thalidomide has been researched along with Spinal Cord Injuries in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of thalidomide on spinal cord ischemia/reperfusion injury via reduced TNF-alpha production." | 7.74 | The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model. ( Kim, CS; Kim, KW; Lee, CJ; Lee, HM; Lim, YJ; Nahm, FS; Park, JH, 2007) |
| "To evaluate the effects of thalidomide on spinal cord ischemia/reperfusion injury via reduced TNF-alpha production." | 3.74 | The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model. ( Kim, CS; Kim, KW; Lee, CJ; Lee, HM; Lim, YJ; Nahm, FS; Park, JH, 2007) |
| "Rats treated with thalidomide showed significant increase in SC water compared with naive rats, but not vehicle-treated rats; their neutrophil infiltration and amount of spared/destroyed cord tissue was not different from vehicle-treated rats; and in no case was motor performance improved after thalidomide." | 1.35 | Thalidomide fails to be therapeutic following contusive spinal cord injury in rats. ( Franco-Bourland, RE; Fuchs, B; Grijalva, I; Guízar-Sahagún, G; Madrazo, I; Martínez-Cruz, A; Reyes-Alva, HJ, 2009) |
| "Thalidomide treatment significantly reduced the degree of: 1) spinal cord inflammation and tissue injury (histological score); 2) neutrophil infiltration (myeloperoxidase evaluation); 3) iNOS, nitrotyrosine, lipid peroxidation, and cytokine expression (TNF-alpha and IL-1beta); 4) apoptosis (terminal deoxynucleotidyltransferase-mediated UTP end labeling staining, and Bax and Bcl-2 expression); and 5) nuclear factor-kappaB activation." | 1.35 | Effect of thalidomide on signal transduction pathways and secondary damage in experimental spinal cord trauma. ( Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Esposito, E; Genovese, T; Mazzon, E; Meli, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koopmans, GC | 1 |
| Deumens, R | 1 |
| Buss, A | 1 |
| Geoghegan, L | 1 |
| Myint, AM | 1 |
| Honig, WH | 1 |
| Kern, N | 1 |
| Joosten, EA | 1 |
| Noth, J | 1 |
| Brook, GA | 1 |
| Reyes-Alva, HJ | 1 |
| Franco-Bourland, RE | 1 |
| Martínez-Cruz, A | 1 |
| Grijalva, I | 1 |
| Fuchs, B | 1 |
| Madrazo, I | 1 |
| Guízar-Sahagún, G | 1 |
| Lee, CJ | 1 |
| Kim, KW | 1 |
| Lee, HM | 1 |
| Nahm, FS | 1 |
| Lim, YJ | 1 |
| Park, JH | 1 |
| Kim, CS | 1 |
| Genovese, T | 1 |
| Mazzon, E | 1 |
| Esposito, E | 1 |
| Di Paola, R | 1 |
| Caminiti, R | 1 |
| Meli, R | 1 |
| Bramanti, P | 1 |
| Cuzzocrea, S | 1 |
4 other studies available for thalidomide and Spinal Cord Injuries
| Article | Year |
|---|---|
Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury.
Topics: Animals; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Enzyme-Linked Immun | 2009 |
Thalidomide fails to be therapeutic following contusive spinal cord injury in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Fema | 2009 |
The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Count; Disease Models, Animal; Immunosuppressive Ag | 2007 |
Effect of thalidomide on signal transduction pathways and secondary damage in experimental spinal cord trauma.
Topics: Animals; Apoptosis; Cytokines; Disease Models, Animal; Immunosuppressive Agents; Lipid Peroxidation; | 2008 |