thalidomide has been researched along with Teratogenesis in 34 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Teratogenesis: The formation of CONGENITAL ABNORMALITIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| " In addition, we consider how the chick limb has been used to study mechanisms involved in teratogenesis with a focus on thalidomide." | 3.88 | The chick limb: embryology, genetics and teratology. ( Davey, MG; Tickle, C; Towers, M; Vargesson, N, 2018) |
| "Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS)." | 3.83 | Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. ( Bassermann, F; Eichner, R; Einsele, H; Fernández-Sáiz, V; Garz, AK; Germing, U; Götze, KS; Haass, C; Heider, M; Jacobs, L; Keller, U; Knop, S; Knorn, AM; Kuster, B; Langer, C; Lemeer, S; Peschel, C; Platzbecker, U; Rudelius, M; Schmid, B; Slawska, J; Targosz, BS; van Bebber, F, 2016) |
| "Thalidomide was first marketed in 1957 but soon withdrawn because of its notorious teratogenicity." | 2.66 | Recent advances in the molecular mechanism of thalidomide teratogenicity. ( Fan, R; Gao, S; Hu, J; Wang, S, 2020) |
| " We conclude that the PluriBeat assay is a novel method for predicting chemicals' adverse effects on embryonic development." | 1.56 | A novel human pluripotent stem cell-based assay to predict developmental toxicity. ( Emnéus, JK; Holst, B; Lauschke, K; Meiser, I; Neubauer, JC; Rasmussen, MA; Rosenmai, AK; Schmidt, K; Taxvig, C; Vinggaard, AM, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (55.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (35.29) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, S | 1 |
| Wang, S | 1 |
| Fan, R | 1 |
| Hu, J | 1 |
| Lauschke, K | 1 |
| Rosenmai, AK | 1 |
| Meiser, I | 1 |
| Neubauer, JC | 1 |
| Schmidt, K | 1 |
| Rasmussen, MA | 1 |
| Holst, B | 1 |
| Taxvig, C | 1 |
| Emnéus, JK | 1 |
| Vinggaard, AM | 1 |
| Yamanaka, S | 1 |
| Murai, H | 1 |
| Saito, D | 1 |
| Abe, G | 1 |
| Tokunaga, E | 1 |
| Iwasaki, T | 1 |
| Takahashi, H | 1 |
| Takeda, H | 1 |
| Suzuki, T | 1 |
| Shibata, N | 1 |
| Tamura, K | 1 |
| Sawasaki, T | 1 |
| Davey, MG | 1 |
| Towers, M | 1 |
| Vargesson, N | 4 |
| Tickle, C | 1 |
| Zakhem, GA | 1 |
| Motosko, CC | 1 |
| Mu, EW | 1 |
| Ho, RS | 1 |
| Gomes, JDA | 1 |
| Kowalski, TW | 3 |
| Fraga, LR | 3 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 2 |
| Schuler-Faccini, L | 3 |
| Vianna, FSL | 2 |
| Ito, T | 1 |
| Ando, H | 1 |
| Handa, H | 1 |
| Eichner, R | 1 |
| Heider, M | 1 |
| Fernández-Sáiz, V | 1 |
| van Bebber, F | 1 |
| Garz, AK | 1 |
| Lemeer, S | 1 |
| Rudelius, M | 1 |
| Targosz, BS | 1 |
| Jacobs, L | 1 |
| Knorn, AM | 1 |
| Slawska, J | 1 |
| Platzbecker, U | 1 |
| Germing, U | 1 |
| Langer, C | 1 |
| Knop, S | 1 |
| Einsele, H | 1 |
| Peschel, C | 1 |
| Haass, C | 1 |
| Keller, U | 1 |
| Schmid, B | 1 |
| Götze, KS | 1 |
| Kuster, B | 1 |
| Bassermann, F | 1 |
| Sales Luiz Vianna, F | 1 |
| Sanseverino, MT | 1 |
| Cassina, M | 1 |
| Cagnoli, GA | 1 |
| Zuccarello, D | 1 |
| Di Gianantonio, E | 1 |
| Clementi, M | 1 |
| Sorensen, D | 1 |
| Sackett, A | 1 |
| Urban, DJ | 1 |
| Maier, J | 1 |
| Sears, KE | 1 |
| Tovo-Rodrigues, L | 1 |
| Hutz, MH | 1 |
| AIAZZI MANCINI, M | 1 |
| MURPHY, ML | 1 |
| GIROUD, A | 1 |
| TUCHMANN-DUPLESSIS, H | 3 |
| MERCIER-PAROT, L | 2 |
