thalidomide has been researched along with Pregnancy in 666 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After the tragic events in the early 1960s, thalidomide has re-emerged as therapeutic for multiple myeloma (MM)." | 8.84 | Thalidomide in multiple myeloma--clinical trials and aspects of drug metabolism and toxicity. ( Anderson, KC; Breitkreutz, I, 2008) |
| "Lenalidomide is a synthetic analog of thalidomide formed by the removal of one keto group (plus the addition of an amino group); it has anti-tumor activities beneficial for the treatment of hematologic malignancies." | 8.12 | Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. ( Ando, K; Kamiya, Y; Machida, S; Murayama, N; Ogiya, D; Saito, R; Shiraiwa, S; Suzuki, R; Tazume, K; Yamazaki, H, 2022) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism." | 7.69 | Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994) |
| "The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain." | 7.65 | Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976) |
| "Thalidomide was developed in the 1950s as a sedative having only a low toxicity." | 6.42 | [New pharmacological availability of thalidomide based on experience in patients with multiple myeloma]. ( Murakami, H, 2004) |
| "Pemphigus vegetans is a rare variant of pemphigus vulgaris." | 5.62 | Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide. ( Jiang, L; Li, W; Qiu, X; Yuan, P, 2021) |
| "Auditory hypersensitivity in autism is frequently observed in clinics." | 5.56 | Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats. ( Ida-Eto, M; Narita, M; Noro, Y; Ohkawara, T; Tsugiyama, LE, 2020) |
| " Adverse events (AEs) occurred in 69 (57." | 5.48 | Efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/\ refractory multiple myeloma: a real-life experience ( Duran, M; Durusoy, R; Patır, P; Şahin, F; Saydam, G; Soyer, N; Töbü, M; Tombuloğlu, M; Ünal, HD; Uysal, A; Vural, F, 2018) |
| "Thalidomide (TD) displays remarkable species specificity, causing birth defects (teratogenesis) in humans and rabbits, but not rats or mice; yet, few determinants of species susceptibility have been identified." | 5.37 | Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture. ( Gonçalves, LL; Lee, CJ; Wells, PG, 2011) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 5.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "Morphologic abnormalities found in autism (e." | 5.31 | Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002) |
| "The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation." | 5.28 | Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990) |
| "Thalidomide was administered to 44 female rhesus monkeys immediately after they had mated." | 5.24 | Thalidomide: effect upon pregnancy in the rhesus monkey. ( BEHRMAN, RE; LUCEY, JF, 1963) |
| "Thalidomide embryopathy results from the ingestion of thalidomide in the first trimester during pregnancy, causing multiple forms of congenital abnormalities of variable severity that involve all systems." | 5.01 | A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE). ( Baple, E; Hall, CM; Mansour, S, 2019) |
| "Celgene has developed and operated pregnancy prevention programs since 1998 with the first approval of thalidomide in the US." | 4.87 | Managing the teratogenic risk of thalidomide and lenalidomide: an industry perspective. ( Bwire, R; Freeman, J; Houn, F, 2011) |
| "The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate." | 4.84 | Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007) |
| "After the tragic events in the early 1960s, thalidomide has re-emerged as therapeutic for multiple myeloma (MM)." | 4.84 | Thalidomide in multiple myeloma--clinical trials and aspects of drug metabolism and toxicity. ( Anderson, KC; Breitkreutz, I, 2008) |
| " Thalidomide was taken in the sensitive period of the pregnancy by the father's mother." | 4.80 | Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause? ( Kunze, J; Neumann, L; Pelz, J, 1998) |
| "One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism." | 4.80 | [Eye muscle paralysis can increase the knowledge on autism]. ( Strömland, K, 2000) |
| "The difficulties in assessing the teratogenic potential of drugs used during pregnancy have been made evident by experiences with thalidomide and diethylstilbestrol (DES)." | 4.76 | In vivo assessment of the teratogenic potential of drugs in humans. ( Stern, L, 1981) |
| "Lenalidomide is a synthetic analog of thalidomide formed by the removal of one keto group (plus the addition of an amino group); it has anti-tumor activities beneficial for the treatment of hematologic malignancies." | 4.12 | Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. ( Ando, K; Kamiya, Y; Machida, S; Murayama, N; Ogiya, D; Saito, R; Shiraiwa, S; Suzuki, R; Tazume, K; Yamazaki, H, 2022) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "As Thalidomide survivors reach their mid-50's they are experiencing a wide range of secondary health problems, in particular musculoskeletal problems, and depression and anxiety, with multimorbidity a growing issue." | 3.91 | The health and quality of life of Thalidomide survivors as they age - Evidence from a UK survey. ( Atkin, K; Glendinning, C; Newbronner, E; Wadman, R, 2019) |
| "Between 1957 and 1962 thalidomide was used as a nonaddictive, nonbarbiturate sedative that also was successful in relieving the symptoms of morning sickness in early pregnancy." | 3.85 | "The legacy of thalidomide" - A multidisciplinary meeting held at the University of York, United Kingdom, on September 30, 2016. ( Atkin, K; Newbronner, E; Vargesson, N, 2017) |
| "We analyzed the frequency of births with phenotypes consistent with thalidomide embryopathy (TEP) and correlated this with the distribution of thalidomide and the prevalence of leprosy between 2005 and 2010 in Brazil." | 3.81 | Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil. ( Camey, SA; de Lyra Rabello Neto, D; de Oliveira, MZ; Lopez-Camelo, J; Morelo, EF; Sales Luiz Vianna, F; Sanseverino, MT; Schuler-Faccini, L, 2015) |
| "Fifty years ago several thousand children were born with severe limb defects after their mothers had been given thalidomide in pregnancy." | 3.78 | The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals. ( Lachmann, PJ, 2012) |
| "Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women." | 3.77 | Thalidomide: the tragedy of birth defects and the effective treatment of disease. ( Kim, JH; Scialli, AR, 2011) |
| "Based on the fact that thalidomide, at a certain point in human pregnancy, produces autism, we propose administering thalidomide to pregnant monkeys at an appropriate point after conception." | 3.72 | A proposed primate animal model of autism. ( Teitelbaum, P, 2003) |
| "Autism has been linked to thalidomide exposure at 20-24 days gestation." | 3.71 | Is autism due to cerebral-cerebellum disconnection? ( Skoyles, JR, 2002) |
| "The teratogenic potency of the thalidomide (Thd) derivative phthalimidophthalimide (Phtpht) was assessed in the common marmoset (Callithrix jacchus), by oral administration of the relatively high daily dose of 50 mg Phtpht/kg body wt, during the susceptible period (days 48-61 of pregnancy)." | 3.69 | Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. 5. Lack of teratogenic effects of phthalimidophthalmide. ( Felies, A; Frankus, E; Klug, S; Neubert, R; Nogueira, AC; Stürje, H, 1994) |
| "Thalidomide, mainly used for the treatment of leprosy, is a current teratogen in South America, and it is reasonable to assume that at present this situation is affecting many births in underdeveloped countries." | 3.69 | Thalidomide, a current teratogen in South America. ( Ashton-Prolla, P; Barreda-Mejia, E; Brunoni, D; Castilla, EE; Cavalcanti, DP; Correa-Neto, J; Delgadillo, JL; Dutra, MG; Felix, T; Giraldo, A; Juarez, N; Lopez-Camelo, JS; Nazer, J; Orioli, IM; Paz, JE; Pessoto, MA; Pina-Neto, JM; Quadrelli, R; Rittler, M; Rueda, S; Saltos, M; Sánchez, O; Schüler, L, 1996) |
| "Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism." | 3.69 | Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994) |
| "A case of thalidomide syndrome diagnosed by ultrasound in the 17th week of pregnancy is presented." | 3.67 | Prenatal diagnosis of thalidomide syndrome. ( Eigier, A; Gollop, TR; Guidugli Neto, J, 1987) |
| "5 ml dimethylformamide (DMF) on day 10, 11, or 12 of the pregnancy." | 3.66 | Embryotoxicity and teratogenicity of thalidomide in rats. ( Parkhie, M; Webb, M, 1983) |
| "The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain." | 3.65 | Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976) |
| " Animal models of hemifacial microsomia and thalidomide-induced otomandibular dysostosis are described; the causal mechanism of malformation appeared to be closely related to the formation of a hematoma at the time of development of the stapedial arterial systems." | 3.65 | Hemorrhage in development of the face. ( Poswillo, D, 1975) |
| " The cats were given daily oral doses of thalidomide as follows: 10 mg/kg on days 10-20 of pregnancy, 240 mg/kg on days 10-14, and 120, 240, and 480 mg/kg on days 15-17 or 18-20 of pregnancy." | 3.65 | Fetal cardiovascular and other defects induced by thalidomide in cats. ( Khera, KS, 1975) |
| "2-diphenyl-methane during the period of organogenesis (the 6th-15th day of pregnancy)." | 3.65 | [Effect of some preservatives on pregnancy and fetal development in experimental animals]. ( Piekacz, H, 1976) |
| "On Day 1 of pregnancy, a thalidomide suspension (." | 3.65 | Responses of pre-implantation mouse embryos to thalidomide exposure in utero. ( Batra, BK; Palayoor, T; Raveendran, P, 1976) |
| " The fate of [(14)C]thalidomide orally administered to pregnant rabbits at the beginning of the sensitive phase of pregnancy has been studied." | 3.64 | The fate of[14C]thalidomide in the pregnant rabbit. ( Fabro, S; Smith, RL; Williams, RT, 1967) |
| "Data are presented on 115 children, including three sets of twins, born in Canada in 1961 and 1962 with congenital malformations associated with the use of thalidomide by their mothers in early pregnancy." | 3.64 | CANADIAN THALIDOMIDE EXPERIENCE. ( WEBB, JF, 1963) |
| " In one case thalidomide had been administered to the mother early in the pregnancy." | 3.64 | Phocomelia: report of three cases. ( COODIN, FJ; MURPHY, CH; UCHIDA, IA, 1962) |
| " The fate in the pregnant New Zealand White rabbit of oral doses of four (14)C-labelled hydrolysis products of thalidomide, namely alpha-(o-carboxybenzamido)-glutarimide, 2-phthalimidoglutaramic acid, 2-phthalimidoglutaric acid and 2-(o-carboxybenzamido)glutaramic acid, administered on the 192nd hour of pregnancy has been studied." | 3.64 | The fate of the hydrolysis products of thalidomide in the pregnant rabbit. ( Fabro, S; Smith, RL; Williams, RT, 1967) |
| "Thalidomide was developed as a sedative drug during the 1950s." | 2.82 | [Development of novel cereblon modulators and their target molecules]. ( Ito, T, 2022) |
| "This analysis allows us to think beyond the safe use of thalidomide, but the safety provided by any type of monitoring system." | 2.82 | Comparative analysis of the use and control of thalidomide in Brazil and different countries: is it possible to say there is safety? ( de Jesus, SM; Leite, SN; Santana, RS, 2022) |
| "Thalidomide is an old well-known drug firstly used as morning sickness relief in pregnant women and then withdrawn from the market due to its severe side effects on fetal normal development." | 2.82 | Recent Advances in the Development of Thalidomide-Related Compounds as Anticancer Drugs. ( Barbarossa, A; Carocci, A; Franchini, C; Iacopetta, D; Sinicropi, MS, 2022) |
| " The minimum dosage used by the authors seems to be adequate on the basis of the results obtained." | 2.64 | [Fixed lupus erythematosus (its treatment with thalidomide)]. ( Barba Rubio, J; Franco González, F, 1977) |
| "The drug caused severe birth defects." | 2.58 | The changing health of Thalidomide survivors as they age: A scoping review. ( Atkin, K; Newbronner, E, 2018) |
| "Thalidomide is a teratogen that affects many organs but primarily induces limb truncations like phocomelia." | 2.55 | The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine. ( Jungck, D; Knobloch, J; Koch, A, 2017) |
| "Thalidomide was synthesised and launched several decades ago as a drug against respiratory infections and was administered to pregnant women for relief of morning sickness." | 2.52 | Therapeutic Potential of Thalidomide and Its Analogues in the Treatment of Cancer. ( Sherbet, GV, 2015) |
| "Thalidomide was originally developed in 1954 as a sedative that was commonly used to ameliorate morning sickness." | 2.48 | Deciphering the mystery of thalidomide teratogenicity. ( Handa, H; Ito, T, 2012) |
| "We found that Duane syndrome and its variants were prominent in individuals who were exposed to thalidomide early in the sensitive period (days 20 to 26±)." | 2.47 | What can we learn from the thalidomide experience: an ophthalmologic perspective. ( Miller, MT; Strömland, KK, 2011) |
| "Environmental causes of birth defects have increasingly been recognized since the mid-20th century." | 2.47 | Causes of birth defects: lessons from history. ( Lancaster, PA, 2011) |
| "Thalidomide is a drug with bad reputation from the 1960's as it appeared to be teratogenic by causing foetal anomalies." | 2.46 | [Thalidomide in oncological and hematological diseases]. ( Anttila, P; Kivivuori, SM, 2010) |
| "Thalidomide is a very potent teratogen capable of causing severe systemic malformations if the fetus is exposed during the sensitive period." | 2.45 | Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. ( Miller, MT; Strömland, K; Ventura, L, 2009) |
| "Thalidomide was developed in the 1950s as a sedative having only a low toxicity." | 2.42 | [New pharmacological availability of thalidomide based on experience in patients with multiple myeloma]. ( Murakami, H, 2004) |
| "Thalidomide has hypnosedative, antiangiogenic, antiinflammatory, and immunomodulatory properties." | 2.42 | Dermatologic and nondermatologic uses of thalidomide. ( Cheigh, NH; Micali, G; Nasca, MR; West, DP; West, LE, 2003) |
| "Thalidomide was marketed in the late-1950s as a sedative and tranquilliser of exceptionally low general toxicity, but in 1961 it was implicated separately by Lenz and MacBride as the cause of the epidemic of congenital malformations that had been puzzling the world for some years." | 2.41 | Thalidomide: 40 years on. ( Diggle, GE, 2001) |
| "Thalidomide was introduced as a non-toxic sleeping pill in 1957 and was prescribed in more than 20 countries." | 2.41 | [Thalidomide--a dreaded drug with new indications]. ( Seidel, C; Waage, A, 2001) |
| "Present knowledge of chromosomal aberrations associated with microphthalmia is surveyed, and some of the syndromes and phenocopies in the mentally retarded in which microphthalmia may be found are reviewed." | 2.35 | The heterogeneity of microphthalmia in the mentally retarded. ( Warburg, M, 1971) |
| "Thalidomide was used as a positive control and was administered orally at 15 mg/kg/day on gestation days 26-28." | 1.72 | Embryo-fetal exposure and developmental outcome of lenalidomide following oral administration to pregnant cynomolgus monkeys. ( Fuchs, A; Hui, JY; Kumar, G, 2022) |
| "Thalidomide is a drug responsible to a spectrum of congenital anomalies known as Thalidomide Embryopathy (TE), which includes mainly limb and heart defects." | 1.72 | Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy. ( Bremm, JM; do Amaral Gomes, J; Fraga, LR; Kowalski, TW; Rengel, BD; Schüler-Faccini, L; Vianna, FSL, 2022) |
| "Pemphigus vegetans is a rare variant of pemphigus vulgaris." | 1.62 | Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide. ( Jiang, L; Li, W; Qiu, X; Yuan, P, 2021) |
| "Auditory hypersensitivity in autism is frequently observed in clinics." | 1.56 | Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats. ( Ida-Eto, M; Narita, M; Noro, Y; Ohkawara, T; Tsugiyama, LE, 2020) |
| "Maternofoetal physiologically-based pharmacokinetic models integrating multi-compartmental maternal and foetal units were developed using Simbiology® to estimate prenatal drug exposure." | 1.51 | Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies. ( Adejuyigbe, E; Atoyebi, SA; Bolaji, O; Olagunju, A; Owen, A; Rajoli, RKR; Siccardi, M, 2019) |
| " Adverse events (AEs) occurred in 69 (57." | 1.48 | Efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/\ refractory multiple myeloma: a real-life experience ( Duran, M; Durusoy, R; Patır, P; Şahin, F; Saydam, G; Soyer, N; Töbü, M; Tombuloğlu, M; Ünal, HD; Uysal, A; Vural, F, 2018) |
| "Thalidomide-treated embryos with the human CYP3A gene cluster showed limb abnormalities, and human CYP3A was expressed in the placenta, suggesting that human CYP3A in the placenta may contribute to the teratogenicity of thalidomide." | 1.43 | Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. ( Abe, S; Akita, M; Kamataki, T; Kazuki, K; Kazuki, Y; Kobayashi, K; Ohta, R; Osaki, M; Oshimura, M; Satoh, D; Takehara, S; Yamazaki, H, 2016) |
| "Thalidomides were initially thought to be broad-range drugs specifically for curing insomnia and relieving morning sickness in pregnant women." | 1.42 | Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin. ( Kunwar, A; Kuppa, A; Panda, D; Rashid, A, 2015) |
| "Thalidomide was approved for the treatment of multiple myeloma in Japan under a risk management program, named TERMS, in 2008." | 1.42 | [Risk Management of Teratogenic Drugs ~The Current States of Practice in Europe, US and Japan~]. ( Amann, S; Hattori, C; Nasu, M; Sato, T; Shirakuni, Y; Takagi, T; van Bennekom, C, 2015) |
| " The post-implantation loss rate and number of placental remnants were increased and the number of live fetuses was decreased in both of the strains in the EFD study and in Kbl:NZW at 300 mg/kg dosed on GD 7-8 in the SP study." | 1.40 | Common nature in the effects of thalidomide on embryo-fetal development in Kbl:JW and Kbl:NZW rabbits. ( Awatsuji, H; Kawamura, Y; Matsumoto, K; Sato, K; Shirotsuka, Y, 2014) |
| "Thalidomide was marketed for the treatment of morning sickness and resulted in foetal death and physical deformities." | 1.39 | Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort. ( Burke, D; Jankelowitz, SK; Spies, JM, 2013) |
| "Thalidomide (TD) displays remarkable species specificity, causing birth defects (teratogenesis) in humans and rabbits, but not rats or mice; yet, few determinants of species susceptibility have been identified." | 1.37 | Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture. ( Gonçalves, LL; Lee, CJ; Wells, PG, 2011) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 1.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "Besides that, she was treated with schizophrenia." | 1.35 | [Thalidomide (Contergan) induced limb deficiency in Hungary?]. ( Bács, E; Czeizel, E; Gidai, J, 2009) |
| "Lenalidomide (Revlimid) is an immunomodulatory drug and an analogue of thalidomide, a known teratogen." | 1.35 | RevAssist: a comprehensive risk minimization programme for preventing fetal exposure to lenalidomide. ( Brandenburg, NA; Bwire, R; Castaneda, CP; Freeman, J; Quigley, C; Zeldis, JB, 2008) |
| "Thalidomide has a potent immunomodulatory property and has now a number of approved and off-label uses in dermatologic, oncologic, infectious and gastrointestinal conditions." | 1.34 | New cases of thalidomide embryopathy in Brazil. ( Castilla, EE; de Sousa, AC; Luna, E; Maximino, C; Schuler-Faccini, L; Schwartz, IV; Soares, RC; Waldman, C, 2007) |
| "In all studies, thalidomide was selectively toxic to development." | 1.34 | Evaluation of the developmental toxicity of lenalidomide in rabbits. ( Christian, MS; Hoberman, A; Laskin, OL; Latriano, L; Sharper, V; Stirling, DI, 2007) |
