theobromine has been researched along with Alzheimer Disease in 8 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we have analyzed naturally occurring MTXs caffeine, theobromine, theophylline, and the synthetic MTXs pentoxifylline and propentofylline also used as drugs in different neuroblastoma cell lines." | 4.12 | Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. ( Bachmann, CM; Griebsch, LV; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Pilz, SM; Theiss, EL; Winkler, J, 2022) |
| "The possible modulatory effect of the functional LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids, on the catecholaminergic and cholinergic neurotransmission, affecting cognition decline during aging has been studied." | 3.81 | Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids. ( Benítez, S; Bolea, I; Esteban, G; Fernández-Fernández, L; Giralt, M; Hidalgo, J; Morelló, JR; Ramírez, B; Reguant, J; Solé, M; Sun, P; Unzeta, M; Valente, T, 2015) |
| "L-theobromine was treated as a log transform and dichotomous form (the highest quantile vs." | 1.72 | Association between Dietary Theobromine and Cognitive Function in a Representative American Population: A Cross-Sectional Study. ( Chen, N; Gao, L; Ge, W; Guo, J; He, L; Peng, C, 2022) |
| "Dementia caused by Alzheimer's disease (AD) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (Aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus." | 1.46 | Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. ( Berumen, LC; García-Alcocer, G; Mendiola-Precoma, J; Miledi, R; Padilla, K; Rodríguez-Cruz, A, 2017) |
| "Theobromine in the CSF was positively correlated with the levels of other xanthines in the CSF, but not in the plasma, suggesting that it may be formed by central metabolic pathways." | 1.42 | Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease? ( Agostinho, P; Baldeiras, I; Blennow, K; Cunha, RA; de Mendon, A; Gkatzima, O; Hasselbalch, SG; Kapaki, E; Manadas, B; Mara, B; Mendes, VM; Santana, I; Sermin, G; Simonsen, A; Travassos, M; Tsolaki, M; Yener, GG; Zetterberg, H, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janitschke, D | 3 |
| Lauer, AA | 3 |
| Bachmann, CM | 3 |
| Winkler, J | 1 |
| Griebsch, LV | 1 |
| Pilz, SM | 1 |
| Theiss, EL | 1 |
| Grimm, HS | 3 |
| Hartmann, T | 3 |
| Grimm, MOW | 3 |
| Gao, L | 1 |
| Ge, W | 1 |
| Peng, C | 1 |
| Guo, J | 1 |
| Chen, N | 1 |
| He, L | 1 |
| Seyfried, M | 1 |
| Cova, I | 1 |
| Leta, V | 1 |
| Mariani, C | 1 |
| Pantoni, L | 1 |
| Pomati, S | 1 |
| Fernández-Fernández, L | 1 |
| Esteban, G | 1 |
| Giralt, M | 1 |
| Valente, T | 1 |
| Bolea, I | 1 |
| Solé, M | 1 |
| Sun, P | 1 |
| Benítez, S | 1 |
| Morelló, JR | 1 |
| Reguant, J | 1 |
| Ramírez, B | 1 |
| Hidalgo, J | 1 |
| Unzeta, M | 1 |
| Travassos, M | 1 |
| Santana, I | 1 |
| Baldeiras, I | 1 |
| Tsolaki, M | 1 |
| Gkatzima, O | 1 |
| Sermin, G | 1 |
| Yener, GG | 1 |
| Simonsen, A | 1 |
| Hasselbalch, SG | 1 |
| Kapaki, E | 1 |
| Mara, B | 1 |
| Cunha, RA | 1 |
| Agostinho, P | 1 |
| Blennow, K | 1 |
| Zetterberg, H | 1 |
| Mendes, VM | 1 |
| Manadas, B | 1 |
| de Mendon, A | 1 |
| Mendiola-Precoma, J | 1 |
| Padilla, K | 1 |
| Rodríguez-Cruz, A | 1 |
| Berumen, LC | 1 |
| Miledi, R | 1 |
| García-Alcocer, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Placebo-controlled, Crossover Study to Investigate the Safety and Efficacy of Qualia Mind on Cognition in a Healthy Population[NCT04389723] | 60 participants (Actual) | Interventional | 2020-05-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for theobromine and Alzheimer Disease
| Article | Year |
|---|---|
Methylxanthines and Neurodegenerative Diseases: An Update.
Topics: Alzheimer Disease; Animals; Caffeine; Coffee; Humans; Multiple Sclerosis; Neurodegenerative Diseases | 2021 |
Exploring cocoa properties: is theobromine a cognitive modulator?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cacao; Caffeine; Central Nervous System Stimulant | 2019 |
6 other studies available for theobromine and Alzheimer Disease
| Article | Year |
|---|---|
Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells.
Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Cholesterol; Humans; Lipids; Neural Stem Cells; Neuro | 2022 |
Association between Dietary Theobromine and Cognitive Function in a Representative American Population: A Cross-Sectional Study.
Topics: Alzheimer Disease; Animals; Cognition; Cross-Sectional Studies; Humans; Nutrition Surveys; Theobromi | 2022 |
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.
Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Gene Expression Regulation; Genes, Essential; Humans; | 2020 |
Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Cacao; Catechol O-Methyltransferase; Cell D | 2015 |
Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Caffeine; Diet; Enzym | 2015 |
Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Brain; Cholesterol; Diet, H | 2017 |