thalidomide has been researched along with Renal Insufficiency, Chronic in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection." | 7.79 | Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013) |
| "Thalidomide was added to the BD therapy but was discontinued because of drug-induced eczema." | 5.43 | Efficacy of pomalidomide in a multiple myeloma patient requiring hemodialysis. ( Hangaishi, A; Hirao, M; Iizuka, H; Kida, M; Usuki, K, 2016) |
| " The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection." | 3.79 | Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013) |
| " The basis of the RI treatment in MM is bortizomib-based regimen, which does not require dosage adjustment in patients with dialysis or renal insufficiency." | 1.46 | [Expert consensus for the diagnosis and treatment of patients with renal impairment of multiple myeloma]. ( , 2017) |
| "Thalidomide was added to the BD therapy but was discontinued because of drug-induced eczema." | 1.43 | Efficacy of pomalidomide in a multiple myeloma patient requiring hemodialysis. ( Hangaishi, A; Hirao, M; Iizuka, H; Kida, M; Usuki, K, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tokuyama, M | 1 |
| Shimizu, T | 1 |
| Yamada, T | 1 |
| Kondoh, A | 1 |
| Mabuchi, T | 1 |
| Mettang, T | 1 |
| Kremer, AE | 1 |
| Kida, M | 1 |
| Hirao, M | 1 |
| Iizuka, H | 1 |
| Hangaishi, A | 1 |
| Usuki, K | 1 |
| Santana, AC | 1 |
| Degaspari, S | 1 |
| Catanozi, S | 1 |
| Dellê, H | 1 |
| de Sá Lima, L | 1 |
| Silva, C | 1 |
| Blanco, P | 1 |
| Solez, K | 1 |
| Scavone, C | 1 |
| Noronha, IL | 1 |
1 review available for thalidomide and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Uremic pruritus.
Topics: Acupuncture Therapy; Amines; Anti-Inflammatory Agents; Calcium Channel Blockers; Cyclohexanecarboxyl | 2015 |
4 other studies available for thalidomide and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
[Expert consensus for the diagnosis and treatment of patients with renal impairment of multiple myeloma].
Topics: Consensus; Creatinine; Dexamethasone; Glomerular Filtration Rate; Humans; Immunoglobulin Light Chain | 2017 |
Case of psoriasis vulgaris with atrial fibrillation, heart failure and chronic kidney disease which were found accidentally through blood examination during apremilast treatment.
Topics: Aged; Atrial Fibrillation; Chemical and Drug Induced Liver Injury; Creatinine; Electrocardiography; | 2019 |
Efficacy of pomalidomide in a multiple myeloma patient requiring hemodialysis.
Topics: Aged; Angiogenesis Inhibitors; Humans; Male; Multiple Myeloma; Renal Dialysis; Renal Insufficiency, | 2016 |
Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice.
Topics: Adenine; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shi | 2013 |