thalidomide has been researched along with Uremia in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our observation that thalidomide administration to a dialysis patient with leprosy alleviated his pruritus led us to conduct this short-term study to assess the efficacy of the drug in this regard." | 9.07 | Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. ( Hoette, M; Lugon, JR; Lugon, NV; Ruzany, F; Silva, SR; Viana, PC, 1994) |
| " The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection." | 7.79 | Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013) |
| "Our observation that thalidomide administration to a dialysis patient with leprosy alleviated his pruritus led us to conduct this short-term study to assess the efficacy of the drug in this regard." | 5.07 | Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. ( Hoette, M; Lugon, JR; Lugon, NV; Ruzany, F; Silva, SR; Viana, PC, 1994) |
| " The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection." | 3.79 | Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mettang, T | 1 |
| Kremer, AE | 1 |
| Pongcharoen, P | 1 |
| Fleischer, AB | 1 |
| Santana, AC | 1 |
| Degaspari, S | 1 |
| Catanozi, S | 1 |
| Dellê, H | 1 |
| de Sá Lima, L | 1 |
| Silva, C | 1 |
| Blanco, P | 1 |
| Solez, K | 1 |
| Scavone, C | 1 |
| Noronha, IL | 1 |
| Silva, SR | 1 |
| Viana, PC | 1 |
| Lugon, NV | 1 |
| Hoette, M | 1 |
| Ruzany, F | 1 |
| Lugon, JR | 1 |
| Moraes, M | 1 |
| Russo, G | 1 |
3 reviews available for thalidomide and Uremia
| Article | Year |
|---|---|
Uremic pruritus.
Topics: Acupuncture Therapy; Amines; Anti-Inflammatory Agents; Calcium Channel Blockers; Cyclohexanecarboxyl | 2015 |
Itch Management: Systemic Agents.
Topics: Amines; Analgesics; Analgesics, Opioid; Anion Exchange Resins; Antidepressive Agents; Aprepitant; Ch | 2016 |
Thalidomide and its dermatologic uses.
Topics: Acquired Immunodeficiency Syndrome; Behcet Syndrome; Dermatologic Agents; Erythema Nodosum; Facial D | 2001 |
1 trial available for thalidomide and Uremia
| Article | Year |
|---|---|
Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial.
Topics: Aged; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Kidney Failure, Chronic; Mal | 1994 |
1 other study available for thalidomide and Uremia
| Article | Year |
|---|---|
Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice.
Topics: Adenine; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shi | 2013 |