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thalidomide and Pregnancy

thalidomide has been researched along with Pregnancy in 666 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"After the tragic events in the early 1960s, thalidomide has re-emerged as therapeutic for multiple myeloma (MM)."8.84Thalidomide in multiple myeloma--clinical trials and aspects of drug metabolism and toxicity. ( Anderson, KC; Breitkreutz, I, 2008)
"Lenalidomide is a synthetic analog of thalidomide formed by the removal of one keto group (plus the addition of an amino group); it has anti-tumor activities beneficial for the treatment of hematologic malignancies."8.12Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. ( Ando, K; Kamiya, Y; Machida, S; Murayama, N; Ogiya, D; Saito, R; Shiraiwa, S; Suzuki, R; Tazume, K; Yamazaki, H, 2022)
"Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy."7.91The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019)
"Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism."7.69Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994)
"The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain."7.65Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976)
"Thalidomide was developed in the 1950s as a sedative having only a low toxicity."6.42[New pharmacological availability of thalidomide based on experience in patients with multiple myeloma]. ( Murakami, H, 2004)
"Pemphigus vegetans is a rare variant of pemphigus vulgaris."5.62Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide. ( Jiang, L; Li, W; Qiu, X; Yuan, P, 2021)
"Auditory hypersensitivity in autism is frequently observed in clinics."5.56Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats. ( Ida-Eto, M; Narita, M; Noro, Y; Ohkawara, T; Tsugiyama, LE, 2020)
" Adverse events (AEs) occurred in 69 (57."5.48Efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/\ refractory multiple myeloma: a real-life experience ( Duran, M; Durusoy, R; Patır, P; Şahin, F; Saydam, G; Soyer, N; Töbü, M; Tombuloğlu, M; Ünal, HD; Uysal, A; Vural, F, 2018)
"Thalidomide (TD) displays remarkable species specificity, causing birth defects (teratogenesis) in humans and rabbits, but not rats or mice; yet, few determinants of species susceptibility have been identified."5.37Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture. ( Gonçalves, LL; Lee, CJ; Wells, PG, 2011)
"Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests."5.36Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010)
"Morphologic abnormalities found in autism (e."5.31Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002)
"The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation."5.28Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990)
"Thalidomide was administered to 44 female rhesus monkeys immediately after they had mated."5.24Thalidomide: effect upon pregnancy in the rhesus monkey. ( BEHRMAN, RE; LUCEY, JF, 1963)
"Thalidomide embryopathy results from the ingestion of thalidomide in the first trimester during pregnancy, causing multiple forms of congenital abnormalities of variable severity that involve all systems."5.01A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE). ( Baple, E; Hall, CM; Mansour, S, 2019)
"Celgene has developed and operated pregnancy prevention programs since 1998 with the first approval of thalidomide in the US."4.87Managing the teratogenic risk of thalidomide and lenalidomide: an industry perspective. ( Bwire, R; Freeman, J; Houn, F, 2011)
"The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate."4.84Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007)
"After the tragic events in the early 1960s, thalidomide has re-emerged as therapeutic for multiple myeloma (MM)."4.84Thalidomide in multiple myeloma--clinical trials and aspects of drug metabolism and toxicity. ( Anderson, KC; Breitkreutz, I, 2008)
" Thalidomide was taken in the sensitive period of the pregnancy by the father's mother."4.80Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause? ( Kunze, J; Neumann, L; Pelz, J, 1998)
"One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism."4.80[Eye muscle paralysis can increase the knowledge on autism]. ( Strömland, K, 2000)
"The difficulties in assessing the teratogenic potential of drugs used during pregnancy have been made evident by experiences with thalidomide and diethylstilbestrol (DES)."4.76In vivo assessment of the teratogenic potential of drugs in humans. ( Stern, L, 1981)
"Lenalidomide is a synthetic analog of thalidomide formed by the removal of one keto group (plus the addition of an amino group); it has anti-tumor activities beneficial for the treatment of hematologic malignancies."4.12Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. ( Ando, K; Kamiya, Y; Machida, S; Murayama, N; Ogiya, D; Saito, R; Shiraiwa, S; Suzuki, R; Tazume, K; Yamazaki, H, 2022)
"Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy."3.91The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019)
"As Thalidomide survivors reach their mid-50's they are experiencing a wide range of secondary health problems, in particular musculoskeletal problems, and depression and anxiety, with multimorbidity a growing issue."3.91The health and quality of life of Thalidomide survivors as they age - Evidence from a UK survey. ( Atkin, K; Glendinning, C; Newbronner, E; Wadman, R, 2019)
"Between 1957 and 1962 thalidomide was used as a nonaddictive, nonbarbiturate sedative that also was successful in relieving the symptoms of morning sickness in early pregnancy."3.85"The legacy of thalidomide" - A multidisciplinary meeting held at the University of York, United Kingdom, on September 30, 2016. ( Atkin, K; Newbronner, E; Vargesson, N, 2017)
"We analyzed the frequency of births with phenotypes consistent with thalidomide embryopathy (TEP) and correlated this with the distribution of thalidomide and the prevalence of leprosy between 2005 and 2010 in Brazil."3.81Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil. ( Camey, SA; de Lyra Rabello Neto, D; de Oliveira, MZ; Lopez-Camelo, J; Morelo, EF; Sales Luiz Vianna, F; Sanseverino, MT; Schuler-Faccini, L, 2015)
"Fifty years ago several thousand children were born with severe limb defects after their mothers had been given thalidomide in pregnancy."3.78The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals. ( Lachmann, PJ, 2012)
"Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women."3.77Thalidomide: the tragedy of birth defects and the effective treatment of disease. ( Kim, JH; Scialli, AR, 2011)
"Based on the fact that thalidomide, at a certain point in human pregnancy, produces autism, we propose administering thalidomide to pregnant monkeys at an appropriate point after conception."3.72A proposed primate animal model of autism. ( Teitelbaum, P, 2003)
"Autism has been linked to thalidomide exposure at 20-24 days gestation."3.71Is autism due to cerebral-cerebellum disconnection? ( Skoyles, JR, 2002)
"The teratogenic potency of the thalidomide (Thd) derivative phthalimidophthalimide (Phtpht) was assessed in the common marmoset (Callithrix jacchus), by oral administration of the relatively high daily dose of 50 mg Phtpht/kg body wt, during the susceptible period (days 48-61 of pregnancy)."3.69Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. 5. Lack of teratogenic effects of phthalimidophthalmide. ( Felies, A; Frankus, E; Klug, S; Neubert, R; Nogueira, AC; Stürje, H, 1994)
"Thalidomide, mainly used for the treatment of leprosy, is a current teratogen in South America, and it is reasonable to assume that at present this situation is affecting many births in underdeveloped countries."3.69Thalidomide, a current teratogen in South America. ( Ashton-Prolla, P; Barreda-Mejia, E; Brunoni, D; Castilla, EE; Cavalcanti, DP; Correa-Neto, J; Delgadillo, JL; Dutra, MG; Felix, T; Giraldo, A; Juarez, N; Lopez-Camelo, JS; Nazer, J; Orioli, IM; Paz, JE; Pessoto, MA; Pina-Neto, JM; Quadrelli, R; Rittler, M; Rueda, S; Saltos, M; Sánchez, O; Schüler, L, 1996)
"Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism."3.69Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994)
"A case of thalidomide syndrome diagnosed by ultrasound in the 17th week of pregnancy is presented."3.67Prenatal diagnosis of thalidomide syndrome. ( Eigier, A; Gollop, TR; Guidugli Neto, J, 1987)
"5 ml dimethylformamide (DMF) on day 10, 11, or 12 of the pregnancy."3.66Embryotoxicity and teratogenicity of thalidomide in rats. ( Parkhie, M; Webb, M, 1983)
"The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain."3.65Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976)
" Animal models of hemifacial microsomia and thalidomide-induced otomandibular dysostosis are described; the causal mechanism of malformation appeared to be closely related to the formation of a hematoma at the time of development of the stapedial arterial systems."3.65Hemorrhage in development of the face. ( Poswillo, D, 1975)
" The cats were given daily oral doses of thalidomide as follows: 10 mg/kg on days 10-20 of pregnancy, 240 mg/kg on days 10-14, and 120, 240, and 480 mg/kg on days 15-17 or 18-20 of pregnancy."3.65Fetal cardiovascular and other defects induced by thalidomide in cats. ( Khera, KS, 1975)
"2-diphenyl-methane during the period of organogenesis (the 6th-15th day of pregnancy)."3.65[Effect of some preservatives on pregnancy and fetal development in experimental animals]. ( Piekacz, H, 1976)
"On Day 1 of pregnancy, a thalidomide suspension (."3.65Responses of pre-implantation mouse embryos to thalidomide exposure in utero. ( Batra, BK; Palayoor, T; Raveendran, P, 1976)
" The fate of [(14)C]thalidomide orally administered to pregnant rabbits at the beginning of the sensitive phase of pregnancy has been studied."3.64The fate of[14C]thalidomide in the pregnant rabbit. ( Fabro, S; Smith, RL; Williams, RT, 1967)
"Data are presented on 115 children, including three sets of twins, born in Canada in 1961 and 1962 with congenital malformations associated with the use of thalidomide by their mothers in early pregnancy."3.64CANADIAN THALIDOMIDE EXPERIENCE. ( WEBB, JF, 1963)
" In one case thalidomide had been administered to the mother early in the pregnancy."3.64Phocomelia: report of three cases. ( COODIN, FJ; MURPHY, CH; UCHIDA, IA, 1962)
" The fate in the pregnant New Zealand White rabbit of oral doses of four (14)C-labelled hydrolysis products of thalidomide, namely alpha-(o-carboxybenzamido)-glutarimide, 2-phthalimidoglutaramic acid, 2-phthalimidoglutaric acid and 2-(o-carboxybenzamido)glutaramic acid, administered on the 192nd hour of pregnancy has been studied."3.64The fate of the hydrolysis products of thalidomide in the pregnant rabbit. ( Fabro, S; Smith, RL; Williams, RT, 1967)
"Thalidomide was developed as a sedative drug during the 1950s."2.82[Development of novel cereblon modulators and their target molecules]. ( Ito, T, 2022)
"This analysis allows us to think beyond the safe use of thalidomide, but the safety provided by any type of monitoring system."2.82Comparative analysis of the use and control of thalidomide in Brazil and different countries: is it possible to say there is safety? ( de Jesus, SM; Leite, SN; Santana, RS, 2022)
"Thalidomide is an old well-known drug firstly used as morning sickness relief in pregnant women and then withdrawn from the market due to its severe side effects on fetal normal development."2.82Recent Advances in the Development of Thalidomide-Related Compounds as Anticancer Drugs. ( Barbarossa, A; Carocci, A; Franchini, C; Iacopetta, D; Sinicropi, MS, 2022)
" The minimum dosage used by the authors seems to be adequate on the basis of the results obtained."2.64[Fixed lupus erythematosus (its treatment with thalidomide)]. ( Barba Rubio, J; Franco González, F, 1977)
"The drug caused severe birth defects."2.58The changing health of Thalidomide survivors as they age: A scoping review. ( Atkin, K; Newbronner, E, 2018)
