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theobromine and Brain Vascular Disorders

theobromine has been researched along with Brain Vascular Disorders in 31 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Research Excerpts

ExcerptRelevanceReference
"Pentoxifylline is a drug known to increase red cell deformability, thus allowing the 7- to 8-micrometers diameter red cell to flow through the narrowest capillaries of 3-5 micrometers diameter."2.36Pentoxifylline and cerebrovascular diseases. ( George, C; Marcel, GA, 1983)
"Pentoxifylline was administered orally at a dose of 1200 mg/day over a period of 30 days (eight patients) or by intravenous infusion of 100 ml saline containing 400 mg of the drug in 1 hour (three patients)."1.26Effect of pentoxifylline on cerebral blood flow in patients with chronic cerebrovascular disease. ( Battistini, N; Nardini, M; Passero, S, 1981)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199029 (93.55)18.7374
1990's2 (6.45)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
COOPER, AJ1
Martin, P1
Vives, P1
Hartmann, A4
Beyreder, J1
Marcel, GA1
George, C1
Szobor, A1
Klein, M1
Bräuer, H1
Ott, E4
Lechner, H3
Fazekas, F1
Müller, R2
Lehrach, F2
Shtok, VN1
Fedorova, NV1
Gadanova, IV1
Passero, S1
Nardini, M1
Battistini, N1
Harwart, D1
Koeppen, G1
Schmidt-Modrow, G1
Ueda, N1
Muteki, T1
Tajiri, M1
Tayama, F1
Tsutsumi, Y1
Watanabe, H1
Sakanashi, K1
Yoshitake, K1
Tessitore, A1
Barone, A1
Koppenhagen, K1
Wenig, HG1
Müller, K1
Theis, H1
Sen, S1
Chakravarty, A1
Ritzmann, D1
Lebedeva, NV1
Khrapova, EV1
Chandra, B1
Bowton, DL1
Stump, DA1
Prough, DS1
Toole, JF1
Lefkowitz, DS1
Coker, L1
Dragunow, M1
Schneider, R1
Nazarova, KhI1
Hsu, CY1
Norris, JW1
Hogan, EL1
Bladin, P1
Dinsdale, HB1
Yatsu, FM1
Earnest, MP1
Scheinberg, P1
Caplan, LR1
Karp, HR1
Tsuda, Y1
Eninia, GI1
Egere, DA1
Robule, VKh1
Maĭore, IKh1
Dreyer, H1
Keussen, M1
Wojtek, L1

Reviews

2 reviews available for theobromine and Brain Vascular Disorders

ArticleYear
Pentoxifylline and cerebrovascular diseases.
    European neurology, 1983, Volume: 22 Suppl 1

    Topics: Animals; Blood Viscosity; Brain Edema; Cerebrovascular Circulation; Cerebrovascular Disorders; Dogs;

1983
Haemorheology and cerebrovascular disease: multifunctional approach with pentoxifylline.
    Current medical research and opinion, 1981, Volume: 7, Issue:4

    Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Edema; Humans; Oxygen Consumption; Pentoxify

1981

Trials

10 trials available for theobromine and Brain Vascular Disorders

ArticleYear
Effect of pentoxifylline on regional cerebral blood flow in patients with cerebral vascular disorders.
    European neurology, 1983, Volume: 22 Suppl 1

    Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Pentoxifyl

1983
Use of pentoxifylline in the treatment of acute cerebrovascular insufficiency.
    European neurology, 1983, Volume: 22 Suppl 1

    Topics: Acute Disease; Benzamides; Cerebrovascular Disorders; Clinical Trials as Topic; Drug Therapy, Combin

1983
[Therapy of chronic cerebrovascular insufficiency. Controlled comparative study of 2 cerebral antihypoxidosis agents].
    MMW, Munchener medizinische Wochenschrift, 1982, Oct-15, Volume: 124, Issue:41

    Topics: Adult; Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Dihydroergotoxine; Drug

1982
Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease.
    Pharmatherapeutica, 1981, Volume: 2, Issue:8

    Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Pen

1981
The treatment of chronic cerebrovascular insufficiency. A double-blind study with pentoxifylline ('Trental' 400).
    Current medical research and opinion, 1979, Volume: 6, Issue:2

    Topics: Administration, Oral; Aged; Cerebrovascular Disorders; Chronic Disease; Clinical Trials as Topic; Do

1979
Clinical experience with pentoxifylline in occlusive cerebrovascular disorders.
    Angiology, 1977, Volume: 28, Issue:5

    Topics: Adult; Cerebrovascular Disorders; Female; Hemiplegia; Humans; Ischemic Attack, Transient; Male; Moto

1977
[Use of sermion, Cavinton and trental in patients with cerebrovascular disorders].
    Sovetskaia meditsina, 1990, Issue:1

    Topics: Administration, Oral; Adult; Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical

1990
Pentoxifylline in acute nonhemorrhagic stroke. A randomized, placebo-controlled double-blind trial.
    Stroke, 1988, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Cerebrovascular Disorders; Clinical Trials as Topic; Double-Blind Method; Huma

1988
A controlled study on the effect of pentoxifylline and an ergot alkaloid derivative on regional cerebral blood flow in patients with chronic cerebrovascular disease.
    Angiology, 1988, Volume: 39, Issue:5

    Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Clinical Trials as Topic; E

1988
[Experience with Cosaldon retard in double blind studies].
    Deutsches medizinisches Journal, 1969, May-27, Volume: 20, Issue:10

