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thalidomide and Seizures

thalidomide has been researched along with Seizures in 12 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine."7.88Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018)
"Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy."5.91Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023)
"Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity."5.40Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014)
" Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine."3.88Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018)
"TNBS-induced colitis increased seizure susceptibility to a subconvulsive dose of pentylenetetrazole; the immunomodulator thalidomide was protective."3.75Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model. ( Avti, PK; Chakrabarti, A; Khanduja, KL; Medhi, B; Prakash, A, 2009)
" Thalidomide is effective in reducing the extent of arthritis as well as reducing the seizure scoring and increasing seizure onset in the adjuvant arthritis group."3.74Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat. ( Arora, SK; Khanduja, KL; Medhi, B; Pandhi, P; Rao, RS; Saikia, UN; Toor, JS, 2008)
"Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy."1.91Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023)
"Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity."1.40Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014)
"Thalidomide was synthesized more than 50 years ago as hypnotic sedative with unique pharmacologic properties."1.37Strong anticonvulsant effect of thalidomide on amygdaloid kindling. ( Custodio-Ramirez, V; Palencia, G; Paz, C; Rubio, C; Sotelo, J, 2011)
"Thalidomide was used as treatment in colitis and arthritis group, whereas etoricoxib was used in CWG group."1.36Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models. ( Khanduja, KL; Medhi, B; Pandhi, P; Rao, RS, 2010)
"Frequency and intensity of epileptic seizures were reduced significantly, and the quality of her life improved."1.32Rasmussen syndrome and long-term response to thalidomide. ( Djordjevic, MS; Kravljanac, RM; Marjanovic, BD; Stojanov, LM; Zdravkovic, DS, 2003)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's0 (0.00)18.2507
2000's3 (25.00)29.6817
2010's5 (41.67)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Hao, Y1
Ou, Y1
Zhang, C1
Chen, H1
Yue, H1
Yang, Z1
Zhong, X1
Hu, W1
Sun, P1
Cumbres-Vargas, IM1
Zamudio, SR1
Pichardo-Macías, LA1
Ramírez-San Juan, E1
Pourshadi, N1
Rahimi, N1
Ghasemi, M1
Faghir-Ghanesefat, H1
Sharifzadeh, M1
Dehpour, AR2
Islas-Espinoza, AM1
Campos-Rodriguez, C1
San Juan, ER1
Payandemehr, B1
Rahimian, R1
Gooshe, M1
Bahremand, A1
Gholizadeh, R1
Berijani, S1
Ahmadi-Dastgerdi, M1
Aminizade, M1
Sarreshte-Dari, A1
Dianati, V1
Amanlou, M1
Simon, AJ1
Lev, A1
Zhang, Y1
Weiss, B1
Rylova, A1
Eyal, E1
Kol, N1
Barel, O1
Cesarkas, K1
Soudack, M1
Greenberg-Kushnir, N1
Rhodes, M1
Wiest, DL1
Schiby, G1
Barshack, I1
Katz, S1
Pras, E1
Poran, H1
Reznik-Wolf, H1
Ribakovsky, E1
Simon, C1
Hazou, W1
Sidi, Y1
Lahad, A1
Katzir, H1
Sagie, S1
Aqeilan, HA1
Glousker, G1
Amariglio, N1
Tzfati, Y1
Selig, S1
Rechavi, G1
Somech, R1
Rao, RS2
Medhi, B3
Saikia, UN1
Arora, SK1
Toor, JS1
Khanduja, KL3
Pandhi, P2
Prakash, A1
Avti, PK1
Chakrabarti, A1
Palencia, G1
Rubio, C1
Custodio-Ramirez, V1
Paz, C1
Sotelo, J1
Marjanovic, BD1
Stojanov, LM1
Zdravkovic, DS1
Kravljanac, RM1
Djordjevic, MS1
Silvestrini, B1
Barcellona, PS1
Garau, A1
Catanese, B1

Other Studies

12 other studies available for thalidomide and Seizures

ArticleYear
Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation.
    Brain research, 2022, 11-15, Volume: 1795

    Topics: Animals; Benzoquinones; Epilepsy; Ferroptosis; Glutathione; Heptanoic Acids; Mice; Pentylenetetrazol

2022
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
    International journal of molecular sciences, 2023, Mar-30, Volume: 24, Issue:7

    Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male;

2023
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions.
    Epilepsy research, 2020, Volume: 164

    Topics: Analgesics, Opioid; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dr

2020
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
    The Journal of toxicological sciences, 2018, Volume: 43, Issue:11

    Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb

2018
Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice.
    Epilepsy & behavior : E&B, 2014, Volume: 34

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitor

2014
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
    The Journal of experimental medicine, 2016, 07-25, Volume: 213, Issue:8

    Topics: Animals; Ataxia; Brain Neoplasms; Calcinosis; Central Nervous System Cysts; Disease Models, Animal;

2016
Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:10

    Topics: Acetic Acid; Analysis of Variance; Animals; Arthritis; Colitis; Cyclooxygenase Inhibitors; Cytokines

2008
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:10

    Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Li

2009
Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models.
    Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:3

    Topics: Animals; Arthritis, Experimental; Colitis; Disease Models, Animal; Granuloma; Inflammation; Lipid Pe

2010
Strong anticonvulsant effect of thalidomide on amygdaloid kindling.
    Epilepsy research, 2011, Volume: 95, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electr

2011
Rasmussen syndrome and long-term response to thalidomide.
    Pediatric neurology, 2003, Volume: 29, Issue:2

    Topics: Adolescent; Anticonvulsants; Brain; Electroencephalography; Encephalitis; Female; Humans; Magnetic R

2003
Toxicology of benzydamine.
    Toxicology and applied pharmacology, 1967, Volume: 10, Issue:1

    Topics: Amines; Animals; Anti-Inflammatory Agents; Ataxia; Body Weight; Cats; Diet; Dogs; Female; Growth; Li

1967