thapsigargin and Pulmonary-Eosinophilia

thapsigargin has been researched along with Pulmonary-Eosinophilia* in 1 studies

Other Studies

1 other study(ies) available for thapsigargin and Pulmonary-Eosinophilia

Article	Year
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides. Bioorganic & medicinal chemistry, 2008, Nov-01, Volume: 16, Issue:21 From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC(50)=77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED(50)=1.3 mg/kg) p.o. Topics: Anilides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Female; Humans; Hypersensitivity; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Male; Mice; Pulmonary Eosinophilia; Pyrazoles; Rats; Rats, Inbred BN; Structure-Activity Relationship; T-Lymphocytes; Thapsigargin	2008

Article

Year

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.

Bioorganic & medicinal chemistry, 2008, Nov-01, Volume: 16, Issue:21

From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC(50)=77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED(50)=1.3 mg/kg) p.o.

Topics: Anilides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Female; Humans; Hypersensitivity; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Male; Mice; Pulmonary Eosinophilia; Pyrazoles; Rats; Rats, Inbred BN; Structure-Activity Relationship; T-Lymphocytes; Thapsigargin

2008