"Thalidomide is a teratogen that affects many organs but primarily induces limb truncations like phocomelia."2.55The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine. ( Jungck, D; Knobloch, J; Koch, A, 2017)
"Thalidomide was synthesised and launched several decades ago as a drug against respiratory infections and was administered to pregnant women for relief of morning sickness."2.52Therapeutic Potential of Thalidomide and Its Analogues in the Treatment of Cancer. ( Sherbet, GV, 2015)
"Thalidomide was originally developed in 1954 as a sedative that was commonly used to ameliorate morning sickness."2.48Deciphering the mystery of thalidomide teratogenicity. ( Handa, H; Ito, T, 2012)
"We found that Duane syndrome and its variants were prominent in individuals who were exposed to thalidomide early in the sensitive period (days 20 to 26±)."2.47What can we learn from the thalidomide experience: an ophthalmologic perspective. ( Miller, MT; Strömland, KK, 2011)
"Environmental causes of birth defects have increasingly been recognized since the mid-20th century."2.47Causes of birth defects: lessons from history. ( Lancaster, PA, 2011)
"Thalidomide is a drug with bad reputation from the 1960's as it appeared to be teratogenic by causing foetal anomalies."2.46[Thalidomide in oncological and hematological diseases]. ( Anttila, P; Kivivuori, SM, 2010)
"Thalidomide is a very potent teratogen capable of causing severe systemic malformations if the fetus is exposed during the sensitive period."2.45Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. ( Miller, MT; Strömland, K; Ventura, L, 2009)
"Thalidomide was developed in the 1950s as a sedative having only a low toxicity."2.42[New pharmacological availability of thalidomide based on experience in patients with multiple myeloma]. ( Murakami, H, 2004)
"Thalidomide has hypnosedative, antiangiogenic, antiinflammatory, and immunomodulatory properties."2.42Dermatologic and nondermatologic uses of thalidomide. ( Cheigh, NH; Micali, G; Nasca, MR; West, DP; West, LE, 2003)
"Thalidomide was marketed in the late-1950s as a sedative and tranquilliser of exceptionally low general toxicity, but in 1961 it was implicated separately by Lenz and MacBride as the cause of the epidemic of congenital malformations that had been puzzling the world for some years."2.41Thalidomide: 40 years on. ( Diggle, GE, 2001)
"Thalidomide was introduced as a non-toxic sleeping pill in 1957 and was prescribed in more than 20 countries."2.41[Thalidomide--a dreaded drug with new indications]. ( Seidel, C; Waage, A, 2001)
"Present knowledge of chromosomal aberrations associated with microphthalmia is surveyed, and some of the syndromes and phenocopies in the mentally retarded in which microphthalmia may be found are reviewed."2.35The heterogeneity of microphthalmia in the mentally retarded. ( Warburg, M, 1971)
"Thalidomide was used as a positive control and was administered orally at 15 mg/kg/day on gestation days 26-28."1.72Embryo-fetal exposure and developmental outcome of lenalidomide following oral administration to pregnant cynomolgus monkeys. ( Fuchs, A; Hui, JY; Kumar, G, 2022)
"Thalidomide is a drug responsible to a spectrum of congenital anomalies known as Thalidomide Embryopathy (TE), which includes mainly limb and heart defects."1.72Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy. ( Bremm, JM; do Amaral Gomes, J; Fraga, LR; Kowalski, TW; Rengel, BD; Schüler-Faccini, L; Vianna, FSL, 2022)
"Pemphigus vegetans is a rare variant of pemphigus vulgaris."1.62Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide. ( Jiang, L; Li, W; Qiu, X; Yuan, P, 2021)
"Auditory hypersensitivity in autism is frequently observed in clinics."1.56Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats. ( Ida-Eto, M; Narita, M; Noro, Y; Ohkawara, T; Tsugiyama, LE, 2020)
"Maternofoetal physiologically-based pharmacokinetic models integrating multi-compartmental maternal and foetal units were developed using Simbiology® to estimate prenatal drug exposure."1.51Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies. ( Adejuyigbe, E; Atoyebi, SA; Bolaji, O; Olagunju, A; Owen, A; Rajoli, RKR; Siccardi, M, 2019)
" Adverse events (AEs) occurred in 69 (57."1.48Efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/\ refractory multiple myeloma: a real-life experience ( Duran, M; Durusoy, R; Patır, P; Şahin, F; Saydam, G; Soyer, N; Töbü, M; Tombuloğlu, M; Ünal, HD; Uysal, A; Vural, F, 2018)
"Thalidomide-treated embryos with the human CYP3A gene cluster showed limb abnormalities, and human CYP3A was expressed in the placenta, suggesting that human CYP3A in the placenta may contribute to the teratogenicity of thalidomide."1.43Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. ( Abe, S; Akita, M; Kamataki, T; Kazuki, K; Kazuki, Y; Kobayashi, K; Ohta, R; Osaki, M; Oshimura, M; Satoh, D; Takehara, S; Yamazaki, H, 2016)
"Thalidomides were initially thought to be broad-range drugs specifically for curing insomnia and relieving morning sickness in pregnant women."1.42Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin. ( Kunwar, A; Kuppa, A; Panda, D; Rashid, A, 2015)
"Thalidomide was approved for the treatment of multiple myeloma in Japan under a risk management program, named TERMS, in 2008."1.42[Risk Management of Teratogenic Drugs ~The Current States of Practice in Europe, US and Japan~]. ( Amann, S; Hattori, C; Nasu, M; Sato, T; Shirakuni, Y; Takagi, T; van Bennekom, C, 2015)
" The post-implantation loss rate and number of placental remnants were increased and the number of live fetuses was decreased in both of the strains in the EFD study and in Kbl:NZW at 300 mg/kg dosed on GD 7-8 in the SP study."1.40Common nature in the effects of thalidomide on embryo-fetal development in Kbl:JW and Kbl:NZW rabbits. ( Awatsuji, H; Kawamura, Y; Matsumoto, K; Sato, K; Shirotsuka, Y, 2014)
"Thalidomide was marketed for the treatment of morning sickness and resulted in foetal death and physical deformities."1.39Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort. ( Burke, D; Jankelowitz, SK; Spies, JM, 2013)
"Thalidomide (TD) displays remarkable species specificity, causing birth defects (teratogenesis) in humans and rabbits, but not rats or mice; yet, few determinants of species susceptibility have been identified."1.37Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture. ( Gonçalves, LL; Lee, CJ; Wells, PG, 2011)
"Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests."1.36Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010)
"Besides that, she was treated with schizophrenia."1.35[Thalidomide (Contergan) induced limb deficiency in Hungary?]. ( Bács, E; Czeizel, E; Gidai, J, 2009)
"Lenalidomide (Revlimid) is an immunomodulatory drug and an analogue of thalidomide, a known teratogen."1.35RevAssist: a comprehensive risk minimization programme for preventing fetal exposure to lenalidomide. ( Brandenburg, NA; Bwire, R; Castaneda, CP; Freeman, J; Quigley, C; Zeldis, JB, 2008)
"Thalidomide has a potent immunomodulatory property and has now a number of approved and off-label uses in dermatologic, oncologic, infectious and gastrointestinal conditions."1.34New cases of thalidomide embryopathy in Brazil. ( Castilla, EE; de Sousa, AC; Luna, E; Maximino, C; Schuler-Faccini, L; Schwartz, IV; Soares, RC; Waldman, C, 2007)
"In all studies, thalidomide was selectively toxic to development."1.34Evaluation of the developmental toxicity of lenalidomide in rabbits. ( Christian, MS; Hoberman, A; Laskin, OL; Latriano, L; Sharper, V; Stirling, DI, 2007)
"The present study determined effects of thalidomide on three successive generations of New Zealand White rabbits after oral dosing to F0 maternal rabbits during the later third of gestation (post major organogenesis) and lactation."1.32Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring. ( Denny, KH; Hoberman, AM; Morseth, S; Stirling, DI; Teo, SK; Thomas, SD, 2004)
"Morphologic abnormalities found in autism (e."1.31Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002)
"Thalidomide was not mutagenic to 6 strains of Salmonella when tested both in the presence and absence of Aroclor-induced rat liver S9 mix."1.30Thalidomide: lack of mutagenic activity across phyla and genetic endpoints. ( Ashby, J; Callander, RD; Clay, P; Ferguson, MJ; Galloway, SM; Gaulden, ME; Greenwood, SK; Hill, RB; Kimber, I; Nivard, M; Parry, JM; Tinwell, H; Vogel, E; Williamson, J, 1997)
"Thalidomide has also prompted commentators to celebrate American drug regulation and the American liability system; Professor Bernstein argues that these paeans are exaggerated."1.30Formed by thalidomide: mass torts as a false cure for toxic exposure. ( Bernstein, A, 1997)
"Thalidomide is a drug associated with devastating side effects."1.30Thalidomide's long and winding road. ( Hanna, L, 1998)
"Thalidomide was withdrawn from the market in the early sixties because of major teratogenic effects such as reduction defects of the limbs."1.30[Thalidomide once more in the spotlight]. ( Cornel, MC; de Jong-van den Berg, LT; Rutgers, J, 1998)
"Thalidomide, once banned, has returned to the center of controversy with the Food and Drug Administration's (FDA's) announcement that thalidomide will be placed on the market for the treatment of erythema nodosum leprosum, a severe dermatological complication of Hansen's disease."1.30Thalidomide and the Titanic: reconstructing the technology tragedies of the twentieth century. ( Annas, GJ; Elias, S, 1999)
"Thalidomide is a teratogenic sedative-hypnotic drug that is structurally similar to phenytoin, which is thought to be bioactivated by prostaglandin H synthase (PHS) and other peroxidases to a teratogenic reactive intermediate."1.29Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate. ( Arlen, RR; Wells, PG, 1996)
"Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately."1.28Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. ( Baird, PA; Froster, UG, 1992)
"The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation."1.28Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990)
"To evaluate the patterns of birth defects associated with diabetic embryopathy, a sensitivity-specificity analysis was performed on 4929 infants with major defects ascertained by the population-based Metropolitan Atlanta Congenital Defects Program between 1968 and 1980."1.28Clinical-epidemiologic assessment of pattern of birth defects associated with human teratogens: application to diabetic embryopathy. ( Becerra, JE; Cordero, JF; Erickson, JD; Khoury, MJ, 1989)
"For example, in the case of Congenital rubella syndrome (CRS), monitoring for the combination of cataracts with deafness and/or patent ductus arteriosus could have led to earlier detection of an epidemic than could monitoring for cataracts alone."1.27Monitoring for multiple malformations in the detection of epidemics of birth defects. ( Adams, MM; Erickson, JD; Khoury, MJ; Rhodes, P, 1987)
"Head anomalies in fetuses (anencephaly, holoprosencephaly and hydrocephaly) were induced at a high frequency by the maternal administration of thalidomide on day 7, and also in a few fetuses on day 8."1.27[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits]. ( Matsubara, Y; Mikami, T, 1985)
" At the most, there is only a marginal loss of sensitivity in respect of detecting the lowest dosage at which effects may occur."1.27An indirect assessment of the Chernoff/Kavlock assay. ( Palmer, AK, 1987)
" Also the toxic dose to the mothers, 3000 mg/kg, given to rabbits in case of one FWA was without these effects."1.25Studies of embryo toxicity in rats and rabbits. ( Lorke, D; Machemer, L, 1975)
"Goiter is relatively common in infants whose mothers were treated with propylthiouracil and other antithyroid drugs, yet they usually show normal thyroid function."1.25Human experiences related to adverse drug reactions to the fetus or neonate from some maternally administered drugs. ( Shirkey, HC, 1972)

