thapsigargin has been researched along with Glaucoma* in 1 studies
1 other study(ies) available for thapsigargin and Glaucoma
| Article | Year |
|---|---|
Calcium dysregulation potentiates wild-type myocilin misfolding: implications for glaucoma pathogenesis.
Myocilin is secreted from trabecular meshwork cells to an eponymous extracellular matrix that is critical for maintaining intraocular pressure. Missense mutations found in the myocilin olfactomedin domain (OLF) lead to intracellular myocilin misfolding and are causative for the heritable form of early-onset glaucoma. The OLF domain contains a unique internal, hetero-dinuclear calcium site. Here, we tested the hypothesis that calcium dysregulation causes wild-type (WT) myocilin misfolding reminiscent of that observed for disease variants. Using two cellular models expressing WT myocilin, we show that the Ca Topics: Calcium; Cytoskeletal Proteins; Escherichia coli; Eye Proteins; Glaucoma; Glycoproteins; Humans; Mutation; Thapsigargin | 2022 |