| SALZGEBER, B | 1 |
| SALAUN, J | 1 |
| RIEMSCHNEIDER, R | 1 |
| BROCKMEYER, K | 1 |
| VOTAVA, Z | 1 |
| ANDRIEU, R | 1 |
| FELISATI, D | 1 |
| NODARI, R | 1 |
| LARSEN, V | 1 |
| FRASER, FC | 1 |
| SEVASTIKOGLOU, JA | 1 |
| CAHEN, R | 1 |
| SAUTAI, M | 1 |
| MONTAGNE, J | 1 |
| LOOSLI, R | 1 |
| THEISS, E | 1 |
| WIEDEMANN, HR | 1 |
| DEKKER, A | 1 |
| MEHRIZI, A | 1 |
| KUEHNE, P | 1 |
| ALEKSANDROV, PN | 1 |
| BOGDANOVA, VA | 1 |
| IVANOV, AI | 1 |
| SKOLDINOV, AP | 1 |
| CHERNUKH, AM | 1 |
6 reviews available for thalidomide and Teratogenesis
| Article | Year |
|---|---|
Recent advances in the molecular mechanism of thalidomide teratogenicity.
Topics: Humans; Teratogenesis; Thalidomide; Ubiquitin-Protein Ligases; Ubiquitination | 2020 |
Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review.
Topics: Acitretin; Adrenal Cortex Hormones; Colchicine; Cyclophosphamide; Dermatologic Agents; Doxycycline; | 2019 |
The teratogenic effects of thalidomide on limbs.
Topics: Abnormalities, Drug-Induced; Extremities; Female; History, 20th Century; History, 21st Century; Huma | 2019 |
[Thalidomide teratogenicity and its direct target identification].
Topics: Adaptor Proteins, Signal Transducing; Animals; Humans; Molecular Targeted Therapy; Multiple Myeloma; | 2015 |
Thalidomide-induced teratogenesis: history and mechanisms.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Female; History, 20th Century; History, 21st Century; H | 2015 |
[CLINICAL OBSERVATIONS ON PHARMACOGENIC TERATOGENESIS].
Topics: Abnormalities, Drug-Induced; Androgens; Infant, Newborn; Pregnancy; Progestins; Quinine; Teratogenes | 1964 |
28 other studies available for thalidomide and Teratogenesis
| Article | Year |
|---|---|
A novel human pluripotent stem cell-based assay to predict developmental toxicity.
Topics: Biological Assay; Cell Line; Developmental Biology; Embryoid Bodies; Epoxy Compounds; Female; Humans | 2020 |
Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chick Embryo; Cytochrome P-450 CYP3A; Humans; Mice; P | 2021 |
The chick limb: embryology, genetics and teratology.
Topics: Animals; Body Patterning; Cell Differentiation; Chick Embryo; Chickens; Embryology; Extremities; Gen | 2018 |
Thalidomide Teratogenic Effects Linked to Degradation of SALL4: After 60 years, researchers have now shed light on the mechanism underlying thalidomide's devastating teratogenic effects.
Topics: Humans; Proteolysis; Teratogenesis; Teratogens; Thalidomide; Transcription Factors | 2018 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.
Topics: Adaptor Proteins, Signal Transducing; Basigin; Cell Cycle Proteins; Humans; Immunologic Factors; Imm | 2016 |
The impact of thalidomide use in birth defects in Brazil.
Topics: Abnormalities, Multiple; Brazil; Congenital Abnormalities; Fetal Diseases; Humans; Leprosy; Teratoge | 2017 |
Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation.
Topics: Abnormalities, Drug-Induced; Angiotensin-Converting Enzyme Inhibitors; Animals; Female; Fetal Diseas | 2017 |
A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic Development; Female; Models, Anim | 2017 |
Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies.
Topics: Abnormalities, Multiple; beta Catenin; Brazil; Cyclooxygenase 2; Female; Genetic Variation; Humans; | 2017 |
[Thalidomide: a teratogenic drug?].
