thalidomide has been researched along with Telangiectasis in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Telangiectasis: Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although epistaxis is usually presented in childhood (mean age 11 ± 7." | 1.48 | Clinical features and treatment of hereditary hemorrhagic telangiectasia. ( Li, S; Wang, SJ; Zhao, YQ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalik, JA | 1 |
| Friedman, H | 1 |
| Bechtel, MA | 1 |
| Gru, AA | 1 |
| Kaffenberger, BH | 1 |
| Li, S | 1 |
| Wang, SJ | 1 |
| Zhao, YQ | 1 |
| Alberto, SF | 1 |
| Felix, J | 1 |
| de Deus, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Open Clinical Trial of Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding[NCT04680195] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-12-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for thalidomide and Telangiectasis
| Article | Year |
|---|---|
Purpura Annularis Telangiectodes of Majocchi Associated With the Initiation and Rechallenge of Apremilast for Psoriasis Vulgaris.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Humans; Male; Middle Aged; Psoriasis; Purpura; Skin | 2017 |
Clinical features and treatment of hereditary hemorrhagic telangiectasia.
Topics: Adult; Angiogenesis Inhibitors; Arteriovenous Malformations; Delayed Diagnosis; Epistaxis; Female; H | 2018 |
Thalidomide for the treatment of severe intestinal bleeding.
Topics: Aged; Angiodysplasia; Angiogenesis Inhibitors; Anti-Inflammatory Agents; Gastrointestinal Hemorrhage | 2008 |