| "The present study determined effects of thalidomide on three successive generations of New Zealand White rabbits after oral dosing to F0 maternal rabbits during the later third of gestation (post major organogenesis) and lactation." | 1.32 | Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring. ( Denny, KH; Hoberman, AM; Morseth, S; Stirling, DI; Teo, SK; Thomas, SD, 2004) |
| "Morphologic abnormalities found in autism (e." | 1.31 | Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002) |
| "Thalidomide was not mutagenic to 6 strains of Salmonella when tested both in the presence and absence of Aroclor-induced rat liver S9 mix." | 1.30 | Thalidomide: lack of mutagenic activity across phyla and genetic endpoints. ( Ashby, J; Callander, RD; Clay, P; Ferguson, MJ; Galloway, SM; Gaulden, ME; Greenwood, SK; Hill, RB; Kimber, I; Nivard, M; Parry, JM; Tinwell, H; Vogel, E; Williamson, J, 1997) |
| "Thalidomide has also prompted commentators to celebrate American drug regulation and the American liability system; Professor Bernstein argues that these paeans are exaggerated." | 1.30 | Formed by thalidomide: mass torts as a false cure for toxic exposure. ( Bernstein, A, 1997) |
| "Thalidomide is a drug associated with devastating side effects." | 1.30 | Thalidomide's long and winding road. ( Hanna, L, 1998) |
| "Thalidomide was withdrawn from the market in the early sixties because of major teratogenic effects such as reduction defects of the limbs." | 1.30 | [Thalidomide once more in the spotlight]. ( Cornel, MC; de Jong-van den Berg, LT; Rutgers, J, 1998) |
| "Thalidomide, once banned, has returned to the center of controversy with the Food and Drug Administration's (FDA's) announcement that thalidomide will be placed on the market for the treatment of erythema nodosum leprosum, a severe dermatological complication of Hansen's disease." | 1.30 | Thalidomide and the Titanic: reconstructing the technology tragedies of the twentieth century. ( Annas, GJ; Elias, S, 1999) |
| "Thalidomide is a teratogenic sedative-hypnotic drug that is structurally similar to phenytoin, which is thought to be bioactivated by prostaglandin H synthase (PHS) and other peroxidases to a teratogenic reactive intermediate." | 1.29 | Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate. ( Arlen, RR; Wells, PG, 1996) |
| "Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately." | 1.28 | Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. ( Baird, PA; Froster, UG, 1992) |
| "The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation." | 1.28 | Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990) |
| "To evaluate the patterns of birth defects associated with diabetic embryopathy, a sensitivity-specificity analysis was performed on 4929 infants with major defects ascertained by the population-based Metropolitan Atlanta Congenital Defects Program between 1968 and 1980." | 1.28 | Clinical-epidemiologic assessment of pattern of birth defects associated with human teratogens: application to diabetic embryopathy. ( Becerra, JE; Cordero, JF; Erickson, JD; Khoury, MJ, 1989) |
| "For example, in the case of Congenital rubella syndrome (CRS), monitoring for the combination of cataracts with deafness and/or patent ductus arteriosus could have led to earlier detection of an epidemic than could monitoring for cataracts alone." | 1.27 | Monitoring for multiple malformations in the detection of epidemics of birth defects. ( Adams, MM; Erickson, JD; Khoury, MJ; Rhodes, P, 1987) |
| "Head anomalies in fetuses (anencephaly, holoprosencephaly and hydrocephaly) were induced at a high frequency by the maternal administration of thalidomide on day 7, and also in a few fetuses on day 8." | 1.27 | [Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits]. ( Matsubara, Y; Mikami, T, 1985) |
| " At the most, there is only a marginal loss of sensitivity in respect of detecting the lowest dosage at which effects may occur." | 1.27 | An indirect assessment of the Chernoff/Kavlock assay. ( Palmer, AK, 1987) |
| " Also the toxic dose to the mothers, 3000 mg/kg, given to rabbits in case of one FWA was without these effects." | 1.25 | Studies of embryo toxicity in rats and rabbits. ( Lorke, D; Machemer, L, 1975) |
| "Goiter is relatively common in infants whose mothers were treated with propylthiouracil and other antithyroid drugs, yet they usually show normal thyroid function." | 1.25 | Human experiences related to adverse drug reactions to the fetus or neonate from some maternally administered drugs. ( Shirkey, HC, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 461 (69.22) | 18.7374 |
| 1990's | 61 (9.16) | 18.2507 |
| 2000's | 54 (8.11) | 29.6817 |
| 2010's | 70 (10.51) | 24.3611 |
| 2020's | 20 (3.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vargesson, N | 5 |
| Stephens, T | 1 |
| Paulus, WE | 1 |
| Lindemann, J | 1 |
| Friebe-Hoffmann, U | 1 |
| Kandasamy, D | 1 |
| Vidyasagar, S | 1 |
| Bolanthakodi, N | 1 |
| Vaidya, AK | 1 |
| Prethika, PA | 1 |
| Mohan, G | 1 |
| Shastry, S | 1 |
| Waggoner, MR | 1 |
| Lyerly, AD | 1 |
| Ogiya, D | 1 |
| Murayama, N | 2 |
| Kamiya, Y | 1 |
| Saito, R | 1 |
| Shiraiwa, S | 1 |
| Suzuki, R | 1 |
| Machida, S | 1 |
| Tazume, K | 1 |
| Ando, K | 1 |
| Yamazaki, H | 4 |
| Shimizu, M | 1 |
| Ito, T | 2 |
| Rengel, BD | 1 |
| Kowalski, TW | 2 |
| Bremm, JM | 1 |
| do Amaral Gomes, J | 1 |
| Schüler-Faccini, L | 5 |
| Vianna, FSL | 2 |
| Fraga, LR | 2 |
| Hui, JY | 2 |
| Fuchs, A | 1 |
| Kumar, G | 2 |
| Atoyebi, SA | 1 |
| Rajoli, RKR | 1 |
| Adejuyigbe, E | 1 |
| Owen, A | 1 |
| Bolaji, O | 1 |
| Siccardi, M | 1 |
| Olagunju, A | 1 |
| Zhao, Y | 1 |
| Chen, Q | 2 |
| Chen, L | 1 |
| Shen, SGF | 1 |
| Dai, J | 1 |
| Foulon, A | 1 |
| Chevreau, J | 1 |
| Yzet, C | 1 |
| Gondry, J | 1 |
| Fumery, M | 1 |
| Holmes, LB | 4 |
| MacDuffie, KE | 1 |
| Kleinhans, NM | 1 |
| Stout, K | 1 |
| Wilfond, BS | 1 |
| Jesus, SM | 1 |
| Santana, RS | 2 |
| Leite, SN | 2 |
| Amare, GG | 1 |
| Meharie, BG | 1 |
| Belayneh, YM | 1 |
| Qiu, X | 1 |
| Yuan, P | 1 |
| Li, W | 1 |
| Jiang, L | 1 |
| Barbarossa, A | 1 |
| Iacopetta, D | 1 |
| Sinicropi, MS | 1 |
| Franchini, C | 1 |
| Carocci, A | 1 |
| de Jesus, SM | 1 |
| Mueller, M | 1 |
| Lewis, DJ | 1 |
| Newbronner, E | 3 |
| Atkin, K | 3 |
| Knobloch, J | 1 |
| Jungck, D | 1 |
| Koch, A | 1 |
| Kazuki, Y | 2 |
| Satoh, D | 2 |
| Arata, K | 1 |
| Harada, T | 1 |
| Shibata, N | 2 |
| Guengerich, FP | 1 |
| Soyer, N | 1 |
| Patır, P | 1 |
| Uysal, A | 1 |
| Duran, M | 1 |
| Ünal, HD | 1 |
| Durusoy, R | 1 |
| Tombuloğlu, M | 1 |
| Şahin, F | 1 |
| Töbü, M | 1 |
| Vural, F | 1 |
| Saydam, G | 1 |
| Saavedra, MA | 1 |
| Romo-Rodríguez, R | 1 |
| Gutiérrez-Ureña, SR | 1 |
| Miranda-Hernández, D | 1 |
| Hernández-Cruz, LI | 1 |
| Jara, LJ | 1 |
| Mildenberger, FG | 1 |
| Winiczenko, R | 1 |
| Górnicki, K | 1 |
| Kaleta, A | 1 |
| Janaszek-Mańkowska, M | 1 |
| Khan, ZA | 1 |
| Singh, C | 1 |
| Khan, T | 1 |
| Ganguly, M | 1 |
| Bradsher, C | 1 |
| Goodwin, P | 1 |
| Petty, JT | 1 |
| Sandau, C | 1 |
| Bove, DG | 1 |
| Marsaa, K | 1 |
| Bekkelund, CS | 1 |
| Lindholm, MG | 1 |
| Salazar, J | 1 |
| Bermúdez, V | 1 |
| Olivar, LC | 1 |
| Torres, W | 1 |
| Palmar, J | 1 |
| Añez, R | 1 |
| Ordoñez, MG | 1 |
| Rivas, JR | 1 |
| Martínez, MS | 1 |
| Hernández, JD | 1 |
| Graterol, M | 1 |
| Rojas, J | 1 |
| Mubarak, Z | 1 |
| Humaira, A | 1 |
| Gani, BA | 1 |
| Muchlisin, ZA | 1 |
| Gremillet, C | 1 |
| Jakobsson, JG | 1 |
| Gomila, A | 1 |
| Shaw, E | 1 |
| Carratalà, J | 1 |
| Leibovici, L | 1 |
| Tebé, C | 1 |
| Wiegand, I | 1 |
| Vallejo-Torres, L | 1 |
| Vigo, JM | 1 |
| Morris, S | 1 |
| Stoddart, M | 1 |
| Grier, S | 1 |
| Vank, C | 1 |
| Cuperus, N | 1 |
| Van den Heuvel, L | 1 |
| Eliakim-Raz, N | 1 |
| Vuong, C | 1 |
| MacGowan, A | 1 |
| Addy, I | 1 |
| Pujol, M | 1 |
| Cobb, A | 1 |
| Rieger, E | 1 |
| Bell, J | 1 |
| Mallik, S | 1 |
| Zhao, Z | 1 |
| Szécsényi, Á | 1 |
| Li, G | 1 |
| Gascon, J | 1 |
| Pidko, EA | 1 |
| Zhang, GR | 1 |
| Wolker, T | 1 |
| Sandbeck, DJS | 1 |
| Munoz, M | 1 |
| Mayrhofer, KJJ | 1 |
| Cherevko, S | 1 |
| Etzold, BJM | 1 |
| Lukashuk, L | 1 |
| Yigit, N | 1 |
| Rameshan, R | 1 |
| Kolar, E | 1 |
| Teschner, D | 1 |
| Hävecker, M | 1 |
| Knop-Gericke, A | 1 |
| Schlögl, R | 1 |
| Föttinger, K | 1 |
| Rupprechter, G | 1 |
| Franconieri, F | 1 |
| Deshayes, S | 1 |
| de Boysson, H | 1 |
| Trad, S | 1 |
| Martin Silva, N | 1 |
| Terrier, B | 1 |
| Bienvenu, B | 1 |
| Galateau-Sallé, F | 1 |
| Emile, JF | 1 |
| Johnson, AC | 1 |
| Aouba, A | 1 |
| Vogt, TJ | 1 |
| Gevensleben, H | 1 |
| Dietrich, J | 1 |
| Kristiansen, G | 1 |
| Bootz, F | 1 |
| Landsberg, J | 1 |
| Goltz, D | 1 |
| Dietrich, D | 1 |
| Idorn, M | 1 |
| Skadborg, SK | 1 |
| Kellermann, L | 1 |
| Halldórsdóttir, HR | 1 |
| Holmen Olofsson, G | 1 |
| Met, Ö | 1 |
| Thor Straten, P | 1 |
| Johnson, LE | 1 |
| Brockstedt, D | 1 |
| Leong, M | 1 |
| Lauer, P | 1 |
| Theisen, E | 1 |
| Sauer, JD | 1 |
| McNeel, DG | 1 |
| Morandi, F | 1 |
| Marimpietri, D | 1 |
| Horenstein, AL | 1 |
| Bolzoni, M | 1 |
| Toscani, D | 1 |
| Costa, F | 1 |
| Castella, B | 1 |
| Faini, AC | 1 |
| Massaia, M | 1 |
| Pistoia, V | 1 |
| Giuliani, N | 1 |
| Malavasi, F | 1 |
| Qiu, J | 1 |
| Peng, S | 1 |
| Yang, A | 1 |
| Ma, Y | 1 |
| Han, L | 1 |
| Cheng, MA | 1 |
| Farmer, E | 1 |
| Hung, CF | 1 |
| Wu, TC | 1 |
| Modak, S | 1 |
| Le Luduec, JB | 1 |
| Cheung, IY | 1 |
| Goldman, DA | 1 |
| Ostrovnaya, I | 1 |
| Doubrovina, E | 1 |
| Basu, E | 1 |
| Kushner, BH | 1 |
| Kramer, K | 1 |
| Roberts, SS | 1 |
| O'Reilly, RJ | 1 |
| Cheung, NV | 1 |
| Hsu, KC | 1 |
| Salgarello, T | 1 |
| Giudiceandrea, A | 1 |
| Calandriello, L | 1 |
| Marangoni, D | 1 |
| Colotto, A | 1 |
| Caporossi, A | 1 |
| Falsini, B | 1 |
| Lefrançois, P | 1 |
| Xie, P | 1 |
| Wang, L | 2 |
| Tetzlaff, MT | 1 |
| Moreau, L | 1 |
| Watters, AK | 1 |
| Netchiporouk, E | 1 |
| Provost, N | 1 |
| Gilbert, M | 1 |
| Ni, X | 1 |
| Sasseville, D | 1 |
| Wheeler, DA | 1 |
| Duvic, M | 1 |
| Litvinov, IV | 1 |
| O'Connor, BJ | 1 |
| Fryda, NJ | 1 |
| Ranglack, DH | 1 |
| Yang, Y | 2 |
| Yang, J | 1 |
| Zhang, X | 2 |
| Grün, AL | 1 |
| Emmerling, C | 1 |
| Aumeeruddy-Elalfi, Z | 1 |
| Ismaël, IS | 1 |
| Hosenally, M | 1 |
| Zengin, G | 1 |
| Mahomoodally, MF | 1 |
| Dotsenko, A | 1 |
| Gusakov, A | 1 |
| Rozhkova, A | 1 |
| Sinitsyna, O | 1 |
| Shashkov, I | 1 |
| Sinitsyn, A | 1 |
| Hong, CE | 1 |
| Kim, JU | 1 |
| Lee, JW | 1 |
| Lee, SW | 1 |
| Jo, IH | 1 |
| Pandiyarajan, S | 1 |
| Premasudha, P | 1 |
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| Buschauer, A | 1 |
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| Santos, VG | 1 |
| Lopes, MTP | 1 |
| Teixeira, LR | 1 |
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| Rodrigues, GLS | 1 |
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| Huvinen, E | 1 |
| Eriksson, JG | 1 |
| Stach-Lempinen, B | 1 |
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| Koivusalo, SB | 1 |
| Malhotra, M | 1 |
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| Zhou, W | 1 |
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| Rausch-Fan, X | 1 |
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| Marques, WL | 1 |
| van der Woude, LN | 1 |
| Luttik, MAH | 1 |
| van den Broek, M | 1 |
| Nijenhuis, JM | 1 |
| Pronk, JT | 1 |
| van Maris, AJA | 1 |
| Mans, R | 1 |
| Gombert, AK | 1 |
| Xu, A | 1 |
| Sun, J | 1 |
| Li, J | 1 |
| Chen, W | 2 |
| Zheng, R | 1 |
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| Shen, WQ | 1 |
| Bao, LP | 1 |
| Hu, SF | 1 |
| Gao, XJ | 1 |
| Xie, YP | 1 |
| Gao, XF | 1 |
| Huang, WH | 1 |
| Lu, X | 1 |
| Gostin, PF | 1 |
| Addison, O | 1 |
| Morrell, AP | 1 |
| Zhang, Y | 2 |
| Cook, AJMC | 1 |
| Liens, A | 1 |
| Stoica, M | 1 |
| Ignatyev, K | 1 |
| Street, SR | 1 |
| Wu, J | 1 |
| Chiu, YL | 1 |
| Davenport, AJ | 1 |
| Qiu, Z | 1 |
| Shu, J | 1 |
| Tang, D | 1 |
| Gao, X | 1 |
| Zhang, J | 3 |
| Huang, K | 1 |
| Wai, H | 1 |
| Du, K | 1 |
| Anesini, J | 1 |
| Kim, WS | 1 |
| Eastman, A | 1 |
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| Huo, XK | 1 |
| Cheng, ZB | 1 |
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| Zhang, TY | 1 |
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| Park, JH | 1 |
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| Kumar, V | 1 |
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| Morla, S | 1 |
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| Saslow, SA | 1 |
| Um, W | 1 |
| Pearce, CI | 1 |
| Bowden, ME | 1 |
| Engelhard, MH | 1 |
| Lukens, WL | 1 |
| Kim, DS | 1 |
| Schweiger, MJ | 1 |
| Kruger, AA | 1 |
| Adair, LS | 1 |
| Kuzawa, C | 1 |
| McDade, T | 1 |
| Carba, DB | 1 |
| Borja, JB | 1 |
| Liang, X | 2 |
| Song, W | 1 |
| Wang, K | 1 |
| Zhang, B | 1 |
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| Luo, HR | 1 |
| Chen, ZY | 1 |
| Fei, JJ | 1 |
| Du, ZJ | 1 |
| Yi, KJ | 1 |
| Im, WT | 1 |
| Kim, DW | 1 |
| Ji, X | 1 |
| Zhang, C | 1 |
| Xu, Z | 1 |
| Ding, Y | 1 |
| Song, Q | 1 |
| Li, B | 2 |
| Zhao, H | 1 |
| Lee, DW | 1 |
| Lee, H | 1 |
| Kwon, BO | 1 |
| Khim, JS | 1 |
| Yim, UH | 1 |
| Park, H | 1 |
| Park, B | 1 |
| Choi, IG | 1 |
| Kim, BS | 1 |
| Kim, JJ | 1 |
| Wang, JJ | 1 |
| Li, YZ | 1 |
| Sakai, M | 1 |
| Yamaguchi, M | 1 |
| Nagao, Y | 1 |
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| Kamiya, T | 1 |
| Takeda, S | 1 |
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| Takahashi, T | 1 |
| Arakawa, K | 1 |
| Nakano, T | 1 |
| Rufo, S | 1 |
| Continentino, MA | 1 |
| Nikolaou, V | 1 |
| Plass, F | 1 |
| Planchat, A | 1 |
| Charisiadis, A | 1 |
| Charalambidis, G | 1 |
| Angaridis, PA | 1 |
| Kahnt, A | 1 |
| Odobel, F | 1 |
| Coutsolelos, AG | 1 |
| Fuentes, I | 1 |
| García-Mendiola, T | 1 |
| Sato, S | 1 |
| Pita, M | 1 |
| Nakamura, H | 1 |
| Lorenzo, E | 1 |
| Teixidor, F | 1 |
| Marques, F | 1 |
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| Liu, F | 1 |
| Qi, P | 1 |
| Zhang, L | 1 |
| Mansour, S | 1 |
| Baple, E | 1 |
| Hall, CM | 1 |
| Glendinning, C | 1 |
| Wadman, R | 1 |
| Samel, C | 1 |
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| Forster, K | 1 |
| Lüngen, M | 1 |
| Niecke, A | 1 |
| Pfaff, H | 1 |
| Peters, KM | 1 |
| Tsugiyama, LE | 1 |
| Ida-Eto, M | 1 |
| Ohkawara, T | 1 |
| Noro, Y | 1 |
| Narita, M | 3 |
| Gomes, JDA | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 1 |
| Schulte-Wissermann, H | 2 |
| Kmietowicz, Z | 1 |
| Smith, D | 1 |
| Stevens, J | 1 |
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| Ingram, W | 1 |
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| Howland, RH | 1 |
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| Okura, M | 1 |
| Zaha, H | 1 |
| Yamamoto, T | 1 |
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| Matsumoto, K | 2 |
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| de Oliveira, MZ | 1 |
| Sanseverino, MT | 2 |
| Morelo, EF | 1 |
| de Lyra Rabello Neto, D | 1 |
| Lopez-Camelo, J | 1 |
| Camey, SA | 1 |
| Verma, R | 1 |
| Vasudevan, B | 1 |
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| Zuccarello, D | 1 |
| Di Gianantonio, E | 1 |
| Clementi, M | 2 |
| Fernández-Martínez, E | 1 |
| Ponce-Monter, H | 1 |
| Soria-Jasso, LE | 1 |
| Ortiz, MI | 1 |
| Arias-Montaño, JA | 1 |
| Barragán-Ramírez, G | 1 |
| Mayén-García, C | 1 |
| Brandenburg, NA | 2 |
| Bwire, R | 3 |
| Freeman, J | 3 |
| Houn, F | 2 |
| Sheehan, P | 1 |
| Zeldis, JB | 4 |
| Sorensen, D | 1 |
| Sackett, A | 1 |
| Urban, DJ | 1 |
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| Nudleman, KL | 1 |
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| Jörgensen, G | 3 |
| Roe, FJ | 1 |
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| Mitchley, BC | 1 |
| Gibson, MA | 1 |
| Bischoff, A | 1 |
| Morgon, A | 1 |
| Charachon, D | 2 |
| Bringuier, N | 1 |
| Nicholls, PJ | 1 |
| Gavan, JA | 1 |
| Hague, DE | 1 |
| Bakay, B | 2 |
| Nyhan, WL | 2 |
| Sugiyama, Y | 1 |
| Bryan, EM | 1 |
| Kohler, HG | 1 |
| Robertson, GM | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Shtenberg, AI | 1 |
| Illum, P | 1 |
| Aschenbrenner, R | 1 |
| Holt, SB | 1 |
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| Kewitz, H | 1 |
| Book, SA | 1 |
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| Kernis, MM | 1 |
| Terapane, J | 1 |
| Jordan, RL | 1 |
| Poswillo, DE | 4 |
| Hamilton, WJ | 2 |
| Tanimura, T | 1 |
| Sopher, D | 1 |
| Jusko, WJ | 1 |
| van Julsingha, EB | 1 |
| Lister, J | 1 |
| Wendel, HA | 1 |
| Elsahy, NI | 1 |
| Jackson, R | 1 |
| Kajii, T | 3 |
| Kida, M | 3 |
| Takahashi, K | 2 |
| Cerutti, R | 1 |
| Kucera, J | 1 |
| Wright, PL | 1 |
| Plank, JB | 1 |
| Tuli, SM | 1 |
| Jackson, BT | 1 |
| Murad, JE | 1 |
| Shakibi, JG | 1 |
| Kozaczenko, J | 1 |
| Taylor, WJ | 1 |
| Suzuki, M | 1 |
| Murai, N | 1 |
| Watanabe, G | 1 |
| Warburg, M | 1 |
| Apt, W | 1 |
| Rafuse, EV | 1 |
| Arstikaitis, M | 1 |
| Brent, HP | 1 |
| Rasore-Quartino, A | 1 |
| Rovei, S | 1 |
| Terapane, JF | 1 |
| Rosedale, SL | 1 |
| Vondruska, JF | 1 |
| Fancher, OE | 1 |
| Lindburg, DG | 1 |
| Kotlan, J | 1 |
| Farkouh, E | 1 |
| Jonsson, BG | 3 |
| Potter, GD | 1 |
| Hauser, GA | 1 |
| Mambourg, A | 1 |
| Keck, EW | 1 |
| Roloff, D | 1 |
| Markworth, P | 1 |
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| Gibbels, E | 1 |
| Schübel, F | 1 |
| Partsch, CJ | 1 |
| Stahl, A | 4 |
| Hartlmaier, KM | 2 |
| Hammarström, L | 1 |
| Henrikson, CO | 1 |
| Larsson, KS | 2 |
| Hancock, JL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Open-label Extended Access Program of Lenalidomide Plus Low-dose Dexamethasone in Chinese Subjects With Relapsed/Refactory Multiple Myeloma Who Participated in Study CC-5013-MM-021 for at Least One Year.[NCT02348528] | Phase 2 | 65 participants (Actual) | Interventional | 2012-09-11 | Completed | ||
| A Pilot Study of Lenalidomide Maintenance Therapy in Stage IIIB/IV Non-small Cell Lung Cancer After First-line Chemotherapy[NCT02018523] | Phase 1 | 7 participants (Actual) | Interventional | 2014-06-30 | Terminated (stopped due to Study did not enroll enough subjects to make a statistically sound conclusion.) | ||
| QUIREDEX: A National, Open-Label, Multicenter, Randomized, Phase III Study of Revlimid (Lenalidomide) and Dexamethasone (ReDex) Treatment Versus Observation in Patients With Smoldering Multiple Myeloma With High Risk of Progression[NCT00480363] | Phase 3 | 120 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| A Double Blinded Randomized Crossover Phase III Study of Oral Thalidomide Versus Placebo in Patients With Stage D0 Androgen Dependent Prostate Cancer Following Limited Hormonal Ablation[NCT00004635] | Phase 3 | 159 participants (Actual) | Interventional | 2000-03-01 | Completed | ||
| A Randomized Phase II Study of Oral Thalidomide in Patients With Hormone-Refractory Prostate Cancer[NCT00001446] | Phase 2 | 64 participants | Interventional | 1995-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here are the total number of participants with adverse events. For the detailed list of adverse events see the adverse event module. (NCT00004635)
Timeframe: Date treatment consent signed to date off study, approximately 60 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Thalidomide | 117 |
| Placebo | 98 |
Time to progression is defined as follows: if the PSA returns to baseline (defined as the PSA value prior to starting leuprolide or goserelin) or increases to the absolute value of 5 ng/ml. (NCT00004635)
Timeframe: 36 months
| Intervention | months (Median) |
|---|---|
| Thalidomide | 15 |
| Placebo | 9.6 |
108 reviews available for thalidomide and Pregnancy
| Article | Year |
|---|---|
[Development of novel cereblon modulators and their target molecules].
