theobromine has been researched along with Body Weight in 28 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0." | 3.69 | Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995) |
| " The methylxanthines; caffeine, theophylline and theobromine, were administered via drinking water in the proportions occurring in tea, at a dose of 50, 1 and 2 mg/kg body-weight respectively to Wistar albino rats throughout pregnancy and for up to the 14th day of lactation." | 3.68 | The effect of methylxanthines on milk volume and composition, and growth of rat pups. ( Grimble, RF; Hart, AD, 1990) |
| " With human bladder cancer cells in culture, cytotoxicity of thiotepa was increased up to 10-fold (P less than 0." | 3.67 | In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa. ( Alley, MC; Chen, ZY; Fingert, HJ; Googe, PB; Pardee, AB; Pu, AT, 1988) |
| "Pentoxifylline, a new xanthine derivative with properties favorably affecting the rheological profile of blood, was administered to male rats weighing 200--300 g in doses of 5, 10, 15, and 20 mg/kg of body weight for five days." | 3.66 | Inhibition cAMP-phosphodiesterase in the rat heart by pentoxifylline--a new xanthine derivative. ( Deo, S; Nair, KG; Nandi, JS, 1980) |
| "Theobromine was removed from CPH by treatment with an isolate of Talaromyces verruculosus (TvTD)." | 1.56 | Nutritional value and safety of animal feed supplemented with Talaromyces verruculosus-treated cocoa pod husks. ( Adamafio, NA; Antwi, S; Nortey, T; Ocloo, A; Oduro-Mensah, D; Okine, LK, 2020) |
| "Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao." | 1.46 | Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. ( Katakura, M; Matsuzaki, K; Ohno-Shosaku, T; Shido, O; Sugimoto, N; Tanigami, H; Yachie, A; Yoneda, M, 2017) |
| "Theobromine was administered orally to male Sprague-Dawley rats at dose levels of 250 and 500 mg/kg for 2 weeks starting at the age of 6 or 8 weeks, and for 4 weeks from the age of 6 weeks." | 1.31 | Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 22). Effects of 2- and 4-week administration of theobromine on the testis. ( Fujioka, M; Funabashi, H; Kohchi, M; Matsuoka, N; Tateishi, Y, 2000) |
| " Sprague-Dawley rats were weighed and dosed daily for 31 days with vehicle, 250 mg/kg theobromine, 2." | 1.28 | Reproductive toxicity of theobromine and cocoa extract in male rats. ( Hikim, AP; Russell, LD; Waller, DP; Wang, Y, 1992) |
| "Pure theobromine was added to diets to furnish the same levels as furnished by 1, 2, 4, and 6% dietary cocoa shell meal, which contained, by analysis, 1." | 1.27 | Toxicity of jimson weed seed and cocoa shell meal to broilers. ( Day, EJ; Dilworth, BC, 1984) |
| " Since serum TBR concentrations and overall toxicity were lower in Ch + TBR-treated animals than in S + TBR treated animals, yet TBR bioavailability was similar, this effect was attributed to the inducing potential of the Ch diet on TBR metabolism and clearance." | 1.27 | Diet-induced alterations in theobromine disposition and toxicity in the rat. ( Shively, CA; Tarka, SM; White, DM, 1986) |
| "Theophylline was the main urinary metabolite." | 1.27 | The fate of chronically consumed caffeine in the monkey (Macaca fascicularis). ( Gilbert, SG; Klassen, RD; Rice, DC; Stavric, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (64.29) | 18.7374 |
