theobromine has been researched along with Aging in 13 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e." | 4.91 | The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015) |
| "The possible modulatory effect of the functional LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids, on the catecholaminergic and cholinergic neurotransmission, affecting cognition decline during aging has been studied." | 3.81 | Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids. ( Benítez, S; Bolea, I; Esteban, G; Fernández-Fernández, L; Giralt, M; Hidalgo, J; Morelló, JR; Ramírez, B; Reguant, J; Solé, M; Sun, P; Unzeta, M; Valente, T, 2015) |
| " Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography." | 2.66 | Comparison of the urinary metabolite profile of caffeine in young and elderly males. ( Blanchard, J; Jonkman, JH; Sawers, SJ; Tang-Liu, DD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernández-Fernández, L | 1 |
| Esteban, G | 1 |
| Giralt, M | 1 |
| Valente, T | 1 |
| Bolea, I | 1 |
| Solé, M | 1 |
| Sun, P | 1 |
| Benítez, S | 1 |
| Morelló, JR | 1 |
| Reguant, J | 1 |
| Ramírez, B | 1 |
| Hidalgo, J | 1 |
| Unzeta, M | 1 |
| Cutler, RG | 1 |
| Camandola, S | 1 |
| Malott, KF | 1 |
| Edelhauser, MA | 1 |
| Mattson, MP | 1 |
| Sachse, KT | 1 |
| Jackson, EK | 1 |
| Wisniewski, SR | 1 |
| Gillespie, DG | 1 |
| Puccio, AM | 1 |
| Clark, RS | 1 |
| Dixon, CE | 1 |
| Kochanek, PM | 1 |
| de Toledo-Morrell, L | 1 |
| Morrell, F | 1 |
| Fleming, S | 1 |
| Cohen, MM | 1 |
| Aldridge, A | 1 |
| Neims, AH | 1 |
| Dormehl, IC | 1 |
| Jordaan, B | 1 |
| Oliver, DW | 1 |
| Croft, S | 1 |
| Kellner, H | 1 |
| Petkov, VD | 1 |
| Belcheva, S | 1 |
| Stoyanova, V | 1 |
| Petkov, VV | 1 |
| Schiffman, SS | 1 |
| Warwick, ZS | 1 |
| Soffietti, MG | 1 |
| Nebbia, C | 1 |
| Valenza, F | 1 |
| Amedeo, S | 1 |
| Re, G | 1 |
| Parnetti, L | 1 |
| Ciuffetti, G | 1 |
| Mercuri, M | 1 |
| Lupattelli, G | 1 |
| Senin, U | 1 |
| Blanchard, J | 1 |
| Sawers, SJ | 1 |
| Jonkman, JH | 1 |
| Tang-Liu, DD | 1 |
| Dreyer, H | 1 |
| Keussen, M | 1 |
| Wojtek, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain Changes in Pediatric Obstructive Sleep Apnea[NCT05368077] | 70 participants (Anticipated) | Interventional | 2022-05-14 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for theobromine and Aging
| Article | Year |
|---|---|
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom | 2015 |
5 trials available for theobromine and Aging
| Article | Year |
|---|---|
SPECT monitoring of improved cerebral blood flow during long-term treatment of elderly patients with nootropic drugs.
Topics: Administration, Oral; Aged; Aging; Brain; Cerebellum; Cerebrovascular Circulation; Cognition; Cross- | 1999 |
[Treatment of cerebral degenerative symptoms due to age. Double blind trial on the effect of Juston (author's transl)].
Topics: Activities of Daily Living; Aged; Aging; Ascorbic Acid; Cachexia; Central Nervous System Diseases; D | 1975 |
The role of haemorheological factors in the ageing brain: long-term therapy with pentoxifylline ('Trental' 400) in elderly patients with initial mental deterioration.
Topics: Aged; Aging; Blood Viscosity; Cerebrovascular Circulation; Dementia; Erythrocyte Deformability; Fema | 1986 |
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromi | 1985 |
[Experience with Cosaldon retard in double blind studies].
Topics: Aged; Aging; Brain; Cerebrovascular Disorders; Clinical Trials as Topic; Geriatrics; Humans; Nicotin | 1969 |
7 other studies available for theobromine and Aging
| Article | Year |
|---|---|
Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Cacao; Catechol O-Methyltransferase; Cell D | 2015 |
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System S | 2008 |
Pentoxifylline reverses age-related deficits in spatial memory.
Topics: Aging; Animals; Choline; Cues; Discrimination Learning; Male; Memory; Mental Recall; Orientation; Pe | 1984 |
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines | 1980 |
Effects of nootropic agents on the performing of active two-way avoidance tasks in young and old rats.
Topics: Aging; Animals; Avoidance Learning; Male; Meclofenoxate; Memory; Piracetam; Psychotropic Drugs; Rats | 1990 |
Use of flavor-amplified foods to improve nutritional status in elderly patients.
Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Mon | 1989 |
Toxic effects of theobromine on mature and immature male rabbits.
Topics: Administration, Oral; Aging; Animals; Body Weight; Male; Myocardium; Rabbits; Testis; Theobromine; T | 1989 |