thalidomide has been researched along with Thrombophilia in 15 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Thrombophilia: A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
Excerpt | Relevance | Reference |
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"Venous thromboembolism (VTE) is a major complication of myeloma therapy recently observed with the increasing use of up-front thalidomide and dexamethasone (thal-dex)." | 9.14 | Thalidomide-dexamethasone as up-front therapy for patients with newly diagnosed multiple myeloma: thrombophilic alterations, thrombotic complications, and thromboprophylaxis with low-dose warfarin. ( Catalano, L; Cavo, M; Cini, M; Gozzetti, A; Legnani, C; Masini, L; Palareti, G; Patriarca, F; Tacchetti, P; Tosi, P; Valdré, L; Zamagni, E, 2010) |
"Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma." | 8.84 | Pathophysiological considerations to thrombophilia in the treatment of multiple myeloma with thalidomide and derivates. ( Gieseler, F, 2008) |
"The therapeutic use of thalidomide in patients with multiple myeloma is often complicated by the development of venous thromboembolism." | 7.75 | Hypercoagulable states in patients with multiple myeloma can affect the thalidomide-associated venous thromboembolism. ( Claxton, D; Fink, LM; Ibrahim, S; Talamo, GP; Tricot, GJ; Zangari, M, 2009) |
"Venous thromboembolism (VTE) is a major complication of myeloma therapy recently observed with the increasing use of up-front thalidomide and dexamethasone (thal-dex)." | 5.14 | Thalidomide-dexamethasone as up-front therapy for patients with newly diagnosed multiple myeloma: thrombophilic alterations, thrombotic complications, and thromboprophylaxis with low-dose warfarin. ( Catalano, L; Cavo, M; Cini, M; Gozzetti, A; Legnani, C; Masini, L; Palareti, G; Patriarca, F; Tacchetti, P; Tosi, P; Valdré, L; Zamagni, E, 2010) |
" We report the results of a prospective randomized trial of 62 newly diagnosed MM patients tested at baseline for hypercoagulability and treated with intensive chemotherapy with or without thalidomide in a randomized fashion." | 5.10 | Activated protein C resistance in the absence of factor V Leiden mutation is a common finding in multiple myeloma and is associated with an increased risk of thrombotic complications. ( Anaissie, E; Badros, A; Barlogie, B; Desikan, R; Fassas, A; Fink, L; Mehta, P; Morris, C; Saghafifar, F; Siegel, E; Toor, A; Tricot, G; Whitfield, D; Zangari, M, 2002) |
"Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma." | 4.84 | Pathophysiological considerations to thrombophilia in the treatment of multiple myeloma with thalidomide and derivates. ( Gieseler, F, 2008) |
" Established risk factors in IBD colitis inpatients with TE included: indwelling catheter (4/10), first-degree family member with TE (2/10), hereditary thrombophilia (3/10), smoking (1/10), oral contraceptive (1/5 females), and thalidomide (1/10)." | 3.79 | Risk factors, morbidity, and treatment of thrombosis in children and young adults with active inflammatory bowel disease. ( Atkinson, BJ; Bousvaros, A; Harney, KM; Levine, AE; Lightdale, JR; Trenor, CC; Verhave, M; Zitomersky, NL, 2013) |