Research

Studies (666)

TimeframeStudies, this research(%)All Research%
pre-1990461 (69.22)18.7374
1990's61 (9.16)18.2507
2000's54 (8.11)29.6817
2010's70 (10.51)24.3611
2020's20 (3.00)2.80

Authors

AuthorsStudies
Vargesson, N5
Stephens, T1
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YAMANE, H1
KATO, T1
HOSODA, Y1
FOGH-ANDERSEN, P1
FERM, VH1
BEAUDOIN, AR1
KEBERLE, H2
LOUSTALOT, P2
MALLER, RK1
FAIGLE, JW2
SCHMID, K2
DWORNIK, JJ1
MOORE, KL1
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McBride, W1
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Maximino, C1
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Alexander, GJ1
Soukup, S1
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McBride, WG9
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Sharpless, MK1
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Parkhie, M1
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Tuman, WG1
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Lindsay, L1
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Melnick, M1
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Muto, R1
Ohashi, H1
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Fieldston, E1
Waage, A1
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Finnell, RH1
Waes, JG1
Eudy, JD1
Rosenquist, TH1
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Philbert, MA1
Harris, C1
Skoyles, JR1
Bonta, I1
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O'Rahilly, R1
McFadyen, RE1
Bremner, DN1
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Sawyer, RH1
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Svoboda, JA1
Pettinelli, MW1
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Waring, GO1
Shields, JA1
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Shen Cheng, CC1
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McCredie, J5
Loewenthal, J1
Barba Rubio, J1
Franco González, F1
Napalkov, NP1
Jarvik, ME1
Chamberlain, JG1
Jackson, AJ1
Schumacher, HJ3
Sofia, RD1
Strasbaugh, JE1
Banerjee, BN1
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Weidenbecher, M1
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Ruffing, L1
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Keplinger, ML3
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Lykke, WJ1
Stephenson, JB1
Gladstone, D1
Robeson, C1
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Lipson, AH1
Froster, UG1
Baird, PA1
Humphrey, GF1
Bensaid, P1
Machet, L1
Vaillant, L1
Machet, MC1
Scotto, B1
Lorette, G1
Mair, J1
Saunders, EJ1
Saunders, JA1
Schaefer, C1
Spielmann, H1
Brown, MA1
Farrell, C1
Newton, P1
Child, RP1
Chamberlain, G1
Michejda, M1
Hodgen, GD1
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Cordero, JF1
Jenkins, S1
Powell, RJ1
Allen, BR1
Littlewood, S1
Maurice, PD1
Smith, NJ1
Palmer, AK2
Grayling, GW1
Young, PN1
Heshka, T1
Heger, W3
Merker, HJ3
Fraser, FC1
Gollop, TR1
Eigier, A1
Guidugli Neto, J1
Sames, K2
Meister, R1
Maouris, PG1
Hirsch, PJ1
Adams, MM1
Rhodes, P1
Kanno, O1
Goldberg, JD1
Golbus, MS1
Hicks, LJ1
Holtzman, NA1
Smith, JR1
Martin, IR1
Shaw, DG1
Robinson, RO1
Smith, RJ1
Laporte, JR1
Diogene, E1
Aragón, C1
Vidal, X1
Matsubara, Y1
Mikami, T1
Onishi, T1
McLeod, JG1
Fraumeni, JF1
Shirkey, HC1
Bohm, R1
Nitsch, K1
Speirs, AL1
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Hellmann, K2
Bore, PJ1
Scothorne, RJ1
Wilson, JS1
Vallance-Owen, J1
Samojlik, E1
Lesinski, J1
Sieber, SM1
Pembrey, ME1
Clarke, CA1
Frais, MM1
Newman, L1
Metcalf, WK1
Gershbein, LL1
Fritz, H1
Achs, R1
Harper, RG1
Jäger, M1
Refior, HJ1
Zenker, H1
Köhler, E1
Nudleman, KL1
Travill, AA1
Jörgensen, G3
Roe, FJ1
Walters, MA1
Mitchley, BC1
Gibson, MA1
Bischoff, A1
Morgon, A1
Charachon, D2
Bringuier, N1
Nicholls, PJ1
Gavan, JA1
Hague, DE1
Bakay, B2
Nyhan, WL2
Sugiyama, Y1
Bryan, EM1
Kohler, HG1
Robertson, GM1
Shapiro, IuL1
Vaĭntrub, MIa1
Grinberg, KN1
Zhurkov, VS1
Shtenberg, AI1
Illum, P1
Aschenbrenner, R1
Holt, SB1
Yager, JW1
Kewitz, H1
Book, SA1
Bustad, LK1
Kernis, MM1
Terapane, J1
Jordan, RL1
Poswillo, DE4
Hamilton, WJ2
Tanimura, T1
Sopher, D1
Jusko, WJ1
van Julsingha, EB1
Lister, J1
Wendel, HA1
Elsahy, NI1
Jackson, R1
Kajii, T3
Kida, M3
Takahashi, K2
Cerutti, R1
Kucera, J1
Wright, PL1
Plank, JB1
Tuli, SM1
Jackson, BT1
Murad, JE1
Shakibi, JG1
Kozaczenko, J1
Taylor, WJ1
Suzuki, M1
Murai, N1
Watanabe, G1
Warburg, M1
Apt, W1
Rafuse, EV1
Arstikaitis, M1
Brent, HP1
Rasore-Quartino, A1
Rovei, S1
Terapane, JF1
Rosedale, SL1
Vondruska, JF1
Fancher, OE1
Lindburg, DG1
Kotlan, J1
Farkouh, E1
Jonsson, BG3
Potter, GD1
Hauser, GA1
Mambourg, A1
Keck, EW1
Roloff, D1
Markworth, P1
Nager, GT1
Gibbels, E1
Schübel, F1
Partsch, CJ1
Stahl, A4
Hartlmaier, KM2
Hammarström, L1
Henrikson, CO1
Larsson, KS2
Hancock, JL1
McGovern, PT1
Stamp, JT1
Cahen, RL1
Gordon, G1
Bodiazhina, VI1
Kiriushchenkov, AP1
Leonov, BV1
Kretchmer, N1
Uemura, Y1
Tamura, H1
Okada, Y1
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Vickers, TH4
Barcellona, PS1
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Buu-Hoï, NP1
Detenbeck, LC1
Abrams, RC1
Gosepath, J1
Kley, W1
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Sjöqvist, F1
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Rett, A2
von Massenbach, W1
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Scheuch, EK1
Kreipe, U1
Töndury, G1
Murmann, W1
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Blake, D1
Gillette, J1
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Atterbäck, B1
Hellgren, K1
Juhlin, IM1
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Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multi-center, Open-label Extended Access Program of Lenalidomide Plus Low-dose Dexamethasone in Chinese Subjects With Relapsed/Refactory Multiple Myeloma Who Participated in Study CC-5013-MM-021 for at Least One Year.[NCT02348528]Phase 265 participants (Actual)Interventional2012-09-11Completed
A Pilot Study of Lenalidomide Maintenance Therapy in Stage IIIB/IV Non-small Cell Lung Cancer After First-line Chemotherapy[NCT02018523]Phase 17 participants (Actual)Interventional2014-06-30Terminated (stopped due to Study did not enroll enough subjects to make a statistically sound conclusion.)
QUIREDEX: A National, Open-Label, Multicenter, Randomized, Phase III Study of Revlimid (Lenalidomide) and Dexamethasone (ReDex) Treatment Versus Observation in Patients With Smoldering Multiple Myeloma With High Risk of Progression[NCT00480363]Phase 3120 participants (Actual)Interventional2007-05-31Completed
A Double Blinded Randomized Crossover Phase III Study of Oral Thalidomide Versus Placebo in Patients With Stage D0 Androgen Dependent Prostate Cancer Following Limited Hormonal Ablation[NCT00004635]Phase 3159 participants (Actual)Interventional2000-03-01Completed
A Randomized Phase II Study of Oral Thalidomide in Patients With Hormone-Refractory Prostate Cancer[NCT00001446]Phase 264 participants Interventional1995-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

The Number of Participants With Adverse Events

Here are the total number of participants with adverse events. For the detailed list of adverse events see the adverse event module. (NCT00004635)
Timeframe: Date treatment consent signed to date off study, approximately 60 months

InterventionParticipants (Count of Participants)
Thalidomide117
Placebo98

Time to Progression

Time to progression is defined as follows: if the PSA returns to baseline (defined as the PSA value prior to starting leuprolide or goserelin) or increases to the absolute value of 5 ng/ml. (NCT00004635)
Timeframe: 36 months

Interventionmonths (Median)
Thalidomide15
Placebo9.6

Reviews

108 reviews available for thalidomide and Pregnancy

ArticleYear
[Development of novel cereblon modulators and their target molecules].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2022, Volume: 63, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Female; Humans; Lenalidomide; Peptide Hydrolases; Pregnancy; T

2022
[IBD and pregnancy: From conception to birth].
    Gynecologie, obstetrique, fertilite & senologie, 2020, Volume: 48, Issue:6

    Topics: Cesarean Section; Colitis, Ulcerative; Crohn Disease; Delivery, Obstetric; Female; Fertilization; Fe

2020
Memories of the Teratology Society: 1972-2020.
    Birth defects research, 2020, 07-15, Volume: 112, Issue:12

    Topics: Female; Fetus; Humans; Misoprostol; Pregnancy; Societies, Medical; Teratogens; Teratology; Thalidomi

2020
The organization, weaknesses, and challenges of the control of thalidomide in Brazil: A review.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:8

    Topics: Abnormalities, Drug-Induced; Brazil; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy;

2020
A drug repositioning success: The repositioned therapeutic applications and mechanisms of action of thalidomide.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:3

    Topics: Cytokines; Drug Repositioning; Female; Humans; Immunosuppressive Agents; Infant, Newborn; Kidney Neo

2021
Recent Advances in the Development of Thalidomide-Related Compounds as Anticancer Drugs.
    Current medicinal chemistry, 2022, Volume: 29, Issue:1

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Female; Humans; Multiple Myeloma; Peripheral Nervous

2022
Comparative analysis of the use and control of thalidomide in Brazil and different countries: is it possible to say there is safety?
    Expert opinion on drug safety, 2022, Volume: 21, Issue:1

    Topics: Brazil; Drug Monitoring; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy; Leprosy, Lep

2022
Implementation of a Pregnancy Prevention Programme (PPP) with a Controlled Distribution System (CDS) for the Generic Teratogenic Phthalimides Thalidomide, Lenalidomide and Pomalidomide.
    Therapeutic innovation & regulatory science, 2021, Volume: 55, Issue:6

    Topics: Child; Female; Humans; Infant, Newborn; Lenalidomide; Phthalimides; Pregnancy; Teratogens; Thalidomi

2021
The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine.
    Current molecular medicine, 2017, Volume: 17, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Biomarkers; Female; Gene Expression Regulation; Humans; Limb D

2017
The changing health of Thalidomide survivors as they age: A scoping review.
    Disability and health journal, 2018, Volume: 11, Issue:2

    Topics: Aging; Comorbidity; Congenital Abnormalities; Disabled Persons; Female; Health Status; Humans; Menta

2018
Targeted drugs in spondyloarthritis during pregnancy and lactation.
    Pharmacological research, 2018, Volume: 136

    Topics: Animals; Breast Feeding; Cytokines; Female; Humans; Janus Kinase Inhibitors; Lactation; Molecular Ta

2018
A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE).
    The Journal of hand surgery, European volume, 2019, Volume: 44, Issue:1

    Topics: Algorithms; Diagnosis, Differential; Female; History, 20th Century; History, 21st Century; Humans; L

2019
The teratogenic effects of thalidomide on limbs.
    The Journal of hand surgery, European volume, 2019, Volume: 44, Issue:1

    Topics: Abnormalities, Drug-Induced; Extremities; Female; History, 20th Century; History, 21st Century; Huma

2019
Pyoderma gangrenosum: a systematic review.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2014, Volume: 149, Issue:5

    Topics: Anti-Inflammatory Agents; Arthritis; Dermatologic Agents; Diagnosis, Differential; Disease Progressi

2014
Thalidomide-induced teratogenesis: history and mechanisms.
    Birth defects research. Part C, Embryo today : reviews, 2015, Volume: 105, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Female; History, 20th Century; History, 21st Century; H

2015
Therapeutic Potential of Thalidomide and Its Analogues in the Treatment of Cancer.
    Anticancer research, 2015, Volume: 35, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Female; Humans; Neoplasms; Pregnancy; Thalidomide

