thalidomide and Seizures
thalidomide has been researched along with Seizures in 12 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 5.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity." | 5.40 | Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "TNBS-induced colitis increased seizure susceptibility to a subconvulsive dose of pentylenetetrazole; the immunomodulator thalidomide was protective." | 3.75 | Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model. ( Avti, PK; Chakrabarti, A; Khanduja, KL; Medhi, B; Prakash, A, 2009) |
| " Thalidomide is effective in reducing the extent of arthritis as well as reducing the seizure scoring and increasing seizure onset in the adjuvant arthritis group." | 3.74 | Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat. ( Arora, SK; Khanduja, KL; Medhi, B; Pandhi, P; Rao, RS; Saikia, UN; Toor, JS, 2008) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 1.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity." | 1.40 | Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014) |
| "Thalidomide was synthesized more than 50 years ago as hypnotic sedative with unique pharmacologic properties." | 1.37 | Strong anticonvulsant effect of thalidomide on amygdaloid kindling. ( Custodio-Ramirez, V; Palencia, G; Paz, C; Rubio, C; Sotelo, J, 2011) |
| "Thalidomide was used as treatment in colitis and arthritis group, whereas etoricoxib was used in CWG group." | 1.36 | Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models. ( Khanduja, KL; Medhi, B; Pandhi, P; Rao, RS, 2010) |
| "Frequency and intensity of epileptic seizures were reduced significantly, and the quality of her life improved." | 1.32 | Rasmussen syndrome and long-term response to thalidomide. ( Djordjevic, MS; Kravljanac, RM; Marjanovic, BD; Stojanov, LM; Zdravkovic, DS, 2003) |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hao, Y | 1 |
| Ou, Y | 1 |
| Zhang, C | 1 |
| Chen, H | 1 |
| Yue, H | 1 |
| Yang, Z | 1 |
| Zhong, X | 1 |
| Hu, W | 1 |
| Sun, P | 1 |
| Cumbres-Vargas, IM | 1 |
| Zamudio, SR | 1 |
| Pichardo-Macías, LA | 1 |
| Ramírez-San Juan, E | 1 |
| Pourshadi, N | 1 |
| Rahimi, N | 1 |
| Ghasemi, M | 1 |
| Faghir-Ghanesefat, H | 1 |
| Sharifzadeh, M | 1 |
| Dehpour, AR | 2 |
| Islas-Espinoza, AM | 1 |
| Campos-Rodriguez, C | 1 |
| San Juan, ER | 1 |
| Payandemehr, B | 1 |
| Rahimian, R | 1 |
| Gooshe, M | 1 |
| Bahremand, A | 1 |
| Gholizadeh, R | 1 |
| Berijani, S | 1 |
| Ahmadi-Dastgerdi, M | 1 |
| Aminizade, M | 1 |
| Sarreshte-Dari, A | 1 |
| Dianati, V | 1 |
| Amanlou, M | 1 |
| Simon, AJ | 1 |
| Lev, A | 1 |
| Zhang, Y | 1 |
| Weiss, B | 1 |
| Rylova, A | 1 |
| Eyal, E | 1 |
| Kol, N | 1 |
| Barel, O | 1 |
| Cesarkas, K | 1 |
| Soudack, M | 1 |
| Greenberg-Kushnir, N | 1 |
| Rhodes, M | 1 |
| Wiest, DL | 1 |
| Schiby, G | 1 |
| Barshack, I | 1 |
| Katz, S | 1 |
| Pras, E | 1 |
| Poran, H | 1 |
| Reznik-Wolf, H | 1 |
| Ribakovsky, E | 1 |
| Simon, C | 1 |
| Hazou, W | 1 |
| Sidi, Y | 1 |
| Lahad, A | 1 |
| Katzir, H | 1 |
| Sagie, S | 1 |
| Aqeilan, HA | 1 |
| Glousker, G | 1 |
| Amariglio, N | 1 |
| Tzfati, Y | 1 |
| Selig, S | 1 |
| Rechavi, G | 1 |
| Somech, R | 1 |
| Rao, RS | 2 |
| Medhi, B | 3 |
| Saikia, UN | 1 |
| Arora, SK | 1 |
| Toor, JS | 1 |
| Khanduja, KL | 3 |
| Pandhi, P | 2 |
| Prakash, A | 1 |
| Avti, PK | 1 |
| Chakrabarti, A | 1 |
| Palencia, G | 1 |
| Rubio, C | 1 |
| Custodio-Ramirez, V | 1 |
| Paz, C | 1 |
| Sotelo, J | 1 |
| Marjanovic, BD | 1 |
| Stojanov, LM | 1 |
| Zdravkovic, DS | 1 |
| Kravljanac, RM | 1 |
| Djordjevic, MS | 1 |
| Silvestrini, B | 1 |
| Barcellona, PS | 1 |
| Garau, A | 1 |
| Catanese, B | 1 |
Other Studies
12 other studies available for thalidomide and Seizures
| Article | Year |
|---|---|
Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation.
Topics: Animals; Benzoquinones; Epilepsy; Ferroptosis; Glutathione; Heptanoic Acids; Mice; Pentylenetetrazol | 2022 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; | 2023 |
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2014 |
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
Topics: Animals; Ataxia; Brain Neoplasms; Calcinosis; Central Nervous System Cysts; Disease Models, Animal; | 2016 |
Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat.
Topics: Acetic Acid; Analysis of Variance; Animals; Arthritis; Colitis; Cyclooxygenase Inhibitors; Cytokines | 2008 |
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Li | 2009 |
Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models.
Topics: Animals; Arthritis, Experimental; Colitis; Disease Models, Animal; Granuloma; Inflammation; Lipid Pe | 2010 |
Strong anticonvulsant effect of thalidomide on amygdaloid kindling.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2011 |
Rasmussen syndrome and long-term response to thalidomide.
Topics: Adolescent; Anticonvulsants; Brain; Electroencephalography; Encephalitis; Female; Humans; Magnetic R | 2003 |
Toxicology of benzydamine.
Topics: Amines; Animals; Anti-Inflammatory Agents; Ataxia; Body Weight; Cats; Diet; Dogs; Female; Growth; Li | 1967 |