theobromine has been researched along with Anemia, Sickle Cell in 15 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months." | 7.68 | Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990) |
| "A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months." | 3.68 | Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990) |
| "Pentoxifylline does not enhance RBC deformability following acute in vitro incubation, and this suggests the need for further evaluation of the mechanism of action of this drug." | 1.28 | Effects of pentoxifylline and metabolite on red blood cell deformability as measured by ektacytometry. ( Ballas, SK; Cummings, DM, 1990) |
| "Pentoxifylline was shown to prevent sickling induced by deoxygenation of SS-genotype blood from sickle cell disease patients." | 1.27 | Studies on the vasoocclusive crisis of sickle cell disease IV. Mechanism of action of pentoxifylline (Trental). ( Ambrus, JL; Gastpar, H; Meky, N; Raposa, T; Sills, RH; Stadler, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khosla, AA | 1 |
| Chintu, C | 1 |
| Seiffge, D | 1 |
| Berthold, R | 1 |
| Berthold, F | 1 |
| Keller, F | 2 |
| Leonhardt, H | 2 |
| Ambrus, JL | 3 |
| Ambrus, CM | 2 |
| Gastpar, H | 3 |
| Bannerman, R | 1 |
| Bettigole, R | 1 |
| Friedman, S | 1 |
| Cummings, DM | 1 |
| Ballas, SK | 1 |
| Frost, ML | 1 |
| Treadwell, P | 1 |
| Teuscher, T | 1 |
| Von Der Ahe, CW | 1 |
| Baillod, P | 1 |
| Holzer, B | 1 |
| Billett, HH | 1 |
| Kaul, DK | 1 |
| Connel, MM | 1 |
| Fabry, ME | 1 |
| Nagel, RL | 1 |
| Clerc, M | 1 |
| Doh-Egueli, D | 1 |
| Chapuis, F | 1 |
| Durin, A | 1 |
| Bertrand, Y | 1 |
| Souillet, G | 1 |
| Philippe, N | 1 |
| Stuart, J | 1 |
| Stone, PC | 1 |
| Bilto, YY | 1 |
| Keidan, AJ | 1 |
| Meky, N | 1 |
| Stadler, S | 1 |
| Sills, RH | 1 |
| Raposa, T | 1 |
| Manrique, RV | 1 |
| Pichard, E | 1 |
| Duflo, B | 1 |
| Coulibaly, S | 1 |
| Mariko, B | 1 |
| Monsempes, JL | 1 |
| Traore, HA | 1 |
| Diallo, AD | 1 |
5 trials available for theobromine and Anemia, Sickle Cell
| Article | Year |
|---|---|
A pilot study: an open clinical trial of pentoxiphylline in patients with painful sickle cell crises.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Clinical Trials as Topic; Female; H | 1984 |
Double-blind randomised clinical trial of pentoxiphyllin in vaso-occlusive sickle cell crisis.
Topics: Acute Disease; Adolescent; Analgesics; Anemia, Sickle Cell; Child; Double-Blind Method; Female; Huma | 1989 |
Pentoxifylline (Trental) has no significant effect on laboratory parameters in sickle cell disease.
Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Bicarbonates; Blood Cell Count; Blood Viscosity; D | 1989 |
Placebo controlled double-blind study of pentoxifylline in sickle cell disease patients.
Topics: Adolescent; Anemia, Sickle Cell; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Count; F | 1987 |
[Effectiveness of treatment during osteoarticular pain crises in drepanocytosis; based on the example of pentoxifylline].
Topics: Adult; Anemia, Sickle Cell; Double-Blind Method; Drug Evaluation; Erythrocyte Deformability; Female; | 1987 |
10 other studies available for theobromine and Anemia, Sickle Cell
| Article | Year |
|---|---|
Effect of pentoxifylline on sickle cell thalassaemia: haemorheological and clinical results.
Topics: Adolescent; Anemia, Sickle Cell; Blood Viscosity; Erythrocytes; Female; Humans; Pentoxifylline; Theo | 1983 |
[Improvement of blood viscosity in sickle-cell anaemia by pentoxifylline (author's transl)].
Topics: Adolescent; Anemia, Sickle Cell; Blood Viscosity; Female; Hemolysis; Humans; Male; Microcirculation; | 1980 |
Studies on platelet aggregation with pentoxifylline: effect on neoplastic disorders and other new indications.
Topics: Anemia, Sickle Cell; Animals; Arteriosclerosis; Blood Viscosity; Embolism; Haplorhini; Humans; Neopl | 1979 |
Amelioration of blood viscosity in sickle cell anemia by pentoxifylline. A case report.
Topics: Adolescent; Anemia, Sickle Cell; Blood Viscosity; Female; Hemolysis; Humans; Pentoxifylline; Theobro | 1979 |
Studies on vasoocclusive crisis of sickle cell disease. I. Effect of pentoxifylline.
Topics: Anemia, Sickle Cell; Animals; Macaca; Magnesium Sulfate; Male; Pentoxifylline; Platelet Aggregation; | 1979 |
Effects of pentoxifylline and metabolite on red blood cell deformability as measured by ektacytometry.
Topics: Anemia, Sickle Cell; Erythrocyte Deformability; Humans; Pentoxifylline; Theobromine | 1990 |
Treatment of sickle cell leg ulcers with pentoxifylline.
Topics: Anemia, Sickle Cell; Chronic Disease; Humans; Leg Ulcer; Male; Middle Aged; Pentoxifylline; Recurren | 1990 |
[Treatment of vaso-occlusive crisis of sickle-cell disease with pentoxifylline].
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Drug Therapy, Combination; Female; | 1989 |
Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells.
Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Calcimycin; Dose-Response Relationship, Drug; Er | 1987 |
Studies on the vasoocclusive crisis of sickle cell disease IV. Mechanism of action of pentoxifylline (Trental).
Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Erythrocyte Deformability; Erythrocyte Indices; Humans; | 1988 |