Topics: Adaptor Proteins, Signal Transducing; Female; Humans; Lenalidomide; Peptide Hydrolases; Pregnancy; T | 2022 |
[IBD and pregnancy: From conception to birth].
Topics: Cesarean Section; Colitis, Ulcerative; Crohn Disease; Delivery, Obstetric; Female; Fertilization; Fe | 2020 |
Memories of the Teratology Society: 1972-2020.
Topics: Female; Fetus; Humans; Misoprostol; Pregnancy; Societies, Medical; Teratogens; Teratology; Thalidomi | 2020 |
The organization, weaknesses, and challenges of the control of thalidomide in Brazil: A review.
Topics: Abnormalities, Drug-Induced; Brazil; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy; | 2020 |
A drug repositioning success: The repositioned therapeutic applications and mechanisms of action of thalidomide.
Topics: Cytokines; Drug Repositioning; Female; Humans; Immunosuppressive Agents; Infant, Newborn; Kidney Neo | 2021 |
Recent Advances in the Development of Thalidomide-Related Compounds as Anticancer Drugs.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Female; Humans; Multiple Myeloma; Peripheral Nervous | 2022 |
Comparative analysis of the use and control of thalidomide in Brazil and different countries: is it possible to say there is safety?
Topics: Brazil; Drug Monitoring; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy; Leprosy, Lep | 2022 |
Implementation of a Pregnancy Prevention Programme (PPP) with a Controlled Distribution System (CDS) for the Generic Teratogenic Phthalimides Thalidomide, Lenalidomide and Pomalidomide.
Topics: Child; Female; Humans; Infant, Newborn; Lenalidomide; Phthalimides; Pregnancy; Teratogens; Thalidomi | 2021 |
The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine.
Topics: Abnormalities, Drug-Induced; Animals; Biomarkers; Female; Gene Expression Regulation; Humans; Limb D | 2017 |
The changing health of Thalidomide survivors as they age: A scoping review.
Topics: Aging; Comorbidity; Congenital Abnormalities; Disabled Persons; Female; Health Status; Humans; Menta | 2018 |
Targeted drugs in spondyloarthritis during pregnancy and lactation.
Topics: Animals; Breast Feeding; Cytokines; Female; Humans; Janus Kinase Inhibitors; Lactation; Molecular Ta | 2018 |
A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE).
Topics: Algorithms; Diagnosis, Differential; Female; History, 20th Century; History, 21st Century; Humans; L | 2019 |
The teratogenic effects of thalidomide on limbs.
Topics: Abnormalities, Drug-Induced; Extremities; Female; History, 20th Century; History, 21st Century; Huma | 2019 |
Pyoderma gangrenosum: a systematic review.
Topics: Anti-Inflammatory Agents; Arthritis; Dermatologic Agents; Diagnosis, Differential; Disease Progressi | 2014 |
Thalidomide-induced teratogenesis: history and mechanisms.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Female; History, 20th Century; History, 21st Century; H | 2015 |
Therapeutic Potential of Thalidomide and Its Analogues in the Treatment of Cancer.
Topics: Angiogenesis Inhibitors; Animals; Female; Humans; Neoplasms; Pregnancy; Thalidomide | 2015 |
Thalidomide in multiple myeloma--clinical trials and aspects of drug metabolism and toxicity.
Topics: Angiogenesis Inhibitors; Animals; Clinical Trials as Topic; Drug Interactions; Female; Humans; Immun | 2008 |
Variability in human embryonic development and its implications for the susceptibility to environmental teratogenesis.
Topics: Embryo, Mammalian; Embryonic Development; Environmental Exposure; Female; Gestational Age; Humans; P | 2009 |
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Topics: Abnormalities, Drug-Induced; Adult; Autistic Disorder; Child; Child, Preschool; Cranial Nerves; Embr | 2009 |
[Thalidomide in oncological and hematological diseases].
Topics: Angiogenesis Inhibitors; Female; Hematologic Diseases; Humans; Multiple Myeloma; Neoplasms; Pregnanc | 2010 |
Rare bladder tumors: caveat emptor.
Topics: Abnormalities, Drug-Induced; Disease Progression; Female; Humans; Lenalidomide; Male; Multiple Myelo | 2010 |
Managing the teratogenic risk of thalidomide and lenalidomide: an industry perspective.
Topics: Abnormalities, Drug-Induced; Contraception; Contraindications; Drug Industry; Female; Humans; Lenali | 2011 |
Causes of birth defects: lessons from history.
Topics: Abnormalities, Drug-Induced; Animals; Australia; Congenital Abnormalities; Female; Fever; History, 2 | 2011 |
What can we learn from the thalidomide experience: an ophthalmologic perspective.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Limb Defo | 2011 |
[The thalidomide experience: review of its effects 50 years later].
Topics: Abnormalities, Drug-Induced; Angiogenesis Inhibitors; Ectromelia; Embryonic Development; Female; His | 2012 |
Deciphering the mystery of thalidomide teratogenicity.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chick Embryo; Female; Fibroblast Growth Factor 8; Hum | 2012 |
Teratogen-induced limb defects.
Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin | 2002 |
Dermatologic and nondermatologic uses of thalidomide.
Topics: Angiogenesis Inhibitors; Anti-HIV Agents; Clinical Trials as Topic; Dermatologic Agents; Female; Hum | 2003 |
THE PROBLEM OF TERATOGENICITY.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Cyclizine; Female; Imipramine; Nicotine; Preg | 1963 |
[CONTRAINDICATED MEASURES IN PREGNANCY].
Topics: Anthelmintics; Anti-Bacterial Agents; Antibiotics, Antitubercular; Anticoagulants; Antiemetics; Cort | 1963 |
[EFFECT OF THALIDOMIDE ON THE PATHOGENESIS OF ABNORMALITIES IN NEWBORN INFANTS].
Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; P | 1963 |
ADVANCES IN OBSTETRICS AND GYNAECOLOGY.
Topics: Anemia; Endocrinology; Erythroblastosis, Fetal; Female; Genital Neoplasms, Female; Gynecology; Hormo | 1963 |
TERATOGENIC AGENTS AND CONGENITAL MALFORMATIONS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Congenital Abnormalities; Female; | 1963 |
[ABNORMALLY SHORTENED EXTREMITIES 1950-1962. RESULTS OF A SURVEY].
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Ear Deformities, Acquired; Ear, External; Ect | 1964 |
FETAL AND NEONATAL HAZARDS FROM DRUGS ADMINISTERED DURING PREGNANCY.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antineoplastic | 1964 |
[EXOGENOUS MALFORMATIONS].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcohols; Androgens; Anesthetics; Congenital A | 1964 |
[CLINICAL OBSERVATIONS ON PHARMACOGENIC TERATOGENESIS].
Topics: Abnormalities, Drug-Induced; Androgens; Infant, Newborn; Pregnancy; Progestins; Quinine; Teratogenes | 1964 |
[CLINICAL-STATISTICAL STUDIES ON CURRENT MALFORMATION PROBLEM. A REVIEW].
Topics: Abnormalities, Drug-Induced; Biomedical Research; Epidemiology; Germany; Germany, West; Pregnancy; S | 1964 |
[ETIOPATHOGENESIS OF DEVELOPMENTAL DISORDERS. EXPERIMENTAL CONTRIBUTION TO THE CONCEPT OF PHENOCOPY].
Topics: Animals; Antimetabolites; Avitaminosis; Congenital Abnormalities; Hypoxia; Mammals; Pregnancy; Pregn | 1964 |
CONGENITAL MALFORMATIONS. CLINICAL AND COMMUNITY CONSIDERATIONS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Achondroplasia; Anencephaly; Cleft Pala | 1965 |
[New pharmacological availability of thalidomide based on experience in patients with multiple myeloma].
Topics: Animals; Blood Vessels; Clinical Trials, Phase II as Topic; Ectromelia; Erythema Nodosum; Female; Hu | 2004 |
[Systemic treatment of cutaneous lupus erythematosus].
Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antimal | 2003 |
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents | 2007 |
Oxidative stress as a mechanism of teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Cell Compartmentation; Cell Cycle; Female; Humans; Models, Bio | 2006 |
[Action mechanism of thalidomide in treatment of multiple myeloma].
Topics: Angiogenesis Inhibitors; Cell Adhesion Molecules; DNA; Female; Humans; Immunosuppressive Agents; Len | 2007 |
Fetal drug exposure-behavioral teratogenesis.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Behavior; Cannabinoids; Child; Chil | 1984 |
Mechanisms of teratogenesis.
Topics: Aminopterin; Androgens; Animals; Antithyroid Agents; Chromosome Aberrations; Coumarins; Diethylstilb | 1984 |
Drugs and pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcoholic Beverages; Animals; Anticonvulsants; | 1980 |
Critical periods of prenatal toxic insults.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Embryo, Mammalian; Female; Fetus; Gestational | 1980 |
Forms and causes of human malformations.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Estrogens; Fanconi Anemia; Female; Genes, Dom | 1980 |
In vivo assessment of the teratogenic potential of drugs in humans.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Cannabis; Diethylstilbestrol; Disease Model | 1981 |
Mechanism of teratogenic action of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Extremities; Female; Humans; Immune System Dise | 1996 |
Never-ending tales of the mode of the teratogenic action of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; DNA Adducts; DNA Damage; Embryo, Mammalian; Female; Humans; Pr | 1997 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause?
Topics: Adult; Fathers; Female; Fingers; Forearm; Genes, Dominant; Hand Deformities, Congenital; Humans; Inf | 1998 |
The possibility of epigenetic transmission of defects induced by teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Humans; Limb Deformities, Congenita | 1998 |
The return of thalidomide: can birth defects be prevented?
Topics: Adult; Animals; Congenital Abnormalities; Female; Humans; Leprostatic Agents; Male; Pregnancy; Terat | 1999 |
Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses.
Topics: Eye Abnormalities; Female; History, 20th Century; HIV Infections; Humans; Infant, Newborn; Leprosy; | 1999 |
[New therapeutic application of thalidomide].
Topics: Autoimmune Diseases; Colitis, Ulcerative; Erythema Multiforme; Female; Histiocytosis; Humans; Immuno | 1996 |
Hypothesis: thalidomide embryopathy-proposed mechanism of action.
Topics: Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female; Gene Expression Regul | 2000 |
Diffuse and limited cutaneous systemic scleroderma.
Topics: Adult; Anti-Inflammatory Agents; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplant | 2000 |
[Eye muscle paralysis can increase the knowledge on autism].
Topics: Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Facial Nerve; Female; Humans; Hypnotics | 2000 |
[Fetal thalidomide syndrome].
Topics: Abnormalities, Drug-Induced; Female; Fetal Diseases; Humans; Hypnotics and Sedatives; Infant, Newbor | 2001 |
[The thalidomide story and its lessons].
Topics: Abnormalities, Drug-Induced; Anti-HIV Agents; Antineoplastic Agents; Female; Germany; History, 20th | 2001 |
[New indications for thalidomide?].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Angiogenesis Inhibitors; Animals; Anti-HIV Agents; A | 2001 |
[Thalidomide--a dreaded drug with new indications].
Topics: Abnormalities, Drug-Induced; Anti-HIV Agents; Contraindications; Dermatologic Agents; Female; Histor | 2001 |
Thalidomide: 40 years on.
Topics: Anti-HIV Agents; Brazil; Drug and Narcotic Control; Female; Humans; Hypnotics and Sedatives; Immunos | 2001 |
New concerns about thalidomide.
Topics: Congenital Abnormalities; Drug Approval; Female; Guidelines as Topic; Humans; Infant, Newborn; Male; | 2002 |
Molecular basis of environmentally induced birth defects.
Topics: Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female; Gene Expression Regul | 2002 |
Pathogenesis of congenital malformations. An hypothesis.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Congenital Abnormalities; Female; Ganglia, Spi | 1978 |
[Transplacental carcinogenesis].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Adenocarcinoma; Animals; Carcinogens; | 1977 |
[Theoretical and applied aspects of experimental teratology].
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dactinomycin; DNA Replication; Dose-Response Rela | 1977 |
Drug-induced somatic alterations.
Topics: Abnormalities, Drug-Induced; Alcoholism; Animals; Anticonvulsants; Cannabis; Environmental Exposure; | 1975 |
Embryological pigment epithelial dystrophies.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Deafness; Female; Fluorescein Angiography; Human | 1976 |
[Langerhans-cell histiocytosis in the adult: regressive parotid involvement following thalidomide therapy].
Topics: Adult; Female; Histiocytosis, Langerhans-Cell; Humans; Intertrigo; Parotid Diseases; Pregnancy; Preg | 1992 |
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat | 1990 |
A short history of thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Female; Humans; Male; Pregnancy; Radiography; Teratogens; Thalidomide | 1988 |
Proposed mechanisms of action in thalidomide embryopathy.
Topics: Embryo, Mammalian; Female; Humans; MEDLARS; Pregnancy; Teratogens; Thalidomide; United States | 1988 |
Clinical and basic science lessons from the thalidomide tragedy: what have we learned about the causes of limb defects?
Topics: Arm; Female; Humans; Infant, Newborn; Leg; Pregnancy; Teratogens; Thalidomide | 1988 |
Monitoring for congenital malformations.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Birth Certificates; England; Environmental Healt | 1986 |
The thalidomide syndrome: risks of exposure and spectrum of malformations.
Topics: Ectromelia; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Risk; Teratoge | 1986 |
Testing drugs for teratogenicity and their effects on fertility. The present position.
Topics: Abnormalities, Drug-Induced; Animals; Cannabis; Chlormadinone Acetate; Female; Fertility; Fetal Deat | 1970 |
[Experimental congenital heart diseases].
Topics: Animals; Chickens; Cricetinae; Dactinomycin; Disease Models, Animal; Dogs; Female; Folic Acid Defici | 1972 |
Dermatoglyphics.
Topics: Abnormalities, Drug-Induced; Anemia, Sickle Cell; Anencephaly; Cerebral Palsy; Chromosome Aberration | 1968 |
Phenocopies.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Aplastic; Anorexia Nervosa; Arm; Cleft | 1973 |
[Several problems of drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Ca | 1971 |
Thalidomide revisited.
Topics: Abnormalities, Drug-Induced; Animals; Dogs; Female; Fetus; Humans; Pregnancy; Rats; Thalidomide | 1972 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
[Nutritional background and sensitivity of the organism to toxic substances].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Diet; Dietary Carbohydrates; Dietary | 1972 |
The Mondini type of cochlear malformation. A survey of the literature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Aged; Animals; Child, Presc | 1972 |
Present status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; | 1973 |
Congenital malformations and environmental influence: the occupational environment of laboratory workers.
Topics: Abnormalities, Drug-Induced; Anesthetics; Anti-Bacterial Agents; Benzene; California; Congenital Abn | 1973 |
Drugs in pregnancy and their effects on pre- and postnatal development.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Anticonvulsants; Antimetabolites; Central N | 1973 |
The fetal and neonatal pig in biomedical research.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Hypochromic; Animals; Animals, Laborat | 1974 |
Principles of teratology.
Topics: Abnormalities, Drug-Induced; Amniocentesis; Animals; Chromosome Aberrations; Chromosome Disorders; C | 1972 |
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
Certain causes of congenital malformations in Homo sapiens and their prevention.
Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Aminopterin; Antigen-Antibody Reactions; Chromos | 1967 |
The pathogenesis of congenital cardiovascular anomalies.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Embryology; Female; Heart; Heart Defects, Conge | 1968 |
[Teratogenic molecules].