| 1990's | 6 (21.43) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Oduro-Mensah, D | 1 |
| Ocloo, A | 1 |
| Nortey, T | 1 |
| Antwi, S | 1 |
| Okine, LK | 1 |
| Adamafio, NA | 1 |
| Yoneda, M | 1 |
| Sugimoto, N | 1 |
| Katakura, M | 1 |
| Matsuzaki, K | 1 |
| Tanigami, H | 1 |
| Yachie, A | 1 |
| Ohno-Shosaku, T | 1 |
| Shido, O | 1 |
| Inoue, H | 1 |
| Kobayashi-Hattori, K | 1 |
| Horiuchi, Y | 1 |
| Oishi, Y | 1 |
| Arai, S | 1 |
| Takita, T | 1 |
| Hirsh, K | 1 |
| Nandi, JS | 1 |
| Nair, KG | 1 |
| Deo, S | 1 |
| Gans, JH | 2 |
| Day, EJ | 1 |
| Dilworth, BC | 1 |
| Aly, ZH | 1 |
| Hasegawa, R | 1 |
| Ogiso, T | 1 |
| Imaida, K | 1 |
| Shirai, T | 1 |
| Ito, N | 1 |
| Wang, Y | 2 |
| Waller, DP | 2 |
| Funabashi, H | 1 |
| Fujioka, M | 1 |
| Kohchi, M | 1 |
| Tateishi, Y | 1 |
| Matsuoka, N | 1 |
| Tarka, SM | 3 |
| Zoumas, BL | 1 |
| Spriet, A | 1 |
| Spriet, C | 1 |
| Larousse, C | 1 |
| Chigot, D | 1 |
| Roux, M | 1 |
| Simon, P | 1 |
| Hikim, AP | 1 |
| Russell, LD | 1 |
| Hart, AD | 2 |
| Grimble, RF | 2 |
| Hudlická, O | 1 |
| Price, S | 1 |
| McPhee, MD | 1 |
| Whiting, SJ | 1 |
| Soffietti, MG | 1 |
| Nebbia, C | 1 |
| Valenza, F | 1 |
| Amedeo, S | 1 |
| Re, G | 1 |
| Fingert, HJ | 1 |
| Pu, AT | 1 |
| Chen, ZY | 1 |
| Googe, PB | 1 |
| Alley, MC | 1 |
| Pardee, AB | 1 |
| Nemiroff, PM | 1 |
| Shively, CA | 1 |
| White, DM | 1 |
| Applebaum, RS | 1 |
| Borzelleca, JF | 1 |
| Gilbert, SG | 1 |
| Stavric, B | 1 |
| Klassen, RD | 1 |
| Rice, DC | 1 |
| Rozanova, VD | 1 |
| Bal'magiia, TA | 1 |
| Fujii, T | 1 |
| Nishimura, H | 1 |
| Woosley, RL | 1 |
| Will, DH | 1 |
| Schultes, E | 1 |
| Popendiker, K | 1 |
| Doerr, BI | 1 |
| Leuschner, F | 1 |
28 other studies available for theobromine and Body Weight
| Article | Year |
|---|---|
Nutritional value and safety of animal feed supplemented with Talaromyces verruculosus-treated cocoa pod husks.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Cacao; Dietary Supple | 2020 |
Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.
Topics: Animals; Blood Glucose; Body Weight; Brain-Derived Neurotrophic Factor; Cacao; Cell Adhesion Molecul | 2017 |
Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet.
Topics: Abdominal Fat; Animals; Body Weight; Caffeine; Cholesterol; Diet; Dietary Fats; Eating; Liver; Male; | 2006 |
Central nervous system pharmacology of the dietary methylxanthines.
Topics: Acetylcholine; Adolescent; Adult; Aged; Body Weight; Caffeine; Central Nervous System; Diet; Dopamin | 1984 |
Inhibition cAMP-phosphodiesterase in the rat heart by pentoxifylline--a new xanthine derivative.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Body Weight; Dose-Response Relationship, Drug; Heart; | 1980 |
Dietary influences on theobromine-induced toxicity in rats.
Topics: Animals; Body Weight; Diet; Dietary Fiber; Eating; Male; Rats; Rats, Inbred Strains; Spermatogenesis | 1982 |
Toxicity of jimson weed seed and cocoa shell meal to broilers.
Topics: Alkaloids; Animal Feed; Animals; Body Weight; Cacao; Chickens; Datura stramonium; Depression, Chemic | 1984 |
[Studies of caffeine and theobromine in sheep. III. Feeding of cacao bean shells].
