Page last updated: 2024-11-05

theobromine and Edema

theobromine has been researched along with Edema in 11 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"The activation of adenosine A2a receptors modulates the pathology of acute pancreatitis through at least two diverse properties."7.71Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. ( Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T; Yamagiwa, T, 2002)
" Additionally, incarvillateine attenuated mechanical allodynia induced by spared nerve injury or paclitaxel, whereas normal mechanical sensation was not affected."3.81Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system. ( Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY, 2015)
" We previously demonstrated that adenosine kinase inhibitors (AKIs) exhibit antiinflammatory effects by inhibiting TNF-alpha production, neutrophil accumulation, and edema formation."3.72Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides. ( Castellino, AJ; DaRe, JS; Erion, MD; Kopcho, JJ; Ramirez-Weinhouse, M; Rosengren, S; Ugarkar, BG, 2003)
"The activation of adenosine A2a receptors modulates the pathology of acute pancreatitis through at least two diverse properties."3.71Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. ( Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T; Yamagiwa, T, 2002)
"The effects of oral administration of UP 202-56, an adenosine analogue, were assessed on carrageenan-induced spinal c-Fos protein expression and peripheral oedema."3.70UP 202-56, an adenosine analogue, selectively acts via A1 receptors to significantly decrease noxiously-evoked spinal c-Fos protein expression. ( Besson, JM; Buritova, J; Chapman, V; Honoré, P, 1998)
" In the present study, we examined the antinociceptive and anti-inflammatory effects produced by the peripheral (intraplantar) administration of 5'-amino-5'-deoxyadenosine (an adenosine kinase inhibitor), 2'-deoxycoformycin (an adenosine deaminase inhibitor), and combinations of both agents in the carrageenan-induced thermal hyperalgesia and paw oedema model in the rat."3.70Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ( Poon, A; Sawynok, J, 1999)
"Pentoxifylline (PF) has been shown to increase tissue oxygen tension."1.27Protective effect of pentoxifylline on gastric mucosa. ( Bui, HX; Sarfeh, IJ; Soliman, MH; Tarnawski, A; Tominaga, G; Waxman, K, 1988)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's3 (27.27)18.2507
2000's2 (18.18)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, ML1
Yu, G1
Yi, SP1
Zhang, FY1
Wang, ZT1
Huang, B1
Su, RB1
Jia, YX1
Gong, ZH1
CONTI, E1
Ugarkar, BG1
Castellino, AJ1
DaRe, JS1
Ramirez-Weinhouse, M1
Kopcho, JJ1
Rosengren, S1
Erion, MD1
Müller, R1
Lehrach, F1
Sawynok, J2
Zarrindast, MR1
Reid, AR1
Doak, GJ1
Honoré, P1
Buritova, J1
Chapman, V1
Besson, JM1
Poon, A1
Satoh, A1
Satoh, K1
Masamune, A1
Yamagiwa, T1
Shimosegawa, T1
Harada, H1
Ishizaka, A1
Yonemaru, M1
Mallick, AA1
Hatherill, JR1
Zheng, H1
Lilly, CM1
O'Hanley, PT1
Raffin, TA1
Tominaga, G1
Waxman, K1
Soliman, MH1
Sarfeh, IJ1
Bui, HX1
Tarnawski, A1
Fujii, T1
Nishimura, H1

Reviews

1 review available for theobromine and Edema

ArticleYear
Haemorheology and cerebrovascular disease: multifunctional approach with pentoxifylline.
    Current medical research and opinion, 1981, Volume: 7, Issue:4

    Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Edema; Humans; Oxygen Consumption; Pentoxify

1981

Other Studies

10 other studies available for theobromine and Edema

ArticleYear
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.
    Scientific reports, 2015, Nov-03, Volume: 5

    Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease

2015
[Clinical study on the diuretic effect of the combined administration of 1-beta-hydroxypropyl-theobromine and 6-chloro-7-sulfamyl-1,2,4-benzothiodiazine-1, 1-dioxido in heart patients with water retention].
    Gazzetta medica italiana, 1961, Volume: 120

    Topics: Chlorothiazide; Combined Modality Therapy; Diuretics; Edema; Heart Failure; Theobromine; Water-Elect

1961
Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides.
    Journal of medicinal chemistry, 2003, Oct-23, Volume: 46, Issue:22

    Topics: Adenosine Kinase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug

2003
Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine.
    European journal of pharmacology, 1997, Aug-20, Volume: 333, Issue:1

    Topics: Animals; Behavior, Animal; Body Temperature; Edema; Histamine Release; Injections, Subcutaneous; Mal

1997
UP 202-56, an adenosine analogue, selectively acts via A1 receptors to significantly decrease noxiously-evoked spinal c-Fos protein expression.
    Pain, 1998, Volume: 75, Issue:2-3

    Topics: Adenosine; Administration, Oral; Animals; Carrageenan; Edema; Hindlimb; Indoles; Male; Proto-Oncogen

1998
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
    European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3

    Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Analgesics; Animals; Anti-Inf

1999
Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis.
    Pancreas, 2002, Volume: 24, Issue:1

    Topics: Adenosine; Amylases; Animals; Ceruletide; Edema; Leukocytes; Male; Pancreatitis; Phenethylamines; Pu

2002
The effects of aminophylline and pentoxifylline on multiple organ damage after Escherichia coli sepsis.
    The American review of respiratory disease, 1989, Volume: 140, Issue:4

    Topics: Albumins; Aminophylline; Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Edema; Escherichia c

1989
Protective effect of pentoxifylline on gastric mucosa.
    The Journal of surgical research, 1988, Volume: 44, Issue:6

    Topics: Animals; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Contents; Hydrogen-Ion Concentration; Oxyg

1988
Fetal hypoproteinemia associated with generalized edema caused by administration of methyl xanthines to the rat during late pregnancy.
    Japanese journal of pharmacology, 1973, Volume: 23, Issue:6

    Topics: Animals; Blood Proteins; Body Water; Body Weight; Caffeine; Edema; Female; Fetal Diseases; Fetus; Ge

1973