    Topics: Aged; Aging; Brain; Cerebrovascular Disorders; Clinical Trials as Topic; Geriatrics; Humans; Nicotin

1969

Other Studies

19 other studies available for theobromine and Brain Vascular Disorders

ArticleYear
A CONTROLLED TRIAL OF COSALDON IN ARTERIOSCLEROTIC DEMENTIA.
    The British journal of psychiatry : the journal of mental science, 1964, Volume: 110

    Topics: Arteriosclerosis; Biomedical Research; Cerebrovascular Disorders; Dementia; Dementia, Vascular; Drug

1964
The effect of pentoxifylline on red cell deformability in cerebrovascular accidents.
    Current medical research and opinion, 1980, Volume: 6, Issue:8

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Capillary Permeability; Cerebrovascular Disorders; Drug Th

1980
Hemorheological effects of pentoxifylline on disturbed flow behavior of blood in patients with cerebrovascular insufficiency.
    European neurology, 1983, Volume: 22 Suppl 1

    Topics: Adenosine Diphosphate; Blood Viscosity; Cerebrovascular Disorders; Epinephrine; Erythrocytes; Female

1983
[Clinical study of the cerebrovascular action of pentoxifylline].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1982, Volume: 82, Issue:1

    Topics: Acute Disease; Adult; Arteriosclerosis; Brain Ischemia; Cerebrovascular Disorders; Chronic Disease;

1982
Special therapeutical aspects of cerebrovascular disease.
    La Ricerca in clinica e in laboratorio, 1981, Volume: 11 Suppl 1

    Topics: Aspirin; Cerebrovascular Disorders; Drug Combinations; Female; Humans; Male; Pentoxifylline; Platele

1981
Hemorheologic conditions in patients with cerebrovascular disease altered by treatment with pentoxifylline.
    La Ricerca in clinica e in laboratorio, 1981, Volume: 11 Suppl 1

    Topics: Blood Viscosity; Cerebrovascular Disorders; Drug Evaluation; Female; Fibrinogen; Hematocrit; Humans;

1981
Effect of pentoxifylline on cerebral blood flow in patients with chronic cerebrovascular disease.
    The Journal of international medical research, 1981, Volume: 9, Issue:3

    Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Female; Humans; Male;

1981
[Treatment of cardiac and cerebrovascular insufficiency with Card-Cosaldon. Result of a field study].
    Therapie der Gegenwart, 1979, Volume: 118, Issue:11

    Topics: Aged; Cerebrovascular Disorders; Digoxin; Drug Combinations; Drug Evaluation; Female; Heart Diseases

1979
Clinical evaluation of the effect of pentoxifylline on circulatory behavior of the brain.
    The Kurume medical journal, 1979, Volume: 26, Issue:4

    Topics: Adult; Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Middle Ag

1979
[Combination of phosphatidylcholine and pentoxifylline in the therapy of progressive obstructive stroke].
    Acta neurologica. Quaderni, 1979, Volume: 39

    Topics: Aged; Blood Viscosity; Cerebrovascular Disorders; Drug Therapy, Combination; Female; Humans; Male; P

1979
Measurement of cerebral blood flow following intravenous administration of pentoxifyline ('Trentral').
    Current medical research and opinion, 1977, Volume: 4, Issue:7

    Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Injections, Intravenou

1977
[5 years of clinico-experimental and therapeutic experiences with pentoxifylline].
    Medizinische Monatsschrift, 1977, Volume: 31, Issue:4

    Topics: Arterial Occlusive Diseases; Cerebrovascular Disorders; Chemical Phenomena; Chemistry; Eye Diseases;

1977
[Treatment of cerebrovascular insufficiency symptoms. Experience from practice].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1976, Dec-10, Volume: 52, Issue:34

    Topics: Adult; Aged; Cerebrovascular Disorders; Drug Combinations; Female; Humans; Male; Middle Aged; Neurol

1976
Pentoxifylline alters the natural course of acute nonhemorrhagic stroke.
    Stroke, 1990, Volume: 21, Issue:1

    Topics: Acute Disease; Cerebrovascular Disorders; Humans; Nervous System; Pentoxifylline; Theobromine

1990
Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease.
    Stroke, 1989, Volume: 20, Issue:12

    Topics: Aged; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders; Dose-Response Relation

1989
Possible complications of pentoxifylline in stroke.
    Stroke, 1989, Volume: 20, Issue:8

    Topics: Animals; Cerebrovascular Disorders; Humans; Pentoxifylline; Receptors, Purinergic; Theobromine

1989
Results of hemorheologically active treatment with pentoxifylline in patients with cerebrovascular disease.
    Angiology, 1989, Volume: 40, Issue:11

    Topics: Blood Pressure; Blood Viscosity; Cerebrovascular Disorders; Erythrocyte Aggregation; Erythrocyte Def

1989
[Effect of the long-term prophylactic use of trental on cerebral blood flow in diabetics].
    Klinicheskaia meditsina, 1988, Volume: 66, Issue:9

    Topics: Adult; Cerebrovascular Disorders; Chronic Disease; Diabetes Complications; Diabetes Mellitus; Diabet

1988
[Indications for using trental in the initial manifestations of inadequate blood supply to the brain].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:1

    Topics: Adult; Blood Coagulation; Blood Viscosity; Cerebrovascular Circulation; Cerebrovascular Disorders; F

1986
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