theobromine has been researched along with Atrophy in 3 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Theobromine was administered orally to male Sprague-Dawley rats at dose levels of 250 and 500 mg/kg for 2 weeks starting at the age of 6 or 8 weeks, and for 4 weeks from the age of 6 weeks." | 1.31 | Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 22). Effects of 2- and 4-week administration of theobromine on the testis. ( Fujioka, M; Funabashi, H; Kohchi, M; Matsuoka, N; Tateishi, Y, 2000) |
| "Pentoxifylline (Trental) has multiple mechanisms of action, including stimulation of prostacyclin synthesis, decreased aggregation of platelets, increased deformability of red blood cells, increased mobility of neutrophils, and increased fibrinolysis." | 1.27 | Therapy of livedo vasculitis with pentoxifylline. ( Bard, JW; Ely, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Funabashi, H | 1 |
| Fujioka, M | 1 |
| Kohchi, M | 1 |
| Tateishi, Y | 1 |
| Matsuoka, N | 1 |
| Ely, H | 1 |
| Bard, JW | 1 |
| Sauer, GC | 1 |
3 other studies available for theobromine and Atrophy
| Article | Year |
|---|---|
Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 22). Effects of 2- and 4-week administration of theobromine on the testis.
Topics: Administration, Oral; Animals; Atrophy; Body Weight; Dose-Response Relationship, Drug; Epididymis; M | 2000 |
Therapy of livedo vasculitis with pentoxifylline.
Topics: Adult; Atrophy; Female; Humans; Leg Ulcer; Middle Aged; Pentoxifylline; Skin; Theobromine; Wound Hea | 1988 |
Pentoxifylline (Trental) therapy for the vasculitis of atrophie blanche.
Topics: Adult; Aged; Atrophy; Female; Humans; Leg; Male; Middle Aged; Pentoxifylline; Skin; Skin Diseases; T | 1986 |