2015
Thalidomide in multiple myeloma--clinical trials and aspects of drug metabolism and toxicity.
    Expert opinion on drug metabolism & toxicology, 2008, Volume: 4, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Clinical Trials as Topic; Drug Interactions; Female; Humans; Immun

2008
Variability in human embryonic development and its implications for the susceptibility to environmental teratogenesis.
    Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:8

    Topics: Embryo, Mammalian; Embryonic Development; Environmental Exposure; Female; Gestational Age; Humans; P

2009
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
    Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:8

    Topics: Abnormalities, Drug-Induced; Adult; Autistic Disorder; Child; Child, Preschool; Cranial Nerves; Embr

2009
[Thalidomide in oncological and hematological diseases].
    Duodecim; laaketieteellinen aikakauskirja, 2010, Volume: 126, Issue:12

    Topics: Angiogenesis Inhibitors; Female; Hematologic Diseases; Humans; Multiple Myeloma; Neoplasms; Pregnanc

2010
Rare bladder tumors: caveat emptor.
    Oncology (Williston Park, N.Y.), 2010, Volume: 24, Issue:9

    Topics: Abnormalities, Drug-Induced; Disease Progression; Female; Humans; Lenalidomide; Male; Multiple Myelo

2010
Managing the teratogenic risk of thalidomide and lenalidomide: an industry perspective.
    Expert opinion on drug safety, 2011, Volume: 10, Issue:1

    Topics: Abnormalities, Drug-Induced; Contraception; Contraindications; Drug Industry; Female; Humans; Lenali

2011
Causes of birth defects: lessons from history.
    Congenital anomalies, 2011, Volume: 51, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Australia; Congenital Abnormalities; Female; Fever; History, 2

2011
What can we learn from the thalidomide experience: an ophthalmologic perspective.
    Current opinion in ophthalmology, 2011, Volume: 22, Issue:5

    Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Limb Defo

2011
[The thalidomide experience: review of its effects 50 years later].
    Medicina clinica, 2012, Jun-02, Volume: 139, Issue:1

    Topics: Abnormalities, Drug-Induced; Angiogenesis Inhibitors; Ectromelia; Embryonic Development; Female; His

2012
Deciphering the mystery of thalidomide teratogenicity.
    Congenital anomalies, 2012, Volume: 52, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Chick Embryo; Female; Fibroblast Growth Factor 8; Hum

2012
Teratogen-induced limb defects.
    American journal of medical genetics, 2002, Oct-15, Volume: 112, Issue:3

    Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin

2002
Dermatologic and nondermatologic uses of thalidomide.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:9

    Topics: Angiogenesis Inhibitors; Anti-HIV Agents; Clinical Trials as Topic; Dermatologic Agents; Female; Hum

2003
THE PROBLEM OF TERATOGENICITY.
    The Practitioner, 1963, Volume: 191

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Cyclizine; Female; Imipramine; Nicotine; Preg

1963
[CONTRAINDICATED MEASURES IN PREGNANCY].
    Medizinische Klinik, 1963, Sep-27, Volume: 58

    Topics: Anthelmintics; Anti-Bacterial Agents; Antibiotics, Antitubercular; Anticoagulants; Antiemetics; Cort

1963
[EFFECT OF THALIDOMIDE ON THE PATHOGENESIS OF ABNORMALITIES IN NEWBORN INFANTS].
    Lekarska veda v zahranici, 1963, Aug-23, Volume: 34

    Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; P

1963
ADVANCES IN OBSTETRICS AND GYNAECOLOGY.
    The Practitioner, 1963, Volume: 191

    Topics: Anemia; Endocrinology; Erythroblastosis, Fetal; Female; Genital Neoplasms, Female; Gynecology; Hormo

1963
TERATOGENIC AGENTS AND CONGENITAL MALFORMATIONS.
    The Journal of pediatrics, 1963, Volume: 63

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Congenital Abnormalities; Female;

1963
[ABNORMALLY SHORTENED EXTREMITIES 1950-1962. RESULTS OF A SURVEY].
    Geburtshilfe und Frauenheilkunde, 1964, Volume: 24

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Ear Deformities, Acquired; Ear, External; Ect

1964
FETAL AND NEONATAL HAZARDS FROM DRUGS ADMINISTERED DURING PREGNANCY.
    New York state journal of medicine, 1964, Feb-15, Volume: 64

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antineoplastic

1964
[EXOGENOUS MALFORMATIONS].
    Wiener klinische Wochenschrift, 1964, Mar-13, Volume: 76

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcohols; Androgens; Anesthetics; Congenital A

1964
[CLINICAL OBSERVATIONS ON PHARMACOGENIC TERATOGENESIS].
    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1964, Volume: 20

    Topics: Abnormalities, Drug-Induced; Androgens; Infant, Newborn; Pregnancy; Progestins; Quinine; Teratogenes

1964
[CLINICAL-STATISTICAL STUDIES ON CURRENT MALFORMATION PROBLEM. A REVIEW].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Abnormalities, Drug-Induced; Biomedical Research; Epidemiology; Germany; Germany, West; Pregnancy; S

1964
[ETIOPATHOGENESIS OF DEVELOPMENTAL DISORDERS. EXPERIMENTAL CONTRIBUTION TO THE CONCEPT OF PHENOCOPY].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Animals; Antimetabolites; Avitaminosis; Congenital Abnormalities; Hypoxia; Mammals; Pregnancy; Pregn

1964
CONGENITAL MALFORMATIONS. CLINICAL AND COMMUNITY CONSIDERATIONS.
    The American journal of the medical sciences, 1965, Volume: 249

    Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Achondroplasia; Anencephaly; Cleft Pala

1965
[New pharmacological availability of thalidomide based on experience in patients with multiple myeloma].
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 2004, Volume: 73, Issue:3

    Topics: Animals; Blood Vessels; Clinical Trials, Phase II as Topic; Ectromelia; Erythema Nodosum; Female; Hu

2004
[Systemic treatment of cutaneous lupus erythematosus].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2003, Volume: 1, Issue:9

    Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antimal

2003
Cutaneous sarcoidosis therapy updated.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents

2007
Oxidative stress as a mechanism of teratogenesis.
    Birth defects research. Part C, Embryo today : reviews, 2006, Volume: 78, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Cell Compartmentation; Cell Cycle; Female; Humans; Models, Bio

2006
[Action mechanism of thalidomide in treatment of multiple myeloma].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:12

    Topics: Angiogenesis Inhibitors; Cell Adhesion Molecules; DNA; Female; Humans; Immunosuppressive Agents; Len

2007
Fetal drug exposure-behavioral teratogenesis.
    Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Behavior; Cannabinoids; Child; Chil

1984
Mechanisms of teratogenesis.
    Annual review of pharmacology and toxicology, 1984, Volume: 24

    Topics: Aminopterin; Androgens; Animals; Antithyroid Agents; Chromosome Aberrations; Coumarins; Diethylstilb

1984
Drugs and pregnancy.
    Progress in clinical and biological research, 1980, Volume: 44

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcoholic Beverages; Animals; Anticonvulsants;

1980
Critical periods of prenatal toxic insults.
    Progress in clinical and biological research, 1980, Volume: 36

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Embryo, Mammalian; Female; Fetus; Gestational

1980
Forms and causes of human malformations.
    Acta morphologica Academiae Scientiarum Hungaricae, 1980, Volume: 28, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Estrogens; Fanconi Anemia; Female; Genes, Dom

1980
In vivo assessment of the teratogenic potential of drugs in humans.
    Obstetrics and gynecology, 1981, Volume: 58, Issue:5 Suppl

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Cannabis; Diethylstilbestrol; Disease Model

1981
Mechanism of teratogenic action of thalidomide.
    Teratology, 1996, Volume: 53, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Extremities; Female; Humans; Immune System Dise

1996
Never-ending tales of the mode of the teratogenic action of thalidomide.
    Teratogenesis, carcinogenesis, and mutagenesis, 1997, Volume: 17, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; DNA Adducts; DNA Damage; Embryo, Mammalian; Female; Humans; Pr

1997
Drugs in pregnancy.
    The New England journal of medicine, 1998, Apr-16, Volume: 338, Issue:16

    Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E

1998
Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause?
    American journal of medical genetics, 1998, Jul-24, Volume: 78, Issue:4

    Topics: Adult; Fathers; Female; Fingers; Forearm; Genes, Dominant; Hand Deformities, Congenital; Humans; Inf

1998
The possibility of epigenetic transmission of defects induced by teratogens.
    Mutation research, 1998, Dec-03, Volume: 422, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Humans; Limb Deformities, Congenita

1998
The return of thalidomide: can birth defects be prevented?
    Drug safety, 1999, Volume: 21, Issue:3

    Topics: Adult; Animals; Congenital Abnormalities; Female; Humans; Leprostatic Agents; Male; Pregnancy; Terat

1999
Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses.
    Teratology, 1999, Volume: 60, Issue:5

    Topics: Eye Abnormalities; Female; History, 20th Century; HIV Infections; Humans; Infant, Newborn; Leprosy;

1999
[New therapeutic application of thalidomide].
    Duodecim; laaketieteellinen aikakauskirja, 1996, Volume: 112, Issue:7

    Topics: Autoimmune Diseases; Colitis, Ulcerative; Erythema Multiforme; Female; Histiocytosis; Humans; Immuno

1996
Hypothesis: thalidomide embryopathy-proposed mechanism of action.
    Teratology, 2000, Volume: 61, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female; Gene Expression Regul

2000
Diffuse and limited cutaneous systemic scleroderma.
    Current opinion in rheumatology, 2000, Volume: 12, Issue:5

    Topics: Adult; Anti-Inflammatory Agents; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplant

2000
[Eye muscle paralysis can increase the knowledge on autism].
    Lakartidningen, 2000, Nov-08, Volume: 97, Issue:45

    Topics: Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Facial Nerve; Female; Humans; Hypnotics

2000
[Fetal thalidomide syndrome].
    Ryoikibetsu shokogun shirizu, 2001, Issue:33

    Topics: Abnormalities, Drug-Induced; Female; Fetal Diseases; Humans; Hypnotics and Sedatives; Infant, Newbor

2001
[The thalidomide story and its lessons].
    Harefuah, 2001, Volume: 140, Issue:7

    Topics: Abnormalities, Drug-Induced; Anti-HIV Agents; Antineoplastic Agents; Female; Germany; History, 20th

2001
[New indications for thalidomide?].
    Deutsche medizinische Wochenschrift (1946), 2001, Oct-19, Volume: 126, Issue:42

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Angiogenesis Inhibitors; Animals; Anti-HIV Agents; A

2001
[Thalidomide--a dreaded drug with new indications].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001, Oct-20, Volume: 121, Issue:25

    Topics: Abnormalities, Drug-Induced; Anti-HIV Agents; Contraindications; Dermatologic Agents; Female; Histor

2001
Thalidomide: 40 years on.
    International journal of clinical practice, 2001, Volume: 55, Issue:9

    Topics: Anti-HIV Agents; Brazil; Drug and Narcotic Control; Female; Humans; Hypnotics and Sedatives; Immunos

2001
New concerns about thalidomide.
    Obstetrics and gynecology, 2002, Volume: 99, Issue:1

    Topics: Congenital Abnormalities; Drug Approval; Female; Guidelines as Topic; Humans; Infant, Newborn; Male;

2002
Molecular basis of environmentally induced birth defects.
    Annual review of pharmacology and toxicology, 2002, Volume: 42

    Topics: Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female; Gene Expression Regul

2002
Pathogenesis of congenital malformations. An hypothesis.
    American journal of surgery, 1978, Volume: 135, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Congenital Abnormalities; Female; Ganglia, Spi

