theobromine has been researched along with Cerebrovascular Disorders in 31 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentoxifylline is a drug known to increase red cell deformability, thus allowing the 7- to 8-micrometers diameter red cell to flow through the narrowest capillaries of 3-5 micrometers diameter." | 2.36 | Pentoxifylline and cerebrovascular diseases. ( George, C; Marcel, GA, 1983) |
| "Pentoxifylline was administered orally at a dose of 1200 mg/day over a period of 30 days (eight patients) or by intravenous infusion of 100 ml saline containing 400 mg of the drug in 1 hour (three patients)." | 1.26 | Effect of pentoxifylline on cerebral blood flow in patients with chronic cerebrovascular disease. ( Battistini, N; Nardini, M; Passero, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (93.55) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| COOPER, AJ | 1 |
| Martin, P | 1 |
| Vives, P | 1 |
| Hartmann, A | 4 |
| Beyreder, J | 1 |
| Marcel, GA | 1 |
| George, C | 1 |
| Szobor, A | 1 |
| Klein, M | 1 |
| Bräuer, H | 1 |
| Ott, E | 4 |
| Lechner, H | 3 |
| Fazekas, F | 1 |
| Müller, R | 2 |
| Lehrach, F | 2 |
| Shtok, VN | 1 |
| Fedorova, NV | 1 |
| Gadanova, IV | 1 |
| Passero, S | 1 |
| Nardini, M | 1 |
| Battistini, N | 1 |
| Harwart, D | 1 |
| Koeppen, G | 1 |
| Schmidt-Modrow, G | 1 |
| Ueda, N | 1 |
| Muteki, T | 1 |
| Tajiri, M | 1 |
| Tayama, F | 1 |
| Tsutsumi, Y | 1 |
| Watanabe, H | 1 |
| Sakanashi, K | 1 |
| Yoshitake, K | 1 |
| Tessitore, A | 1 |
| Barone, A | 1 |
| Koppenhagen, K | 1 |
| Wenig, HG | 1 |
| Müller, K | 1 |
| Theis, H | 1 |
| Sen, S | 1 |
| Chakravarty, A | 1 |
| Ritzmann, D | 1 |
| Lebedeva, NV | 1 |
| Khrapova, EV | 1 |
| Chandra, B | 1 |
| Bowton, DL | 1 |
| Stump, DA | 1 |
| Prough, DS | 1 |
| Toole, JF | 1 |
| Lefkowitz, DS | 1 |
| Coker, L | 1 |
| Dragunow, M | 1 |
| Schneider, R | 1 |
| Nazarova, KhI | 1 |
| Hsu, CY | 1 |
| Norris, JW | 1 |
| Hogan, EL | 1 |
| Bladin, P | 1 |
| Dinsdale, HB | 1 |
| Yatsu, FM | 1 |
| Earnest, MP | 1 |
| Scheinberg, P | 1 |
| Caplan, LR | 1 |
| Karp, HR | 1 |
| Tsuda, Y | 1 |
| Eninia, GI | 1 |
| Egere, DA | 1 |
| Robule, VKh | 1 |
| Maĭore, IKh | 1 |
| Dreyer, H | 1 |
| Keussen, M | 1 |
| Wojtek, L | 1 |
2 reviews available for theobromine and Cerebrovascular Disorders
| Article | Year |
|---|---|
Pentoxifylline and cerebrovascular diseases.
Topics: Animals; Blood Viscosity; Brain Edema; Cerebrovascular Circulation; Cerebrovascular Disorders; Dogs; | 1983 |
Haemorheology and cerebrovascular disease: multifunctional approach with pentoxifylline.
Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Edema; Humans; Oxygen Consumption; Pentoxify | 1981 |
10 trials available for theobromine and Cerebrovascular Disorders
| Article | Year |
|---|---|
Effect of pentoxifylline on regional cerebral blood flow in patients with cerebral vascular disorders.
Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Pentoxifyl | 1983 |
Use of pentoxifylline in the treatment of acute cerebrovascular insufficiency.
Topics: Acute Disease; Benzamides; Cerebrovascular Disorders; Clinical Trials as Topic; Drug Therapy, Combin | 1983 |
[Therapy of chronic cerebrovascular insufficiency. Controlled comparative study of 2 cerebral antihypoxidosis agents].
Topics: Adult; Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Dihydroergotoxine; Drug | 1982 |
Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease.
Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Pen | 1981 |
The treatment of chronic cerebrovascular insufficiency. A double-blind study with pentoxifylline ('Trental' 400).
Topics: Administration, Oral; Aged; Cerebrovascular Disorders; Chronic Disease; Clinical Trials as Topic; Do | 1979 |
Clinical experience with pentoxifylline in occlusive cerebrovascular disorders.
Topics: Adult; Cerebrovascular Disorders; Female; Hemiplegia; Humans; Ischemic Attack, Transient; Male; Moto | 1977 |
[Use of sermion, Cavinton and trental in patients with cerebrovascular disorders].
