Page last updated: 2024-11-05

thalidomide and Pulmonary Consumption

thalidomide has been researched along with Pulmonary Consumption in 10 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"Thalidomide treatment was well tolerated, without serious adverse events."6.68Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis. ( Akarasewi, P; Burroughs, M; Johnson, B; Kaplan, G; Klausner, JD; Makonkawkeyoon, S; Molloy, A; Rom, W; Tramontana, JM; Utaipat, U, 1995)
"Thalidomide treatment was well tolerated, without serious adverse events."2.68Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis. ( Akarasewi, P; Burroughs, M; Johnson, B; Kaplan, G; Klausner, JD; Makonkawkeyoon, S; Molloy, A; Rom, W; Tramontana, JM; Utaipat, U, 1995)
"Thalidomide-treated and untreated animals showed the same amount of M."1.32Experimental murine mycobacteriosis: evaluation of the functional activity of alveolar macrophages in thalidomide- treated mice. ( Arruda, MS; Oliveira, SM; Richini, VB; Vilani-Moreno, FR, 2004)
"Thalidomide treatment resulted in a significant reduction in tumor necrosis factor-alpha, interleukin 6 (IL-6) and IL-10 protein levels (blood) and mRNA expression (lungs)."1.30Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. ( Freedman, VH; Freeman, S; Kaplan, G; Laochumroonvorapong, P; Moreira, AL; Tsenova-Berkova, L; Wang, J, 1997)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's3 (30.00)18.2507
2000's2 (20.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Liu, P1
Pei, N1
Liu, X1
Huang, W1
Lu, S1
Subbian, S1
Tsenova, L1
O'Brien, P1
Yang, G1
Koo, MS1
Peixoto, B1
Fallows, D1
Zeldis, JB1
Muller, G1
Kaplan, G4
Guo, S1
Zhao, J1
Arruda, MS1
Richini, VB1
Oliveira, SM1
Vilani-Moreno, FR1
Marcus, JC1
Cornea, P1
Vladutiu, A1
Marcovici, G1
Tramontana, JM1
Utaipat, U1
Molloy, A1
Akarasewi, P2
Burroughs, M1
Makonkawkeyoon, S2
Johnson, B1
Klausner, JD2
Rom, W1
Nakata, K1
Kasinrerk, W1
Corral, L1
Dewar, RL1
Lane, HC1
Freedman, VH2
Moreira, AL1
Tsenova-Berkova, L1
Wang, J1
Laochumroonvorapong, P1
Freeman, S1
Gori, A1
Rossi, MC1
Trabattoni, D1
Marchetti, G1
Fusi, ML1
Molteni, C1
Clerici, M1
Franzetti1, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00004276]Phase 250 participants Interventional1990-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for thalidomide and Pulmonary Consumption

ArticleYear
Immunotherapy for tuberculosis: what's the better choice?
    Frontiers in bioscience (Landmark edition), 2012, 06-01, Volume: 17, Issue:7

    Topics: Cytokines; Etanercept; Humans; Immunoglobulin G; Immunoglobulins, Intravenous; Immunologic Factors;

2012

Trials

2 trials available for thalidomide and Pulmonary Consumption

ArticleYear
Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis.
    Molecular medicine (Cambridge, Mass.), 1995, Volume: 1, Issue:4

    Topics: Adult; Aged; Cells, Cultured; Cytokines; Humans; Hypersensitivity, Delayed; Immunosuppressive Agents

1995
The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 and M. tuberculosis infection.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Mar-01, Volume: 11, Issue:3

    Topics: Adult; Body Weight; CD4 Lymphocyte Count; Double-Blind Method; HIV Infections; HIV-1; Humans; Immuno

1996

Other Studies

7 other studies available for thalidomide and Pulmonary Consumption

ArticleYear
Thalidomide in the treatment of human immunodeficiency virus-negative tuberculous meningitis: A case report.
    Medicine, 2020, Oct-02, Volume: 99, Issue:40

    Topics: Adrenal Cortex Hormones; Adult; Antitubercular Agents; Asian People; Brain; Drug Therapy, Combinatio

2020
Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology.
    The American journal of pathology, 2011, Volume: 179, Issue:1

    Topics: Animals; Antitubercular Agents; Blotting, Western; Colony-Forming Units Assay; Cyclic Nucleotide Pho

2011
Experimental murine mycobacteriosis: evaluation of the functional activity of alveolar macrophages in thalidomide- treated mice.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2004, Volume: 37, Issue:4

    Topics: Animals; Colony Count, Microbial; Immunosuppressive Agents; Lung; Macrophages, Alveolar; Male; Mice;

2004
Non-teratogenicity of antituberculous drugs.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1967, Aug-12, Volume: 41, Issue:30

    Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Antitubercular Agents; Drug Synergism; Ethionamid

1967
The immuno-suppressive effect of thalidomide in experimental tuberculosis in guinea-pigs.
    Tubercle, 1967, Volume: 48, Issue:1

    Topics: Animals; Female; Guinea Pigs; Injections, Intradermal; Judgment; Male; Thalidomide; Tuberculin Test;

1967
Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis.
    Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 1997, Volume: 78, Issue:1

    Topics: Acute Disease; Animals; Apoptosis; Cytokines; Female; Immunosuppressive Agents; Interleukin-10; Inte

1997
Tumor necrosis factor-alpha increased production during thalidomide treatment in patients with tuberculosis and human immunodeficiency virus coinfection.
    The Journal of infectious diseases, 2000, Volume: 182, Issue:2

    Topics: HIV Infections; Humans; Thalidomide; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha

2000