thalidomide has been researched along with Spinal Cord Diseases in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Spinal Cord Diseases: Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-alpha (TNF-alpha), an important mediator in CNS inflammation, by enhancing TNF-alpha mRNA degradation." | 5.34 | Thalidomide for acute treatment of neurosarcoidosis. ( Hammond, ER; Kaplin, AI; Kerr, DA, 2007) |
| "Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-alpha (TNF-alpha), an important mediator in CNS inflammation, by enhancing TNF-alpha mRNA degradation." | 1.34 | Thalidomide for acute treatment of neurosarcoidosis. ( Hammond, ER; Kaplin, AI; Kerr, DA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, SW | 1 |
| Kim, KT | 1 |
| Youn, YC | 1 |
| Kwon, OS | 1 |
| Kim, YB | 1 |
| Hammond, ER | 1 |
| Kaplin, AI | 1 |
| Kerr, DA | 1 |
| Forrester, RM | 1 |
| Fotopulos, D | 1 |
4 other studies available for thalidomide and Spinal Cord Diseases
| Article | Year |
|---|---|
Isolated spinal cord neurosarcoidosis diagnosed by cord biopsy and thalidomide trial.
Topics: Adrenal Cortex Hormones; Biopsy; Central Nervous System Diseases; Female; Humans; Immunosuppressive | 2011 |
Thalidomide for acute treatment of neurosarcoidosis.
Topics: Adult; Brain; Granuloma; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Proprio | 2007 |
Motor handicap in children: a study of a population in 1965.
Topics: Abnormalities, Drug-Induced; Adolescent; Arthritis, Juvenile; Brain Damage, Chronic; Cerebral Palsy; | 1967 |
[Huntington's chorea and chronic-progressive spinal muscular atrophy].
Topics: Adult; Anxiety; Arm; Chronic Disease; Female; Functional Laterality; Humans; Huntington Disease; Men | 1966 |