1978
[Transplacental carcinogenesis].
    Vestnik Akademii meditsinskikh nauk SSSR, 1977, Issue:10

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Adenocarcinoma; Animals; Carcinogens;

1977
[Theoretical and applied aspects of experimental teratology].
    Ontogenez, 1977, Volume: 8, Issue:6

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dactinomycin; DNA Replication; Dose-Response Rela

1977
Drug-induced somatic alterations.
    Clinical obstetrics and gynecology, 1975, Volume: 18, Issue:4

    Topics: Abnormalities, Drug-Induced; Alcoholism; Animals; Anticonvulsants; Cannabis; Environmental Exposure;

1975
Embryological pigment epithelial dystrophies.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1976, Volume: 172, Issue:6

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Deafness; Female; Fluorescein Angiography; Human

1976
[Langerhans-cell histiocytosis in the adult: regressive parotid involvement following thalidomide therapy].
    Annales de dermatologie et de venereologie, 1992, Volume: 119, Issue:4

    Topics: Adult; Female; Histiocytosis, Langerhans-Cell; Humans; Intertrigo; Parotid Diseases; Pregnancy; Preg

1992
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
    Health care for women international, 1990, Volume: 11, Issue:4

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat

1990
A short history of thalidomide embryopathy.
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Humans; Male; Pregnancy; Radiography; Teratogens; Thalidomide

1988
Proposed mechanisms of action in thalidomide embryopathy.
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Embryo, Mammalian; Female; Humans; MEDLARS; Pregnancy; Teratogens; Thalidomide; United States

1988
Clinical and basic science lessons from the thalidomide tragedy: what have we learned about the causes of limb defects?
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Arm; Female; Humans; Infant, Newborn; Leg; Pregnancy; Teratogens; Thalidomide

1988
Monitoring for congenital malformations.
    Annual review of public health, 1986, Volume: 7

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Birth Certificates; England; Environmental Healt

1986
The thalidomide syndrome: risks of exposure and spectrum of malformations.
    Clinics in perinatology, 1986, Volume: 13, Issue:3

    Topics: Ectromelia; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Risk; Teratoge

1986
Testing drugs for teratogenicity and their effects on fertility. The present position.
    British medical bulletin, 1970, Volume: 26, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Cannabis; Chlormadinone Acetate; Female; Fertility; Fetal Deat

1970
[Experimental congenital heart diseases].
    Nihon rinsho. Japanese journal of clinical medicine, 1972, Volume: 30, Issue:1

    Topics: Animals; Chickens; Cricetinae; Dactinomycin; Disease Models, Animal; Dogs; Female; Folic Acid Defici

1972
Dermatoglyphics.
    American journal of obstetrics and gynecology, 1968, Aug-01, Volume: 101, Issue:7

    Topics: Abnormalities, Drug-Induced; Anemia, Sickle Cell; Anencephaly; Cerebral Palsy; Chromosome Aberration

1968
Phenocopies.
    Journal of medical genetics, 1973, Volume: 10, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Aplastic; Anorexia Nervosa; Arm; Cleft

1973
[Several problems of drug therapy in pregnancy].
    Iryo, 1971, Volume: 25, Issue:9

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Ca

1971
Thalidomide revisited.
    The Journal of the Oklahoma State Medical Association, 1972, Volume: 65, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Dogs; Female; Fetus; Humans; Pregnancy; Rats; Thalidomide

1972
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1972, Volume: 72, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent

1972
[Nutritional background and sensitivity of the organism to toxic substances].
    Gigiena i sanitariia, 1972, Volume: 37, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Diet; Dietary Carbohydrates; Dietary

1972
The Mondini type of cochlear malformation. A survey of the literature.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1972, Volume: 96, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Aged; Animals; Child, Presc

1972
Present status of drugs as teratogens in man.
    Teratology, 1973, Volume: 7, Issue:1

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics;

1973
Congenital malformations and environmental influence: the occupational environment of laboratory workers.
    Journal of occupational medicine. : official publication of the Industrial Medical Association, 1973, Volume: 15, Issue:9

    Topics: Abnormalities, Drug-Induced; Anesthetics; Anti-Bacterial Agents; Benzene; California; Congenital Abn

1973
Drugs in pregnancy and their effects on pre- and postnatal development.
    Research publications - Association for Research in Nervous and Mental Disease, 1973, Volume: 51

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Anticonvulsants; Antimetabolites; Central N

1973
The fetal and neonatal pig in biomedical research.
    Journal of animal science, 1974, Volume: 38, Issue:5

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Hypochromic; Animals; Animals, Laborat

1974
Principles of teratology.
    Obstetrics and gynecology annual, 1972, Volume: 1, Issue:0

    Topics: Abnormalities, Drug-Induced; Amniocentesis; Animals; Chromosome Aberrations; Chromosome Disorders; C

1972
Abnormalities of intrauterine development in non-human primates.
    Acta endocrinologica. Supplementum, 1972, Volume: 166

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic

1972
Certain causes of congenital malformations in Homo sapiens and their prevention.
    Journal of the Indian Medical Association, 1967, Dec-01, Volume: 49, Issue:11

    Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Aminopterin; Antigen-Antibody Reactions; Chromos

1967
The pathogenesis of congenital cardiovascular anomalies.
    The New England journal of medicine, 1968, Jul-11, Volume: 279, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Embryology; Female; Heart; Heart Defects, Conge

1968
[Teratogenic molecules].
    Hospital (Rio de Janeiro, Brazil), 1967, Volume: 72, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Drug-Related Side Effects and Adverse Reactions; Female; Human

1967
Etiology of congenital heart disease.
    Henry Ford Hospital medical journal, 1969,Summer, Volume: 17, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders;

1969
[Effect of drugs, ingested by the mother during pregnancy, on the fetus].
    Ginekologia polska, 1969, Volume: 40, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Meclizine; Pregnancy;

1969
[Some current problems of experimental teratology].
    Vestnik Akademii meditsinskikh nauk SSSR, 1967, Volume: 22, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Female; Hypoxia; Methods; Mice; Pregnancy; Rabbi

1967
[Fetal diseases caused by environmental polltuion].
    Sanfujinka no jissai. Practice of gynecology and obstetrics, 1971, Volume: 20, Issue:10

    Topics: Abnormalities, Drug-Induced; Air Pollution; Congenital Abnormalities; Environment; Environmental Pol

1971
[Experimental epidemiology].
    Saishin igaku. Modern medicine, 1971, Volume: 26, Issue:10

    Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Cleft Palate; Congenital Abnormalities; Diabe

1971
The heterogeneity of microphthalmia in the mentally retarded.
    Birth defects original article series, 1971, Volume: 7, Issue:3

    Topics: Abnormalities, Multiple; Abortifacient Agents; Adolescent; Adult; Brain Injuries; Child, Preschool;

1971
Malformations caused by drugs in pregnancy.
    American journal of diseases of children (1960), 1966, Volume: 112, Issue:2

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Cyclophosphamide; Female; Humans; Infant, Newborn

1966
Experimental and clinical chemoteratogenesis.
    Advances in pharmacology, 1966, Volume: 4

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Female; Hormones; Humans; In Vitro Tech

1966
The mechanism of thalidomide deformities correlated with the pathogenic effects of prolonged dosage in adults.
    Developmental medicine and child neurology, 1966, Volume: 8, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregna

1966

Trials

4 trials available for thalidomide and Pregnancy

ArticleYear
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
Thalidomide in America: a brush with tragedy.
    Clio medica (Amsterdam, Netherlands), 1976, Volume: 11, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Clinical Trials as Topic; Drug Evaluation; Fem

1976
[Fixed lupus erythematosus (its treatment with thalidomide)].
    Medicina cutanea ibero-latino-americana, 1977, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Lupus Erythemato

1977
New drug development.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1969, Volume: 2, Issue:2

    Topics: Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Female; History, 16th Cen

1969

Other Studies

554 other studies available for thalidomide and Pregnancy

ArticleYear
Thalidomide: history, withdrawal, renaissance, and safety concerns.
    Expert opinion on drug safety, 2021, Volume: 20, Issue:12

    Topics: Female; History, 20th Century; Humans; Immunosuppressive Agents; Pregnancy; Safety-Based Drug Withdr

2021
[Otorhinolaryngological diseases in pregnancy-which drugs are approved?]
    HNO, 2022, Volume: 70, Issue:3

    Topics: Child; Female; Humans; Otorhinolaryngologic Diseases; Pharmaceutical Preparations; Pregnancy; Thalid

2022
Unveiling the masked native blood group following thalidomide therapy in a thalassemia patient: A 5 WHY analysis approach.
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2022, Volume: 61, Issue:4

    Topics: Adult; Blood Group Antigens; Blood Grouping and Crossmatching; Female; Humans; Pregnancy; Rh-Hr Bloo

2022
Clinical trials in pregnancy and the "shadows of thalidomide": Revisiting the legacy of Frances Kelsey.
    Contemporary clinical trials, 2022, Volume: 119

    Topics: Clinical Trials as Topic; Female; France; Humans; Pregnancy; Thalidomide; United States; United Stat

2022
Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies.
    Annals of hematology, 2022, Volume: 101, Issue:9

    Topics: Animals; Cell Membrane Permeability; Female; Hematologic Neoplasms; Humans; Lenalidomide; Multiple M

2022
Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:1

    Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Female; Humans; Microsomes, Liver; Oxidation-Red

2023
Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy.
    Birth defects research, 2022, 12-01, Volume: 114, Issue:20

    Topics: Abnormalities, Multiple; Basic Helix-Loop-Helix Transcription Factors; Female; Fetal Diseases; Genet

2022
Embryo-fetal exposure and developmental outcome of lenalidomide following oral administration to pregnant cynomolgus monkeys.
    Reproductive toxicology (Elmsford, N.Y.), 2022, Volume: 114

    Topics: Administration, Oral; Animals; Cesarean Section; Female; Lenalidomide; Macaca fascicularis; Placenta

2022
Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Dec-01, Volume: 140

    Topics: Alkynes; Benzoxazines; Computer Simulation; Cyclopropanes; Cytochrome P-450 Enzyme System; Female; F

2019
Thalidomide leads to mandible hypoplasia through inhibiting angiogenesis and secondary hemorrhage in the fetal craniofacial region in rabbits.
    Toxicology letters, 2020, Feb-01, Volume: 319

    Topics: Animals; Craniofacial Abnormalities; Down-Regulation; Female; Hemorrhage; Mandible; Maxillofacial Ab

2020
Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.
    Pediatrics, 2020, Volume: 146, Issue:Suppl 1

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Ethics, Research; Female; Hu

2020
Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2021, Volume: 132, Issue:2

    Topics: Autoimmune Diseases; Cesarean Section; Female; Humans; Methylprednisolone; Pemphigus; Pregnancy; Tha

2021
"The legacy of thalidomide" - A multidisciplinary meeting held at the University of York, United Kingdom, on September 30, 2016.
    Birth defects research, 2017, Mar-01, Volume: 109, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Aging; Child; Disabled Persons; Female; Humans; Hypnotics and Se

2017
Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:3

    Topics: Cells, Cultured; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Humans; Liver; Oxidation-Reductio

2017
Efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/\ refractory multiple myeloma: a real-life experience
    Turkish journal of medical sciences, 2018, Aug-16, Volume: 48, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol

2018
[Anatomist, Anti-Abortionist, Anti-Darwinian. The three lives of Erich Blechschmidt (1904–1992)].
    Medizinhistorisches Journal, 2016, Volume: 51, Issue:3

    Topics: Abortion, Induced; Anatomists; Animals; Biological Evolution; Embryonic Development; Female; History

2016
The health and quality of life of Thalidomide survivors as they age - Evidence from a UK survey.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Adult; Aging; Anxiety; Depression; Employment; Female; Humans; Hypnotics and Sedatives; Male; Middle

