KF1
Künkel, HP1
Schneider-May, H1
Spengel, F1
Symann, O1
Werner, HJ1
Crowder, JE1
Cohn, JB1
Savitsky, JP3
Morgan, DL1
Slywka, J1
Cobert, BL1
Hryniewicki, SW1
Piccirillo, RT1
Wilcox, CS1
Lindgärde, F1
Jelnes, R1
Björkman, H1
Adielsson, G1
Kjellström, T1
Palmquist, I1
Stavenow, L1
Gadeholt, G1
Taylor, LM1
Chopra, HK1
Chopra, KL1
Aggarwal, KK1
Parashar, SK1
Cameron, HA1
Waller, PC1
Ramsay, LE1
Roeren, T1
LeVeen, RF1
Nugent, L1
Johnson, G1
Rössner, M1
Müller, R1
Gillings, D2
Kiesewetter, H1
Blume, J1
Jung, F1
Gerhards, M1
Leipnitz, G1
Hawkins, ES1
Ribeiro, HA1
Reilly, DT2
Quinton, DN1
Barrie, WW1
Green, RM1
McNamara, J1
Matrai, A1
Ernst, E1
Gómez Reyes, D1
Rojas Hidalgo, E1
Thomas, JH1
Swannack, CJ1
McAnaw, M1
Klein, S1
Kinnaman, ML1
Iliopoulos, JI1
Hermreck, AS1
Pierce, GE1
Simpson, LO2
Ehrly, AM1
Saeger-Lorenz, K1
Loyd, RG1
Prian, GW1
Gomez, H1
Laub, J1
Mertz, GH1
Spittell, JA1
Johnson, WC1
Sentissi, JM1
Baldwin, D1
Hamilton, J1
Dion, J1
Hartshorn, JC1
Deans, KW1
Koch, G1
Stager, WJ1
Pierce, WL1
Crowhurst, JA1
Caneva, RG1
Gallus, AS1
Gleadow, F1
Dupont, P1
Walsh, J1
Morley, AA1
Wenzel, A1
Alderman, M1
Chivers, D1
Baker, DE1
Campbell, RK1
Spittel, JA1
Berkowitz, P1
May, GS1
Brobst, J1
McCann, WJ1
Pepper, GA1
Dammann, C1

Reviews

6 reviews available for theobromine and Intermittent Claudication

ArticleYear
Clinical considerations and treatment of diabetic angiopathy.
    Journal of medicine, 1979, Volume: 10, Issue:5

    Topics: Adult; Arterial Occlusive Diseases; Coronary Disease; Diabetic Angiopathies; Humans; Intermittent Cl

1979
Conservative management of intermittent claudication.
    Annals of internal medicine, 1990, Jul-15, Volume: 113, Issue:2

    Topics: Double-Blind Method; Exercise Therapy; Humans; Intermittent Claudication; Locomotion; Meta-Analysis

1990
Pentoxifylline (Trental)--a new drug for the treatment of peripheral chronic occlusive arterial disease.
    Journal of medicine, 1988, Volume: 19, Issue:2

    Topics: Administration, Oral; Adult; Aged; Arterial Occlusive Diseases; Clinical Trials as Topic; Female; Hu

1988
[Treatment of vascular diseases of the extremities using pentoxifylline].
    La Ricerca in clinica e in laboratorio, 1988, Volume: 18 Suppl 2

    Topics: Aminophylline; Arteriosclerosis Obliterans; Clinical Trials as Topic; Drug Evaluation; Humans; Inter

1988
Pentoxifylline review.
    Journal of the American Podiatric Medical Association, 1987, Volume: 77, Issue:12

    Topics: Aminophylline; Biomechanical Phenomena; Humans; Intermittent Claudication; Pentoxifylline; Theobromi

1987
Pentoxifylline: a new agent for intermittent claudication.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:5

    Topics: Delayed-Action Preparations; Half-Life; Humans; Intermittent Claudication; Kinetics; Pentoxifylline;

1985

Trials

29 trials available for theobromine and Intermittent Claudication

ArticleYear
[Intermittent claudication treated with pentoxifylline. A controlled trial].
    Ugeskrift for laeger, 1983, Nov-21, Volume: 145, Issue:47

    Topics: Aged; Blood Viscosity; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intermittent C

1983
Does oxpentifylline ('Trental') have a place in the treatment of intermittent claudication?
    Current medical research and opinion, 1984, Volume: 9, Issue:1

    Topics: Adult; Aged; Blood Viscosity; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Membrane; F

1984
Effects of flunarizine and pentoxifylline on walking distance and blood rheology in claudication.
    Angiology, 1984, Volume: 35, Issue:6

    Topics: Aged; Arteriosclerosis; Blood Pressure; Blood Viscosity; Cinnarizine; Clinical Trials as Topic; Doub