Topics: Abnormalities, Drug-Induced; Animals; Drug-Related Side Effects and Adverse Reactions; Female; Human | 1967 |
Etiology of congenital heart disease.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; | 1969 |
[Effect of drugs, ingested by the mother during pregnancy, on the fetus].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Meclizine; Pregnancy; | 1969 |
[Some current problems of experimental teratology].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Female; Hypoxia; Methods; Mice; Pregnancy; Rabbi | 1967 |
[Fetal diseases caused by environmental polltuion].
Topics: Abnormalities, Drug-Induced; Air Pollution; Congenital Abnormalities; Environment; Environmental Pol | 1971 |
[Experimental epidemiology].
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Cleft Palate; Congenital Abnormalities; Diabe | 1971 |
The heterogeneity of microphthalmia in the mentally retarded.
Topics: Abnormalities, Multiple; Abortifacient Agents; Adolescent; Adult; Brain Injuries; Child, Preschool; | 1971 |
Malformations caused by drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Cyclophosphamide; Female; Humans; Infant, Newborn | 1966 |
Experimental and clinical chemoteratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Female; Hormones; Humans; In Vitro Tech | 1966 |
The mechanism of thalidomide deformities correlated with the pathogenic effects of prolonged dosage in adults.
Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregna | 1966 |
4 trials available for thalidomide and Pregnancy
| Article | Year |
|---|---|
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Thalidomide in America: a brush with tragedy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Clinical Trials as Topic; Drug Evaluation; Fem | 1976 |
[Fixed lupus erythematosus (its treatment with thalidomide)].
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Lupus Erythemato | 1977 |
New drug development.
Topics: Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Female; History, 16th Cen | 1969 |
554 other studies available for thalidomide and Pregnancy
| Article | Year |
|---|---|
Thalidomide: history, withdrawal, renaissance, and safety concerns.
Topics: Female; History, 20th Century; Humans; Immunosuppressive Agents; Pregnancy; Safety-Based Drug Withdr | 2021 |
[Otorhinolaryngological diseases in pregnancy-which drugs are approved?]
Topics: Child; Female; Humans; Otorhinolaryngologic Diseases; Pharmaceutical Preparations; Pregnancy; Thalid | 2022 |
Unveiling the masked native blood group following thalidomide therapy in a thalassemia patient: A 5 WHY analysis approach.
Topics: Adult; Blood Group Antigens; Blood Grouping and Crossmatching; Female; Humans; Pregnancy; Rh-Hr Bloo | 2022 |
Clinical trials in pregnancy and the "shadows of thalidomide": Revisiting the legacy of Frances Kelsey.
Topics: Clinical Trials as Topic; Female; France; Humans; Pregnancy; Thalidomide; United States; United Stat | 2022 |
Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies.
Topics: Animals; Cell Membrane Permeability; Female; Hematologic Neoplasms; Humans; Lenalidomide; Multiple M | 2022 |
Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Female; Humans; Microsomes, Liver; Oxidation-Red | 2023 |
Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy.
Topics: Abnormalities, Multiple; Basic Helix-Loop-Helix Transcription Factors; Female; Fetal Diseases; Genet | 2022 |
Embryo-fetal exposure and developmental outcome of lenalidomide following oral administration to pregnant cynomolgus monkeys.
Topics: Administration, Oral; Animals; Cesarean Section; Female; Lenalidomide; Macaca fascicularis; Placenta | 2022 |
Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies.
Topics: Alkynes; Benzoxazines; Computer Simulation; Cyclopropanes; Cytochrome P-450 Enzyme System; Female; F | 2019 |
Thalidomide leads to mandible hypoplasia through inhibiting angiogenesis and secondary hemorrhage in the fetal craniofacial region in rabbits.
Topics: Animals; Craniofacial Abnormalities; Down-Regulation; Female; Hemorrhage; Mandible; Maxillofacial Ab | 2020 |
Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Ethics, Research; Female; Hu | 2020 |
Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide.
Topics: Autoimmune Diseases; Cesarean Section; Female; Humans; Methylprednisolone; Pemphigus; Pregnancy; Tha | 2021 |
"The legacy of thalidomide" - A multidisciplinary meeting held at the University of York, United Kingdom, on September 30, 2016.
Topics: Abnormalities, Drug-Induced; Adult; Aging; Child; Disabled Persons; Female; Humans; Hypnotics and Se | 2017 |
Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
Topics: Cells, Cultured; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Humans; Liver; Oxidation-Reductio | 2017 |
Efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/\
refractory multiple myeloma: a real-life experience
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2018 |
[Anatomist, Anti-Abortionist, Anti-Darwinian. The three lives of Erich Blechschmidt (1904–1992)].
Topics: Abortion, Induced; Anatomists; Animals; Biological Evolution; Embryonic Development; Female; History | 2016 |
The health and quality of life of Thalidomide survivors as they age - Evidence from a UK survey.
Topics: Adult; Aging; Anxiety; Depression; Employment; Female; Humans; Hypnotics and Sedatives; Male; Middle | 2019 |
[Upcoming challenges in providing care for thalidomide impaired individuals].
Topics: Child; Cross-Sectional Studies; Female; Germany; Humans; Pregnancy; Prenatal Exposure Delayed Effect | 2019 |
Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats.
Topics: Acoustic Stimulation; Animals; Autistic Disorder; Brain Stem; Female; Hyperacusis; Immunosuppressive | 2020 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
[Independence of former Contergan children compromised].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Pregn | 2013 |
More drug studies need to include pregnant women, says bulletin.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Industry; Female; Humans; Hypnotics and Sedatives; M | 2013 |
Myeloma presenting during pregnancy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cesarean Section; | 2014 |
Concern for truth: driving defensively when confronting a zombie epidemic.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor | 2013 |
Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Brain; Cerebral Arteries; Dopamine; Female; Fetu | 2013 |
Common nature in the effects of thalidomide on embryo-fetal development in Kbl:JW and Kbl:NZW rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic | 2014 |
Effects of thalidomide on Fgf8, Bmp4 and Hoxa11 expression in the limb bud in Kbl:JW rabbit embryos.
Topics: Abnormalities, Drug-Induced; Animals; Bone Morphogenetic Protein 4; Embryo, Mammalian; Embryonic Dev | 2014 |
'Something there is that doesn't love a wall': histories of the placental barrier.
Topics: Attitude of Health Personnel; Behavior; Female; Fetal Development; Fetus; History, 20th Century; Hum | 2014 |
Professor David Poswillo CBE (1927-2003): Skilled oral and maxillofacial surgeon, influential scientist, teacher and adviser.
Topics: Animals; Cleft Palate; England; Faculty, Dental; Female; History, 20th Century; History, 21st Centur | 2014 |
Cases of babies in Brazil born with thalidomide defects.
Topics: Abnormalities, Drug-Induced; Brazil; Drug Repositioning; Ethics, Pharmacy; Female; Humans; Infant; M | 2013 |
50 years ago in the Journal of pediatrics: Drug testing in animals for teratogenic effects. Thalidomide in the pregnant rat.
Topics: Abnormalities, Drug-Induced; Animals; Female; History, 20th Century; Models, Animal; Pediatrics; Per | 2014 |
Embryo-fetal exposure and developmental outcome of thalidomide following oral and intravaginal administration to pregnant rabbits.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Administration, Oral; Animals; Embryo, Ma | 2014 |
A peek into the atomic details of thalidomide's clinical effects.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Female; Humans; Models, Molecu | 2014 |
Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin.
Topics: Binding Sites; Cell Proliferation; Female; Humans; Isoindoles; Kinetics; MCF-7 Cells; Microtubules; | 2015 |
Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil.
Topics: Abnormalities, Drug-Induced; Brazil; Drug Prescriptions; Female; Humans; Infant, Newborn; Leprosy; P | 2015 |
Bullous erythema nodosum leprosum manifesting in the post partum period with unusual features.
Topics: Adult; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromato | 2015 |
[Risk Management of Teratogenic Drugs ~The Current States of Practice in Europe, US and Japan~].
Topics: Contraception; Europe; Female; Humans; Japan; Male; Pregnancy; Risk Management; Teratogens; Thalidom | 2015 |
Drugs in Pregnancy.
Topics: Female; History, 20th Century; Humans; Pharmaceutical Preparations; Pregnancy; Prenatal Exposure Del | 2015 |
Attacking the devil: the thalidomide story.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Europe; Female; History, 20th Century; Humans; Male | 2016 |
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Embryo | 2016 |
Zika: Worse Than Thalidomide?
Topics: Adult; Caribbean Region; Craniofacial Abnormalities; Female; Humans; Outcome Assessment, Health Care | 2016 |
Internal anomalies in thalidomide embryopathy: results of imaging screening by CT and MRI.
Topics: Abnormalities, Multiple; Causality; Female; Gallbladder; Humans; Japan; Liver; Magnetic Resonance Im | 2016 |
Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation.
Topics: Abnormalities, Drug-Induced; Angiotensin-Converting Enzyme Inhibitors; Animals; Female; Fetal Diseas | 2017 |
Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade.
Topics: Adolescent; Adult; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; Dose-Response Rel | 2016 |
Effectiveness of Risk Evaluation and Mitigation Strategies (REMS) for Lenalidomide and Thalidomide: Patient Comprehension and Knowledge Retention.
Topics: Adolescent; Adult; Child; Comprehension; Contraception; Female; Follow-Up Studies; Health Knowledge, | 2017 |
A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic Development; Female; Models, Anim | 2017 |
RevAssist: a comprehensive risk minimization programme for preventing fetal exposure to lenalidomide.
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Female; Fetus; Humans; Lenalidomide; Male; Mater | 2008 |
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions.
Topics: Adherens Junctions; Angiogenesis Inhibitors; Animals; Antigens, CD; Antineoplastic Agents; Basic Hel | 2009 |
A 24-year-old pregnant woman with inflammatory bowel disease.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Breast Feeding; Crohn Disease; Female; Fetus; Huma | 2009 |
[Thalidomide (Contergan) induced limb deficiency in Hungary?].
Topics: Diagnosis, Differential; Female; Femur; Fibula; Humans; Hungary; Lower Extremity Deformities, Congen | 2009 |
Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Gene Expression; Gene Expression Profiling; Gestationa | 2010 |
Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat.
Topics: Age Factors; Animals; Autistic Disorder; Disease Models, Animal; Exploratory Behavior; Female; Inter | 2010 |
Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models.
Topics: Animals; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dose-Res | 2010 |
[Reinventing thalidomide under high supervision].
Topics: Abnormalities, Drug-Induced; Adult; Aged; Antineoplastic Agents; Device Approval; Female; History, 2 | 2010 |
Les bébés du thalidomide.
Topics: Abnormalities, Drug-Induced; Drug Industry; Ectromelia; Female; France; History, 20th Century; Human | 2011 |
Frances Kelsey honored for FDA legacy: award notes her work on thalidomide, clinical trials.
Topics: Awards and Prizes; Clinical Trials as Topic; Drug Approval; Ectromelia; Europe; Female; History, 20t | 2010 |
What has happened to people affected by thalidomide 50 years on?
Topics: Activities of Daily Living; Adult; Arm; Disabled Persons; Female; Health Status; Humans; Leg; Male; | 2011 |
Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture.
Topics: Abnormalities, Drug-Induced; Animals; DNA Damage; DNA Glycosylases; DNA Repair; DNA Repair-Deficienc | 2011 |
Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.
Topics: Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationsh | 2011 |
Thalidomide: the tragedy of birth defects and the effective treatment of disease.
Topics: Abnormalities, Drug-Induced; Angiogenesis Inhibitors; Animals; Dose-Response Relationship, Drug; Ect | 2011 |
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil.
Topics: Abnormalities, Drug-Induced; Adult; Brazil; Female; Fetal Diseases; Geography; Humans; Infant, Newbo | 2011 |
US lawsuit extends thalidomide's reach.
Topics: Animals; Chick Embryo; Congenital Abnormalities; Drug Industry; Ectromelia; Female; Humans; Liabilit | 2011 |
Carbamazepine use in pregnancy and coincidental thalidomide-like phocomelia in a newborn.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Ectromelia; Female; Humans; Infant, New | 2012 |
Adaptive toothbrush handle: case report of a Thalidomide patient.
Topics: Dental Devices, Home Care; Dental Plaque Index; Ectromelia; Equipment Design; Female; Humans; Male; | 2012 |
The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals.
Topics: Abnormalities, Drug-Induced; Animals; Child; Drug Costs; Female; Humans; Jurisprudence; Licensure; M | 2012 |
Correspondence.
Topics: Adenocarcinoma; Adolescent; Adult; Diethylstilbestrol; Female; Humans; Incidental Findings; Limb Def | 2012 |
[Thalidomide: this "mea culpa" which isn't one].
Topics: Child, Preschool; Dissent and Disputes; Drug Industry; Female; Germany; Humans; Jurisprudence; Limb | 2012 |
Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort.
Topics: Antiemetics; Australasia; Australia; Cohort Studies; Disease Progression; Female; Humans; Male; Midd | 2013 |
Regarding how safe is "safe"?
Topics: Adenocarcinoma; Diethylstilbestrol; Female; Humans; Limb Deformities, Congenital; Pregnancy; Rubella | 2013 |
[Thalidomide epidemics: 50 years after].
Topics: Abnormalities, Drug-Induced; Female; History, 20th Century; Humans; Infant; Limb Deformities, Congen | 2012 |
Development of an in vitro system detecting pro-embryotoxin.
Topics: Animals; Benzo(a)pyrene; Biological Assay; Cell Survival; Cells, Cultured; Dose-Response Relationshi | 2002 |
Offspring of male and female parents with thalidomide embryopathy: birth defects and functional anomalies.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Congenital Abnormalities; F | 2002 |
Thalidomide prescribers cannot assign survey responsibility to pharmacists.
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Data Collection; Drug Prescriptions; Female; Hum | 2002 |
Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism.
Topics: Animals; Autistic Disorder; Biogenic Monoamines; Brain; Female; Pregnancy; Rats; Rats, Sprague-Dawle | 2002 |
Thalidomide in multiple myeloma: current status and future prospects.
Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Angiogenesis Inhibitors; Antineoplastic Combine | 2003 |
A proposed primate animal model of autism.
Topics: Animals; Animals, Newborn; Autistic Disorder; Child; Disease Models, Animal; Female; Haplorhini; Hum | 2003 |
Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation.
Topics: Animals; Antibodies; Antioxidants; Blotting, Western; Cell Count; Cell Division; Cell Survival; Cell | 2003 |
Thalidomide makes a comeback.
Topics: Abnormalities, Drug-Induced; Angiogenesis Inhibitors; Ectromelia; Erythema Nodosum; Female; Humans; | 2003 |
Research with pregnant women and fetuses: update on the ethics and the law.
Topics: Clinical Trials as Topic; Embryo Research; Ethics, Research; Female; Fetal Research; Fetus; Governme | 2000 |
Trial of thalidomide in insomnia associated with the third trimester.
Topics: Female; Humans; Hypnotics and Sedatives; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Th | 1961 |
Drugs in pregnancy--thalidomide.
Topics: Congenital Abnormalities; Hypnotics and Sedatives; Pregnancy; Thalidomide | 1962 |
Thalidomide: effect upon pregnancy in the rhesus monkey.
Topics: Animals; Embryo Implantation; Female; Macaca mulatta; Pregnancy; Pregnancy, Animal; Thalidomide | 1963 |
Passage of drugs across the placenta.
Topics: Anesthetics; Anti-Bacterial Agents; Atropa belladonna; Barbiturates; Female; Humans; Hypnotics and S | 1962 |
[Consumption of drugs by pregnant women after the thalidomide warning].
Topics: Biological Phenomena; Female; Humans; Pharmaceutical Preparations; Physiological Phenomena; Pregnanc | 1963 |
[Consumption of drugs by pregnant women after the thalidomide warning. Supplement to Part I, section of "Statistical information on drug consumption"].
Topics: Biometry; Dietary Supplements; Female; Humans; Pharmaceutical Preparations; Pregnancy; Thalidomide | 1963 |
Phocomelic deformity and maternal thalidomide administration. A report of four cases.
Topics: Ectromelia; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Thalidomide | 1962 |
Drugs and congenital abnormalities.
Topics: Animals; Female; Fetal Death; Pregnancy; Pregnancy, Animal; Thalidomide | 1963 |
[Initial statistical elements relative to congenital malformations in Belgium].
Topics: Belgium; Biometry; Congenital Abnormalities; Diabetes Mellitus; Female; Humans; Pregnancy; Pregnancy | 1963 |
[Nil nocere: Roentgen examination in pregnancy after thalidomide use?].
Topics: Abortion, Induced; Abortion, Spontaneous; Abortion, Therapeutic; Congenital Abnormalities; Female; H | 1962 |
[The significance of new exogenous noxae for the developmental damage of germ cells and ova and their prevention].
Topics: Abortion, Induced; Congenital Abnormalities; Ectromelia; Female; Fetal Death; Germ Cells; Iatrogenic | 1962 |
[Thalidomide and abnormalities of development].
Topics: Animals; Congenital Abnormalities; Female; Pregnancy; Pregnancy, Animal; Thalidomide | 1962 |
[On the increase in deformities of the extremities and external ear since 1960 with reference to exogenous factors].
Topics: Congenital Abnormalities; Ear Deformities, Acquired; Ear, External; Extremities; Female; Humans; Pre | 1962 |
[Influence of increasing doses of glutethimide (Doriden) on pregnancy and fetal development in the rabbit].
Topics: Animals; Congenital Abnormalities; Female; Fetal Development; Glutethimide; Leadership; Pregnancy; P | 1963 |
Phocomelia: report of three cases.
Topics: Death; Ectromelia; Female; Humans; Infant; Infant, Newborn; Mothers; Pregnancy; Thalidomide | 1962 |
[CONTINUOUS RISE IN THE INCIDENCE OF PHOCOMELIA IN NEWBORN INFANTS IN WESTERN EUROPE AND ITS RELATION TO THALIDOMIDE ADMINISTRATION. CURRENT STATUS OF THE PROBLEM].
Topics: Abnormalities, Drug-Induced; Drug Tolerance; Ectromelia; Europe; Female; Germany; Germany, West; Inc | 1963 |
[1ST CASE REPORT FROM FORMOSA OF A CONGENITAL ANOMALY PROBABLY INDUCED BY THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Arm; China; Hand; Pregnancy; Taiwan; Thalidomide; Toxicology | 1962 |
[PSYCHIATRIC USE OF SOME PSYCHOPHARMACOLOGICAL DRUGS IN PREGNANCY].
Topics: Chlordiazepoxide; Chlorpromazine; Fetus; Haloperidol; Imipramine; Isocarboxazid; Meprobamate; Nialam | 1963 |
[MEDICAL THERAPY IN PREGNANCY AND ITS REPERCUSSIONS ON THE FETUS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androgens; Anti-Bacterial Agents; Anticoagulan | 1963 |
CANADIAN THALIDOMIDE EXPERIENCE.
Topics: Abnormalities, Drug-Induced; Canada; Ectromelia; Extremities; Female; Fetal Death; Humans; Infant; I | 1963 |
[EFFECT OF DRUGS ON THE DEVELOPMENT OF THE FETUS WITH REFERENCE TO THE TERATOGENIC EFFECT OF THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Female; Fetus; Humans; Pharmacology; Pregnancy; Te | 1963 |
CONGENITAL DEFORMITIES ASSOCIATED WITH THE USE OF THALIDOMIDE DURING PREGNANCY, BRITISH COLUMBIA, 1961-62.
Topics: Abnormalities, Drug-Induced; British Columbia; Canada; Ectromelia; Humans; Infant, Newborn; Infant, | 1963 |
[PHOCOMELIA SYNDROME CAUSED BY THALIDOMIDE].
Topics: Ectromelia; Female; Infant, Newborn; Pregnancy; Pregnancy Complications; Radiography; Syndrome; Thal | 1963 |
INFLUENCE OF THE ENVIRONMENT ON THE UNBORN.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Communicable Diseases; Congenital Abnormalities; | 1963 |
THE EFFECT OF THALIDOMIDE ON THE UNBORN PUPPY.