2019
[Upcoming challenges in providing care for thalidomide impaired individuals].
    Pflege, 2019, Volume: 32, Issue:3

    Topics: Child; Cross-Sectional Studies; Female; Germany; Humans; Pregnancy; Prenatal Exposure Delayed Effect

2019
Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats.
    Congenital anomalies, 2020, Volume: 60, Issue:3

    Topics: Acoustic Stimulation; Animals; Autistic Disorder; Brain Stem; Female; Hyperacusis; Immunosuppressive

2020
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
    Scientific reports, 2019, 08-06, Volume: 9, Issue:1

    Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C

2019
[Independence of former Contergan children compromised].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2013, Volume: 32, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Pregn

2013
More drug studies need to include pregnant women, says bulletin.
    BMJ (Clinical research ed.), 2013, Jun-14, Volume: 346

    Topics: Anticonvulsants; Clinical Trials as Topic; Drug Industry; Female; Humans; Hypnotics and Sedatives; M

2013
Myeloma presenting during pregnancy.
    Hematological oncology, 2014, Volume: 32, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cesarean Section;

2014
Concern for truth: driving defensively when confronting a zombie epidemic.
    Journal of psychosocial nursing and mental health services, 2013, Volume: 51, Issue:11

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor

2013
Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring.
    Environmental toxicology, 2013, Volume: 28, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Brain; Cerebral Arteries; Dopamine; Female; Fetu

2013
Common nature in the effects of thalidomide on embryo-fetal development in Kbl:JW and Kbl:NZW rabbits.
    Congenital anomalies, 2014, Volume: 54, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic

2014
Effects of thalidomide on Fgf8, Bmp4 and Hoxa11 expression in the limb bud in Kbl:JW rabbit embryos.
    Congenital anomalies, 2014, Volume: 54, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Bone Morphogenetic Protein 4; Embryo, Mammalian; Embryonic Dev

2014
'Something there is that doesn't love a wall': histories of the placental barrier.
    Studies in history and philosophy of biological and biomedical sciences, 2014, Volume: 47 Pt B

    Topics: Attitude of Health Personnel; Behavior; Female; Fetal Development; Fetus; History, 20th Century; Hum

2014
Professor David Poswillo CBE (1927-2003): Skilled oral and maxillofacial surgeon, influential scientist, teacher and adviser.
    Journal of medical biography, 2014, Volume: 22, Issue:1

    Topics: Animals; Cleft Palate; England; Faculty, Dental; Female; History, 20th Century; History, 21st Centur

2014
Cases of babies in Brazil born with thalidomide defects.
    Monash bioethics review, 2013, Volume: 31, Issue:2

    Topics: Abnormalities, Drug-Induced; Brazil; Drug Repositioning; Ethics, Pharmacy; Female; Humans; Infant; M

2013
50 years ago in the Journal of pediatrics: Drug testing in animals for teratogenic effects. Thalidomide in the pregnant rat.
    The Journal of pediatrics, 2014, Volume: 164, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Female; History, 20th Century; Models, Animal; Pediatrics; Per

2014
Embryo-fetal exposure and developmental outcome of thalidomide following oral and intravaginal administration to pregnant rabbits.
    Reproductive toxicology (Elmsford, N.Y.), 2014, Volume: 48

    Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Administration, Oral; Animals; Embryo, Ma

2014
A peek into the atomic details of thalidomide's clinical effects.
    Nature structural & molecular biology, 2014, Volume: 21, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Female; Humans; Models, Molecu

2014
Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin.
    Biochemistry, 2015, Mar-31, Volume: 54, Issue:12

    Topics: Binding Sites; Cell Proliferation; Female; Humans; Isoindoles; Kinetics; MCF-7 Cells; Microtubules;

2015
Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil.
    Reproductive toxicology (Elmsford, N.Y.), 2015, Volume: 53

    Topics: Abnormalities, Drug-Induced; Brazil; Drug Prescriptions; Female; Humans; Infant, Newborn; Leprosy; P

2015
Bullous erythema nodosum leprosum manifesting in the post partum period with unusual features.
    Leprosy review, 2015, Volume: 86, Issue:1

    Topics: Adult; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromato

2015
[Risk Management of Teratogenic Drugs ~The Current States of Practice in Europe, US and Japan~].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2015, Volume: 135, Issue:10

    Topics: Contraception; Europe; Female; Humans; Japan; Male; Pregnancy; Risk Management; Teratogens; Thalidom

2015
Drugs in Pregnancy.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2015, Volume: 37, Issue:6

    Topics: Female; History, 20th Century; Humans; Pharmaceutical Preparations; Pregnancy; Prenatal Exposure Del

2015
Attacking the devil: the thalidomide story.
    BMJ (Clinical research ed.), 2016, Jan-21, Volume: 352

    Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Europe; Female; History, 20th Century; Humans; Male

2016
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.
    Scientific reports, 2016, Feb-23, Volume: 6

    Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Embryo

2016
Zika: Worse Than Thalidomide?
    JAMA, 2016, Sep-27, Volume: 316, Issue:12

    Topics: Adult; Caribbean Region; Craniofacial Abnormalities; Female; Humans; Outcome Assessment, Health Care

2016
Internal anomalies in thalidomide embryopathy: results of imaging screening by CT and MRI.
    Clinical radiology, 2016, Volume: 71, Issue:11

    Topics: Abnormalities, Multiple; Causality; Female; Gallbladder; Humans; Japan; Liver; Magnetic Resonance Im

2016
Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation.
    European journal of medical genetics, 2017, Volume: 60, Issue:1

    Topics: Abnormalities, Drug-Induced; Angiotensin-Converting Enzyme Inhibitors; Animals; Female; Fetal Diseas

2017
Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade.
    Molecules (Basel, Switzerland), 2016, Oct-07, Volume: 21, Issue:10

    Topics: Adolescent; Adult; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; Dose-Response Rel

2016
Effectiveness of Risk Evaluation and Mitigation Strategies (REMS) for Lenalidomide and Thalidomide: Patient Comprehension and Knowledge Retention.
    Drug safety, 2017, Volume: 40, Issue:4

    Topics: Adolescent; Adult; Child; Comprehension; Contraception; Female; Follow-Up Studies; Health Knowledge,

2017
A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica.
    Reproductive toxicology (Elmsford, N.Y.), 2017, Volume: 70

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic Development; Female; Models, Anim

2017
RevAssist: a comprehensive risk minimization programme for preventing fetal exposure to lenalidomide.
    Drug safety, 2008, Volume: 31, Issue:9

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Female; Fetus; Humans; Lenalidomide; Male; Mater

2008
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions.
    Microvascular research, 2009, Volume: 77, Issue:2

    Topics: Adherens Junctions; Angiogenesis Inhibitors; Animals; Antigens, CD; Antineoplastic Agents; Basic Hel

2009
A 24-year-old pregnant woman with inflammatory bowel disease.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009, Volume: 7, Issue:9

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Breast Feeding; Crohn Disease; Female; Fetus; Huma

2009
[Thalidomide (Contergan) induced limb deficiency in Hungary?].
    Orvosi hetilap, 2009, Jun-21, Volume: 150, Issue:25

    Topics: Diagnosis, Differential; Female; Femur; Fibula; Humans; Hungary; Lower Extremity Deformities, Congen

2009
Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 29, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Female; Gene Expression; Gene Expression Profiling; Gestationa

2010
Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat.
    Neuroscience research, 2010, Volume: 66, Issue:1

    Topics: Age Factors; Animals; Autistic Disorder; Disease Models, Animal; Exploratory Behavior; Female; Inter

2010
Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models.
    Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:2

    Topics: Animals; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dose-Res

2010
[Reinventing thalidomide under high supervision].
    Annales pharmaceutiques francaises, 2010, Volume: 68, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Aged; Antineoplastic Agents; Device Approval; Female; History, 2

2010
Les bébés du thalidomide.
    Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:3

    Topics: Abnormalities, Drug-Induced; Drug Industry; Ectromelia; Female; France; History, 20th Century; Human

2011
Frances Kelsey honored for FDA legacy: award notes her work on thalidomide, clinical trials.
    JAMA, 2010, Nov-17, Volume: 304, Issue:19

    Topics: Awards and Prizes; Clinical Trials as Topic; Drug Approval; Ectromelia; Europe; Female; History, 20t

2010
What has happened to people affected by thalidomide 50 years on?
    Irish journal of medical science, 2011, Volume: 180, Issue:2

    Topics: Activities of Daily Living; Adult; Arm; Disabled Persons; Female; Health Status; Humans; Leg; Male;

2011
Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; DNA Damage; DNA Glycosylases; DNA Repair; DNA Repair-Deficienc

2011
Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationsh

2011
Thalidomide: the tragedy of birth defects and the effective treatment of disease.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:1

    Topics: Abnormalities, Drug-Induced; Angiogenesis Inhibitors; Animals; Dose-Response Relationship, Drug; Ect

2011
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Abnormalities, Drug-Induced; Adult; Brazil; Female; Fetal Diseases; Geography; Humans; Infant, Newbo

2011
US lawsuit extends thalidomide's reach.
    Nature, 2011, Nov-10, Volume: 479, Issue:7372

    Topics: Animals; Chick Embryo; Congenital Abnormalities; Drug Industry; Ectromelia; Female; Humans; Liabilit

2011
Carbamazepine use in pregnancy and coincidental thalidomide-like phocomelia in a newborn.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2012, Volume: 32, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Ectromelia; Female; Humans; Infant, New

2012
Adaptive toothbrush handle: case report of a Thalidomide patient.
    The European journal of prosthodontics and restorative dentistry, 2012, Volume: 20, Issue:2

    Topics: Dental Devices, Home Care; Dental Plaque Index; Ectromelia; Equipment Design; Female; Humans; Male;

2012
The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals.
    QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:12

    Topics: Abnormalities, Drug-Induced; Animals; Child; Drug Costs; Female; Humans; Jurisprudence; Licensure; M

2012
Correspondence.
    Birth defects research. Part A, Clinical and molecular teratology, 2012, Volume: 94, Issue:9

    Topics: Adenocarcinoma; Adolescent; Adult; Diethylstilbestrol; Female; Humans; Incidental Findings; Limb Def

2012
[Thalidomide: this "mea culpa" which isn't one].
    Revue medicale suisse, 2012, Sep-12, Volume: 8, Issue:353

    Topics: Child, Preschool; Dissent and Disputes; Drug Industry; Female; Germany; Humans; Jurisprudence; Limb

2012
Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort.
    European journal of neurology, 2013, Volume: 20, Issue:3

    Topics: Antiemetics; Australasia; Australia; Cohort Studies; Disease Progression; Female; Humans; Male; Midd

2013
Regarding how safe is "safe"?
    Birth defects research. Part A, Clinical and molecular teratology, 2013, Volume: 97, Issue:1

    Topics: Adenocarcinoma; Diethylstilbestrol; Female; Humans; Limb Deformities, Congenital; Pregnancy; Rubella

2013
[Thalidomide epidemics: 50 years after].
    Casopis lekaru ceskych, 2012, Volume: 151, Issue:12

    Topics: Abnormalities, Drug-Induced; Female; History, 20th Century; Humans; Infant; Limb Deformities, Congen

2012
Development of an in vitro system detecting pro-embryotoxin.
    Japanese journal of pharmacology, 2002, Volume: 89, Issue:3

    Topics: Animals; Benzo(a)pyrene; Biological Assay; Cell Survival; Cells, Cultured; Dose-Response Relationshi

2002
Offspring of male and female parents with thalidomide embryopathy: birth defects and functional anomalies.
    Teratology, 2002, Volume: 66, Issue:3