1984
Pentoxifylline in the treatment of intermittent claudication of the lower limbs.
    Angiology, 1984, Volume: 35, Issue:7

    Topics: Clinical Trials as Topic; Female; Humans; Intermittent Claudication; Male; Middle Aged; Pentoxifylli

1984
Trental 400 in the treatment of intermittent claudication: results of long-term, placebo-controlled administration.
    Angiology, 1984, Volume: 35, Issue:7

    Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intermittent Claudication; Male

1984
Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs.
    Angiology, 1984, Volume: 35, Issue:7

    Topics: Adenosine Diphosphate; Aged; Blood Flow Velocity; Blood Viscosity; Cholesterol; Clinical Trials as T

1984
Pentoxifylline for intermittent claudication.
    The Medical letter on drugs and therapeutics, 1984, Nov-23, Volume: 26, Issue:675

    Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Intermittent Claudication; Pentoxifylline; Th

1984
Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication.
    Angiology, 1983, Volume: 34, Issue:1

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intermittent Claudicatio

1983
Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients.
    American heart journal, 1982, Volume: 104, Issue:1

    Topics: Aged; Arterial Occlusive Diseases; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; E

1982
Pharmacologic treatment of intermittent claudication.
    Surgery, 1982, Volume: 92, Issue:6

    Topics: Double-Blind Method; Drug Evaluation; Erythrocytes; Female; Humans; Intermittent Claudication; Male;

1982
[Treatment of arterial diseases with trental 400. Results of a double-blind study].
    Die Medizinische Welt, 1978, Aug-11, Volume: 29, Issue:32

    Topics: Arterial Occlusive Diseases; Double-Blind Method; Drug Evaluation; Humans; Intermittent Claudication

1978
Conservative management of intermittent claudication.
    Annals of internal medicine, 1990, Jul-15, Volume: 113, Issue:2

    Topics: Double-Blind Method; Exercise Therapy; Humans; Intermittent Claudication; Locomotion; Meta-Analysis

1990
Acenocoumarol and pentoxifylline in intermittent claudication. A controlled clinical study. The APIC Study Group.
    Angiology, 1989, Volume: 40, Issue:4 Pt 1

    Topics: Acenocoumarol; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Extremities

1989
Intravenous treatment of chronic peripheral occlusive arterial disease: a double-blind, placebo-controlled, randomized, multicenter trial of pentoxifylline.
    Angiology, 1989, Volume: 40, Issue:7

    Topics: Adult; Aged; Arterial Occlusive Diseases; Blood Pressure; Clinical Trials as Topic; Double-Blind Met

1989
Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication.
    Angiology, 1989, Volume: 40, Issue:9

    Topics: Aged; Arterial Occlusive Diseases; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Electr

1989
Conservative drug treatment in patients with moderately severe chronic occlusive peripheral arterial disease. Scandinavian Study Group.
    Circulation, 1989, Volume: 80, Issue:6

    Topics: Aged; Arterial Occlusive Diseases; Blood Pressure; Double-Blind Method; Female; Humans; Intermittent

1989
Pentoxifylline (Trental)--a new drug for the treatment of peripheral chronic occlusive arterial disease.
    Journal of medicine, 1988, Volume: 19, Issue:2

    Topics: Administration, Oral; Adult; Aged; Arterial Occlusive Diseases; Clinical Trials as Topic; Female; Hu

1988
Drug treatment of intermittent claudication: a critical analysis of the methods and findings of published clinical trials, 1965-1985.
    British journal of clinical pharmacology, 1988, Volume: 26, Issue:5

    Topics: Clinical Trials as Topic; Exercise Test; Female; Humans; Hydrocarbons, Chlorinated; Intermittent Cla

1988
[Treatment of vascular diseases of the extremities using pentoxifylline].
    La Ricerca in clinica e in laboratorio, 1988, Volume: 18 Suppl 2

    Topics: Aminophylline; Arteriosclerosis Obliterans; Clinical Trials as Topic; Drug Evaluation; Humans; Inter

1988
On the assessment of the efficacy of pentoxifylline (Trental).
    Journal of medicine, 1987, Volume: 18, Issue:1

    Topics: Animals; Cats; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intermittent Claudicat

1987
Effects of pentoxifylline on severe intermittent claudication.
    Angiology, 1987, Volume: 38, Issue:9

    Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intermittent Claudication; Loco

1987
[Training by walking and drug therapy of peripheral arterial occlusive disease].
    VASA. Supplementum, 1987, Volume: 20

    Topics: Aged; Arterial Occlusive Diseases; Clinical Trials as Topic; Combined Modality Therapy; Double-Blind