Topics: Abnormalities, Drug-Induced; Animals; Dogs; Extremities; Female; Humans; Pregnancy; Pregnancy, Anima | 1963 |
DRUG EMBRYOPATHY: THE THALIDOMIDE STORY.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Female; Fetal Diseases; Glutethimide; Humans; In | 1963 |
[HOW TO EXPLAIN THE TERATOGENIC ACTION OF THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Ectromelia; Pregnancy; Teratogenesis; Teratogens; Thalidomide; Toxicolo | 1963 |
EFFECTS OF PARENTAL THALIDOMIDE TREATMENT ON GESTATION AND FETAL DEVELOPMENT.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Development; Humans; Lagomorpha; Maternal-Fetal | 1963 |
[TERATOGENIC ACTION OF DRUGS IN THE PREGNANT WOMAN].
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Avitaminosis; Chlorpromazine; Cortisone; Female; | 1963 |
[CASE OF TOTAL AMELIA THOUGHT TO BE DUE TO THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Ectromelia; Extremities; Infant, Newborn; Pregnancy; Radiography; Thali | 1963 |
THALIDOMIDE INDUCED ALTERATIONS IN THE BLASTOCYST AND PLACENTA OF THE ARMADILLO, DASYPUS NOVEMCINCTUS MEXICANUS, INCLUDING A CHORIOCARCINOMA.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Abortion, Veterinary; Animals | 1963 |
EFFECTS OF THALIDOMIDE IN THE RAT FOETUS.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetus; Humans; Maternal-Fetal Exchan | 1963 |
[DRUG CONSUMPTION BY PREGNANT WOMEN AFTER CAUTIONS ON THALIDOMIDE. II. III].
Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Health Education; Humans; Pharmaceutical Preparati | 1963 |
[CONGENITAL MALFORMATIONS IN JAPAN].
Topics: Abnormalities, Drug-Induced; Classification; Congenital Abnormalities; Infant, Newborn; Japan; Pregn | 1963 |
[THE CONGENITAL ABNORMALITY, PHOCOMELIA, CAUSED BY CHEMICAL SUBSTANCES].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Ectromelia; Female; Guinea Pigs; Humans; Pha | 1963 |
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY 1960-1961.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fetal Diseases; Geriatrics; Germany; Germany, | 1964 |
TERATOGENIC ACTIVITY OF DRUGS.
Topics: Abnormalities, Drug-Induced; Fetal Death; Guanethidine; Pregnancy; Rats; Research; Reserpine; Thalid | 1964 |
TERATOGENIC ACTION OF THALIDOMIDE.
Topics: Abnormalities, Drug-Induced; Female; Folic Acid; Glutamine; Niacinamide; Pregnancy; Pregnancy Compli | 1964 |
EFFECT OF METHAQUALONE HYDROCHLORIDE IN PREGNANT RABBITS AND RATS.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Hypnotics and Sedatives; Methaqualone; Pregnan | 1963 |
[THALIDOMIDE EMBRYOPATHIES IN MILANO AND SUBURBS. ANATOMO-CLINICAL STUDY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Biomedical Research; Ectromelia; Fetal Disease | 1963 |
[TOXIC AND TERATOGENIC EFFECTS OF THALIDOMIDE ON A RABBIT FETUS].
Topics: Abnormalities, Drug-Induced; Animals, Newborn; Ectromelia; Fetal Diseases; Fetus; Pregnancy; Pregnan | 1963 |
THALIDOMIDE: EFFECTS ON ENZYMES OF GLUTAMIC ACID METABOLISM IN MICE.
Topics: Aspartate Aminotransferases; Brain; Carboxy-Lyases; Embryo, Mammalian; Embryo, Nonmammalian; Glutama | 1964 |
[DRUG USE DURING PREGNANCY AFTER DISCOVERY OF THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Ectromelia; Female; | 1964 |
[CONGENITAL MALFORMATIONS OF SKELETON IN RABBITS].
Topics: Abnormalities, Drug-Induced; Animals; Bone Diseases; Female; Humans; Lagomorpha; Mucopolysaccharidos | 1964 |
[TERATOGENIC SUBSTANCES?].
Topics: Abnormalities, Drug-Induced; Ectromelia; Fetal Diseases; Infant, Newborn; Meclizine; Phenmetrazine; | 1964 |
[A NEW THALIDOMIDE CASE].
Topics: Abnormalities, Drug-Induced; Arm; Hand Deformities; Infant, Newborn; Pregnancy; Radiography; Radius; | 1964 |
THE TERATOGENIC EFFECTS OF THALIDOMIDE, IMIPRAMINE HC1 AND IMIPRAMINE-N-OXIDE HC1 ON WHITE DANISH RABBITS.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetal Diseases; Humans; Imipramine; | 1963 |
[TERSTOGENIC SUBSTANCES?].
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meclizine; Ph | 1963 |
PSYCHIATRIC INDICATIONS FOR THERAPEUTIC ABORTION AND STERILIZATION.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Therapeutic; Depression; Family; Female; H | 1964 |
[THALIDOMIDE SYNDROME AND THE TREATMENT OF THALIDOMIDE CASES].
Topics: Abnormalities, Drug-Induced; Hand Deformities; Infant, Newborn; Pregnancy; Syndrome; Thalidomide; To | 1964 |
[ACTION ON PREGNANCY AND FETAL DEVELOPMENT OF A GLUTARIMIC DERIVATIVE, ATURBANE].
Topics: Abnormalities, Drug-Induced; Animals; Fetal Development; Fetus; Hypnotics and Sedatives; Lagomorpha; | 1964 |
[INVESTIGATION ON THE POSSIBLE RELATION OF FETAL INJURIES AND DRUGS. IV. RETROSPECTIVE STUDY ON DRUG CONSUMPTION AMONG MOTHERS WITH MALFORMED CHILDREN].
Topics: Abnormalities, Drug-Induced; Diphenhydramine; Down Syndrome; Fetal Diseases; Hip Dislocation; Hip Di | 1964 |
THE RELATIONSHIP BETWEEN GROUP COMPOSITION AND DRUG ACTION IN MICE.
Topics: Animals; Behavior, Animal; Female; Humans; Mice; Pharmacology; Pregnancy; Research; Thalidomide | 1964 |
[THALIDOMIDE ABNORMALITIES].
Topics: Abnormalities, Drug-Induced; Child; Child Care; Child Welfare; Ectromelia; Humans; Infant, Newborn; | 1964 |
REPORT FROM THE DUKE UNIVERSITY POISON CONTROL CENTER. DRUG DANGERS (MATERNAL MEDICATION) TO THE FETUS.
Topics: Abnormalities, Drug-Induced; Aminopterin; Anti-Bacterial Agents; Antimetabolites; Chloramphenicol; C | 1964 |
DRUG TESTING IN ANIMALS FOR TERATOGENIC EFFECTS. THALIDOMIDE IN THE PREGNANT RAT.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryo, Nonmammalian; Female; Humans; Injec | 1964 |
[THE PATHOGENESIS OF VARIOUS EXTERNAL MALFORMATIONS AS A CONSEQUENCE OF EXOGENOUS STIMULI IN MAMMALS].
Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Ectromelia; Female; Humans; Lagomorpha; Mamm | 1963 |
MAMMALIAN BLASTOPATHIOS DUE TO DRUGS.
Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Female; Humans; Mammals; Mechlorethamine; Pr | 1964 |
IDENTIFICATION OF THALIDOMIDE IN RABBIT BLASTOCYSTS.
Topics: Animals; Blastocyst; Carbon Isotopes; Chromatography; Embryo, Mammalian; Embryo, Nonmammalian; Femal | 1964 |
MALFORMATIONS INDUCED IN THE MOUSE BY THALIDOMIDE.
Topics: Abnormalities, Drug-Induced; Animals; Bone Diseases; Embryo, Mammalian; Embryo, Nonmammalian; Female | 1964 |
THALIDOMIDE EMBRYOPATHY IN HYBRID RABBITS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Extremities; Female; Fetal Diseases; Humans; K | 1964 |
THE USE OF SWINE IN DRUG TOXICITY STUDIES.
Topics: Abnormalities, Drug-Induced; Amphotericin B; Animals; Drug-Related Side Effects and Adverse Reaction | 1964 |
[RESEARCH ON THE TERATOGENIC EFFECT OF 2-DIETHYLAMINOPROPIOPHENONE].
Topics: Abnormalities, Drug-Induced; Animals; Diethylpropion; Female; Humans; Mice; Pregnancy; Rats; Researc | 1964 |
EFFECTS OF D,1-3-PHTHALIMIDOGLUTARIMIDE AND N-PHTHALYL-D,L-ASPARTIMIDE ON RAT PREGNANCY.
Topics: Abnormalities, Drug-Induced; Animals; Aspartic Acid; Female; Humans; Imides; Pharmacology; Phthalic | 1963 |
[ON POTENTIATION OF THE EMBRYOTOXIC EFFECTS OF THALIDOMIDE IN THE FEMALE RAT].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Pharmacology; Pregnancy; Rats; Research; Ribof | 1964 |
[METHODS AND PROBLEMS IN EXPERIMENTAL DRUG-INDUCED TERATOGENESIS].
Topics: Abnormalities, Drug-Induced; Animals; Drugs, Investigational; Female; Humans; Lagomorpha; Pregnancy; | 1964 |
[REPERCUSSIONS OF NEUROLEPTIC AND ANTITUMOR AGENTS ON PRENATAL DEVELOPMENT].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ant | 1964 |
AUTORADIOGRAPHIC INVESTIGATIONS OF 14-C-LABELLED THALIDOMIDE AND GLUTETHIMIDE IN PREGNANT MICE.
Topics: Abnormalities, Drug-Induced; Animals; Female; Glutethimide; Humans; Maternal-Fetal Exchange; Metabol | 1964 |
OCULAR DEFECTS IN THALIDOMIDE BABIES.
Topics: Abnormalities, Drug-Induced; Eye; Eye Diseases; Female; Humans; Infant; Infant, Newborn; Infant, New | 1964 |
EFFECTS OF THALIDOMIDE ON PREGNANCY IN THE RABBIT.
Topics: Abnormalities, Drug-Induced; Animals; Cell Biology; Embryo, Mammalian; Embryo, Nonmammalian; Female; | 1964 |
[THALIDOMIDE AND EAR-MALFORMATION].
Topics: Abnormalities, Drug-Induced; Ear, External; Humans; Infant; Pregnancy; Thalidomide; Toxicology | 1964 |
THE EFFECTS OF THALIDOMIDE ON THE ELECTRICAL ACTIVITY OF THE BRAIN IN THE INTRAUTERINE GUINEA-PIG FOETUS.
Topics: Animals; Brain; Electrocardiography; Electroencephalography; Female; Fetus; Guinea Pigs; Humans; Pha | 1964 |
PHARMACOLOGICAL PROPERTIES AND TERATOGENIC ACTION OF 2-(HEXAHYDROPHTHALIMIDO) GLUTARIMIDE AND 2-PHTHALIMIDO-N-METHYLGLUTARIMIDE.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Mice; Piperidines; Piperidones; Pregnancy; Pre | 1964 |
TERATOGENIC ACTIVITY OF THALIDOMIDE AND RELATED COMPOUNDS.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Pharmacology; Piperidines; Pregnancy; Rabbits; | 1964 |
THALIDOMIDE SYNDROME IN MONKEYS.
Topics: Abnormalities, Drug-Induced; Animals; Embryo Implantation; Extremities; Female; Fetus; Haplorhini; H | 1964 |
[THE EFFECT OF THALIDOMIDE ON THE FERTILITY OF RATS IN REPRODUCTION EXPERIMENTS OVER 2 GENERATIONS].
Topics: Endocrine System Diseases; Fertility; Pharmacology; Pregnancy; Pregnancy, Animal; Rats; Reproduction | 1964 |
VIRAL AND DRUG HAZARDS IN PREGNANCY.
Topics: Abnormalities, Drug-Induced; Androgens; Chickenpox; Congenital Abnormalities; Female; Hand Deformiti | 1964 |
EFFECT OF ACETYLSALICYLIC ACID ON FOETAL RATS.
Topics: Abnormalities, Drug-Induced; Aspirin; Caseins; Fetus; Pharmacology; Pregnancy; Rats; Research; Reser | 1964 |
HAZARDS OF OBSTETRICAL AND GYNECOLOGICAL DRUGS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Androgens; Drug Therapy; Estrogens; Female; Gy | 1964 |
[CHONDRODYSTROPHY AFTER THALIDOMIDE MEDICATION].
Topics: Abnormalities, Drug-Induced; Bone Diseases, Developmental; Drug Therapy; Ectromelia; Enchondromatosi | 1964 |
[EAR MALFORMATIONS IN THE FRAMEWORK OF THALIDOMIDE EMBRYOPATHY. (BASED ON A SURVEY OF 70 INFANTS BORN DURING 1959-1962)].
Topics: Abnormalities, Drug-Induced; Deafness; Ear Deformities, Acquired; Ear, External; Fetal Diseases; Hea | 1964 |
THALIDOMIDE-INDUCED APLASIA OF THE INNER EAR.
Topics: Abnormalities, Drug-Induced; Ear Deformities, Acquired; Ear, External; Ear, Inner; Facial Paralysis; | 1964 |
[THALIDOMIDE EMBRYOPATHY IN RABBITS FOLLOWING TRANSIENT LIVER DAMAGE IN THE MOTHER BY CARBON TETRACHLORIDE].
Topics: Abnormalities, Drug-Induced; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1964 |
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists; | 1964 |
MICROBIOLOGICALLY DETERMINED PANTOTHENIC ACID AND NICOTINIC ACID CONTENT OF CHICK EMBRYOS AFTER TREATMENT WITH THALIDOMIDE AND OF RAT FETUSES, NEWBORNS AND PLACENTAS FROM MOTHERS TREATED WITH THALIDOMIDE.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Biological Assay; Chick Embryo; Embryo, Mamm | 1964 |
[DRUGS WHICH SHOULD NOT BE GIVEN TO A PREGNANT WOMAN].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Antineoplastic Agents; Dihydrostreptomycin Sul | 1964 |
[EAR DEFORMATIONS RELATED TO THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Ear Deformities, Acquired; Ear, External; Infant, Newborn; Pregnancy; T | 1964 |
MORPHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THALIDOMIDE AND TRYPAN BLUE ON UTERI AND CONCEPTI OF GRAVID MICE.
Topics: Abnormalities, Drug-Induced; Amnion; Amniotic Fluid; Animals; Animals, Newborn; Ectromelia; Female; | 1965 |
[OCULOMOTOR PARALYSIS IN THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fetal Diseases; Ophthalmoplegia | 1964 |
[CONTERGAN INJURY WITH EYE INVOLVEMENT].
Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena | 1964 |
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena | 1964 |
[INDUCTION OF FETAL MALFORMATIONS IN RABBITS WITH THALIDOMIDE].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Lagomorpha; Pregnancy; Pregnancy, Animal; Rabb | 1964 |
[THE PROCEDURES FOR THE TESTING OF TERATOGENIC EFFECTS TAKE SHAPE].
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Haplorhini; Humans; Pregnancy; Sodium Chlori | 1965 |
[EMBRYOTOXIC EFFECTS IN RATS].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Ethionamide; Female; Fetal Death; Hu | 1965 |
[FETAL MALFORMATIONS PRODUCED BY THALIDOMIDE IN THE MOUSE].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Infant, Newborn; Mice; Pregnancy; Research; Th | 1964 |
RADIOGRAPHIC STUDIES OF THALIDOMIDE-INDUCED MALFORMATIONS IN MICE.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Ectromelia; Female; Humans; Kyphosis; | 1965 |
THALIDOMIDE EMBRYOPATHY AND LIMB DEFECTS; ESPERIENCES IN HABILITATION OF CHILDREN WITH ECTROMELIAS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Angiography; Artificial Limbs; Child; Ectromel | 1965 |
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY, 1960-1961.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Industry; Female; Fetal Diseases; Germany | 1965 |
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS.
Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female; | 1965 |
EFFECTS OF THALIDOMIDE ON FETAL DEVELOPMENT IN RABBITS AND ON ESTABLISHMENT OF PREGNANCY IN MONKEYS.
Topics: Abnormalities, Drug-Induced; Animals; Arthrogryposis; Extremities; Fetal Death; Fetal Development; F | 1965 |
TERATOGENIC EFFECTS OF THALIDOMIDE IN RABBITS, RATS, HAMSTERS, AND MICE.
Topics: Abnormalities, Drug-Induced; Animals; Avitaminosis; Cricetinae; Female; Humans; Mice; Pharmacology; | 1965 |
[ANATOMICAL FINDINGS OF THE SO-CALLED "THALIDOMIDE BABIES" WITH SPECIAL REFERENCE TO LIMBS].
Topics: Abnormalities, Drug-Induced; Ectromelia; Extremities; Female; Humans; Infant; Infant, Newborn; Mater | 1965 |
[THALIDOMIDE AND CLEFT LIP, JAW AND PALATE].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Female; Humans; Infant; Infant, Newborn; Pregn | 1965 |
EFFECT OF THALIDOMIDE WARNING ON MEDICINE PRESCRIBED FOR PREGNANT WOMEN. ANALYSIS OF FREE MEDICINES DELIVERED TO EXPECTANT MOTHERS IN THE VAESTERBOTTEN COUNTY OF SWEDEN DURING 1961 AND 1962.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Medicine; Mothers; Pregnancy; Prenatal Care; S | 1965 |
AN ATTEMPTED REVERSAL OF THALIDOMIDE EMBRYOPATHY IN THE RAT BY GLUTAMINE.
Topics: Abnormalities, Drug-Induced; Fetal Diseases; Glutamates; Glutamine; Pathology; Pharmacology; Pregnan | 1965 |
STUDIES ON THE EFFECT OF TRYPAN BLUE IN THE PREGNANT ARMADILLO, DASYPUS NOVEMCINCTUS.
Topics: Abnormalities, Drug-Induced; Animals; Armadillos; Blood Proteins; Female; Humans; Maternal-Fetal Exc | 1965 |
BIOCHEMICAL EFFECTS OF DRUGS ON THE MAMMALIAN CONCEPTUS.
Topics: Abnormalities, Drug-Induced; Animals; Blood; Electrophoresis; Embryology; Female; Glutamates; Humans | 1965 |
SKELETAL MALFORMATIONS IN THE HOLTZMAN RAT EMBRYO FOLLOWING THE ADMINISTRATION OF THALIDOMIDE.
Topics: Abnormalities, Drug-Induced; Animals; Bone Diseases; Female; Humans; Injections; Injections, Intrape | 1965 |
[THALIDOMIDE EMBRYOPATHY IN ANIMAL EXPERIMENT. REPRODUCTION OF THE THALIDOMIDE EMBRYOPATHY IN A TERATOLOGIC EXPERIMENT IN RABBITS WITH TRANSIENT LIVER DAMAGE].
Topics: Abnormalities, Drug-Induced; Animal Experimentation; Animals; Carbon Tetrachloride Poisoning; Female | 1964 |
[FETAL DAMAGE CAUSED BY PHARMACEUTICAL AGENTS].
Topics: Abnormalities, Drug-Induced; Endocrine System Diseases; Fetal Diseases; Humans; Morphine Dependence; | 1965 |
Health of thalidomide victims and their progeny.
Topics: Abnormalities, Drug-Induced; Cause of Death; Child of Impaired Parents; Congenital Abnormalities; Fe | 2004 |
Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring.
Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Body Weight; Dose-Resp | 2004 |
Thalidomide: tragic past and promising future.
Topics: Angiogenesis Inhibitors; Female; Humans; Infant, Newborn; Multiple Myeloma; Pregnancy; Teratogens; T | 2004 |
Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide.
Topics: Duane Retraction Syndrome; Fathers; Female; Hearing Loss; Humans; Male; Mutation; Pregnancy; Prenata | 2004 |
Pre-20th century evidence for the placental passage of drugs.
Topics: Coloring Agents; Female; History, 19th Century; History, 20th Century; Humans; Infant, Newborn; Inor | 2005 |
[Surgical improvement of hearing in atresia auris congenita].
Topics: Abnormalities, Drug-Induced; Audiometry, Pure-Tone; Deafness; Ear, External; Female; Humans; Infant; | 1966 |
Thalidomide embryopathy cases in Brazil after 1965.
Topics: Adult; Brazil; Drug Utilization Review; Erythema Nodosum; Female; Fetal Diseases; Humans; Leprosy, L | 2006 |
Thalidomide use in the US : experience with pregnancy testing in the S.T.E.P.S. programme.
Topics: Drug and Narcotic Control; Drug Prescriptions; Female; Humans; Pregnancy; Pregnancy Tests; Retrospec | 2006 |
Lenalidomide (Revlimid) for anemia of myelodysplastic syndrome.