Topics: Administration, Oral; Adult; Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical | 1990 |
Pentoxifylline in acute nonhemorrhagic stroke. A randomized, placebo-controlled double-blind trial.
Topics: Acute Disease; Adult; Cerebrovascular Disorders; Clinical Trials as Topic; Double-Blind Method; Huma | 1988 |
A controlled study on the effect of pentoxifylline and an ergot alkaloid derivative on regional cerebral blood flow in patients with chronic cerebrovascular disease.
Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Clinical Trials as Topic; E | 1988 |
[Experience with Cosaldon retard in double blind studies].
Topics: Aged; Aging; Brain; Cerebrovascular Disorders; Clinical Trials as Topic; Geriatrics; Humans; Nicotin | 1969 |
19 other studies available for theobromine and Cerebrovascular Disorders
| Article | Year |
|---|---|
A CONTROLLED TRIAL OF COSALDON IN ARTERIOSCLEROTIC DEMENTIA.
Topics: Arteriosclerosis; Biomedical Research; Cerebrovascular Disorders; Dementia; Dementia, Vascular; Drug | 1964 |
The effect of pentoxifylline on red cell deformability in cerebrovascular accidents.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Capillary Permeability; Cerebrovascular Disorders; Drug Th | 1980 |
Hemorheological effects of pentoxifylline on disturbed flow behavior of blood in patients with cerebrovascular insufficiency.
Topics: Adenosine Diphosphate; Blood Viscosity; Cerebrovascular Disorders; Epinephrine; Erythrocytes; Female | 1983 |
[Clinical study of the cerebrovascular action of pentoxifylline].
Topics: Acute Disease; Adult; Arteriosclerosis; Brain Ischemia; Cerebrovascular Disorders; Chronic Disease; | 1982 |
Special therapeutical aspects of cerebrovascular disease.
Topics: Aspirin; Cerebrovascular Disorders; Drug Combinations; Female; Humans; Male; Pentoxifylline; Platele | 1981 |
Hemorheologic conditions in patients with cerebrovascular disease altered by treatment with pentoxifylline.
Topics: Blood Viscosity; Cerebrovascular Disorders; Drug Evaluation; Female; Fibrinogen; Hematocrit; Humans; | 1981 |
Effect of pentoxifylline on cerebral blood flow in patients with chronic cerebrovascular disease.
Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Female; Humans; Male; | 1981 |
[Treatment of cardiac and cerebrovascular insufficiency with Card-Cosaldon. Result of a field study].
Topics: Aged; Cerebrovascular Disorders; Digoxin; Drug Combinations; Drug Evaluation; Female; Heart Diseases | 1979 |
Clinical evaluation of the effect of pentoxifylline on circulatory behavior of the brain.
Topics: Adult; Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Middle Ag | 1979 |
[Combination of phosphatidylcholine and pentoxifylline in the therapy of progressive obstructive stroke].
Topics: Aged; Blood Viscosity; Cerebrovascular Disorders; Drug Therapy, Combination; Female; Humans; Male; P | 1979 |
Measurement of cerebral blood flow following intravenous administration of pentoxifyline ('Trentral').
Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Injections, Intravenou | 1977 |
[5 years of clinico-experimental and therapeutic experiences with pentoxifylline].
Topics: Arterial Occlusive Diseases; Cerebrovascular Disorders; Chemical Phenomena; Chemistry; Eye Diseases; | 1977 |
[Treatment of cerebrovascular insufficiency symptoms. Experience from practice].
Topics: Adult; Aged; Cerebrovascular Disorders; Drug Combinations; Female; Humans; Male; Middle Aged; Neurol | 1976 |
Pentoxifylline alters the natural course of acute nonhemorrhagic stroke.
Topics: Acute Disease; Cerebrovascular Disorders; Humans; Nervous System; Pentoxifylline; Theobromine | 1990 |
Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease.
Topics: Aged; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders; Dose-Response Relation | 1989 |
Possible complications of pentoxifylline in stroke.
Topics: Animals; Cerebrovascular Disorders; Humans; Pentoxifylline; Receptors, Purinergic; Theobromine | 1989 |
Results of hemorheologically active treatment with pentoxifylline in patients with cerebrovascular disease.
Topics: Blood Pressure; Blood Viscosity; Cerebrovascular Disorders; Erythrocyte Aggregation; Erythrocyte Def | 1989 |
[Effect of the long-term prophylactic use of trental on cerebral blood flow in diabetics].
Topics: Adult; Cerebrovascular Disorders; Chronic Disease; Diabetes Complications; Diabetes Mellitus; Diabet | 1988 |
[Indications for using trental in the initial manifestations of inadequate blood supply to the brain].
Topics: Adult; Blood Coagulation; Blood Viscosity; Cerebrovascular Circulation; Cerebrovascular Disorders; F | 1986 |