thalidomide has been researched along with Sjogren's Syndrome in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lenalidomide therapy was started after the diagnosis and the patient had a favorable outcome." | 1.46 | Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report. ( Akiyama, H; Hara, D; Hasegawa, Y; Hoshikawa, M; Nukui, S; Shimizu, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hara, D | 1 |
| Akiyama, H | 1 |
| Nukui, S | 1 |
| Shimizu, T | 1 |
| Hoshikawa, M | 1 |
| Hasegawa, Y | 1 |
| Pillemer, SR | 1 |
| Leakan, RA | 2 |
| Sankar, V | 2 |
| Manny, J | 1 |
| Baum, BJ | 1 |
| Smith, J | 1 |
| Chaudhry, U | 1 |
| Fox, PC | 1 |
| Radfar, L | 1 |
| Ligier, S | 1 |
| Brennan, MT | 1 |
| Moutsopoulos, NM | 1 |
| Angelov, N | 1 |
| Pillemer, S | 1 |
| Wahl, SM | 1 |
2 trials available for thalidomide and Sjogren's Syndrome
| Article | Year |
|---|---|
Prominent adverse effects of thalidomide in primary Sjögren's syndrome.
Topics: Double-Blind Method; Drug Administration Schedule; Humans; Immunosuppressive Agents; Sjogren's Syndr | 2004 |
Immunological consequences of thalidomide treatment in Sjögren's syndrome.
Topics: Cytokines; Double-Blind Method; Female; Humans; Immunophenotyping; Immunosuppressive Agents; Leukocy | 2006 |
1 other study available for thalidomide and Sjogren's Syndrome
| Article | Year |
|---|---|
Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report.
Topics: Arthritis, Rheumatoid; Cell Proliferation; Diagnosis, Differential; Female; Humans; Immunoelectropho | 2017 |