Topics: Anemia; Chromosome Deletion; Chromosomes, Human, Pair 5; Contraindications; Female; Humans; Lenalido | 2006 |
Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations.
Topics: Action Potentials; Animals; Animals, Newborn; Aorta; Blotting, Western; Cattle; Central Nervous Syst | 2006 |
45 years later...where do we stand?
Topics: Abnormalities, Drug-Induced; Canada; Drug-Related Side Effects and Adverse Reactions; Female; Foreca | 2007 |
Evaluation of the developmental toxicity of lenalidomide in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Embryonic Development; Female; Fetal Death; Fetus; Lenalidomid | 2007 |
New cases of thalidomide embryopathy in Brazil.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Brazil; Contraindications; | 2007 |
[The significance of group B vitamins and genetic factors on the reaction of the rat embryo to thalidomide].
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Diet; Drug Hypersensitivity; E | 1966 |
[Thalidomide embryopathy in animal experiments. II. Thalidomide blood level in experimental animals with normal and damaged liver].
Topics: Abnormalities, Drug-Induced; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Live | 1966 |
The embryotoxic effect on rabbits of monophenylbutazone (monazan) compared with phenylbutazone and thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetal Death; Male; Phenylbutazone; Pregnanc | 1966 |
[Otoneurological studies of facial nerve paralysis in thalidomide dysplasia].
Topics: Abducens Nerve; Abnormalities, Drug-Induced; Child; Child, Preschool; Ear Deformities, Acquired; Ele | 1967 |
Non-teratogenicity of antituberculous drugs.
Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Antitubercular Agents; Drug Synergism; Ethionamid | 1967 |
LSD: effects on offspring.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lysergic Acid Diethylamide; Pregnancy; Pregnanc | 1967 |
The fate of[14C]thalidomide in the pregnant rabbit.
Topics: Adipose Tissue; Animals; Blood Chemical Analysis; Brain Chemistry; Carbon Isotopes; Embryo, Mammalia | 1967 |
The fate of the hydrolysis products of thalidomide in the pregnant rabbit.
Topics: Adipose Tissue; Animals; Blood Chemical Analysis; Brain Chemistry; Carbon Isotopes; Digestive System | 1967 |
Toxicity and teratogenicity of optical isomers of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry, Physical; Female; Fetus; Hexoba | 1967 |
Chromosome changes in embryos treated with various teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure | 1967 |
[Cleft lip and palate in thalidomide-induced embryopathies].
Topics: Abnormalities, Drug-Induced; Adult; Arm; Child; Child, Preschool; Cleft Lip; Cleft Palate; Ear Defor | 1967 |
The effect of thalidomide on the developing rat foetus.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Pregnancy; Pregnancy, Animal; Rats; Thali | 1967 |
[The sensitivity period of thalidomide embryopathy in monkeys and humans].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Pregnancy; Thalidomide; Time Factors | 1967 |
Effects of maternal thalidomide treatment on pregnancy, fetal development, and mortality of the offspring in random-bred mice.
Topics: Animals; Female; Fetal Death; Fetus; Mice; Pregnancy; Pregnancy, Animal; Thalidomide | 1967 |
Effects of thalidomide treatment of inbred female mice on pregnancy, fetal development, and mortality of offspring.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Mice; Pregnancy; Pre | 1967 |
Another, late thalidomide abnormality.
Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Thalidomide; | 1981 |
Thalidomide: 20 years on.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Europe; Female; History, 20th Century; Humans; Male; | 1981 |
Studies on the hypothetical relationship of thalidomide-induced embryopathy and collagen biosynthesis.
Topics: Abnormalities, Drug-Induced; Animals; Collagen; Female; Hydroxyproline; Pregnancy; Procollagen-Lysin | 1981 |
Effect of thalidomide-derivatives on limb development in culture.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Extremities; Female; Limb Deformities, Cong | 1983 |
Medical achievements this century--high technology or community health approach.
Topics: Communicable Disease Control; Community Medicine; Female; Genetic Engineering; Hip Prosthesis; Histo | 1983 |
Classic illustration. Figure showing the relationship between malformations of the thalidomide type and the sales of thalidomide.
Topics: Abnormalities, Drug-Induced; Female; History, 20th Century; Humans; Infant, Newborn; Pregnancy; Thal | 1984 |
Embryotoxicity and teratogenicity of thalidomide in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethylformamide; Eye Abnormalities; Female; Fetal Death; Pre | 1983 |
[Teratogenic action of Rifaximin in the rat and rabbit and its effect on perinatal development in the rat].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Hydroxyurea; Pregnancy; Prenatal Exposure Delay | 1984 |
[Maternal drug therapy as a risk factor for congenital heart disease].
Topics: Anticonvulsants; Female; Heart Defects, Congenital; Hormones; Humans; Infant, Newborn; Lithium; Mate | 1984 |
Bioactivation of thalidomide by a monkey liver fraction in a rat limb culture system.
Topics: Animals; Biotransformation; Extremities; Female; Liver; Macaca nemestrina; Male; Organ Culture Techn | 1983 |
Another specific effect of prenatal acetazolamide exposure in the mouse.
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Acetazolamide; Animals; Bromodeoxyuridine; Female; Mice; Pesticid | 1983 |
Biographies of great American pediatricians--Helen Brooke Taussig: the mother of pediatric cardiology.
Topics: Cardiology; Female; Heart Defects, Congenital; History of Medicine; Humans; Infant, Newborn; Pediatr | 1982 |
Holt Oram syndrome mistaken for thalidomide embryopathy--embryological considerations.
Topics: Abnormalities, Drug-Induced; Adult; Diagnosis, Differential; Ectromelia; Female; Genetic Counseling; | 1982 |
[Teratogenic effect of drugs].
Topics: Abnormalities, Drug-Induced; Animals; Female; History, 16th Century; History, 17th Century; History, | 1982 |
Dissimilar effects of thalidomide in dizygotic twins.
Topics: Abnormalities, Drug-Induced; Adult; Brazil; Diseases in Twins; Ectromelia; Female; Humans; Pregnancy | 1980 |
Fetal ear malformations induced by maternal ingestion of thalidomide in the bonnet monkey (Macaca radiata).
Topics: Abnormalities, Drug-Induced; Animals; Ear; Female; Gestational Age; Macaca radiata; Pregnancy; Thali | 1981 |
[Consequences of unexpected drug effects, beginning with contergan studies by pediatrists].
Topics: Abnormalities, Drug-Induced; Acrodynia; Bacterial Infections; Child; Child, Preschool; Chloramphenic | 1981 |
Causal inference in teratology.
Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Diazepam; Epidemiologic Methods; Female; Humans; I | 1980 |
[Synthesis and teratogenic activity of some thalidomide analogous indane-1,3-diones (author's transl)].
Topics: Animals; Female; Indans; Mice; Pregnancy; Teratogens; Thalidomide | 1980 |
Nonteratogenicity of a structural analog of thalidomide in pregnant baboons (Papio cynocephalus).
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Drug Evaluation, Preclinical; Female; P | 1980 |
A metabolite of a structural analog of thalidomide lacks teratogenic effect in pregnant rhesus monkeys.
Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation, Preclinical; Female; Macaca; Macaca mulatta; | 1980 |
The experimental approach to teratogenicity.
Topics: Animals; Embryo, Mammalian; Embryo, Nonmammalian; Environmental Pollutants; Female; Fetus; Polychlor | 1980 |
Contraceptive efficacy.
Topics: Abnormalities, Drug-Induced; Contraception; Female; Humans; Isotretinoin; Pregnancy; Teratogens; Tha | 1995 |
Amniotic band sequence in child of thalidomide victim.
Topics: Amniotic Band Syndrome; Female; Hand Deformities, Congenital; Humans; Infant, Newborn; Limb Deformit | 1994 |
Evidence for teratogenicity of thalidomide using congenic and recombinant inbred rat strains.
Topics: Abnormalities, Drug-Induced; Alleles; Animals; Embryonic and Fetal Development; Female; Fetus; Genot | 1994 |
Thalidomide in leprosy reaction.
Topics: Erythema Nodosum; Female; Humans; Leprosy, Lepromatous; Pregnancy; Thalidomide | 1994 |
Thalidomide: 35 years on and still deforming.
Topics: Abnormalities, Drug-Induced; Brazil; Female; Humans; Infant, Newborn; Pregnancy; Thalidomide | 1994 |
Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. 5. Lack of teratogenic effects of phthalimidophthalmide.
Topics: Animals; Callithrix; Female; Integrins; Male; Pregnancy; Teratogens; Thalidomide | 1994 |
Autism in thalidomide embryopathy: a population study.
Topics: Adult; Autistic Disorder; Deafness; Female; Humans; Intellectual Disability; Male; Pregnancy; Prenat | 1994 |
Representative and misrepresentative associations of birth defects in livebirths. Conditions under which relative risks greater than unity in livebirths necessarily imply relative risks greater than unity in all conceptuses.
Topics: Congenital Abnormalities; Embryo, Mammalian; Female; Fetal Death; Fetus; Humans; Infant, Newborn; Mo | 1993 |
Down-regulation of adhesion receptors on cells of primate embryos as a probable mechanism of the teratogenic action of thalidomide.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Callithrix; Cells, Cultured; Down-Regulation; Embryo, | 1996 |
Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Female; Pregnancy; Prostaglandins; Rabbits; Tera | 1996 |
The place of thalidomide in the treatment of inflammatory disease.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cytokines; | 1996 |
Stereoselective distribution of the teratogenic thalidomide analogue EM12 in the early embryo of marmoset monkey, Wistar rat and NMRI mouse.
Topics: Animals; Autoradiography; Callithrix; Embryonic and Fetal Development; Female; Maternal-Fetal Exchan | 1996 |
A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Female; Humans; Isotretinoin; Keratol | 1997 |
Thalidomide, a current teratogen in South America.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Leprostatic Agents; Leprosy; Male; Pre | 1996 |
Therapeutic Teratology: the 1996 Teratology Society Public Affairs Symposium.
Topics: Abnormalities, Drug-Induced; Female; Humans; Isotretinoin; Patient Education as Topic; Pregnancy; Te | 1996 |
Clinical appearance of spontaneous and induced first and second branchial arch syndromes.
Topics: Adult; Animals; Branchial Region; Craniofacial Dysostosis; Disease Models, Animal; Facial Asymmetry; | 1997 |
Interaction of [glutarimide-2-14C]-thalidomide with rat embryonic DNA in vivo.
Topics: Animals; Carbon Radioisotopes; DNA; DNA Adducts; DNA Damage; Embryo, Mammalian; Female; Fetal Death; | 1997 |
Jekyll and Hyde: a new license for thalidomide?
Topics: Abnormalities, Drug-Induced; Acquired Immunodeficiency Syndrome; Antineoplastic Agents; Clinical Tri | 1997 |
The return of thalidomide: are birth defects surveillance systems ready?
Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Georgia; Humans; Infant; Infant, Newborn; Lim | 1997 |
Thalidomide: lack of mutagenic activity across phyla and genetic endpoints.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cells, Cultured; CHO Cells; Chromosome Aber | 1997 |
Thalidomide: was the tragedy preventable?
Topics: Congenital Abnormalities; Ectromelia; Female; History, 16th Century; History, 18th Century; History, | 1998 |
Was tumour necrosis factor-alpha responsible for the fetal malformations associated with thalidomide in the early 1960s?
Topics: Abnormalities, Drug-Induced; Antigens, CD; Female; Humans; Models, Biological; Pregnancy; Receptors, | 1998 |
Does thalidomide cause second generation birth defects?
Topics: Abnormalities, Drug-Induced; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Thalidomi | 1998 |
Thalidomide and the Titanic: reconstructing the technology tragedies of the twentieth century.
Topics: Drug Approval; Female; Government Regulation; History, 20th Century; Humans; Internationality; Lepro | 1999 |
[Thalidomide once more in the spotlight].
Topics: Adult; Bone Marrow Transplantation; Contraindications; Drug and Narcotic Control; Drug Approval; Fem | 1998 |
Formed by thalidomide: mass torts as a false cure for toxic exposure.
Topics: Abnormalities, Drug-Induced; Canada; Europe; Female; Government Agencies; Humans; Japan; Legislation | 1997 |
S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide.
Topics: Dermatologic Agents; Drug and Narcotic Control; Drug Monitoring; Female; Humans; Immunosuppressive A | 1999 |
Thalidomide on the comeback trail.
Topics: Adjuvants, Immunologic; Animals; DNA; Drug Approval; Erythema Nodosum; Female; Free Radicals; Matern | 1999 |
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.
Topics: Animals; Cyclic N-Oxides; DNA Damage; Drug Resistance; Embryo Loss; Embryo, Mammalian; Female; Free | 1999 |
Was the thalidomide tragedy preventable?
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; History, 20th Century; Humans; | 1998 |
Oxidative DNA damage and embryo development.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; DNA Damage; Embryonic and Fetal Development; Fem | 1999 |
The problem with Cytotec is that it has not been approved for obstetrical use.
Topics: Diethylstilbestrol; Female; Humans; Labor, Induced; Misoprostol; Oxytocics; Pregnancy; Thalidomide; | 1999 |
Interaction of thalidomide with DNA of rabbit embryos: a possible explanation for its immunosuppressant and teratogenic effects.
Topics: Animals; Biotransformation; DNA; Embryo, Mammalian; Female; Immunosuppressive Agents; Pregnancy; Rab | 1999 |
Tort liability and the availability of contraceptive drugs and devices in the United States.
Topics: Antiemetics; Breast Implants; Contraceptive Agents; Delivery of Health Care; Doxylamine; Drug Indust | 1997 |
Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone.
Topics: Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Fema | 2000 |
[The Contergan (Thalidomide) case. Catastrophic consequences].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Infan | 2000 |
The re-emergence of thalidomide: results of a scientific conference.
Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Adolescent; Adult; Anti-HIV Agents; Anti-Inflam | 2000 |
Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.
Topics: Animals; Antigens, CD; Apoptosis; Cell Division; Culture Techniques; Female; Immunohistochemistry; M | 2001 |
Thalidomide study.
Topics: Clinical Trials as Topic; Drug Approval; HIV Wasting Syndrome; Humans; Oral Ulcer; Placebos; Pregnan | 1997 |
The rehabilitation of thalidomide.
Topics: Abnormalities, Drug-Induced; CD4 Lymphocyte Count; Conflict of Interest; Contraception; Drug Approva | 1998 |
Thalidomide's long and winding road.
Topics: Abnormalities, Drug-Induced; Clinical Trials as Topic; Drug Approval; Female; Health Services Access | 1998 |
[The thalidomide story: the Israeli chapter].
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Female; History, 20th Century; Humans; Israel; P | 2001 |
[On the history of the Contergan (thalidomide) catastrophe in the light of drug legislation].
Topics: Abnormalities, Drug-Induced; Animals; Drug Industry; Female; Fetus; France; Germany; History, 19th C | 2001 |
AIDS, thalidomide and maternal-fetal rights in conflict.
Topics: Abortion, Eugenic; Acquired Immunodeficiency Syndrome; Coercion; Contraception; Drug-Related Side Ef | 1998 |
Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Cysteine; Female; Fluo | 2002 |
Is autism due to cerebral-cerebellum disconnection?
Topics: Animals; Autistic Disorder; Axons; Brain Stem; Cerebellum; Cerebral Cortex; Female; Gestational Age; | 2002 |
Thalidomide disaster: old wine in new bottles?
Topics: Congenital Abnormalities; Disasters; Female; History, 20th Century; History, 21st Century; History, | 2001 |
Editorial: Postscript to thalidomide.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Child; Child, Preschool; Ectodermal Dysplasia; Fema | 1975 |
Letter: Postscript to thalidomide.
Topics: Abnormalities, Drug-Induced; Female; Fetus; Humans; Maternal-Fetal Exchange; Pregnancy; Thalidomide | 1975 |
Letter: Neural crest, limb development, and thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Animals; Arm; Ectromelia; Female; Fetus; Gestational Age; Haplorhini; H | 1976 |
Teratogenic action of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Ectromelia; Embryo, Mammalian; Female; Forelimb; | 1978 |
Agenesis of appendix: a further thalidomide anomaly.
Topics: Abnormalities, Drug-Induced; Adolescent; Appendix; Female; Humans; Maternal-Fetal Exchange; Pregnanc | 1978 |
Developmental staging and thalidomide teratogenicity in the green monkey (Cercopithecus aethiops).
Topics: Abnormalities, Drug-Induced; Animals; Chlorocebus aethiops; Female; Gestational Age; Haplorhini; Lim | 1978 |
Unusual muscle abnormalities associated with thalidomide treatment in a rhesus monkey: a case report.
Topics: Abnormalities, Drug-Induced; Animals; Female; Forearm; Haplorhini; Macaca mulatta; Muscles; Pregnanc | 1979 |
Fetal cardiovascular and other defects induced by thalidomide in cats.
Topics: Animals; Cardiomegaly; Cats; Coronary Vessels; Female; Fetal Heart; Heart Atria; Heart Defects, Cong | 1975 |
Partial unilateral cryptophthalmos with syndactyly, brachycephaly, and renal anomalies.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Eye Abnormalities; Eyelids; | 1975 |
A survey of thalidomide embryopathy in Taiwan.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Male; Pregnancy; Taiwan; Thalidomide | 1977 |
Experimental aspects and clinical implications.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Chick Embryo; Congenital Abn | 1979 |
Necessary risks.
Topics: Animals; Antiemetics; Dogs; Dronabinol; Drug Industry; Drug-Related Side Effects and Adverse Reactio | 1979 |
Thalidomide and lack of teratogenesis in Long-Evans rats.
Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Rats; Thalidomide | 1979 |
The teratogenic activity of a thalidomide analogus EM12 in rats on a low-zinc diet.
Topics: Abnormalities, Drug-Induced; Animals; Diet; Female; Forelimb; Gestational Age; Male; Pregnancy; Rats | 1979 |
Teratologic evaluation of synthetic delta 9-tetrahydrocannabinol in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dronabinol; Eating; Female; Fetal Viability; Gest | 1979 |
[Scholastic and professional rehabilitation of patients with abnormalities of the upper extremities].
Topics: Abnormalities, Drug-Induced; Arm; Ectromelia; Female; Humans; Learning Disabilities; Male; Pregnancy | 1979 |
Drug and chemical effects on mother and child.
Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Contraceptive Agents, Female; Environmental Pollut | 1979 |
Teratogenicity of therapeutic agents.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Anima | 1979 |
[The behavior of the facial nerve in vitamin A and thalidomide induced atresia auris congenita. A microsurgical and histological animal study (author's transl)].
Topics: Animals; Ear, External; Ear, Middle; Facial Nerve; Female; Fetus; Microsurgery; Petrous Bone; Pregna | 1979 |
[The development of the postural and motor apparatus in juveniles with thalidomide embryopathy].
Topics: Ectromelia; Female; Fetal Diseases; Hip Joint; Humans; Musculoskeletal Development; Pregnancy; Shoul | 1978 |
[Development of the extremities in the embryo].
Topics: Abnormalities, Drug-Induced; Animals; Arm; Congenital Abnormalities; Female; Humans; Infant, Newborn | 1978 |
[Teratogenic effect of N-phthaloyl-L-aspartic acid on the mouse (author's transl)].
Topics: Animals; Aspartic Acid; Female; Mice; Mice, Inbred Strains; Phthalimides; Pregnancy; Stereoisomerism | 1977 |
[Teratologic-neurotoxicologic studies on biglumide (K-2004) and thalidomide].
Topics: Animals; Bone Marrow; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Central Nervous System; Cyc | 1977 |
[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)].
Topics: Animals; Chromatography; Embryo, Mammalian; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Pregnanc | 1979 |
Non-confirmation of thalidomide induced teratogenesis in rats and mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Resorption; Mice; Pharmaceutical Vehicles; Polys | 1977 |
The effect of thalidomide on a prosimian: the greater galago (Galago crassicaudatus).
Topics: Abnormalities, Drug-Induced; Animals; Female; Galago; Pregnancy; Thalidomide | 1977 |
Thalidomide and neurological damage revisited.
Topics: Abnormalities, Drug-Induced; Central Nervous System Diseases; Female; Fetus; Humans; Infant, Newborn | 1978 |
Poisoned people: psychotropic drugs in pregnancy: morphological and psychological adverse effects on offspring.
