theobromine has been researched along with Disease Models, Animal in 33 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The increasing incidence of multidrug-resistant (MDR) pulmonary infections in the cystic fibrosis (CF) population has prompted the investigation of innovative silver based therapeutics." | 7.75 | A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens. ( Cannon, CL; Han, DS; Hindi, KM; Panzner, MJ; Taylor, JB; Wright, BD; Youngs, WJ, 2009) |
| " Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects." | 7.73 | Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. ( Chaimovitz, C; Douvdevani, A; Mazar, J; Nakav, S; Rogachev, B; Ziv, NY; Zlotnik, M, 2006) |
| " Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks." | 7.71 | Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001) |
| " The effect of the haemorrheological agent pentoxifylline was investigated in a canine model of acute myocardial infarction, induced by occlusion of the left anterior descending coronary for 6 h." | 7.67 | Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction. ( Campbell, CA; Clavenna, CF; Kloner, RA; Wynne, J, 1988) |
| "Cough is a common and protective reflex, but persistent coughing is debilitating and impairs quality of life." | 6.71 | Theobromine inhibits sensory nerve activation and cough. ( Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Korbonits, D; Korbonits, M; Patel, HJ; Usmani, OS, 2005) |
| "Transient global cerebral ischemia (tGCI) is a cerebrovascular disorder characterized by a brief decline in blood flow, neurological deficits, and is often predictive of stroke." | 5.62 | Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model. ( Bhat, JA; Gupta, S; Kumar, M, 2021) |
| "Ten patients with chronic occlusive arteriosclerosis received single oral doses of 100, 200, 400, 800, and 1200 mg pentoxifylline in a single-blind, placebo-controlled study." | 5.06 | Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies. ( Ambrus, JL; Anain, JM; Anain, PM; Anain, SM; Brobst, JA; Cobert, BL; Mitchell, P; Savitsky, JP; Stadler, S, 1990) |
| " Additionally, incarvillateine attenuated mechanical allodynia induced by spared nerve injury or paclitaxel, whereas normal mechanical sensation was not affected." | 3.81 | Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system. ( Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY, 2015) |
| "The increasing incidence of multidrug-resistant (MDR) pulmonary infections in the cystic fibrosis (CF) population has prompted the investigation of innovative silver based therapeutics." | 3.75 | A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens. ( Cannon, CL; Han, DS; Hindi, KM; Panzner, MJ; Taylor, JB; Wright, BD; Youngs, WJ, 2009) |
| "Evaluate the potential inhibition of cough in a mouse model induced by sulfur dioxide gas of methanol and chloroform extracts of aerial parts of Chamaedorea tepejilote." | 3.74 | Evaluation of anti-tussive activity of Chamaedorea tepejilote. ( Pérez G, C; Pérez G, S; Ponce M, H; Ventura R, E; Zavala S, MA, 2008) |
| " Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects." | 3.73 | Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. ( Chaimovitz, C; Douvdevani, A; Mazar, J; Nakav, S; Rogachev, B; Ziv, NY; Zlotnik, M, 2006) |
| " Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks." | 3.71 | Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001) |
| "The beneficial effects of post-insult administration of pentoxifylline, a novel hemorheologic agent experimentally studied in various ischemic diseases, were evaluated in two models of acute renal failure (ARF): direct nephrotoxicity (mercuric chloride 4 mg/kg via femoral vein) and hemoglobinuria (glycerol 10 ml/kg i." | 3.67 | Effects of pentoxifylline in experimental acute renal failure. ( Brunner, LJ; Luke, DR; Vadiei, K, 1989) |
| " The effect of the haemorrheological agent pentoxifylline was investigated in a canine model of acute myocardial infarction, induced by occlusion of the left anterior descending coronary for 6 h." | 3.67 | Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction. ( Campbell, CA; Clavenna, CF; Kloner, RA; Wynne, J, 1988) |
| "Cough is a common and protective reflex, but persistent coughing is debilitating and impairs quality of life." | 2.71 | Theobromine inhibits sensory nerve activation and cough. ( Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Korbonits, D; Korbonits, M; Patel, HJ; Usmani, OS, 2005) |
| "Pentoxifylline (Trental) is a well-known vasoactive drug with proven clinical efficacy in various circulatory disorders." | 2.38 | The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug. ( Schade, UF; Schönharting, MM, 1989) |
| "Treatment with theobromine significantly attenuated neurological deficits and improved sensorimotor functions and memory in rats with CH." | 1.72 | Neuroprotective Effects of Theobromine in permanent bilateral common carotid artery occlusion rat model of cerebral hypoperfusion. ( Bhat, JA; Kumar, M, 2022) |
| "Transient global cerebral ischemia (tGCI) is a cerebrovascular disorder characterized by a brief decline in blood flow, neurological deficits, and is often predictive of stroke." | 1.62 | Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model. ( Bhat, JA; Gupta, S; Kumar, M, 2021) |
| "Dementia caused by Alzheimer's disease (AD) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (Aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus." | 1.46 | Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. ( Berumen, LC; García-Alcocer, G; Mendiola-Precoma, J; Miledi, R; Padilla, K; Rodríguez-Cruz, A, 2017) |
| "potentiated seizures induced by the selective adenosine A1 receptor antagonist 8-[4-[[[[(2-aminoethyl)amino]carbonyl]methyl]oxy]-phenyl]- 1,3-dipropylxanthine (XAC)." | 1.29 | Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models. ( Klitgaard, H; Knutsen, LJ; Thomsen, C, 1993) |
| " A total of 48 rats were orally dosed with CSA 25 mg/kg for 10 days with either PTX 45 mg/kg i." | 1.28 | Prevention of cyclosporine-induced nephrotoxicity with pentoxifylline. ( Brunner, LJ; Iyer, LV; Luke, DR; Vadiei, K, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 6 (18.18) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 6 (18.18) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Bhat, JA | 2 |
| Kumar, M | 2 |
| Shojaei-Zarghani, S | 1 |
| Yari Khosroushahi, A | 1 |
| Rafraf, M | 1 |
