thalidomide has been researched along with Spinal Neoplasms in 9 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Spinal Neoplasms: New abnormal growth of tissue in the SPINE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An open-label phase I trial of thalidomide (TL) in 20 patients with neurofibromatosis 1 (NF1) treated symptomatic plexiform neurofibroma (PNF)." | 9.10 | Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1. ( Cohen, BH; Gupta, A; Packer, RJ; Phillips, PC; Ruggieri, P, 2003) |
| "An open-label phase I trial of thalidomide (TL) in 20 patients with neurofibromatosis 1 (NF1) treated symptomatic plexiform neurofibroma (PNF)." | 5.10 | Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1. ( Cohen, BH; Gupta, A; Packer, RJ; Phillips, PC; Ruggieri, P, 2003) |
| " Although treatment was initiated with thalidomide, the patient developed multiple organ dysfunction syndrome (MODS) and succumbed to his disease." | 3.73 | Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon. ( Bölke, E; Budach, W; Gripp, S; Orth, K; Peiper, M; Reinecke, P; Schwarz, A; van de Nes, JA, 2006) |
| "Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal." | 1.35 | Kaposiform hemangioendothelioma in multiple spinal levels without skin changes. ( Bradeen, HA; Kalof, AN; Lisle, JW, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Suresh, KV | 1 |
| Xu, AL | 1 |
| Groves, ML | 1 |
| Sponseller, PD | 1 |
| Lisle, JW | 1 |
| Bradeen, HA | 1 |
| Kalof, AN | 1 |
| Ninan, MJ | 1 |
| Datta, YH | 1 |
| Kayaci, S | 1 |
| Yildiz, O | 1 |
| Gucer, H | 1 |
| Mandel, NM | 1 |
| Gupta, A | 1 |
| Cohen, BH | 1 |
| Ruggieri, P | 1 |
| Packer, RJ | 1 |
| Phillips, PC | 1 |
| Gaur, S | 1 |
| Oo, TH | 1 |
| Aish, LS | 1 |
| Mansoor, S | 1 |
| Bölke, E | 1 |
| Gripp, S | 1 |
| Peiper, M | 1 |
| Budach, W | 1 |
| Schwarz, A | 1 |
| Orth, K | 1 |
| Reinecke, P | 1 |
| van de Nes, JA | 1 |
| Dytfeld, D | 1 |
| Matuszak, M | 1 |
| Lewandowski, K | 1 |
| Komarnicki, M | 1 |
| Mawrin, C | 1 |
| Aumann, V | 1 |
| Kirches, E | 1 |
| Schneider-Stock, R | 1 |
| Scherlach, C | 1 |
| Vogel, S | 1 |
| Mittler, U | 1 |
| Dietzmann, K | 1 |
| Krause, G | 1 |
| Weis, S | 1 |
2 reviews available for thalidomide and Spinal Neoplasms
| Article | Year |
|---|---|
Spinal screening, malignancy, medical therapy, and surgical correction of deformity in pediatric patients with neurofibromatosis type 1: a systematic review.
Topics: Child; Humans; Kyphosis; Mitogen-Activated Protein Kinase Kinases; Neurofibromatosis 1; Sirolimus; S | 2022 |
Post-transplant lymphoproliferative disorder presenting as multiple myeloma.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy | 2010 |
1 trial available for thalidomide and Spinal Neoplasms
| Article | Year |
|---|---|
Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1.
Topics: Adolescent; Adult; Angiogenesis Inhibitors; Child; Cohort Studies; Dermatologic Agents; Dose-Respons | 2003 |
6 other studies available for thalidomide and Spinal Neoplasms
| Article | Year |
|---|---|
Kaposiform hemangioendothelioma in multiple spinal levels without skin changes.
Topics: Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Celecoxib; Chil | 2009 |
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy.
Topics: Angiogenesis Inhibitors; Biopsy; Cervical Vertebrae; Chemoradiotherapy; Hemangiosarcoma; Humans; Liv | 2012 |
Gastric relapse of solitary bone plasmacytoma.
Topics: Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combin | 2005 |
Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon.
Topics: Angiogenesis Inhibitors; Diagnosis, Differential; Fatal Outcome; Hemangioendothelioma, Epithelioid; | 2006 |
Bortezomib in combination with thalidomide and dexamethasone--a successful treatment regimen in refractory extramedullary multiple myeloma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Humans; Ma | 2008 |
Gliomatosis cerebri: post-mortem molecular and immunohistochemical analyses in a case treated with thalidomide.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Diagnosis, Diff | 2001 |