Topics: Abnormalities, Drug-Induced; Alcoholism; Behavior; Female; Fetal Alcohol Spectrum Disorders; Fetus; | 1978 |
[Thalidomide analogs. 10. Transplacental distribution kinetics of biglumide in the mouse].
Topics: Animals; Bridged Bicyclo Compounds; Female; Kinetics; Maternal-Fetal Exchange; Mice; Pregnancy; Thal | 1978 |
Hemorrhage in development of the face.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Arteries; Craniofacial Dysostosis; Di | 1975 |
[Epidemiology of congenital abnormalities].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Epidemiologic Method | 1977 |
[Drug therapy during pregnancy and the lactation period].
Topics: Androgens; Anti-Bacterial Agents; Barbiturates; Cortisone; Drug-Related Side Effects and Adverse Rea | 1977 |
Early foetal thrombosis induced by thalidomide in mouse: possible explanation for teratogenicity.
Topics: Animals; Extremities; Female; Fetal Diseases; Hemorrhage; Mice; Mice, Inbred C57BL; Pregnancy; Thali | 1977 |
Linear growth of children with limb deformities following exposure to thalidomide in utero.
Topics: Abnormalities, Drug-Induced; Adolescent; Body Height; Child; Female; Growth; Humans; Limb Deformitie | 1977 |
Teratology study of two isoglutamine derivatives.
Topics: Abnormalities, Drug-Induced; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Chemical Ph | 1976 |
[Effect of some preservatives on pregnancy and fetal development in experimental animals].
Topics: Animals; Benzhydryl Compounds; Chlorophenols; Female; Fetus; Maternal-Fetal Exchange; Methane; Pharm | 1976 |
[Teratogenic effect and stereospecificity of a thalidomide metabolite].
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Female; Fetus; Glutamates; Isomerism; Mi | 1976 |
Responses of pre-implantation mouse embryos to thalidomide exposure in utero.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic Development; Female; Mice; Mitosi | 1976 |
Predictiveness and limitations of test methods in teratology: overview.
Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation, Preclinical; Environmental Exposure; Female; | 1976 |
Metabolic and toxic behavior of phthalimide derivates. I. Fate of imidan in the fetus.
Topics: Animals; Animals, Newborn; Biotransformation; Female; Fetus; Insecticides; Maternal-Fetal Exchange; | 1976 |
[Pregnancy and drugs].
Topics: Anti-Bacterial Agents; Barbiturates; Chloramphenicol; Chlorothiazide; Female; Hormones; Humans; Preg | 1975 |
Studies of embryo toxicity in rats and rabbits.
Topics: Animals; Biphenyl Compounds; Coloring Agents; Embryo, Mammalian; Female; Fetus; Male; Pregnancy; Rab | 1975 |
Mutagenicity studies with captan, captofol, folpet and thalidomide.
Topics: Animals; Captan; Chlorine; Chloroform; Cyclohexenes; Embryo Implantation; Female; Fetal Death; Fungi | 1975 |
A clinical look at the problem of drugs in pregnancy and their effect on the fetus.
Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse | 1975 |
Congenital fusion of bones: radiology, embryology and pathogenesis.
Topics: Abnormalities, Drug-Induced; Bone and Bones; Bone Development; Carpal Bones; Cartilage; Child, Presc | 1975 |
Reproductive, teratogenic, perinatal and postnatal studies with cyclazocine.
Topics: Animals; Cyclazocine; Female; Fertility; Fetus; Gestational Age; Growth; Male; Pregnancy; Rabbits; R | 1975 |
Teratogenesis.
Topics: Abnormalities, Drug-Induced; Alcoholism; Aminopterin; Animals; Anticonvulsants; Dose-Response Relati | 1976 |
Drug therapy and the developing human: who cares?
Topics: Anticonvulsants; Drug Industry; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; E | 1976 |
Ultrastructural changes in the dorsal root ganglia evoked by thalidomide in rabbits.
Topics: Animals; Female; Fetus; Ganglia, Spinal; Gestational Age; Pregnancy; Rabbits; Schwann Cells; Thalido | 1976 |
Epilepsy: a neurological complication of thalidomide embryopathy.
Topics: Adolescent; Ear; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Heart Defects, C | 1976 |
The perception of teratogenic risk of cocaine.
Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Cocaine; Counseling; Education, Medical; Female; | 1992 |
Thalidomide for systemic lupus erythematosus.
Topics: Abnormalities, Drug-Induced; Female; Humans; Lupus Erythematosus, Systemic; Pregnancy; Thalidomide | 1992 |
Comments on "Reply to 'Comments on "Moebius syndrome: animal model--human correlations and evidence for a brainstem vascular etiology"'".
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain Stem; Female; Humans; Pregnancy; Syndrom | 1992 |
Thalidomide retrospective: what did the clinical teratologist learn?
Topics: Abnormalities, Drug-Induced; Female; Germany; History, 20th Century; Humans; Infant, Newborn; Pregna | 1992 |
The contributions of Widukind Lenz to teratology and science: comments on "Thalidomide retrospective: what did the clinical teratologist learn?".
Topics: Abnormalities, Drug-Induced; Female; Germany; History, 20th Century; Humans; Infant, Newborn; Pregna | 1992 |
A personal perspective on the thalidomide tragedy.
Topics: Abnormalities, Drug-Induced; Female; Germany; History, 20th Century; Humans; Infant, Newborn; Pregna | 1992 |
Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Alcoholism; Animals; British Columbia; Cocaine | 1992 |
Scientific fraud: the McBride case.
Topics: Abnormalities, Drug-Induced; Animals; Biomedical Research; Editorial Policies; Female; Humans; Infan | 1992 |
Ocular teratology. Observations, speculations, questions, principles reaffirmed.
Topics: Ethanol; Eye; Eye Abnormalities; Female; Gestational Age; Humans; Pregnancy; Prenatal Exposure Delay | 1992 |
Foetal life and a legal duty of care.
Topics: Abnormalities, Drug-Induced; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male | 1991 |
Thalidomide induced alteration in secondary structure of rat embryonic DNA in vivo.
Topics: Animals; Chromatography, DEAE-Cellulose; DNA; DNA Damage; DNA Repair; Female; Maternal-Fetal Exchang | 1990 |
[Cocaine in pregnancy: a second Contergan?].
Topics: Abnormalities, Drug-Induced; Cocaine; Female; Humans; Infant, Newborn; Pregnancy; Risk Factors; Thal | 1990 |
Thalidomide, pregnancy and renal failure.
Topics: Adult; Antihypertensive Agents; Combined Modality Therapy; Female; Humans; Hypertension; Kidney Fail | 1990 |
The obstetric problems of the thalidomide children.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Pregnanc | 1989 |
Induction of neural-tube defects in nonhuman primates.
Topics: Abnormalities, Drug-Induced; alpha-Fetoproteins; Animals; Female; Macaca mulatta; Neural Tube Defect | 1985 |
Clinical-epidemiologic assessment of pattern of birth defects associated with human teratogens: application to diabetic embryopathy.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Diabetes Mellitus, Type 1; Female; Georgia; H | 1989 |
Thalidomide, orogenital ulcers, and risk of teratogenicity.
Topics: Abnormalities, Drug-Induced; Female; Genital Diseases, Female; Humans; Pregnancy; Risk; Stomatitis, | 1985 |
Thalidomide in dermatology and leprosy.
Topics: Female; Humans; Leprosy; Male; Pregnancy; Skin Diseases; Thalidomide | 1985 |
An indirect assessment of the Chernoff/Kavlock assay.
Topics: Animals; Body Weight; Eating; Female; Fetus; Growth; Hemodynamics; Lethal Dose 50; Pregnancy; Rats; | 1987 |
Anaesthesia and thalidomide-related abnormalities.
Topics: Abnormalities, Drug-Induced; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; | 1989 |
After the tragedy: living with the consequences.
Topics: Abnormalities, Drug-Induced; Attitude to Health; Disabled Persons; Female; Humans; Infant, Newborn; | 1988 |
Embryotoxic effects of thalidomide derivatives on the non-human primate Callithrix jacchus; 3. Teratogenic potency of the EM 12 enantiomers.
Topics: Abnormalities, Drug-Induced; Animals; Callithrix; Female; Pregnancy; Stereoisomerism; Thalidomide | 1988 |
Thalidomide retrospective: what did we learn?
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Pregnancy; Teratogens; Thalidomide | 1988 |
Why I doubted that thalidomide was the cause of the epidemic of limb defects of 1959 to 1961.
Topics: Animals; Arm; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Leg; Pregnancy; Teratog | 1988 |
Thalidomide update: regulatory aspects.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Legislation, Drug; Pregnancy; Teratoge | 1988 |
Prenatal diagnosis of thalidomide syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Ectromelia; Female; Fetal Diseases; Humans; Pregnancy; Prenatal | 1987 |
Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Callithrix; Dose-Response Relationship, Drug; | 1988 |
Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. II. Elucidation of the susceptible period and of the variability of embryonic stages.
Topics: Animals; Callithrix; Embryo, Mammalian; Embryonic and Fetal Development; Female; Gestational Age; Ma | 1988 |
Pregnancy in women with thalidomide-induced disabilities. Case report and a questionnaire study.
Topics: Abnormalities, Drug-Induced; Adult; Cesarean Section; Ectromelia; Female; Humans; Infant, Newborn; P | 1988 |
Monitoring for multiple malformations in the detection of epidemics of birth defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Biometry; Female; Humans; Pregnancy; Rubella; | 1987 |
Electroencephalographic study of 137 patients with thalidomide embryopathy.
Topics: Adolescent; Adult; Brain; Child; Electroencephalography; Epilepsy; Female; Fetal Diseases; Hearing D | 1987 |
The value of case reports in human teratology.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth | 1986 |
Acetylcholine and choline levels in rabbit fetuses exposed to anticholinergics.
Topics: Acetylcholine; Animals; Choline; Female; Fetal Diseases; Fetus; Gestational Age; Maternal-Fetal Exch | 1987 |
Progressive non-infectious anterior vertebral fusion.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Fetal Diseases; Humans; Kyphosis; Lumbar V | 1986 |
Preventive surgery for congenital deformities of the hand.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Fetus; Genetic Engineering; | 1985 |
[Detection and quantification of adverse reactions on the embryo and the fetus: studies and registries of congenital malformations].
Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Pregnancy; Registries; Research Design; Spa | 1986 |
The role of cholinergic nerves in development.
Topics: Abnormalities, Drug-Induced; Animals; Extremities; Female; Humans; Limb Deformities, Congenital; Par | 1985 |
Thalidomide embryopathy in Germany, 1959-1961.
Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Germany, West; Humans; Infant, Newborn; Male; Pregn | 1985 |
Temporomandibular malformations in the bonnet monkey (Macaca radiata) fetus following maternal ingestion of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetus; Gestational A | 1985 |
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
Topics: Abdomen; Abnormalities, Multiple; Cardiovascular Abnormalities; Cranial Nerves; Dentition; Embryo, M | 1985 |
On predicting environmentally-induced human reproductive hazards: an overview and historical perspective.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dose-Response Relationship, Drug; Female; Humans; | 1985 |
[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits].
Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Female; Heart Defects, Congenital; Hydroce | 1985 |
Blame, compensation and birth defects.
Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation; Drug Industry; Female; Humans; Infant, Newbor | 1985 |
Thalidomide and congenital Charcot's joints.
Topics: Abnormalities, Drug-Induced; Ankle; Arthrography; Arthropathy, Neurogenic; Bone and Bones; Child; Em | 1973 |
Letter: Thalidomide and embryonic neuropathy.
Topics: Abnormalities, Drug-Induced; Animals; Cervical Plexus; Female; Ganglia, Spinal; Pregnancy; Rabbits; | 1974 |
The susceptibility of the fetus and child to chemical pollutants. Chemicals in human teratogenesis and transplacental carcinogenesis.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Amphetamine; Androgens; Anticonvulsants; Antithyroid | 1974 |
Human experiences related to adverse drug reactions to the fetus or neonate from some maternally administered drugs.
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Antithyroid Agents; Contraceptives, Oral; Diethy | 1972 |
Another chance for thalidomide?
Topics: Abnormalities, Drug-Induced; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Culture | 1966 |
Thalidomide.
Topics: Abnormalities, Drug-Induced; Anodontia; Child, Preschool; Female; Humans; Pregnancy; Thalidomide; To | 1965 |
Minor ocular abnormalities associated with thalidomide.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Choroid; Eye Abnormalities; Female; Humans; Infant; I | 1966 |
Immunosuppression by thalidomide: implications for teratology.
Topics: Abnormalities, Drug-Induced; Abortion, Habitual; Female; Humans; Immunosuppressive Agents; Pregnancy | 1966 |
Effect of thalidomide on survival of skin homografts in rabbits.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Female; Immunosuppressive Agents; Pregn | 1966 |
Congenital deformities and insulin antagonism.
Topics: Carbohydrate Metabolism; Consanguinity; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 1966 |
Influence of thalidomide on fertility and on reproductive organs in rats. Preliminary communication.
Topics: Animals; Endometrium; Estrus; Female; Fertility; Ovary; Ovulation; Pregnancy; Rats; Staining and Lab | 1968 |
Is lysergide a teratogen?
Topics: Abnormalities, Drug-Induced; Animals; Female; Lysergic Acid Diethylamide; Pregnancy; Rabbits; Specie | 1968 |
Teratology.
Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Chick Embryo; Congenital Abnormalities; Embryo, Ma | 1969 |
[Problems posed by the effects of medication on offspring].
Topics: Abnormalities, Drug-Induced; Animals; Dactinomycin; Female; Fetus; Glutethimide; Humans; Hypoglycemi | 1969 |
Normal child after maternal thalidomide ingestion in critical period of pregnancy.
Topics: Child; Female; Gestational Age; Humans; Male; Pregnancy; Thalidomide | 1970 |
Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys.
Topics: Abnormalities, Drug-Induced; Animals; Arm; Bone and Bones; Brain; Dose-Response Relationship, Drug; | 1973 |
The sensitive period and malformation syndrome produced by thalidomide in crab-eating monkey (Macaca fascicularis).
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Coccyx; Female; Femur; Fingers; Gestatio | 1973 |
The relation of vitamin-B complex to the effect of thalidomide on the sensitivity of intracellular haemoglobin to oxidation.
Topics: Animals; Erythrocytes; Female; Glutethimide; Hemoglobins; Male; Niacinamide; Oxidation-Reduction; Ph | 1967 |
Effect of transplanted tumor and various agents on liver regeneration during pregnancy.
Topics: Animals; Benzofurans; Carcinoma 256, Walker; Female; Fetal Death; Hepatectomy; Liver Regeneration; N | 1966 |
[On the penetration of foreign body materials into the young vertebrate embryo].
Topics: Animals; Deferoxamine; Embryo Implantation; Embryo, Mammalian; Female; Glycosaminoglycans; Lipids; P | 1966 |
[Comparative studies on the problem of the further development disorders of the vertebral column in children with dysmelia syndrome and children with peromelia].
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Diagnosis, Differential; Ectromelia; Female; H | 1967 |
[Teratologic study of a new, structurally related to thalidomide, sedative-hypnotic effective compound (K-2004)].
Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Her | 1969 |
Hypothetical explanation of the embryotoxic action of thalidomide.
Topics: Animals; Ascorbic Acid; Collagen; Embryo, Mammalian; Embryo, Nonmammalian; Female; Isoenzymes; Ketog | 1970 |
A morphological and histochemical study of thalidomide-induced upper limb malformations in rabbit fetuses.
Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Bone and Bones; Calcium; Cartilage; Embr | 1971 |
[Abnormalities in the field of otorhinolaryngology. Genetic report].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Chromosome Aberrations | 1972 |
Tumour-incidence in progeny of thalidomide-treated mice.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Female; Hodgkin D | 1967 |
Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animal Feed; Animals; Birth Weight; Chlorproma | 1969 |
A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Car | 1968 |
[Drug-induced polyneuropathy].
Topics: Abnormalities, Drug-Induced; Adult; Animals; Drug-Related Side Effects and Adverse Reactions; Female | 1970 |
Disorders of the auditory apparatus caused by embryopathy or foetopathy: prophylaxis and treatment (a) deafness as a result of congenital malformations occurring during the first three months (b) deafness resulting from diseases of the foetus occurring af
Topics: Child, Preschool; Deafness; Ear; Ear, Inner; Female; Humans; Pregnancy; Pregnancy Complications; Rad | 1971 |
[Genetic analysis of skeletal diseases. Genetic report].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Bone Diseases; Child; Chromoso | 1973 |
Editorial: The pathogenesis of congenital malformations.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Female; Humans; Infant, Newborn; Pregnancy; P | 1974 |
A note on the absorption and excretion of 14C-labelled thalidomide in pregnant mice.
Topics: Animals; Carbon Isotopes; Digestive System; Feces; Female; Fetus; Maternal-Fetal Exchange; Mice; Pla | 1966 |
Congenital malformations in nonhuman primates: spontaneous and experimentally induced.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Congenital Abnormalities; Female; Haplor | 1967 |
The fate of [14C] thalidomide in the pregnant hamster.
Topics: Animals; Carbon Isotopes; Cricetinae; Embryo, Mammalian; Female; Maternal-Fetal Exchange; Pregnancy; | 1967 |
Effects of thalidomide and chlorcyclizine on the biosynthesis of nucleic acids and proteins in fetal and maternal tissues of the rat.
Topics: Amino Acids; Animals; Carbon Isotopes; Chromatography, Thin Layer; Dactinomycin; DNA; Female; Fetus; | 1970 |
[Embryotoxicity of N-phthaloyl-DL-glutamine].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Glutamine; Mice; Phthalic Acids; Pr | 1971 |
[Embryotoxic acitivity of N-phthaloyl-DL-isoglutamine].
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Glutamine; Mice; Mice, Inbred Strains; | 1971 |
Fetal nerve cell degeneration produced by thalidomide in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Cell Nucleolus; Cell Nucleus; Dose-Response Relationship, Drug | 1974 |
Teratogenicity and embryotoxicity of thalidomide and 3-aza-thalidomide in mice.
Topics: Abnormalities, Drug-Induced; Animals; Aza Compounds; Body Weight; Bone and Bones; Depression, Chemic | 1974 |
Problems associated with the screening of drugs for possible teratogenic activity.
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Rela | 1974 |
The missing umbilical artery. I. Prospective study based on a maternity unit.
Topics: Adult; Anencephaly; Birth Weight; Congenital Abnormalities; Female; Gestational Age; Humans; Hydroce | 1974 |
[Teratological study on the thalidomide-like compounds K-2004 and K-2604 in the mouse and rat].
Topics: Abnormalities, Drug-Induced; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Drug Evalua | 1974 |
Teratogenicity from drugs--an increasing problem.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Amniocentesis; Animals; Anti-Bact | 1974 |
Drugs and the unborn child.
Topics: Female; Fetus; Maternal-Fetal Exchange; Morphine; Phenothiazines; Pregnancy; Reserpine; Scopolamine; | 1972 |
[The doctor's responsibility and risk in the prescribing of drugs].
Topics: Adult; Amphetamine; Appetite Depressants; Drug and Narcotic Control; Drug Industry; Drug Packaging; | 1973 |
The significance of dermatoglyphics in medicine. A short survey and summary.
Topics: Abnormalities, Drug-Induced; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 13-15 | 1973 |
[Drugs as cause of diseases].
Topics: Abnormalities, Drug-Induced; Berlin; Contraceptives, Oral; Cortisone; Drug-Related Side Effects and | 1974 |
The teratogenic activity of a thalidomide analogue, EM 12 in rabbits, rats, and monkeys.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Bone Diseases, Developmental; Female; Fetal De | 1972 |
The marmoset as a model for teratological research.
Topics: Abnormalities, Drug-Induced; Animals; Estrus; Female; Haplorhini; Pregnancy; Thalidomide; Twins; Vit | 1972 |
Limb reduction anomalies induced in the marmoset by thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Female; Haplorhini; Limb Deformities, Congenital; | 1972 |
Effects on macaque embryos of drugs reported or suspected to be teratogenic to humans.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Cesarean Section; Embryo, Mammalian; Fem | 1972 |
The marmoset as an animal model for teratological research.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Disease Models, Animal; Female; Fetu | 1972 |
Pharmacodynamic principles in chemical teratology: dose-effect relationships.
Topics: Abnormalities, Drug-Induced; Adsorption; Cyclophosphamide; Dose-Response Relationship, Drug; Drug-Re | 1972 |
Television programme no contempt.
