thalidomide has been researched along with Proctitis in 7 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Proctitis: INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats." | 7.74 | Thalidomide effect in endothelial cell of acute radiation proctitis. ( Chae, HS; Cho, YS; Choi, KY; Choi, W; Kang, SJ; Kim, HK; Kim, JS; Kim, KT; Rho, SY, 2008) |
| "To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats." | 3.74 | Thalidomide effect in endothelial cell of acute radiation proctitis. ( Chae, HS; Cho, YS; Choi, KY; Choi, W; Kang, SJ; Kim, HK; Kim, JS; Kim, KT; Rho, SY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Charles, P | 1 |
| Richaud, C | 1 |
| Beley, S | 1 |
| Bodard, L | 1 |
| Simon, M | 1 |
| Kim, KT | 1 |
| Chae, HS | 1 |
| Kim, JS | 1 |
| Kim, HK | 1 |
| Cho, YS | 1 |
| Choi, W | 1 |
| Choi, KY | 1 |
| Rho, SY | 1 |
| Kang, SJ | 1 |
| Farmer, AD | 1 |
| Zanetto, U | 1 |
| Lewis, MJ | 1 |
| Pizarro Moreno, A | 1 |
| Garzón Benavides, M | 1 |
| Araujo Miguez, A | 1 |
| Bozada García, JM | 1 |
| Craanen, ME | 1 |
| van Triest, B | 1 |
| Verheijen, RH | 1 |
| Mulder, CJ | 1 |
| Fu, CS | 1 |
| Conteas, CN | 1 |
| LaRiviere, MJ | 1 |
| Georghiou, PR | 1 |
| Allworth, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Open Clinical Trial of Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding[NCT04680195] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-12-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for thalidomide and Proctitis
| Article | Year |
|---|---|
Pseudotumoral recto-sigmoid herpes simplex virus type 2 in an HIV-infected patient: Dramatic improvement with thalidomide.
Topics: Adult; Female; Granuloma, Plasma Cell; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; Human | 2016 |
Thalidomide effect in endothelial cell of acute radiation proctitis.
Topics: Animals; Endothelial Cells; Female; Microcirculation; Proctitis; Radiation Injuries, Experimental; R | 2008 |
Explosive proctitis: potential treatments and pitfalls in the treatment of chronic radiation proctitis.
Topics: Aged; Argon; Fatal Outcome; Humans; Laser Coagulation; Male; Multiple Organ Failure; Proctitis; Radi | 2008 |
[Thalidomide associated to endoscopic treatment with argon plasma coagulation in rectal bleeding caused by vascular injury secundary to severe actinic proctitis].
Topics: Angiogenesis Inhibitors; Argon Plasma Coagulation; Chronic Disease; Gastrointestinal Hemorrhage; Hum | 2012 |
Thalidomide in refractory haemorrhagic radiation induced proctitis.
Topics: Aged; Angiogenesis Inhibitors; Female; Gastrointestinal Hemorrhage; Humans; Proctitis; Radiation Inj | 2006 |
Successful treatment of idiopathic colitis and proctitis using thalidomide in persons infected with human immunodeficiency virus.
Topics: Adult; Colitis, Ulcerative; HIV Infections; Humans; Immunosuppressive Agents; Male; Middle Aged; Pro | 1998 |
Thalidomide in painful AIDS-associated proctitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Opportunistic Infections; Proctitis; Thalid | 1992 |