Topics: Congenital Abnormalities; Hypnotics and Sedatives; Teratogenesis; Teratogens; Thalidomide | 1962 |
Teratogenic effects in rats of growth inhibiting chemicals, including studies on thalidomide.
Topics: Animals; Antineoplastic Agents; Congenital Abnormalities; Humans; Male; Oligospermia; Rats; Teratoge | 1962 |
[Observatios on the teratogenic repercussions of thalidomide in the mouse and rabbit].
Topics: Animals; Congenital Abnormalities; Mice; Rabbits; Teratogenesis; Teratogens; Thalidomide | 1962 |
[Teratogenic action of thalidomide on the chick embryo, at different stages of development].
Topics: Animals; Chick Embryo; Congenital Abnormalities; Teratogenesis; Teratogens; Thalidomide | 1963 |
[The teratogenic risk].
Topics: Congenital Abnormalities; Drug Therapy; Ectromelia; Risk; Teratogenesis; Teratogens; Thalidomide | 1963 |
[TERATOGENIC EFFECT OF ORGANIC COMPOUNDS. III. FURTHER THALIDOMIDE EXPERIMENTS].
Topics: Abnormalities, Drug-Induced; Animals; Mammals; Organic Chemicals; Research; Teratogenesis; Thalidomi | 1963 |
[EFFECT OF DRUGS ON THE DEVELOPMENT OF THE FETUS WITH REFERENCE TO THE TERATOGENIC EFFECT OF THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Female; Fetus; Humans; Pharmacology; Pregnancy; Te | 1963 |
[HOW TO EXPLAIN THE TERATOGENIC ACTION OF THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Ectromelia; Pregnancy; Teratogenesis; Teratogens; Thalidomide; Toxicolo | 1963 |
[TOXIC AND TERATOGENIC EFFECTS OF THALIDOMIDE ON A RABBIT FETUS].
Topics: Abnormalities, Drug-Induced; Animals, Newborn; Ectromelia; Fetal Diseases; Fetus; Pregnancy; Pregnan | 1963 |
THE TERATOGENIC EFFECTS OF THALIDOMIDE, IMIPRAMINE HC1 AND IMIPRAMINE-N-OXIDE HC1 ON WHITE DANISH RABBITS.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetal Diseases; Humans; Imipramine; | 1963 |
EXPERIMENTAL TERATOGENESIS IN RELATION TO CONGENITAL MALFORMATIONS IN MAN.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Caffeine; Cortisone; Insulin; Lagomorph | 1964 |
[THALIDOMIDE TERATOGENESIS IN CHICKS].
Topics: Abnormalities, Drug-Induced; Chick Embryo; Research; Teratogenesis; Thalidomide; Toxicology | 1964 |
[RESEARCH ON THE TERATOGENIC EFFECT OF 2-DIETHYLAMINOPROPIOPHENONE].
Topics: Abnormalities, Drug-Induced; Animals; Diethylpropion; Female; Humans; Mice; Pregnancy; Rats; Researc | 1964 |
[APROPOS OF TERATOGENIC TESTS. SPONTANEOUS MALFORMATIONS IN RABBITS].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Lagomorpha; Rabbits; Research; Terat | 1964 |
[METHODS AND PROBLEMS IN EXPERIMENTAL DRUG-INDUCED TERATOGENESIS].
Topics: Abnormalities, Drug-Induced; Animals; Drugs, Investigational; Female; Humans; Lagomorpha; Pregnancy; | 1964 |
THE USE OF THALIDOMIDE AS TERATOGENIC AGENT IN RABBITS.
Topics: Abnormalities, Drug-Induced; Animal Experimentation; Animals; Ectromelia; Lagomorpha; Pathology; Rab | 1964 |
[THE PROCEDURES FOR THE TESTING OF TERATOGENIC EFFECTS TAKE SHAPE].
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Haplorhini; Humans; Pregnancy; Sodium Chlori | 1965 |
[METHOD OF PRELIMINARY EVALUATION OF THE TERATOGENIC EFFECT OF DRUGS ON CHICK EMBRYOS].
Topics: Abnormalities, Drug-Induced; Chick Embryo; Research; Teratogenesis; Thalidomide; Toxicology | 1965 |