thalidomide has been researched along with Rectal Diseases in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Rectal Diseases: Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pizarro Moreno, A | 1 |
| Garzón Benavides, M | 1 |
| Araujo Miguez, A | 1 |
| Bozada García, JM | 1 |
| Craanen, ME | 1 |
| van Triest, B | 1 |
| Verheijen, RH | 1 |
| Mulder, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Open Clinical Trial of Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding[NCT04680195] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-12-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for thalidomide and Rectal Diseases
| Article | Year |
|---|---|
[Thalidomide associated to endoscopic treatment with argon plasma coagulation in rectal bleeding caused by vascular injury secundary to severe actinic proctitis].
Topics: Angiogenesis Inhibitors; Argon Plasma Coagulation; Chronic Disease; Gastrointestinal Hemorrhage; Hum | 2012 |
Thalidomide in refractory haemorrhagic radiation induced proctitis.
Topics: Aged; Angiogenesis Inhibitors; Female; Gastrointestinal Hemorrhage; Humans; Proctitis; Radiation Inj | 2006 |