1987
A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects.
    The New Zealand medical journal, 1987, Jul-22, Volume: 100, Issue:828

    Topics: Adult; Aged; Blood Viscosity; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Deformabili

1987
Pentoxifylline and intermittent claudication.
    The New Zealand medical journal, 1987, Aug-26, Volume: 100, Issue:830

    Topics: Erythrocyte Deformability; Humans; Intermittent Claudication; Pentoxifylline; Theobromine

1987
Pentoxifylline and intermittent claudication.
    The New Zealand medical journal, 1987, Oct-14, Volume: 100, Issue:833

    Topics: Erythrocyte Deformability; Humans; Intermittent Claudication; Pentoxifylline; Theobromine

1987
Pentoxifylline and intermittent claudication.
    The New Zealand medical journal, 1987, Nov-11, Volume: 100, Issue:835

    Topics: Erythrocyte Deformability; Humans; Intermittent Claudication; Pentoxifylline; Theobromine

1987
Influence of pentoxifylline on muscle tissue oxygen tension (pO2) of patients with intermittent claudication before and after pedal ergometer exercise.
    Angiology, 1987, Volume: 38, Issue:2 Pt 1

    Topics: Arterial Occlusive Diseases; Chronic Disease; Clinical Trials as Topic; Exercise Test; Humans; Inter

1987
Intermittent claudication: a double-blind crossover trial of pentoxifylline.
    Australian and New Zealand journal of medicine, 1985, Volume: 15, Issue:4

    Topics: Aged; Blood Flow Velocity; Double-Blind Method; Exercise Test; Female; Humans; Intermittent Claudica

1985
[Experiences with new Cosaldon forms].
    Medizinische Klinik, 1969, Feb-21, Volume: 64, Issue:8

    Topics: Adult; Aged; Arteriosclerosis; Cholesterol; Dosage Forms; Female; Geriatrics; Humans; Hypertension;

1969

Other Studies

27 other studies available for theobromine and Intermittent Claudication

ArticleYear
Peripheral vasodilators versus pentoxifylline for the treatment of intermittent claudication.
    La Ricerca in clinica e in laboratorio, 1983, Volume: 13 Suppl 3

    Topics: Absorption; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Ancrod; Double-Blind Method; Dru

1983
Pharmacology of pentoxifylline, a hemorheologic agent for the treatment of intermittent claudication.
    Angiology, 1984, Volume: 35, Issue:7

    Topics: Absorption; Ancrod; Blood Viscosity; Epoprostenol; Erythrocytes; Hemodynamics; History, 20th Century

1984
[Use of pentoxifylline in diabetes with intermittent claudication].
    La Ricerca in clinica e in laboratorio, 1983, Volume: 13 Suppl 3

    Topics: Cholesterol; Diabetic Angiopathies; Erythrocytes; Fibrinogen; Glycated Hemoglobin; Humans; Intermitt

1983
[The influence of chronic pentroxifylline medication on ergometric and hemodynamic parameters in intermittent claudication (author's transl)].
    Medizinische Klinik, 1979, Jul-13, Volume: 74, Issue:28-29

    Topics: Arterial Occlusive Diseases; Exercise Therapy; Femoral Artery; Humans; Hyperemia; Intermittent Claud

1979
Effect of pentoxifylline on carbohydrate metabolism in type II diabetics.
    Archives of internal medicine, 1990, Volume: 150, Issue:4

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Intermittent Claudication; Pentoxifylline; Theobro

1990
Effects of pentoxifylline administration on blood viscosity and leukocyte cytoskeletal function in patients with intermittent claudication.
    The Journal of laboratory and clinical medicine, 1990, Volume: 115, Issue:6

    Topics: Actins; Blood Viscosity; Cell Separation; Colchicine; Cytoskeleton; Drug Evaluation; Humans; Immunol

1990
Effects and limitations of pentoxifylline therapy in various stages of peripheral vascular disease of the lower extremity.
    American journal of surgery, 1990, Volume: 160, Issue:3

    Topics: Diabetes Complications; Humans; Intermittent Claudication; Leg; Locomotion; Pentoxifylline; Severity

1990
[Drug therapy in intermittent claudication].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1989, Nov-20, Volume: 109, Issue:32

    Topics: Drug Information Services; Humans; Intermittent Claudication; Norway; Pentoxifylline; Theobromine

1989
Pentoxifylline increases extremity blood flow in diabetic atherosclerotic patients.
    Archives of surgery (Chicago, Ill. : 1960), 1989, Volume: 124, Issue:4

    Topics: Arteries; Arteriosclerosis; Diabetes Mellitus; Diabetic Angiopathies; Exercise Test; Female; Humans;

1989
[Drug therapy of intermittent claudication].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1989, Sep-30, Volume: 109, Issue:27

