thalidomide has been researched along with Uveitis, Anterior in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Uveitis, Anterior: Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A dosage of 400 mg/kg per day of thalidomide was efficient in reducing inflammation whether given in three doses (at -24 h, -4 h and +4 h relative to LPS challenge = THAL-1; p < 0." | 1.29 | The effect of thalidomide and supidimide on endotoxin-induced uveitis in rats. ( Guex-Crosier, Y; Herbort, CP; Pittet, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guex-Crosier, Y | 1 |
| Pittet, N | 1 |
| Herbort, CP | 1 |
| Sheskin, J | 2 |
| Zauberman, H | 1 |
1 trial available for thalidomide and Uveitis, Anterior
| Article | Year |
|---|---|
[Therapeutic experience on the effect of thalidomidomide on lepra reaction].
Topics: Aspirin; Climate; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Israel; Lepro | 1975 |
2 other studies available for thalidomide and Uveitis, Anterior
| Article | Year |
|---|---|
The effect of thalidomide and supidimide on endotoxin-induced uveitis in rats.
Topics: Acute Disease; Animals; Anterior Chamber; Aqueous Humor; Bacterial Toxins; Endotoxins; Enterotoxins; | 1995 |
Iridocyclitis in lepra reaction treated with thalidomide.
Topics: Adult; Female; Humans; Leprosy; Male; Middle Aged; Thalidomide; Uveitis, Anterior | 1970 |