thalidomide has been researched along with SAPHO Syndrome in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals." | 5.48 | Successful treatment of SAPHO syndrome with apremilast. ( Adamo, S; Cozzio, A; French, LE; Kolios, AGA; Krebs, A; Nilsson, J; Steiner, U, 2018) |
| "A FREQUENT AFFECTION: Ankylosing spondylitis is a chronic inflammatory rheumatism usually affecting young adults and characterized by an inflammatory enthesiopathy progressing towards ossification and ankylosis." | 2.42 | [Ankylosing spondylitis]. ( El Maghraoui, A, 2004) |
| "The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals." | 1.48 | Successful treatment of SAPHO syndrome with apremilast. ( Adamo, S; Cozzio, A; French, LE; Kolios, AGA; Krebs, A; Nilsson, J; Steiner, U, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adamo, S | 1 |
| Nilsson, J | 1 |
| Krebs, A | 1 |
| Steiner, U | 1 |
| Cozzio, A | 1 |
| French, LE | 1 |
| Kolios, AGA | 1 |
| Firinu, D | 1 |
| El Maghraoui, A | 1 |
1 review available for thalidomide and SAPHO Syndrome
| Article | Year |
|---|---|
[Ankylosing spondylitis].
Topics: Acquired Hyperostosis Syndrome; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 2004 |
2 other studies available for thalidomide and SAPHO Syndrome
| Article | Year |
|---|---|
Successful treatment of SAPHO syndrome with apremilast.
Topics: Acquired Hyperostosis Syndrome; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Resistance; Fem | 2018 |
A promising new treatment for SAPHO syndrome that deserves further studies.
Topics: Acquired Hyperostosis Syndrome; Humans; Thalidomide | 2018 |