| Gupta, S | 1 |
| Ruchel, JB | 1 |
| Bernardes, VM | 1 |
| Braun, JBS | 1 |
| Manzoni, AG | 1 |
| Passos, DF | 1 |
| Castilhos, LG | 1 |
| Abdalla, FH | 1 |
| de Oliveira, JS | 1 |
| de Andrade, CM | 1 |
| Casali, EA | 1 |
| da Cruz, IBM | 1 |
| Leal, DBR | 1 |
| Papadimitriou, A | 1 |
| Silva, KC | 1 |
| Peixoto, EB | 1 |
| Borges, CM | 1 |
| Lopes de Faria, JM | 1 |
| Lopes de Faria, JB | 1 |
| Minutoli, L | 1 |
| Arena, S | 1 |
| Antonuccio, P | 1 |
| Romeo, C | 1 |
| Bitto, A | 1 |
| Magno, C | 1 |
| Rinaldi, M | 1 |
| Micali, A | 1 |
| Irrera, N | 1 |
| Pizzino, G | 1 |
| Galfo, F | 1 |
| Squadrito, F | 1 |
| Altavilla, D | 1 |
| Marini, H | 1 |
| Wang, ML | 1 |
| Yu, G | 1 |
| Yi, SP | 1 |
| Zhang, FY | 1 |
| Wang, ZT | 1 |
| Huang, B | 1 |
| Su, RB | 1 |
| Jia, YX | 1 |
| Gong, ZH | 1 |
| Mendiola-Precoma, J | 1 |
| Padilla, K | 1 |
| Rodríguez-Cruz, A | 1 |
| Berumen, LC | 1 |
| Miledi, R | 1 |
| García-Alcocer, G | 1 |
| Oñatibia-Astibia, A | 1 |
| Franco, R | 1 |
| Martínez-Pinilla, E | 1 |
| Pérez G, C | 1 |
| Zavala S, MA | 1 |
| Ventura R, E | 1 |
| Pérez G, S | 1 |
| Ponce M, H | 1 |
| Panzner, MJ | 1 |
| Hindi, KM | 1 |
| Wright, BD | 1 |
| Taylor, JB | 1 |
| Han, DS | 1 |
| Youngs, WJ | 1 |
| Cannon, CL | 1 |
| Usmani, OS | 1 |
| Belvisi, MG | 1 |
| Patel, HJ | 1 |
| Crispino, N | 1 |
| Birrell, MA | 1 |
| Korbonits, M | 1 |
| Korbonits, D | 1 |
| Barnes, PJ | 1 |
| Rogachev, B | 1 |
| Ziv, NY | 1 |
| Mazar, J | 1 |
| Nakav, S | 1 |
| Chaimovitz, C | 1 |
| Zlotnik, M | 1 |
| Douvdevani, A | 1 |
| Ming, Z | 1 |
| Fan, YJ | 1 |
| Yang, X | 1 |
| Lautt, WW | 1 |
| Gallenkämper, W | 1 |
| Rücker, W | 1 |
| Schrör, K | 1 |
| Sugiura, Y | 1 |
| Kato, T | 1 |
| Goto, Y | 1 |
| Yamamoto, K | 1 |
| Aochi, O | 1 |
| Steen, PA | 1 |
| Michenfelder, JD | 1 |
| Chiang, PH | 1 |
| Wu, SN | 1 |
| Tsai, EM | 1 |
| Wu, CC | 1 |
| Shen, MR | 1 |
| Huang, CH | 1 |
| Chiang, CP | 1 |
| Klitgaard, H | 1 |
| Knutsen, LJ | 1 |
| Thomsen, C | 1 |
| Cronstein, BN | 1 |
| Naime, D | 1 |
| Ostad, E | 1 |
| Reggio, R | 1 |
| Pèzzola, A | 1 |
| Popoli, P | 1 |
| Chen, JF | 1 |
| Xu, K | 1 |
| Petzer, JP | 1 |
| Staal, R | 1 |
| Xu, YH | 1 |
| Beilstein, M | 1 |
| Sonsalla, PK | 1 |
| Castagnoli, K | 1 |
| Castagnoli, N | 1 |
| Schwarzschild, MA | 1 |
| Richter, A | 1 |
| Hamann, M | 1 |
| Yasuda, T | 1 |
| Okamoto, K | 1 |
| Iwamoto, T | 1 |
| Miki, S | 1 |
| Yoshinaga, N | 1 |
| Sato, S | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Dagenais, M | 1 |
| Pomier-Layrargues, G | 1 |
| Rocheleau, B | 1 |
| Giroux, L | 1 |
| Huet, PM | 1 |
| Ambrus, JL | 1 |
| Anain, JM | 2 |
| Anain, SM | 1 |
| Anain, PM | 1 |
| Stadler, S | 1 |
| Mitchell, P | 1 |
| Brobst, JA | 1 |
| Cobert, BL | 1 |
| Savitsky, JP | 1 |
| Brunner, LJ | 2 |
| Vadiei, K | 2 |
| Iyer, LV | 1 |
| Luke, DR | 2 |
| Sáez-Llorens, X | 1 |
| Ramilo, O | 1 |
| Mustafa, MM | 1 |
| Mertsola, J | 1 |
| Hansen, EJ | 1 |
| McCracken, GH | 1 |
| Schönharting, MM | 1 |
| Schade, UF | 1 |
| Campbell, CA | 1 |
| Clavenna, CF | 1 |
| Wynne, J | 1 |
| Kloner, RA | 1 |
2 reviews available for theobromine and Disease Models, Animal
| Article | Year |
|---|---|
Health benefits of methylxanthines in neurodegenerative diseases.
