theobromine has been researched along with Abnormalities, Autosome in 6 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chromosome abnormalities are caused by both theobromine and theophylline in plant cells and in mammalian cells in culture, and both have anti-mitotic activity." | 2.35 | Theobromine and theophylline. ( Timson, J, 1975) |
| "Theobromine was not mutagenic in the Ames assay up to a maximum concentration of 5000 micrograms/plate either with or without S9 activation." | 1.27 | Genotoxicity of theobromine in a series of short-term assays. ( Brusick, D; Galloway, S; Jagannath, DR; Myhr, B; Rundell, J; Tarka, S, 1986) |
| "Theobromine was also positive in the micronucleus test at 2 X 40 mg/animal and negative in the chromosome aberration test at 1 X 40 mg/animal." | 1.26 | Genotoxicity of cocoa examined by microbial and mammalian systems. ( Münzner, R; Renner, HW, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Renner, HW | 1 |
| Münzner, R | 1 |
| Timson, J | 1 |
| Sturelid, S | 1 |
| Kihlman, BA | 1 |
| Fingert, HJ | 1 |
| Chang, JD | 1 |
| Pardee, AB | 1 |
| Brusick, D | 1 |
| Myhr, B | 1 |
| Galloway, S | 1 |
| Rundell, J | 1 |
| Jagannath, DR | 1 |
| Tarka, S | 1 |
| Bender, MA | 1 |
| Griggs, HG | 1 |
| Bedford, JS | 1 |
2 reviews available for theobromine and Abnormalities, Autosome
| Article | Year |
|---|---|
Theobromine and theophylline.
Topics: Animals; Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosomes; Drosophila; Escherichia col | 1975 |
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.
Topics: Alkylating Agents; Animals; Caffeine; Chromosome Aberrations; Cyanides; Cytarabine; Deoxyadenosines; | 1974 |
4 other studies available for theobromine and Abnormalities, Autosome
| Article | Year |
|---|---|
Genotoxicity of cocoa examined by microbial and mammalian systems.
Topics: Animals; Bone Marrow Cells; Cacao; Caffeine; Chromosome Aberrations; Cricetinae; Cricetulus; Crossin | 1982 |
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations.
Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug | 1975 |
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.
Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosom | 1986 |
Genotoxicity of theobromine in a series of short-term assays.
Topics: Animals; Biotransformation; Caffeine; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Fem | 1986 |