theanine and Prediabetic-State

This study investigated the association between serum ethylamine levels as an indicator of l-theanine consumption and the development of type 2 diabetes in a Japanese community.. A total of 2,253 community-dwelling Japanese individuals aged 40-79 years without diabetes were monitored for 7 years. Serum ethylamine levels were divided into quartiles: ≤0.86, 0.87-2.10, 2.11-5.28, and ≥5.29 ng/mL. Kinetic analysis of serum ethylamine concentrations was performed after ingestion of l-theanine-rich green tea products containing 8 mg of l-theanine by 12 healthy volunteers.. Higher serum ethylamine was significantly associated with lower risk of the development of type 2 diabetes in a general Japanese population. The measurement of serum ethylamine concentration would be a useful biomarker for the objective estimation of l-theanine consumption.

Topics: Adult; Aged; Biomarkers; Diabetes Mellitus, Type 2; Drinking Behavior; Eating; Ethylamines; Female; Glutamates; Humans; Incidence; Insulin Resistance; Japan; Male; Middle Aged; Prediabetic State; Risk Factors; Tea