thallium-201 and Coronary-Stenosis

The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR).. Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%.. FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory.. DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Coronary Angiography; Coronary Stenosis; Exercise Test; Female; Fractional Flow Reserve, Myocardial; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Radiopharmaceuticals; Sensitivity and Specificity; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Young Adult

Topics: Coronary Stenosis; Humans; Myocardial Perfusion Imaging; Technetium Tc 99m Sestamibi; Thallium Radioisotopes

Topics: Coronary Stenosis; Humans; Myocardial Perfusion Imaging; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon

Topics: Computed Tomography Angiography; Coronary Stenosis; Coronary Vessels; Female; Fractional Flow Reserve, Myocardial; Humans; Middle Aged; Myocardial Perfusion Imaging; Thallium Radioisotopes