Page last updated: 2024-11-05

theobromine and Cerebral Ischemia

theobromine has been researched along with Cerebral Ischemia in 17 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Research Excerpts

ExcerptRelevanceReference
"To assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke."8.82Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Bath, PM; Bath-Hextall, FJ, 2004)
"The objective of this review was to assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke."8.80Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Asplund, K; Bath, FJ; Bath, PM, 2000)
"The effect of pentoxifylline on regional cerebral ischemia was evaluated in 22 cats."7.66Pentoxifylline in regional cerebral ischemia in cats. ( Michenfelder, JD; Milde, JH; Steen, PA, 1982)
"Transient global cerebral ischemia (tGCI) is a cerebrovascular disorder characterized by a brief decline in blood flow, neurological deficits, and is often predictive of stroke."5.62Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model. ( Bhat, JA; Gupta, S; Kumar, M, 2021)
"To assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke."4.82Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Bath, PM; Bath-Hextall, FJ, 2004)
"The objective of this review was to assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke."4.80Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Asplund, K; Bath, FJ; Bath, PM, 2000)
"The effect of pentoxifylline on regional cerebral ischemia was evaluated in 22 cats."3.66Pentoxifylline in regional cerebral ischemia in cats. ( Michenfelder, JD; Milde, JH; Steen, PA, 1982)
"Treatment with theobromine significantly attenuated neurological deficits and improved sensorimotor functions and memory in rats with CH."1.72Neuroprotective Effects of Theobromine in permanent bilateral common carotid artery occlusion rat model of cerebral hypoperfusion. ( Bhat, JA; Kumar, M, 2022)
"Transient global cerebral ischemia (tGCI) is a cerebrovascular disorder characterized by a brief decline in blood flow, neurological deficits, and is often predictive of stroke."1.62Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model. ( Bhat, JA; Gupta, S; Kumar, M, 2021)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199012 (70.59)18.7374
1990's1 (5.88)18.2507
2000's2 (11.76)29.6817
2010's0 (0.00)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Bhat, JA2
Kumar, M2
Gupta, S1
Bath, PM2
Bath-Hextall, FJ1
Schneider, R2
Schmid-Schönbein, H1
Kiesewetter, H2
Shtok, VN1
Fedorova, NV1
Gadanova, IV1
Steen, PA1
Milde, JH1
Michenfelder, JD1
Strano, A1
Davì, G1
Novo, S1
Avellone, G1
Pinto, A1
Muggeo, M1
Calabrò, A1
Businaro, V1
Patussi, L1
Volpe, A1
Signorini, GP1
Crepaldi, G1
Barth, A1
Newell, DW1
Nguyen, LB1
Winn, HR1
Wender, R1
Meno, JR1
Janigro, D1
Bath, FJ1
Asplund, K1
Müller, R2
Schröer, R1
Cohen, MM1
Harrison, W1
Gray, R1
Becker, R1
Johansson, BB1
Olsson, AL1
Ott, E1
Körner, E1
Lechner, H1
Yayá, R1
Aznar, J1
Vayá, A1
Villa, P1
Santos, T1
Vallés, J1
Martinez-Sales, V1

Reviews

4 reviews available for theobromine and Cerebral Ischemia

ArticleYear
Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke.
    The Cochrane database of systematic reviews, 2004, Issue:3

    Topics: Brain Ischemia; Humans; Neuroprotective Agents; Pentoxifylline; Platelet Aggregation Inhibitors; Str

2004
Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Brain Ischemia; Humans; Neuroprotective Agents; Pentoxifylline; Platelet Aggregation Inhibitors; Str

2000
Pentoxifylline -- a biomedical profile.
    Journal of medicine, 1979, Volume: 10, Issue:5

    Topics: Arterial Occlusive Diseases; Blood Viscosity; Brain Ischemia; Cerebrovascular Circulation; Erythrocy

1979
Cerebrovascular circulatory disorders: new aspects of pathophysiology and therapy.
    Journal of medicine, 1979, Volume: 10, Issue:5

    Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Cell Membrane Permeability; Cer

1979

Trials

2 trials available for theobromine and Cerebral Ischemia

ArticleYear
Hemorheologic treatment of cerebral reversible ischemic episodes with pentoxifylline--a prospective study.
    Angiology, 1988, Volume: 39, Issue:6

    Topics: Aged; Blood Circulation; Brain Ischemia; Erythrocyte Deformability; Female; Humans; Male; Middle Age

1988
Effect of dipyridamole plus pentoxifylline in patients with diffuse cerebrovascular insufficiency.
    Thrombosis and haemostasis, 1985, Dec-17, Volume: 54, Issue:4

    Topics: Aged; Brain Ischemia; Clinical Trials as Topic; Dipyridamole; Drug Therapy, Combination; Female; Hum

1985

Other Studies

11 other studies available for theobromine and Cerebral Ischemia

ArticleYear
Neuroprotective Effects of Theobromine in permanent bilateral common carotid artery occlusion rat model of cerebral hypoperfusion.
    Metabolic brain disease, 2022, Volume: 37, Issue:6

    Topics: Acetylcholinesterase; Animals; Brain; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Commo

2022
Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model.
    Biochemical and biophysical research communications, 2021, 09-24, Volume: 571

    Topics: Administration, Oral; Animals; Brain Ischemia; Disease Models, Animal; Female; Glutathione; Ischemic

2021
The rheological efficiency of parenteral pentoxifylline (Trental) in patients with ischemic brain lesions. Preliminary results.
    European neurology, 1983, Volume: 22 Suppl 1

    Topics: Adult; Aged; Blood Viscosity; Brain Ischemia; Erythrocyte Aggregation; Erythrocytes; Female; Hematoc

1983
[Clinical study of the cerebrovascular action of pentoxifylline].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1982, Volume: 82, Issue:1

    Topics: Acute Disease; Adult; Arteriosclerosis; Brain Ischemia; Cerebrovascular Disorders; Chronic Disease;

1982
Pentoxifylline in regional cerebral ischemia in cats.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:1

    Topics: Animals; Brain Ischemia; Cats; Cerebral Infarction; Cerebrovascular Circulation; Female; Male; Pento

1982
[Parenteral pentoxifylline treatment of ischemic cerebrovascular accident. Preliminary results].
    Deutsche medizinische Wochenschrift (1946), 1982, Nov-05, Volume: 107, Issue:44

    Topics: Aged; Blood Viscosity; Brain Ischemia; Erythrocyte Aggregation; Female; Hematocrit; Humans; Infusion

1982
[Clinical evaluation of the effects of pentoxifylline in patients with chronic peripheral circulatory disorders].
    La Ricerca in clinica e in laboratorio, 1981, Volume: 11 Suppl 1

    Topics: Aged; Arteriosclerosis Obliterans; Blood Pressure; Blood Viscosity; Brain Ischemia; Drug Evaluation;

1981
[Hemocoagulation, fibrinolytic and rheologic parameters in ischemic vasculopathy. Effects of pentoxifylline in the treatment of acute cerebral vasculopathy].
    La Ricerca in clinica e in laboratorio, 1981, Volume: 11 Suppl 1

    Topics: Acute Disease; Blood Coagulation; Brain Ischemia; Drug Evaluation; Female; Fibrinogen; Fibrinolysis;

1981
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
    Brain research, 1997, Jul-11, Volume: 762, Issue:1-2

    Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br

1997
The effect of pentoxifylline on cerebral ischemia and amino acid incorporation into gerbil brain.
    Transactions of the American Neurological Association, 1979, Volume: 104

    Topics: Amino Acids; Animals; Brain; Brain Ischemia; Gerbillinae; Pentoxifylline; Theobromine

1979
Pentoxifylline does not reduce cerebral ischemic edema in hypertensive rats.
    Acta neurologica Scandinavica, 1989, Volume: 80, Issue:3

    Topics: Animals; Brain Edema; Brain Ischemia; Male; Pentoxifylline; Rats; Rats, Inbred SHR; Theobromine

1989