thalidomide has been researched along with Tuberculosis, Meningeal in 15 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide was developed nearly seventy years ago and has been a highly controversial drug." | 2.72 | The use of thalidomide to treat children with tuberculosis meningitis: A review. ( Marceline van Furth, A; Schoeman, JF; Seddon, JA; Solomons, RS; van der Kuip, M; van Toorn, R; Zaharie, SD, 2021) |
| "Childhood tuberculous meningitis is associated with serious long-term sequelae, including mental retardation, behavior disturbances, and motor handicap." | 2.71 | Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study. ( Hanekom, WA; Haslett, PA; Kaplan, G; Schoeman, JF; Springer, P; Swanevelder, S; van Rensburg, AJ, 2004) |
| "Thalidomide was administered via nasogastric tube in a dosage of 6 mg/kg/day, 12 mg/kg/day, or 24 mg/kg/day." | 2.69 | Adjunctive thalidomide therapy of childhood tuberculous meningitis: possible anti-inflammatory role. ( Bekker, LG; Donald, PR; Hanekom, WA; Haslett, PA; Kaplan, G; Ravenscroft, A; Schoeman, JF; Springer, P; van Rensburg, AJ, 2000) |
| "Tuberculous meningitis is a highly morbid, often fatal disease." | 1.48 | Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report. ( Ajassa, C; Caraffa, E; Ciardi, MR; Lichtner, M; Massetti, AP; Mastroianni, CM; Russo, G; Vita, S; Vullo, V, 2018) |
| "Thalidomide was introduced as an immunomodulatory adjunct and subsequently the patient made a complete neurological recovery." | 1.32 | The use of thalidomide in the treatment of intracranial tuberculomas in adults: two case reports. ( Carmichael, A; Lever, AM; Mendelson, M; Meyer, P; Roberts, MT, 2003) |
| "When thalidomide treatment was combined with antibiotics, there was a marked reduction in TNF-alpha levels, leukocytosis, and brain pathology." | 1.30 | A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death. ( Freedman, VH; Kaplan, G; Sokol, K; Tsenova, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Toorn, R | 4 |
| Zaharie, SD | 1 |
| Seddon, JA | 2 |
| van der Kuip, M | 1 |
| Marceline van Furth, A | 1 |
| Schoeman, JF | 7 |
| Solomons, RS | 2 |
| Kumar, R | 1 |
| Kolloli, A | 1 |
| Singh, P | 1 |
| Vinnard, C | 1 |
| Kaplan, G | 5 |
| Subbian, S | 1 |
| Liu, P | 1 |
| Pei, N | 1 |
| Liu, X | 1 |
| Huang, W | 1 |
| Lu, S | 1 |
| Caraffa, E | 1 |
| Russo, G | 1 |
| Vita, S | 1 |
| Lichtner, M | 1 |
| Massetti, AP | 1 |
| Mastroianni, CM | 1 |
| Vullo, V | 1 |
| Ciardi, MR | 1 |
| Ajassa, C | 1 |
| du Plessis, AM | 1 |
| Schaaf, HS | 1 |
| Buys, H | 1 |
| Hewlett, RH | 1 |
| Stefan, DC | 2 |
| Andronikou, S | 2 |
| Freeman, N | 2 |
| Schoeman, J | 1 |
| Roberts, MT | 1 |
| Mendelson, M | 1 |
| Meyer, P | 1 |
| Carmichael, A | 1 |
| Lever, AM | 1 |
| Springer, P | 2 |
| van Rensburg, AJ | 2 |
| Swanevelder, S | 1 |
| Hanekom, WA | 2 |
| Haslett, PA | 2 |
| Tsenova, L | 2 |
| Sokol, K | 1 |
| Freedman, VH | 2 |
| Ravenscroft, A | 1 |
| Donald, PR | 1 |
| Bekker, LG | 1 |
| Mangaliso, B | 1 |
| Muller, G | 1 |
| Chen, Y | 1 |
| Stirling, D | 1 |
| Kewitz, H | 1 |
2 reviews available for thalidomide and Tuberculosis, Meningeal
| Article | Year |
|---|---|
The use of thalidomide to treat children with tuberculosis meningitis: A review.
Topics: Antitubercular Agents; Child; Cytokines; Humans; Thalidomide; Tuberculosis, Meningeal; Tumor Necrosi | 2021 |
Thalidomide and Phosphodiesterase 4 Inhibitors as Host Directed Therapeutics for Tuberculous Meningitis: Insights From the Rabbit Model.
Topics: Animals; Antitubercular Agents; Blood-Brain Barrier; Brain; Cytokines; Disease Models, Animal; Human | 2019 |
3 trials available for thalidomide and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antitubercular Agents; Chemotherapy, Adjuvant; Ch | 2004 |
Adjunctive thalidomide therapy of childhood tuberculous meningitis: possible anti-inflammatory role.
Topics: Adjuvants, Immunologic; Antitubercular Agents; Biomarkers; Brain; Child; Child, Preschool; Clinical | 2000 |
Thalidomide therapy in childhood tuberculous menigitis.
Topics: Child; Double-Blind Method; Fatal Outcome; Humans; Immunosuppressive Agents; Motor Skills Disorders; | 2000 |
10 other studies available for thalidomide and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Thalidomide in the treatment of human immunodeficiency virus-negative tuberculous meningitis: A case report.
Topics: Adrenal Cortex Hormones; Adult; Antitubercular Agents; Asian People; Brain; Drug Therapy, Combinatio | 2020 |
Thalidomide Use for Complicated Central Nervous System Tuberculosis in Children: Insights From an Observational Cohort.
Topics: Adult; Antitubercular Agents; Child; Humans; Retrospective Studies; Thalidomide; Tuberculosis, Centr | 2021 |
Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report.
Topics: Antitubercular Agents; Brain; Cerebrospinal Fluid; Child; Female; Glucocorticoids; Humans; Hydroceph | 2018 |
Clinicoradiologic response of neurologic tuberculous mass lesions in children treated with thalidomide.
Topics: Adolescent; Antitubercular Agents; Child; Child, Preschool; Female; Head; Humans; Immunosuppressive | 2015 |
Recovery of vision after adjuvant thalidomide in a child with tuberculous meningitis and acute lymphoblastic leukemia.
Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Blindness; Brain; Chemother | 2009 |
Tuberculous meningitis-related optic neuritis: recovery of vision with thalidomide in 4 consecutive cases.
Topics: Antitubercular Agents; Brain; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Ma | 2010 |
The use of thalidomide in the treatment of intracranial tuberculomas in adults: two case reports.
Topics: Adult; Female; Humans; Immunosuppressive Agents; Thalidomide; Treatment Outcome; Tuberculoma, Intrac | 2003 |
A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death.
Topics: Animals; Antibiotics, Antitubercular; Disease Models, Animal; Drug Therapy, Combination; Immunosuppr | 1998 |
Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis.
Topics: Animals; Antitubercular Agents; Brain; Central Nervous System; Female; Immunosuppressive Agents; Len | 2002 |
[Drugs as cause of diseases].
Topics: Abnormalities, Drug-Induced; Berlin; Contraceptives, Oral; Cortisone; Drug-Related Side Effects and | 1974 |