"The therapeutic use of thalidomide in patients with multiple myeloma is often complicated by the development of venous thromboembolism." | 3.75 | Hypercoagulable states in patients with multiple myeloma can affect the thalidomide-associated venous thromboembolism. ( Claxton, D; Fink, LM; Ibrahim, S; Talamo, GP; Tricot, GJ; Zangari, M, 2009) |
"Thrombosis was not associated with inferior progression-free survival (PFS) or overall survival (OS), apart from inferior OS for patients with arterial events (aHR, 1." | 2.94 | Thrombosis in patients with myeloma treated in the Myeloma IX and Myeloma XI phase 3 randomized controlled trials. ( Bradbury, CA; Cairns, DA; Child, JA; Cook, G; Craig, Z; Davies, FE; Drayson, MT; Gregory, WM; Hockaday, A; Jackson, GH; Jenner, MW; Jones, JR; Kaiser, MF; Morgan, GJ; Owen, RG; Paterson, A; Pawlyn, C, 2020) |
"Thalidomide is a synthetic glutamic acid derivative first introduced in 1956 in Germany as an over the counter medications." | 2.50 | [Current therapeutic indications of thalidomide and lenalidomide]. ( Cosiglio, FJ; Ordi-Ros, J, 2014) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 8 (53.33) | 29.6817 |
2010's | 5 (33.33) | 24.3611 |
2020's | 2 (13.33) | 2.80 |
Authors | Studies |
---|---|
Cornell, RF | 1 |
Goldhaber, SZ | 1 |
Engelhardt, BG | 1 |
Moslehi, J | 1 |
Jagasia, M | 1 |
Harrell, S | 1 |
Rubinstein, SM | 1 |
Hall, R | 1 |
Wyatt, H | 1 |
Piazza, G | 1 |
Bradbury, CA | 1 |
Craig, Z | 1 |
Cook, G | 1 |
Pawlyn, C | 1 |
Cairns, DA | 1 |
Hockaday, A | 1 |
Paterson, A | 1 |
Jenner, MW | 1 |
Jones, JR | 1 |
Drayson, MT | 1 |
Owen, RG | 1 |
Kaiser, MF | 1 |
Gregory, WM | 1 |
Davies, FE | 1 |
Child, JA | 1 |
Morgan, GJ | 1 |
Jackson, GH | 1 |
Storrar, NPF | 1 |
Mathur, A | 1 |
Johnson, PRE | 1 |
Roddie, PH | 1 |
Zitomersky, NL | 1 |
Levine, AE | 1 |
Atkinson, BJ | 1 |
Harney, KM | 1 |
Verhave, M | 1 |
Bousvaros, A | 1 |
Lightdale, JR | 1 |
Trenor, CC | 1 |
Ordi-Ros, J | 1 |
Cosiglio, FJ | 1 |
Kovacs, MJ | 1 |
Davies, GA | 1 |
Chapman, JA | 1 |
Bahlis, N | 1 |
Voralia, M | 1 |
Roy, J | 1 |
Kouroukis, CT | 1 |
Chen, C | 1 |
Belch, A | 1 |
Reece, D | 1 |
Zhu, L | 1 |
Meyer, RM | 1 |
Shepherd, L | 1 |
Stewart, KA | 1 |
Gieseler, F | 1 |
Talamo, GP | 1 |
Ibrahim, S | 1 |
Claxton, D | 1 |
Tricot, GJ | 1 |
Fink, LM | 1 |
Zangari, M | 3 |
Cini, M | 1 |
Zamagni, E | 1 |
Valdré, L | 1 |
Palareti, G | 1 |
Patriarca, F | 1 |
Tacchetti, P | 1 |
Legnani, C | 1 |
Catalano, L | 1 |
Masini, L | 1 |
Tosi, P | 1 |
Gozzetti, A | 1 |
Cavo, M | 1 |
Rodeghiero, F | 1 |
Elice, F | 2 |
Kaushal, V | 1 |
Kaushal, GP | 1 |
Melkaveri, SN | 1 |
Mehta, P | 2 |
Potenza, L | 1 |
Luppi, M | 1 |
Morselli, M | 1 |
Saviola, A | 1 |
Ferrari, A | 1 |
Riva, G | 1 |
Longo, G | 1 |
Marietta, M | 1 |
Torelli, G | 1 |
Fink, L | 2 |
Tricot, G | 2 |
Pitini, V | 1 |
Arrigo, C | 1 |
Aloi, G | 1 |
Azzarello, D | 1 |
La Gattuta, G | 1 |
Saghafifar, F | 1 |
Anaissie, E | 1 |
Badros, A | 1 |
Desikan, R | 1 |
Fassas, A | 1 |
Morris, C | 1 |
Toor, A | 1 |
Whitfield, D | 1 |
Siegel, E | 1 |
Barlogie, B | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized Phase III Study Of Thalidomide And Prednisone As Maintenance Therapy Following Autologous Stem Cell Transplant in Patients With Multiple Myeloma[NCT00049673] | Phase 3 | 332 participants (Actual) | Interventional | 2002-10-15 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for thalidomide and Thrombophilia
Article | Year |
---|---|
[Current therapeutic indications of thalidomide and lenalidomide].