Topics: Abnormalities, Drug-Induced; Child; Female; Humans; Jurisprudence; Pregnancy; Television; Thalidomid | 1972 |
Thalidomide injunction granted.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Humans; Jurisprudence; Newspapers as Topic; P | 1972 |
[Drug therapy in females of the reproductive age with reference to teratologic aspects].
Topics: Abnormalities, Drug-Induced; Age Factors; Aminopterin; Drug-Related Side Effects and Adverse Reactio | 1972 |
The use of an incubator in detecting drug-induced congenital malformations.
Topics: Abnormalities, Drug-Induced; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotra | 1972 |
Drug testing for teratogenicity: its implications, limitations and application to man.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Animals; Animals, Laboratory; Communication; Compute | 1972 |
Disabled children--free contraception for all? More liberal liquor laws?
Topics: Abnormalities, Drug-Induced; Adult; Alcoholism; Child; Contraception; Family Planning Services; Fema | 1973 |
Congenital malformations and their control.
Topics: Abnormalities, Drug-Induced; Animals; Dogs; Female; Humans; Mice; Pregnancy; Rats; Thalidomide | 1973 |
Moebius syndrome associated with the mother taking thalidomide during gestation. Case report.
Topics: Abducens Nerve; Abnormalities, Drug-Induced; Abnormalities, Multiple; Anxiety; Facial Expression; Fa | 1973 |
The fetus: medicine's newest patient.
Topics: Abnormalities, Drug-Induced; Embryonic and Fetal Development; Female; Fetal Diseases; Fetus; Humans; | 1973 |
[Teratological tests of the hydrolysis products of thalidomide].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Gestational Age; Glutamates; Hydrolysis; Matern | 1973 |
The effect of thalidomide intake during 113 human pregnancies.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Gestational Age; Humans; Japan; Pregnanc | 1973 |
[Action of psychopharmacological agents on the product of conception].
Topics: Abnormalities, Drug-Induced; Amphetamine; Animals; Anticonvulsants; Embryo, Mammalian; Female; Fetal | 1973 |
Thalidomide and critical period. Prescription for 113 pregnant women in a maternity.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Child; Female; Fetal Death; Fetus; Follow-Up Stu | 1973 |
Prospects and limitations of epidemiology in human teratology.
Topics: Abnormalities, Drug-Induced; Carcinogens; Chromosome Aberrations; Chromosome Disorders; Congenital A | 1973 |
Orofacial malformations.
Topics: Animals; Antimetabolites; Cell Differentiation; Cleft Lip; Cleft Palate; Dermoid Cyst; Eye Neoplasms | 1974 |
Teratologic studies with FD and C red no. 2 in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Autopsy; Body Weight; Cleft Palate; Coloring Agents; Female; F | 1974 |
[The teratogenic risk].
Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Busulfan; Carbutamide; Congenital Abnormalities; | 1968 |
[Congenital transmission of Trypanosoma cruzi. I. Effect of thalidomide on T. cruzi infection in rats].
Topics: Animals; Animals, Newborn; Chagas Disease; Female; Mice; Placenta; Pregnancy; Pregnancy, Animal; Tha | 1965 |
The teratogenic activity of thalidomide in the rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Eye Abnormalities; Female; Limb Deformities, Congenital; Nervo | 1966 |
Ocular findings in thalidomide children.
Topics: Abnormalities, Drug-Induced; Blepharoptosis; Canada; Coloboma; Eye Abnormalities; Female; Humans; In | 1967 |
Drug toxicity in the animal fetus.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cats; Cricetinae; Dogs; Embryo, Mammalian; Female; Fe | 1967 |
[A case of thalidomide anotia].
Topics: Abnormalities, Drug-Induced; Ataxia; Blepharoptosis; Child; Ear; Eye Abnormalities; Female; Humans; | 1967 |
[A comparison of the sensitive phase for thalidomide in animal experiment and in man].
Topics: Abnormalities, Drug-Induced; Animals; Arm; Ear; Female; Fetal Diseases; Haplorhini; Humans; Infant, | 1968 |
Thalidomide: disposition in rhesus monkey and studies of its hydrolysis in tissues of this and other species.
Topics: Absorption; Animals; Brain; Brain Chemistry; Cricetinae; Dogs; Feces; Female; Haplorhini; In Vitro T | 1970 |
An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates.
Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Female; Fetus; Haplorhini; Humerus; Indoles | 1971 |
Motor skills of infant rhesus monkeys with thalidomide-induced forelimb malformations.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Disease Models, Animal; Exploratory Behavior | 1969 |
[Thalidomide analogues. IV].
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Culture Techniques; Embryo, Mamm | 1972 |
Teratological studies on thalidomide in rats.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Bone and Bones; Cesarean Section; F | 1972 |
Teratological studies on thalidomide in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Autolysis; Birth Weight; Body Weight; Bone and Bones; Cesarean | 1972 |
Thalidomide teratology in swine: a preparatory study.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Bone and Bones; Female; Fetus; Gestation | 1972 |
Michel's deafness.
Topics: Abnormalities, Drug-Induced; Child; Deafness; Ear Canal; Ear, Inner; Female; Humans; Pregnancy; Thal | 1972 |
[Synthesis and teratologic examination of various thalidomide metabolites].
Topics: Animals; Benzoates; Embryo, Mammalian; Female; Glutamates; Glutamine; Hydrolysis; Imides; Mice; Phth | 1972 |
[Drugs during pregnancy].
Topics: Antineoplastic Agents; Calcium; Coumarins; Ergot Alkaloids; Female; Hormones; Humans; Iron; Pregnanc | 1971 |
[Compensation of the teratogenic effect of a thalidomide metabolite using L-glutamic acid].
Topics: Abnormalities, Drug-Induced; Animals; Drug Antagonism; Female; Glutamates; Injections, Intraperitone | 1971 |
[Teratological determination of some thalidomide metabolites].
Topics: Abnormalities, Drug-Induced; Amides; Animals; Benzoates; Drug Interactions; Female; Fetus; Glutamate | 1971 |
[Cardiovascular findings in children with the thalidomide-dysmelia-syndrome].
Topics: Abnormalities, Drug-Induced; Child; Ectromelia; Female; Germany, West; Heart Defects, Congenital; Hu | 1971 |
Congenital aural atresia: anatomy and surgical management.
Topics: Abnormalities, Drug-Induced; Chromosome Aberrations; Congenital Abnormalities; Ear; Female; Follow-U | 1971 |
[Toxic injuries in thalidomide medication].
Topics: Adult; Depression; Female; Humans; Male; Middle Aged; Polyneuropathies; Pregnancy; Pregnancy Complic | 1967 |
[Thalidomide-embryopathies and their effect on dentition].
Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Infant, Newborn; Jaw Abnormalities; Pregnan | 1965 |
[Dysplasia in the mouth, jaw and teeth in dysmelia. Contribution to the thalidomide-embryopathies].
Topics: Abnormalities, Drug-Induced; Dental Caries; Ectromelia; Female; Humans; Infant, Newborn; Male; Pregn | 1967 |
[Dysgnathias in the deciduous dentition in dysmelia: contribution to thalidomide embryopathy].
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Dentition; Diastema; Ectromelia; Female; Human | 1966 |
[Cephalometric findings in dysmelic children with symptoms of thalidomide embryopathy].
Topics: Abnormalities, Drug-Induced; Cephalometry; Child; Child, Preschool; Female; Humans; Infant; Male; Mo | 1968 |
[It's not only contergan. In May the big lawsuit begins. It touches on basic problems].
Topics: Abnormalities, Drug-Induced; Drug Industry; Female; Forensic Medicine; Germany, West; Humans; Infant | 1968 |
Clinical, orthodontic and radiological findings in the jaws and face of children with dysmelia associated with thalidomide-embryopathy.
Topics: Abnormalities, Drug-Induced; Ankylosis; Cephalometry; Child, Preschool; Cleft Lip; Cleft Palate; Fem | 1968 |
Anomalies of the teeth in a child with upper phocomelia. Report of a case.
Topics: Abnormalities, Drug-Induced; Arm; Child; Ectromelia; Face; Female; Humans; Male; Pregnancy; Pregnanc | 1970 |
[The contergan tragedy--a brutal lesson].
Topics: Female; Humans; Legislation, Pharmacy; Pregnancy; Thalidomide | 1971 |
Failure of gestation of goat x sheep hybrids in goats and sheep.
Topics: Animals; Azathioprine; Embryo, Mammalian; Female; Fetal Death; Fetus; Gestational Age; Goats; Hybrid | 1968 |
[Characteristics of the action of medicinal substances on the fetus at various periods of intrauterine development].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antine | 1969 |
Developmental biology.
Topics: Abnormalities, Drug-Induced; Biology; Cell Differentiation; Cortisone; DNA; Embryonic and Fetal Deve | 1969 |
[Congenital gustolacrimal syndrome complicated with bilateral Duane's syndrome and gustolacrimal reflex, with special emphasis on the etiology].
Topics: Child; Child, Preschool; Female; Humans; Male; Ophthalmoplegia; Pregnancy; Reflex, Abnormal; Taste; | 1969 |
[Teratologic studies with imipramine in rats and rabbits. Planning and interpretation of teratologic studies under consideration of the biochemistry and toxicology of test substance].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Body Weight; Desipramine; Drug Toleranc | 1969 |
Teratogenic activity of several phthalimide derivatives in the golden hamster.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Cricetinae; Embryo, Mammalian; | 1970 |
The alimentary tract malformations in the rabbit thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Animals; Colon; Digestive System Abnormalities; Diverticulum, Colon; Es | 1970 |
Investigations on the possible teratogenic effects of trazodone in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Cyclizine; Female; Maternal-Fetal Exchange; Piperazines; Pregn | 1970 |
Phenocopy.
Topics: Abnormalities, Multiple; Anemia, Aplastic; Arm; Congenital Hypothyroidism; Deafness; Female; Feminiz | 1970 |
Teratological studies of p-butoxyphenylacethydroxamic acid (CP 1044 J3) in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Hydroxamic Acids; Hydr | 1970 |
[The L-isomer as teratogenic principle of N-phthalyl-DL-glutamic acid].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Glutamates; Isotonic S | 1970 |
Congenital symmetric limb deformities.
Topics: Abnormalities, Drug-Induced; Arm; Black People; Congenital Abnormalities; Female; Humans; Infant, Ne | 1970 |
[Surgery in middle ear abnormalities].
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Ear Ossicles; Ear, Middle; Ectromelia; Female; | 1970 |
[Lesions of the auditory apparatus during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Bacterial Infections; Deafness; Drug-Related Side Effects and | 1970 |
Report of Inter-Society Commission for Heart Disease Resources. Prevention of Cardiovascular Disease. Primary prevention of congenital heart disease.
Topics: Child; Chromosome Aberrations; Female; Fetal Death; Heart Defects, Congenital; Humans; Infant; Infan | 1970 |
[Teratogenic effect of N-phthalyl-DL-glutamic acid following intraperitoneal application in mice].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetus; Glutamates; Mice; Phthalic Acids; | 1970 |
[Study of the thalidomide effect on chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Eggs; Extremities; Female; Fetal Death; Pregnanc | 1970 |
Chromosomal breakage and teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Chromosome Aberrations; Chromosom | 1971 |
[Drugs and pregnancy].
Topics: Drug-Related Side Effects and Adverse Reactions; Female; Fetus; Humans; Pregnancy; Thalidomide | 1967 |
[The front line in research in experimental teratology].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Hominidae; Humans; Pregnancy | 1967 |
[Species differences in the metabolism of drugs].
Topics: Abnormalities, Drug-Induced; Animals; Dogs; Female; Mice; Pharmaceutical Preparations; Pregnancy; Ra | 1967 |
[Teratogenesis and drug control].
Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Androgens; Animals; Chlordiazepoxide; Drug and Na | 1967 |
[Significance of exogenous influences for the development of human abnormalities].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Fetal Diseases; Humans; Infa | 1967 |
[Symposium on congential malformations. Introduction].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Humans; Infa | 1967 |
[Dysmelia from the view-point of the obstetrician].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ectromelia; Female; Germany, East; Germany, We | 1967 |
[Malformation and liver damage. On the necessary 2nd noxa in experimental thalidomide embryopathies].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbon Tetrachloride; Chemical and Dr | 1967 |
[On methods and statistics in dysmelia research].
Topics: Abnormalities, Drug-Induced; Ectromelia; Factor Analysis, Statistical; Female; Health Surveys; Human | 1967 |
[Concluding remarks on the preceding comment by W. Lenz].
Topics: Abnormalities, Drug-Induced; Austria; Ectromelia; Female; Humans; Pregnancy; Thalidomide | 1967 |
[Remarks on the work of A. Rett: "The Thalidomide Problem in Austria" Wien. med. Wschr. (1965):21].
Topics: Abnormalities, Drug-Induced; Austria; Ectromelia; Female; Humans; Pregnancy; Thalidomide | 1967 |
[Abnormalities of internal organs in thalidomide embryopathy. A contribution to the determination of the sensitivity phase in thalidomide administration during early pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Digestive System Abnormalities; Ear Deformities, Acquired; Femal | 1967 |
[The genesis of congenital malformations].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Antineoplastic Agents; Cell Division; C | 1967 |
Drug testing in animals for fetal toxicity.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetus; Male; Pregnancy; Propylene Glycols; | 1967 |
Concerning the morphogeneis of thalidomide dysmelia in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Bone and Bones; Cell Differentiation; Ectromeli | 1967 |
[The so-called dysmelia syndrome (Thalidomide embryopathy) and its differential diagnosis].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnosis, Differential; Ectromelia; Facial Ex | 1967 |
[The importance of psychology in the research on the etiology of dysmelia].
Topics: Abnormalities, Drug-Induced; Anxiety; Ectromelia; Female; Health Surveys; Humans; Maternal-Fetal Exc | 1967 |
[Inhibition of the immune reaction by thalidomide and the results of this process on the theory of the teratogenous effect of this substance].
Topics: Abnormalities, Drug-Induced; Animals; Female; Genes; Immunosuppressive Agents; Mice; Pregnancy; Thal | 1967 |
[Further studies on the growth inhibitory effect of hypnotics in embryos of Sinapis alba].
Topics: Caffeine; Chloral Hydrate; Chlorophyll; Depression, Chemical; Embryo, Mammalian; Embryo, Nonmammalia | 1967 |
A comparison of the teratogenic activity of thalidomide in rabbits and rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Dimethyl Sulfoxide; Embryo Implantation; Femal | 1968 |
Binding of thalidomide by macromolecules in the fetal and maternal rat.
Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema | 1968 |
Binding of thalidomide by macromolecules in the fetal and maternal rat.
Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema | 1968 |
Binding of thalidomide by macromolecules in the fetal and maternal rat.
Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema | 1968 |
Binding of thalidomide by macromolecules in the fetal and maternal rat.
Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema | 1968 |
A Swedish register of congenital malformations. Experience with continuous registration during 2 years with special reference to multiple malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Fetal Death; | 1968 |
Effect of thalidomide on the antibody response.
Topics: Animals; Antibody Formation; Culture Techniques; Female; Hemagglutination Tests; Immunosuppressive A | 1968 |
The cardiovascular malformations in the rabbit thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Animals; Aorta; Bronchial Arteries; Cardiovascular Abnormalities; Cardi | 1968 |
Thalidomide. A study of biochemical teratology.
Topics: Abnormalities, Drug-Induced; Amines; Animals; Chemistry, Pharmaceutical; Ectromelia; Embryo, Mammali | 1968 |
The susceptible period for thalidomide malformations in man and monkey.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Humans; Monkey Diseases; Pregnancy; | 1968 |
[Action of thalidomide on the rate of malformations in rats with preformed genetic damage caused by malachite green].
Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Coloring Agents; Dwarfism; Female; Fetal De | 1968 |
Genetical, social, and medical aspects of abortion.
Topics: Abnormalities, Drug-Induced; Abortion, Criminal; Abortion, Legal; Abortion, Therapeutic; Adolescent; | 1968 |
[Prenatal and neonatal drug-induced lesions].
Topics: Abnormalities, Drug-Induced; Adult; Androgens; Drug-Related Side Effects and Adverse Reactions; Eryt | 1968 |
[Treatment of leprous reaction of the erythema nodosum type with thalidomide (N-phthalimidoglutarimide)].
Topics: Ectromelia; Erythema Nodosum; Female; Humans; Leprosy; Male; Pregnancy; Sex Factors; Thalidomide | 1968 |
[Thalidomide embryopathy in Japan].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ear; Ectromelia; Female; Fetal Diseases; Finge | 1968 |
[Malformations].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Embryology; Female; Fetal Diseases; | 1968 |
[Chemotherapeutic fetopathy].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Hypnotics and Sedatives; Maternal-Fetal Exchan | 1968 |
Relationship between teratogeny and structure in the thalidomide field.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Aortic Valve Stenosis; Chemical Phenomena; Chemistry; | 1968 |
Thalidomide syndrome in rhesus monkeys (Macaca mulatta).
Topics: Animals; Female; Fetal Diseases; Monkey Diseases; Pregnancy; Thalidomide | 1969 |
[Thalidomide embryopathy. V. Kidney malformations].
Topics: Abnormalities, Drug-Induced; Female; Humans; Kidney; Pregnancy; Thalidomide | 1965 |
Persistent stapedial artery.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Deafness; Ear Ossicles; Ear, Middle; Female; Humans; | 1965 |
The metabolism of thalidomide: some biological effects of thalidomide and its metabolites.
Topics: Animals; Carboxy-Lyases; Chemical Phenomena; Chemistry; Female; Glutamate Dehydrogenase; Glutamates; | 1965 |
Susceptibility of certain inbred strains of hamsters to teratogenic effects of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Breeding; Cricetinae; Female; Fetus; In Vitro Techniques; Preg | 1965 |
Embryotoxic activity of some pesticides and drugs related to phthalimide.
Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Chemical Phenomena; Chemistry; Female; Imid | 1965 |
Thalidomide malformations and genetic background in the rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Rabbits; Thalidomide | 1965 |
[The sensitive phase in thalidomide embryopathy].
Topics: Female; Fetus; Humans; Pregnancy; Thalidomide | 1965 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |
Teratogenetic properties of thalidomide.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Humans; Pregnancy; Thalidomide | 1965 |
Thalidomide injury to the myocardium of armadillo embryos.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Heart; Myocardium; Necrosis; Pregna | 1965 |
Thalidomide experience in Japan.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Ectromelia; Female; Humans; Infant, Newborn; J | 1965 |
[Disorders of induction and morphogenesis caused by drugs].
Topics: Abnormalities, Drug-Induced; Cell Differentiation; DNA; Embryo, Mammalian; Enzymes; Female; Genetic | 1965 |
Medical and psychosocial aspects of the habilitation of thalidomide children.
Topics: Abnormalities, Drug-Induced; Adult; Artificial Limbs; Child, Preschool; Deafness; Ear Deformities, A | 1966 |
Thalidomide solutions.
Topics: Animals; Chemical Phenomena; Chemistry; Female; Methylcellulose; Pregnancy; Rabbits; Solutions; Thal | 1966 |
Thalidomide solutions.
Topics: Animals; Female; Methylcellulose; Pregnancy; Rabbits; Solutions; Thalidomide | 1966 |
Thalidomide: the case for legal action.
Topics: Abnormalities, Drug-Induced; Australia; Drug Industry; Female; Humans; Jurisprudence; Pregnancy; Tha | 1966 |
[Thalidomide-damaged children with multiple handicaps. The problem of diagnosis and rehabilitation].
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Pregnancy; Sweden; Thalidomide | 1966 |
Hazards to the newlyborn infant from thalidomide-containing drugs administered to pregnant mothers. (Report on three cases).
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Limb Deformities, Congenital; Male; Pregnancy; | 1966 |
Teratological studies in the thalidomide field.
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Fetal Death; Hexobarbital; Mice; Pregn | 1966 |
[Considerations on the occurrence of human abnormalities].
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Environment; Environmental Exposure; Female; | 1966 |
[Thalidomide embryopathy in animal experiments. 3. Teratologic tests of thalidomide catabolic products].
Topics: Abnormalities, Drug-Induced; Animals; Encephalocele; Female; Glutamates; Glutamine; Phthalic Acids; | 1966 |
[Embryopathies and fetal diseases of therapeutic origin].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Anticoagulants; Antimalarials; Antineop | 1966 |