thebaine has been researched along with Anaphylaxis* in 1 studies
1 other study(ies) available for thebaine and Anaphylaxis
| Article | Year |
|---|---|
Thebaine induces anaphylactic reactions via the MRGPRX2 receptor pathway on mast cells.
Morphine derivatives are clinically important anesthetic and sedative drugs, which often show anaphylactic side effects. Mas-related G-protein coupled receptor member X2 (MRGPRX2) triggers mast cell degranulation, which is important process in anaphylactic reactions. MRGPRX2-HEK293 and LAD2 cell membrane chromatographic (CMC) models were used to screen morphine derivatives binding to MRGPRX2. Furthermore, most morphine derivatives significantly enhanced Ca Topics: Anaphylaxis; Animals; Cell Degranulation; HEK293 Cells; Humans; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thebaine | 2022 |