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents; Antineoplastic Agents; Collagen Diseases; End | 2014 |
Pathophysiological considerations to thrombophilia in the treatment of multiple myeloma with thalidomide and derivates.
Topics: Antineoplastic Agents; Blood Coagulation; Fibrinolytic Agents; Humans; Lenalidomide; Multiple Myelom | 2008 |
Thrombosis in multiple myeloma.
Topics: Angiogenesis Inhibitors; Anticoagulants; Antineoplastic Agents; Blood Coagulation Factors; Cytokines | 2007 |
5 trials available for thalidomide and Thrombophilia
Article | Year |
---|---|
Primary prevention of venous thromboembolism with apixaban for multiple myeloma patients receiving immunomodulatory agents.
Topics: Aged; Comorbidity; Consolidation Chemotherapy; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Imm | 2020 |
Thrombosis in patients with myeloma treated in the Myeloma IX and Myeloma XI phase 3 randomized controlled trials.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; De | 2020 |
Thalidomide-prednisone maintenance following autologous stem cell transplant for multiple myeloma: effect on thrombin generation and procoagulant markers in NCIC CTG MY.10.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antithrombin III; Combined Modality The | 2015 |
Thalidomide-dexamethasone as up-front therapy for patients with newly diagnosed multiple myeloma: thrombophilic alterations, thrombotic complications, and thromboprophylaxis with low-dose warfarin.
Topics: Activated Protein C Resistance; Adult; Aged; Anticoagulants; Case-Control Studies; Dexamethasone; Fa | 2010 |
Activated protein C resistance in the absence of factor V Leiden mutation is a common finding in multiple myeloma and is associated with an increased risk of thrombotic complications.
Topics: Activated Protein C Resistance; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood C | 2002 |
7 other studies available for thalidomide and Thrombophilia
Article | Year |
---|---|
Safety and efficacy of apixaban for routine thromboprophylaxis in myeloma patients treated with thalidomide- and lenalidomide-containing regimens.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Dise | 2019 |
Risk factors, morbidity, and treatment of thrombosis in children and young adults with active inflammatory bowel disease.
Topics: Adolescent; Adult; Antibodies, Anticardiolipin; Anticoagulants; Catheterization; Catheters, Indwelli | 2013 |
Hypercoagulable states in patients with multiple myeloma can affect the thalidomide-associated venous thromboembolism.
Topics: Activated Protein C Resistance; Angiogenesis Inhibitors; Anticoagulants; Antineoplastic Combined Che | 2009 |
Thalidomide and thrombosis.
Topics: Humans; Incidence; Neoplasms; Thalidomide; Thrombophilia; Thrombosis | 2003 |
Thalidomide protects endothelial cells from doxorubicin-induced apoptosis but alters cell morphology.
Topics: Angiogenesis Inhibitors; Apoptosis; Caspase 3; Caspases; Cell Size; Cell Survival; Cells, Cultured; | 2004 |
Thrombotic complications associated with thalidomide in multiple myeloma: an old problem with new questions and quandaries in decision-making.
Topics: Aged; Decision Making; Female; Humans; Male; Middle Aged; Multiple Myeloma; Practice Guidelines as T | 2004 |
Diabetic foot disease in a patient with multiple myeloma receiving thalidomide.
Topics: Angiogenesis Inhibitors; Collateral Circulation; Combined Modality Therapy; Diabetes Mellitus, Type | 2002 |