Topics: Animal Feed; Animals; Body Weight; Cacao; Caffeine; Male; Sheep; Theobromine | 1981 |
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; | 1995 |
Theobromine toxicity on Sertoli cells and comparison with cocoa extract in male rats.
Topics: Animals; Body Weight; Cacao; Male; Rats; Rats, Sprague-Dawley; Sertoli Cells; Theobromine | 1994 |
Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 22). Effects of 2- and 4-week administration of theobromine on the testis.
Topics: Administration, Oral; Animals; Atrophy; Body Weight; Dose-Response Relationship, Drug; Epididymis; M | 2000 |
Short-term effects of graded levels of theobromine in laboratory rodents.
Topics: Administration, Oral; Adrenal Glands; Animals; Appetite; Body Weight; Brain; Cricetinae; Digestive S | 1979 |
Methodology and results of a survey of adverse reactons to a drug in private practice.
Topics: Adult; Age Factors; Aged; Body Weight; Drug Combinations; Drug Therapy; Female; France; Humans; Info | 1977 |
Reproductive toxicity of theobromine and cocoa extract in male rats.
Topics: Animals; Body Weight; Cacao; Chromatography, High Pressure Liquid; Genitalia, Male; Male; Organ Size | 1992 |
The effect of methylxanthines on milk volume and composition, and growth of rat pups.
Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Fatty Acids; Female; Lactation; Milk; Pregnancy; R | 1990 |
Effect of methylxanthines on lactational performance of rats.
Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Drinking; Eating; Female; Lactation; Pregnancy; Ra | 1990 |
Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply.
Topics: Animals; Blood Pressure; Body Weight; Capillaries; In Vitro Techniques; Male; Muscle Contraction; Mu | 1990 |
The effect of adenosine and adenosine analogues on methylxanthine-induced hypercalciuria in the rat.
Topics: Adenosine; Animals; Body Weight; Caffeine; Calcium; Diet; Diuresis; Male; Rats; Rats, Inbred Strains | 1989 |
Toxic effects of theobromine on mature and immature male rabbits.
Topics: Administration, Oral; Aging; Animals; Body Weight; Male; Myocardium; Rabbits; Testis; Theobromine; T | 1989 |
In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cells, Cultured; Drug Synergis | 1988 |
Synergistic effects of pentoxifylline and hyperbaric oxygen on skin flaps.
Topics: Animals; Body Weight; Drug Synergism; Graft Survival; Hyperbaric Oxygenation; Male; Pentoxifylline; | 1988 |
Diet-induced alterations in theobromine disposition and toxicity in the rat.
Topics: Animals; Body Weight; Diet; Male; Rats; Rats, Inbred Strains; Testis; Theobromine; Thymus Gland | 1986 |
Evaluation of the perinatal, postnatal and teratogenic effects of cocoa powder and theobromine in Sprague-Dawley/CD rats.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Bone and Bones; Cacao; Dose-Res | 1986 |
The fate of chronically consumed caffeine in the monkey (Macaca fascicularis).
Topics: Animals; Biotransformation; Body Weight; Caffeine; Chromatography, High Pressure Liquid; Eating; Fem | 1985 |
[Effect of methylated dioxypurines in accelerating the growth of young rats].
Topics: Animals; Body Weight; Caffeine; Flavonoids; Growth; Rats; Theobromine | 1972 |
Fetal hypoproteinemia associated with generalized edema caused by administration of methyl xanthines to the rat during late pregnancy.
Topics: Animals; Blood Proteins; Body Water; Body Weight; Caffeine; Edema; Female; Fetal Diseases; Fetus; Ge | 1973 |
Influence of theobromine magnesium oleate on formation of experimental atheroma.
Topics: Administration, Oral; Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol; Diet, Atherogenic; | 1973 |
[Toxicity of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine in animal experiment].
Topics: Administration, Oral; Animals; Blood Chemical Analysis; Body Weight; Dogs; Drug Tolerance; Female; F | 1971 |