thalidomide has been researched along with Reperfusion Injury in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of thalidomide on spinal cord ischemia/reperfusion injury via reduced TNF-alpha production." | 7.74 | The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model. ( Kim, CS; Kim, KW; Lee, CJ; Lee, HM; Lim, YJ; Nahm, FS; Park, JH, 2007) |
| "Thalidomide has shown protective effects in different models of ischemia/reperfusion damage." | 5.42 | Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia/reperfusion injury in rats. ( Farfán, DJ; Medrano, JÁN; Ortiz-Plata, A; Palencia, G; Sánchez, A; Sotelo, J; Trejo-Solís, C, 2015) |
| "Thalidomide treatment decreases PMNL infiltration, retinal edema, VEGF, and TNF-alpha synthesis following I/R injury to the guinea pig retina." | 5.35 | The effect of thalidomide on vascular endothelial growth factor and tumor necrosis factor-alpha levels in retinal ischemia/reperfusion injury. ( Akpolat, N; Aydoğan, S; Celiker, U; Ilhan, N; Türkçüoğlu, P, 2008) |
| "Thalidomide treatment increased retinal endostatin level in ischemia/reperfusion-injured guinea pig retinas." | 5.34 | Effect of thalidomide on endostatin levels in retinal ischemia/reperfusion injury. ( Aydoğan, S; Celiker, U; Ilhan, N; Türkçüoğlu, P, 2007) |
| "To evaluate the effects of thalidomide on spinal cord ischemia/reperfusion injury via reduced TNF-alpha production." | 3.74 | The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model. ( Kim, CS; Kim, KW; Lee, CJ; Lee, HM; Lim, YJ; Nahm, FS; Park, JH, 2007) |
| "Thalidomide treatment significantly decreased the infarct volume and neurological deficits of MCAO/R rats." | 1.48 | The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity. ( Asahi, T; Fujiwara, M; Hayashi, H; Sawamura, N; Takagi, N; Yamada, H; Yamada, M, 2018) |
| "Thalidomide has shown protective effects in different models of ischemia/reperfusion damage." | 1.42 | Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia/reperfusion injury in rats. ( Farfán, DJ; Medrano, JÁN; Ortiz-Plata, A; Palencia, G; Sánchez, A; Sotelo, J; Trejo-Solís, C, 2015) |
| "Thalidomide treatment decreases PMNL infiltration, retinal edema, VEGF, and TNF-alpha synthesis following I/R injury to the guinea pig retina." | 1.35 | The effect of thalidomide on vascular endothelial growth factor and tumor necrosis factor-alpha levels in retinal ischemia/reperfusion injury. ( Akpolat, N; Aydoğan, S; Celiker, U; Ilhan, N; Türkçüoğlu, P, 2008) |
| "Thalidomide treatment increased retinal endostatin level in ischemia/reperfusion-injured guinea pig retinas." | 1.34 | Effect of thalidomide on endostatin levels in retinal ischemia/reperfusion injury. ( Aydoğan, S; Celiker, U; Ilhan, N; Türkçüoğlu, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Mohammed, RA | 1 |
| El-Yamany, MF | 1 |
| Abdel-Rahman, AA | 1 |
| Nassar, NN | 1 |
| Al-Shorbagy, MY | 1 |
| Sawamura, N | 1 |
| Yamada, M | 1 |
| Fujiwara, M | 1 |
| Yamada, H | 1 |
| Hayashi, H | 1 |
| Takagi, N | 1 |
| Asahi, T | 1 |
| Palencia, G | 1 |
| Medrano, JÁN | 1 |
| Ortiz-Plata, A | 1 |
| Farfán, DJ | 1 |
| Sotelo, J | 1 |
| Sánchez, A | 1 |
| Trejo-Solís, C | 1 |
| Esposito, E | 1 |
| Cuzzocrea, S | 1 |
| Cámara-Lemarroy, CR | 1 |
| Guzmán-de la Garza, FJ | 1 |
| Alarcón-Galván, G | 1 |
| Cordero-Pérez, P | 1 |
| Muñoz-Espinosa, LE | 1 |
| Fernández-Garza, NE | 1 |
| Lee, CJ | 1 |
| Kim, KW | 1 |
| Lee, HM | 1 |
| Nahm, FS | 1 |
| Lim, YJ | 1 |
| Park, JH | 1 |
| Kim, CS | 1 |
| Aydoğan, S | 2 |
| Celiker, U | 2 |
| Türkçüoğlu, P | 2 |
| Ilhan, N | 2 |
| Akpolat, N | 1 |
1 review available for thalidomide and Reperfusion Injury
| Article | Year |
|---|---|
TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Humans; Immunosuppressive A | 2009 |
7 other studies available for thalidomide and Reperfusion Injury
| Article | Year |
|---|---|
Role of pERK1/2-NFκB signaling in the neuroprotective effect of thalidomide against cerebral ischemia reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Disease Models, Animal; Hippocampus; Male; Memory | 2021 |
The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity.
Topics: AMP-Activated Protein Kinases; Animals; ATP-Dependent Proteases; Brain Ischemia; Cell Death; Cell Li | 2018 |
Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia/reperfusion injury in rats.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Inflammation; M | 2015 |
Effects of thalidomide and pentoxyphylline over local and remote organ injury after intestinal ischemia/reperfusion.
Topics: Animals; Aspartate Aminotransferases; Enzyme-Linked Immunosorbent Assay; Intestinal Mucosa; Intestin | 2010 |
The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Count; Disease Models, Animal; Immunosuppressive Ag | 2007 |
The effect of thalidomide on vascular endothelial growth factor and tumor necrosis factor-alpha levels in retinal ischemia/reperfusion injury.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Guinea | 2008 |
Effect of thalidomide on endostatin levels in retinal ischemia/reperfusion injury.
Topics: Animals; Endostatins; Guinea Pigs; Intubation, Gastrointestinal; Male; Reperfusion Injury; Retina; R | 2007 |