thalidomide has been researched along with Retinopathy of Prematurity in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Retinopathy of Prematurity: A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is a well-known anti-angiogenic drug." | 5.35 | The effect of thalidomide on neovascularization in a mouse model of retinopathy of prematurity. ( Katz, G; Pri-Chen, S; Rabinowitz, R; Rosner, M; Spierer, A, 2008) |
| "Thalidomide is a well-known anti-angiogenic drug." | 1.35 | The effect of thalidomide on neovascularization in a mouse model of retinopathy of prematurity. ( Katz, G; Pri-Chen, S; Rabinowitz, R; Rosner, M; Spierer, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabinowitz, R | 1 |
| Katz, G | 1 |
| Rosner, M | 1 |
| Pri-Chen, S | 1 |
| Spierer, A | 1 |
| Silverman, WA | 1 |
2 other studies available for thalidomide and Retinopathy of Prematurity
| Article | Year |
|---|---|
The effect of thalidomide on neovascularization in a mouse model of retinopathy of prematurity.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Dextrans; Disease Models, Animal; Fluoresceins; | 2008 |
Medical inflation.
Topics: Financing, Government; History, 20th Century; Humans; Infant Nutritional Physiological Phenomena; In | 1980 |