thalidomide has been researched along with Schwartzman Phenomenon in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histologically, the intensity of the Shwartzman reaction was reduced." | 1.29 | Effects of thalidomide on the local Shwartzman reaction in mice and rabbits. ( Geist, C; Schneider, J; Wöhrmann, T; Zwingenberger, K, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wöhrmann, T | 2 |
| Geist, C | 2 |
| Schneider, J | 2 |
| Matthiesen, T | 1 |
| Zwingenberger, K | 3 |
| Hess, S | 1 |
| Akermann, MA | 1 |
| Wnendt, S | 1 |
| Eger, K | 1 |
3 other studies available for thalidomide and Schwartzman Phenomenon
| Article | Year |
|---|---|
Local skin reactivity after induction of Shwartzman reaction in rabbits.
Topics: Animals; Dexamethasone; Lipopolysaccharides; Male; Rabbits; Shwartzman Phenomenon; Skin; Thalidomide | 1995 |
Effects of thalidomide on the local Shwartzman reaction in mice and rabbits.
Topics: Animals; Capillary Permeability; Dexamethasone; Intercellular Adhesion Molecule-1; Macrophage-1 Anti | 1995 |
Synthesis and immunological activity of water-soluble thalidomide prodrugs.
Topics: Animals; Binding Sites; Drug Stability; Humans; Hydrogen-Ion Concentration; Hydrolysis; Interleukin- | 2001 |