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Congenital Abnormalities; F

2002
Thalidomide prescribers cannot assign survey responsibility to pharmacists.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, Sep-15, Volume: 59, Issue:18

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Data Collection; Drug Prescriptions; Female; Hum

2002
Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism.
    Pediatric research, 2002, Volume: 52, Issue:4

    Topics: Animals; Autistic Disorder; Biogenic Monoamines; Brain; Female; Pregnancy; Rats; Rats, Sprague-Dawle

2002
Thalidomide in multiple myeloma: current status and future prospects.
    British journal of haematology, 2003, Volume: 120, Issue:1

    Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Angiogenesis Inhibitors; Antineoplastic Combine

2003
A proposed primate animal model of autism.
    European child & adolescent psychiatry, 2003, Volume: 12, Issue:1

    Topics: Animals; Animals, Newborn; Autistic Disorder; Child; Disease Models, Animal; Female; Haplorhini; Hum

2003
Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:4

    Topics: Animals; Antibodies; Antioxidants; Blotting, Western; Cell Count; Cell Division; Cell Survival; Cell

2003
Thalidomide makes a comeback.
    RN, 2003, Volume: 66, Issue:5

    Topics: Abnormalities, Drug-Induced; Angiogenesis Inhibitors; Ectromelia; Erythema Nodosum; Female; Humans;

2003
Research with pregnant women and fetuses: update on the ethics and the law.
    Journal of nursing law, 2000, Volume: 7, Issue:3

    Topics: Clinical Trials as Topic; Embryo Research; Ethics, Research; Female; Fetal Research; Fetus; Governme

2000
Trial of thalidomide in insomnia associated with the third trimester.
    American journal of obstetrics and gynecology, 1961, Volume: 81

    Topics: Female; Humans; Hypnotics and Sedatives; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Th

1961
Drugs in pregnancy--thalidomide.
    The Journal of pediatrics, 1962, Volume: 61

    Topics: Congenital Abnormalities; Hypnotics and Sedatives; Pregnancy; Thalidomide

1962
Thalidomide: effect upon pregnancy in the rhesus monkey.
    Science (New York, N.Y.), 1963, Mar-29, Volume: 139, Issue:3561

    Topics: Animals; Embryo Implantation; Female; Macaca mulatta; Pregnancy; Pregnancy, Animal; Thalidomide

1963
Passage of drugs across the placenta.
    American journal of obstetrics and gynecology, 1962, Dec-01, Volume: 84

    Topics: Anesthetics; Anti-Bacterial Agents; Atropa belladonna; Barbiturates; Female; Humans; Hypnotics and S

1962
[Consumption of drugs by pregnant women after the thalidomide warning].
    Social-Medicinsk tidskrift, 1963, Volume: 40

    Topics: Biological Phenomena; Female; Humans; Pharmaceutical Preparations; Physiological Phenomena; Pregnanc

1963
[Consumption of drugs by pregnant women after the thalidomide warning. Supplement to Part I, section of "Statistical information on drug consumption"].
    Social-Medicinsk tidskrift, 1963, Volume: 40

    Topics: Biometry; Dietary Supplements; Female; Humans; Pharmaceutical Preparations; Pregnancy; Thalidomide

1963
Phocomelic deformity and maternal thalidomide administration. A report of four cases.
    The British journal of radiology, 1962, Volume: 35

    Topics: Ectromelia; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Thalidomide

1962
Drugs and congenital abnormalities.
    Lancet (London, England), 1963, Mar-02, Volume: 1, Issue:7279

    Topics: Animals; Female; Fetal Death; Pregnancy; Pregnancy, Animal; Thalidomide

1963
[Initial statistical elements relative to congenital malformations in Belgium].
    Archives belges de medecine sociale, hygiene, medecine du travail et medecine legale. Belgisch archief van sociale geneeskunde, hygiene, arbeidsgeneeskunde en gerechtelijke geneeskunde, 1963, Volume: 21

    Topics: Belgium; Biometry; Congenital Abnormalities; Diabetes Mellitus; Female; Humans; Pregnancy; Pregnancy

1963
[Nil nocere: Roentgen examination in pregnancy after thalidomide use?].
    Munchener medizinische Wochenschrift (1950), 1962, Oct-05, Volume: 104

    Topics: Abortion, Induced; Abortion, Spontaneous; Abortion, Therapeutic; Congenital Abnormalities; Female; H

1962
[The significance of new exogenous noxae for the developmental damage of germ cells and ova and their prevention].
    Wiener medizinische Wochenschrift (1946), 1962, Oct-13, Volume: 112

    Topics: Abortion, Induced; Congenital Abnormalities; Ectromelia; Female; Fetal Death; Germ Cells; Iatrogenic

1962
[Thalidomide and abnormalities of development].
    Orvosi hetilap, 1962, Dec-30, Volume: 103

    Topics: Animals; Congenital Abnormalities; Female; Pregnancy; Pregnancy, Animal; Thalidomide

1962
[On the increase in deformities of the extremities and external ear since 1960 with reference to exogenous factors].
    Geburtshilfe und Frauenheilkunde, 1962, Volume: 22

    Topics: Congenital Abnormalities; Ear Deformities, Acquired; Ear, External; Extremities; Female; Humans; Pre

1962
[Influence of increasing doses of glutethimide (Doriden) on pregnancy and fetal development in the rabbit].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1963, Volume: 157

    Topics: Animals; Congenital Abnormalities; Female; Fetal Development; Glutethimide; Leadership; Pregnancy; P

1963
Phocomelia: report of three cases.
    Canadian Medical Association journal, 1962, Oct-06, Volume: 87

    Topics: Death; Ectromelia; Female; Humans; Infant; Infant, Newborn; Mothers; Pregnancy; Thalidomide

1962
[CONTINUOUS RISE IN THE INCIDENCE OF PHOCOMELIA IN NEWBORN INFANTS IN WESTERN EUROPE AND ITS RELATION TO THALIDOMIDE ADMINISTRATION. CURRENT STATUS OF THE PROBLEM].
    Casopis lekaru ceskych, 1963, May-24, Volume: 102

    Topics: Abnormalities, Drug-Induced; Drug Tolerance; Ectromelia; Europe; Female; Germany; Germany, West; Inc

1963
[1ST CASE REPORT FROM FORMOSA OF A CONGENITAL ANOMALY PROBABLY INDUCED BY THALIDOMIDE].
    [Tsa chih] [Journal of the] Alumni of the University of Takau. Gaoxiong yi xue yuan. Tong xue hui, 1962, Nov-28, Volume: 61

    Topics: Abnormalities, Drug-Induced; Arm; China; Hand; Pregnancy; Taiwan; Thalidomide; Toxicology

1962
[PSYCHIATRIC USE OF SOME PSYCHOPHARMACOLOGICAL DRUGS IN PREGNANCY].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1963, Jun-30, Volume: 87

    Topics: Chlordiazepoxide; Chlorpromazine; Fetus; Haloperidol; Imipramine; Isocarboxazid; Meprobamate; Nialam

1963
[MEDICAL THERAPY IN PREGNANCY AND ITS REPERCUSSIONS ON THE FETUS].
    Minerva ginecologica, 1963, Jul-31, Volume: 15

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androgens; Anti-Bacterial Agents; Anticoagulan

1963
CANADIAN THALIDOMIDE EXPERIENCE.
    Canadian Medical Association journal, 1963, Nov-09, Volume: 89

    Topics: Abnormalities, Drug-Induced; Canada; Ectromelia; Extremities; Female; Fetal Death; Humans; Infant; I

1963
[EFFECT OF DRUGS ON THE DEVELOPMENT OF THE FETUS WITH REFERENCE TO THE TERATOGENIC EFFECT OF THALIDOMIDE].
    Ceskoslovenska farmacie, 1963, Volume: 12

    Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Female; Fetus; Humans; Pharmacology; Pregnancy; Te

1963
CONGENITAL DEFORMITIES ASSOCIATED WITH THE USE OF THALIDOMIDE DURING PREGNANCY, BRITISH COLUMBIA, 1961-62.
    Canadian journal of public health = Revue canadienne de sante publique, 1963, Volume: 54

    Topics: Abnormalities, Drug-Induced; British Columbia; Canada; Ectromelia; Humans; Infant, Newborn; Infant,

1963
[PHOCOMELIA SYNDROME CAUSED BY THALIDOMIDE].
    Chirurgia italiana, 1963, Volume: 15

    Topics: Ectromelia; Female; Infant, Newborn; Pregnancy; Pregnancy Complications; Radiography; Syndrome; Thal

1963
INFLUENCE OF THE ENVIRONMENT ON THE UNBORN.
    California medicine, 1963, Volume: 99

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Communicable Diseases; Congenital Abnormalities;

1963
THE EFFECT OF THALIDOMIDE ON THE UNBORN PUPPY.
    Proceedings of the staff meetings. Mayo Clinic, 1963, Nov-06, Volume: 38

    Topics: Abnormalities, Drug-Induced; Animals; Dogs; Extremities; Female; Humans; Pregnancy; Pregnancy, Anima

1963
DRUG EMBRYOPATHY: THE THALIDOMIDE STORY.
    Maryland state medical journal, 1963, Volume: 12

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Female; Fetal Diseases; Glutethimide; Humans; In

1963
[HOW TO EXPLAIN THE TERATOGENIC ACTION OF THALIDOMIDE].
    Clinique (Paris, France), 1963, Volume: 58

    Topics: Abnormalities, Drug-Induced; Ectromelia; Pregnancy; Teratogenesis; Teratogens; Thalidomide; Toxicolo

1963
EFFECTS OF PARENTAL THALIDOMIDE TREATMENT ON GESTATION AND FETAL DEVELOPMENT.
    Experimental and molecular pathology. Supplement, 1963, Volume: 2

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Development; Humans; Lagomorpha; Maternal-Fetal

1963
[TERATOGENIC ACTION OF DRUGS IN THE PREGNANT WOMAN].
    Journal des sciences medicales de Lille, 1963, Volume: 81

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Avitaminosis; Chlorpromazine; Cortisone; Female;

1963
[CASE OF TOTAL AMELIA THOUGHT TO BE DUE TO THALIDOMIDE].
    Nihon Sanka Fujinka Gakkai zasshi, 1963, Volume: 15

    Topics: Abnormalities, Drug-Induced; Ectromelia; Extremities; Infant, Newborn; Pregnancy; Radiography; Thali

1963
THALIDOMIDE INDUCED ALTERATIONS IN THE BLASTOCYST AND PLACENTA OF THE ARMADILLO, DASYPUS NOVEMCINCTUS MEXICANUS, INCLUDING A CHORIOCARCINOMA.
    The American journal of pathology, 1963, Volume: 43

    Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Abortion, Veterinary; Animals

1963
EFFECTS OF THALIDOMIDE IN THE RAT FOETUS.
    Experientia, 1963, Dec-15, Volume: 19

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetus; Humans; Maternal-Fetal Exchan

1963
[DRUG CONSUMPTION BY PREGNANT WOMEN AFTER CAUTIONS ON THALIDOMIDE. II. III].
    Social-Medicinsk tidskrift, 1963, Volume: 40

    Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Health Education; Humans; Pharmaceutical Preparati

1963
[CONGENITAL MALFORMATIONS IN JAPAN].
    [Sogo rinsho] Clinic all-round, 1963, Volume: 12

    Topics: Abnormalities, Drug-Induced; Classification; Congenital Abnormalities; Infant, Newborn; Japan; Pregn

1963
[THE CONGENITAL ABNORMALITY, PHOCOMELIA, CAUSED BY CHEMICAL SUBSTANCES].
    [Sogo rinsho] Clinic all-round, 1963, Volume: 12

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Ectromelia; Female; Guinea Pigs; Humans; Pha

1963
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY 1960-1961.
    The South Dakota journal of medicine and pharmacy, 1964, Volume: 17