    Topics: Humans; Intermittent Claudication; Pentoxifylline; Theobromine

1989
Drug treatment of claudication: vasodilators, hemorrheologic agents, and antiserotonin drugs.
    Journal of vascular surgery, 1986, Volume: 3, Issue:2

    Topics: Double-Blind Method; Erythrocyte Deformability; Humans; Intermittent Claudication; Ketanserin; Pento

1986
Photoplethysmographic documentation of improved microcirculation after pentoxifylline therapy.
    Angiology, 1988, Volume: 39, Issue:11

    Topics: Follow-Up Studies; Humans; Intermittent Claudication; Leg; Male; Microcirculation; Middle Aged; Pent

1988
Pentoxifylline and claudication.
    Journal of vascular surgery, 1988, Volume: 8, Issue:5

    Topics: Blood Viscosity; Exercise; Humans; Intermittent Claudication; Pentoxifylline; Theobromine

1988
The effects of pentoxifylline on patients with intermittent claudication.
    Journal of vascular surgery, 1988, Volume: 7, Issue:2

    Topics: Drug Evaluation; Follow-Up Studies; Humans; Intermittent Claudication; Pentoxifylline; Theobromine;

1988
[Improvement in leukocyte rheology with pentoxifylline].
    Medizinische Klinik (Munich, Germany : 1983), 1988, Jan-29, Volume: 83, Issue:2

    Topics: Humans; Intermittent Claudication; Leukocytes; Membrane Fluidity; Pentoxifylline; Theobromine

1988
[Therapeutic results with xanthine derivatives in the intermittent claudication syndrome in diabetic patients].
    Revista clinica espanola, 1988, Volume: 182, Issue:1

    Topics: Adult; Aged; Diabetic Angiopathies; Drug Therapy, Combination; Female; Humans; Intermittent Claudica

1988
Determinants of response to pentoxifylline therapy in patients with intermittent claudication.
    American journal of surgery, 1987, Volume: 154, Issue:6

    Topics: Adult; Aged; Blood Pressure; Female; Humans; Intermittent Claudication; Locomotion; Male; Middle Age

1987
Failure of pentoxifylline for end-stage peripheral vascular disease.
    Angiology, 1987, Volume: 38, Issue:4

    Topics: Aged; Aged, 80 and over; Arterial Occlusive Diseases; Coronary Disease; Humans; Intermittent Claudic

1987
Pentoxifylline and vascular disease.
    Rational drug therapy, 1986, Volume: 20, Issue:11

    Topics: Humans; Intermittent Claudication; Pentoxifylline; Theobromine; Vascular Diseases

1986
Treatment of claudication with pentoxifylline: are benefits related to improvement in viscosity?
    Journal of vascular surgery, 1987, Volume: 6, Issue:3

    Topics: Blood Viscosity; Drug Evaluation; Exercise Test; Humans; Intermittent Claudication; Pentoxifylline;

1987
Pharmacologic treatment of intermittent claudication with special emphasis on pentoxifylline.
    The Journal of cardiovascular nursing, 1987, Volume: 1, Issue:2

    Topics: Humans; Intermittent Claudication; Patient Education as Topic; Pentoxifylline; Theobromine

1987
Another look at the pentoxifylline efficacy data for intermittent claudication.
    Journal of clinical pharmacology, 1987, Volume: 27, Issue:8

    Topics: Aged; Aged, 80 and over; Exercise Test; Female; Humans; Intermittent Claudication; Male; Middle Aged

1987
Pentoxifylline. A new drug review and case report.
    Journal of the American Podiatric Medical Association, 1986, Volume: 76, Issue:7

    Topics: Aged; Diabetic Neuropathies; Humans; Intermittent Claudication; Male; Pentoxifylline; Theobromine

1986
Hemorheology and therapy of vascular disease.
    American pharmacy, 1986, Volume: NS26, Issue:8

    Topics: Blood Circulation; Humans; Intermittent Claudication; Pentoxifylline; Rheology; Theobromine

1986
Pentoxifylline and intermittent claudication.
    Annals of internal medicine, 1985, Volume: 102, Issue:1

    Topics: Blood Viscosity; Erythrocyte Deformability; Humans; Intermittent Claudication; Pentoxifylline; Theob

1985
Pentoxifylline treatment of moderate to severe chronic occlusive arterial disease.
    Clinical cardiology, 1985, Volume: 8, Issue:3

    Topics: Aged; Arterial Occlusive Diseases; Exercise Test; Humans; Intermittent Claudication; Ischemia; Leg;

1985
New drug for intermittent claudication.
    The Nurse practitioner, 1985, Volume: 10, Issue:5

    Topics: Humans; Intermittent Claudication; Patient Education as Topic; Pentoxifylline; Theobromine

1985