thalidomide has been researched along with Sciatica in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Sciatica: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, XH | 1 |
| Zang, Y | 1 |
| Chen, X | 1 |
| Pang, RP | 1 |
| Xu, JT | 1 |
| Zhou, X | 1 |
| Wei, XH | 1 |
| Li, YY | 1 |
| Xin, WJ | 1 |
| Qin, ZH | 1 |
| Liu, XG | 1 |
| Mulleman, D | 1 |
| Mammou, S | 1 |
| Griffoul, I | 1 |
| Watier, H | 1 |
| Goupille, P | 1 |
1 review available for thalidomide and Sciatica
| Article | Year |
|---|---|
Pathophysiology of disk-related low back pain and sciatica. II. Evidence supporting treatment with TNF-alpha antagonists.
Topics: Animals; Antibodies, Monoclonal; Doxycycline; Humans; Infliximab; Low Back Pain; Neuralgia; Pentoxif | 2006 |
1 other study available for thalidomide and Sciatica
| Article | Year |
|---|---|
TNF-α contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Electric Stimulation; Functional Laterality; Gangl | 2010 |