Topics: Animals; Cacao; Caffeine; Coffee; Disease Models, Animal; Humans; Ilex paraguariensis; Meta-Analysis | 2017 |
The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug.
Topics: Animals; Disease Models, Animal; Mice; Pentoxifylline; Shock, Septic; Theobromine | 1989 |
3 trials available for theobromine and Disease Models, Animal
| Article | Year |
|---|---|
Theobromine inhibits sensory nerve activation and cough.
Topics: Adult; Animals; Antitussive Agents; Capsaicin; Citric Acid; Codeine; Cough; Cross-Over Studies; Dise | 2005 |
Adenosine modulation of neurotransmission in penile erection.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Aged; Alprostadil; Animals; Antihypertensive Ag | 1994 |
Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies.
Topics: Animals; Arteriosclerosis; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocyte Def | 1990 |
28 other studies available for theobromine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Neuroprotective Effects of Theobromine in permanent bilateral common carotid artery occlusion rat model of cerebral hypoperfusion.
Topics: Acetylcholinesterase; Animals; Brain; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Commo | 2022 |
Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model.
Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Colon; Colonic Neoplasms; Dimethylhydrazines; | 2021 |
Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model.
Topics: Administration, Oral; Animals; Brain Ischemia; Disease Models, Animal; Female; Glutathione; Ischemic | 2021 |
Lipotoxicity-associated inflammation is prevented by guarana (
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Anim | 2021 |
Theobromine increases NAD⁺/Sirt-1 activity and protects the kidney under diabetic conditions.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Kidney; Male; NAD; Oxidative Stres | 2015 |
Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele.
Topics: Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Fertility; Gene Expression Regul | 2015 |
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.
Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease | 2015 |
Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Brain; Cholesterol; Diet, H | 2017 |
Evaluation of anti-tussive activity of Chamaedorea tepejilote.
Topics: Administration, Oral; Animals; Antitussive Agents; Arecaceae; Cough; Disease Models, Animal; Dose-Re | 2008 |
A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens.
Topics: Animals; Anti-Bacterial Agents; Crystallography, X-Ray; Cystic Fibrosis; Disease Models, Animal; Dos | 2009 |
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Ant | 2006 |
Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Chemical and Drug Ind | 2006 |
Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cathepsin D; Cathepsins; Cats; Coronary Disease; Creatine Kin | 1984 |
[Experimental study on the effect of pentoxifylline on blood rheology and microcirculation--a study using an endotoxin shock model].
Topics: Animals; Blood Flow Velocity; Blood Viscosity; Disease Models, Animal; Microcirculation; Pentoxifyll | 1983 |
Pentoxifylline does not protect mice against hypoxia.
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Energy Metabolism; Hypoxia; Mice; Mice | 1981 |
Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Glutamates; Glutamic Acid; Male; Mice | 1993 |
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-S | 1993 |
The intrastratial injection of an adenosine A(2) receptor antagonist prevents frontal cortex EEG abnormalities in a rat model of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Electroencephalography; Frontal Lobe; Huntington D | 1999 |
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Caffeine; Cat | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; | 2001 |
A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Guinea Pigs; Hyperalgesia; Imm | 2001 |
Systemic and splanchnic haemodynamic effects of pentifylline in rats with portal hypertension.
Topics: Animals; Cardiac Output; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Male; Rats; Rat | 1992 |
Prevention of cyclosporine-induced nephrotoxicity with pentoxifylline.
Topics: Acute Kidney Injury; Animals; Biological Availability; Cyclosporins; Disease Models, Animal; Epopros | 1989 |
Effects of pentoxifylline in experimental acute renal failure.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glycerol; Hemogl | 1989 |
Modulation of meningeal inflammation by treatment with pentoxifylline.
Topics: Animals; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Meningitis, Haemophilus; | 1989 |
Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction.
Topics: Animals; Blood Pressure; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs; Heart Rat | 1988 |