theaflavin-3-3--digallate has been researched along with Cardiomegaly* in 1 studies
1 other study(ies) available for theaflavin-3-3--digallate and Cardiomegaly
| Article | Year |
|---|---|
The Prevention Role of Theaflavin-3,3'-digallate in Angiotensin II Induced Pathological Cardiac Hypertrophy via CaN-NFAT Signal Pathway.
Theaflavin-3,3'-digallate (TF3) is a representative theaflavin of black tea and is remarkable for the anti-coronary heart disease effect. As an adaptive response to heart failure, pathological cardiac hypertrophy (PCH) has attracted great interest. In this study, the PCH cell model was established with H9c2 cells by angiotensin II, and the prevention effect and mechanisms of TF3 were investigated. The results showed that the cell size and fetal gene mRNA level were significantly reduced as pretreated with TF3 at the concentration range of 1-10 μM, also the balance of the redox system was recovered by TF3 at the concentration of 10 μM. The intracellular Ca Topics: Angiotensin II; Antioxidants; Biflavonoids; Calcineurin; Cardiomegaly; Catechin; Heart Failure; Humans; Myocytes, Cardiac; Signal Transduction | 2022 |