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fetal Diseases; Geriatrics; Germany; Germany,

1964
TERATOGENIC ACTIVITY OF DRUGS.
    The Journal of pharmacy and pharmacology, 1964, Volume: 16

    Topics: Abnormalities, Drug-Induced; Fetal Death; Guanethidine; Pregnancy; Rats; Research; Reserpine; Thalid

1964
TERATOGENIC ACTION OF THALIDOMIDE.
    Lancet (London, England), 1964, Mar-28, Volume: 1, Issue:7335

    Topics: Abnormalities, Drug-Induced; Female; Folic Acid; Glutamine; Niacinamide; Pregnancy; Pregnancy Compli

1964
EFFECT OF METHAQUALONE HYDROCHLORIDE IN PREGNANT RABBITS AND RATS.
    Nature, 1963, Nov-16, Volume: 200

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Hypnotics and Sedatives; Methaqualone; Pregnan

1963
[THALIDOMIDE EMBRYOPATHIES IN MILANO AND SUBURBS. ANATOMO-CLINICAL STUDY].
    Minerva pediatrica, 1963, Nov-17, Volume: 15

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Biomedical Research; Ectromelia; Fetal Disease

1963
[TOXIC AND TERATOGENIC EFFECTS OF THALIDOMIDE ON A RABBIT FETUS].
    Schweizerische medizinische Wochenschrift, 1963, Nov-02, Volume: 93

    Topics: Abnormalities, Drug-Induced; Animals, Newborn; Ectromelia; Fetal Diseases; Fetus; Pregnancy; Pregnan

1963
THALIDOMIDE: EFFECTS ON ENZYMES OF GLUTAMIC ACID METABOLISM IN MICE.
    Science (New York, N.Y.), 1964, Mar-20, Volume: 143, Issue:3612

    Topics: Aspartate Aminotransferases; Brain; Carboxy-Lyases; Embryo, Mammalian; Embryo, Nonmammalian; Glutama

1964
[DRUG USE DURING PREGNANCY AFTER DISCOVERY OF THALIDOMIDE EMBRYOPATHY].
    Deutsche medizinische Wochenschrift (1946), 1964, Feb-21, Volume: 89

    Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Ectromelia; Female;

1964
[CONGENITAL MALFORMATIONS OF SKELETON IN RABBITS].
    Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 10

    Topics: Abnormalities, Drug-Induced; Animals; Bone Diseases; Female; Humans; Lagomorpha; Mucopolysaccharidos

1964
[TERATOGENIC SUBSTANCES?].
    Medizinische Klinik, 1964, Jan-31, Volume: 59

    Topics: Abnormalities, Drug-Induced; Ectromelia; Fetal Diseases; Infant, Newborn; Meclizine; Phenmetrazine;

1964
[A NEW THALIDOMIDE CASE].
    Nordisk medicin, 1964, Apr-23, Volume: 71

    Topics: Abnormalities, Drug-Induced; Arm; Hand Deformities; Infant, Newborn; Pregnancy; Radiography; Radius;

1964
THE TERATOGENIC EFFECTS OF THALIDOMIDE, IMIPRAMINE HC1 AND IMIPRAMINE-N-OXIDE HC1 ON WHITE DANISH RABBITS.
    Acta pharmacologica et toxicologica, 1963, Volume: 20

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetal Diseases; Humans; Imipramine;

1963
[TERSTOGENIC SUBSTANCES?].
    Medizinische Klinik, 1963, Dec-13, Volume: 58

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meclizine; Ph

1963
PSYCHIATRIC INDICATIONS FOR THERAPEUTIC ABORTION AND STERILIZATION.
    Clinical obstetrics and gynecology, 1964, Volume: 13

    Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Therapeutic; Depression; Family; Female; H

1964
[THALIDOMIDE SYNDROME AND THE TREATMENT OF THALIDOMIDE CASES].
    Ugeskrift for laeger, 1964, Mar-26, Volume: 126

    Topics: Abnormalities, Drug-Induced; Hand Deformities; Infant, Newborn; Pregnancy; Syndrome; Thalidomide; To

1964
[ACTION ON PREGNANCY AND FETAL DEVELOPMENT OF A GLUTARIMIC DERIVATIVE, ATURBANE].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1964, Mar-02, Volume: 258

    Topics: Abnormalities, Drug-Induced; Animals; Fetal Development; Fetus; Hypnotics and Sedatives; Lagomorpha;

1964
[INVESTIGATION ON THE POSSIBLE RELATION OF FETAL INJURIES AND DRUGS. IV. RETROSPECTIVE STUDY ON DRUG CONSUMPTION AMONG MOTHERS WITH MALFORMED CHILDREN].
    Svenska lakartidningen, 1964, Mar-18, Volume: 61

    Topics: Abnormalities, Drug-Induced; Diphenhydramine; Down Syndrome; Fetal Diseases; Hip Dislocation; Hip Di

1964
THE RELATIONSHIP BETWEEN GROUP COMPOSITION AND DRUG ACTION IN MICE.
    Psychopharmacologia, 1964, Mar-11, Volume: 5

    Topics: Animals; Behavior, Animal; Female; Humans; Mice; Pharmacology; Pregnancy; Research; Thalidomide

1964
[THALIDOMIDE ABNORMALITIES].
    [Sanfujinka chiryo] Obstetrical and gynecological therapy, 1964, Volume: 9

    Topics: Abnormalities, Drug-Induced; Child; Child Care; Child Welfare; Ectromelia; Humans; Infant, Newborn;

1964
REPORT FROM THE DUKE UNIVERSITY POISON CONTROL CENTER. DRUG DANGERS (MATERNAL MEDICATION) TO THE FETUS.
    North Carolina medical journal, 1964, Volume: 25

    Topics: Abnormalities, Drug-Induced; Aminopterin; Anti-Bacterial Agents; Antimetabolites; Chloramphenicol; C

1964
DRUG TESTING IN ANIMALS FOR TERATOGENIC EFFECTS. THALIDOMIDE IN THE PREGNANT RAT.
    The Journal of pediatrics, 1964, Volume: 64

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryo, Nonmammalian; Female; Humans; Injec

1964
[THE PATHOGENESIS OF VARIOUS EXTERNAL MALFORMATIONS AS A CONSEQUENCE OF EXOGENOUS STIMULI IN MAMMALS].
    Die Medizinische Welt, 1963, Dec-14, Volume: 50

    Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Ectromelia; Female; Humans; Lagomorpha; Mamm

1963
MAMMALIAN BLASTOPATHIOS DUE TO DRUGS.
    Nature, 1964, Mar-21, Volume: 201

    Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Female; Humans; Mammals; Mechlorethamine; Pr

1964
IDENTIFICATION OF THALIDOMIDE IN RABBIT BLASTOCYSTS.
    Nature, 1964, Mar-14, Volume: 201

    Topics: Animals; Blastocyst; Carbon Isotopes; Chromatography; Embryo, Mammalian; Embryo, Nonmammalian; Femal

1964
MALFORMATIONS INDUCED IN THE MOUSE BY THALIDOMIDE.
    The Anatomical record, 1964, Volume: 149

    Topics: Abnormalities, Drug-Induced; Animals; Bone Diseases; Embryo, Mammalian; Embryo, Nonmammalian; Female

1964
THALIDOMIDE EMBRYOPATHY IN HYBRID RABBITS.
    The New England journal of medicine, 1964, Aug-27, Volume: 271

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Extremities; Female; Fetal Diseases; Humans; K

1964
THE USE OF SWINE IN DRUG TOXICITY STUDIES.
    Annals of the New York Academy of Sciences, 1964, Apr-24, Volume: 111

    Topics: Abnormalities, Drug-Induced; Amphotericin B; Animals; Drug-Related Side Effects and Adverse Reaction

1964
[RESEARCH ON THE TERATOGENIC EFFECT OF 2-DIETHYLAMINOPROPIOPHENONE].
    Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 10

    Topics: Abnormalities, Drug-Induced; Animals; Diethylpropion; Female; Humans; Mice; Pregnancy; Rats; Researc

1964
EFFECTS OF D,1-3-PHTHALIMIDOGLUTARIMIDE AND N-PHTHALYL-D,L-ASPARTIMIDE ON RAT PREGNANCY.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Abnormalities, Drug-Induced; Animals; Aspartic Acid; Female; Humans; Imides; Pharmacology; Phthalic

1963
[ON POTENTIATION OF THE EMBRYOTOXIC EFFECTS OF THALIDOMIDE IN THE FEMALE RAT].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Pharmacology; Pregnancy; Rats; Research; Ribof

1964
[METHODS AND PROBLEMS IN EXPERIMENTAL DRUG-INDUCED TERATOGENESIS].
    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1964, Volume: 20

    Topics: Abnormalities, Drug-Induced; Animals; Drugs, Investigational; Female; Humans; Lagomorpha; Pregnancy;

1964
[REPERCUSSIONS OF NEUROLEPTIC AND ANTITUMOR AGENTS ON PRENATAL DEVELOPMENT].
    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1964, Volume: 20

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ant

1964
AUTORADIOGRAPHIC INVESTIGATIONS OF 14-C-LABELLED THALIDOMIDE AND GLUTETHIMIDE IN PREGNANT MICE.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 116

    Topics: Abnormalities, Drug-Induced; Animals; Female; Glutethimide; Humans; Maternal-Fetal Exchange; Metabol

1964
OCULAR DEFECTS IN THALIDOMIDE BABIES.
    The British journal of ophthalmology, 1964, Volume: 48

    Topics: Abnormalities, Drug-Induced; Eye; Eye Diseases; Female; Humans; Infant; Infant, Newborn; Infant, New

1964
EFFECTS OF THALIDOMIDE ON PREGNANCY IN THE RABBIT.
    Journal of reproduction and fertility, 1964, Volume: 8

    Topics: Abnormalities, Drug-Induced; Animals; Cell Biology; Embryo, Mammalian; Embryo, Nonmammalian; Female;

1964
[THALIDOMIDE AND EAR-MALFORMATION].
    Nihon Jibiinkoka Gakkai kaiho, 1964, Volume: 67

    Topics: Abnormalities, Drug-Induced; Ear, External; Humans; Infant; Pregnancy; Thalidomide; Toxicology

1964
THE EFFECTS OF THALIDOMIDE ON THE ELECTRICAL ACTIVITY OF THE BRAIN IN THE INTRAUTERINE GUINEA-PIG FOETUS.
    Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 11

    Topics: Animals; Brain; Electrocardiography; Electroencephalography; Female; Fetus; Guinea Pigs; Humans; Pha

1964
PHARMACOLOGICAL PROPERTIES AND TERATOGENIC ACTION OF 2-(HEXAHYDROPHTHALIMIDO) GLUTARIMIDE AND 2-PHTHALIMIDO-N-METHYLGLUTARIMIDE.
    Life sciences (1962), 1964, Volume: 3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Mice; Piperidines; Piperidones; Pregnancy; Pre

1964
TERATOGENIC ACTIVITY OF THALIDOMIDE AND RELATED COMPOUNDS.
    Life sciences (1962), 1964, Volume: 3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Pharmacology; Piperidines; Pregnancy; Rabbits;

1964
THALIDOMIDE SYNDROME IN MONKEYS.
    Science (New York, N.Y.), 1964, Dec-04, Volume: 146, Issue:3649

    Topics: Abnormalities, Drug-Induced; Animals; Embryo Implantation; Extremities; Female; Fetus; Haplorhini; H

1964
[THE EFFECT OF THALIDOMIDE ON THE FERTILITY OF RATS IN REPRODUCTION EXPERIMENTS OVER 2 GENERATIONS].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1964, May-05, Volume: 247

    Topics: Endocrine System Diseases; Fertility; Pharmacology; Pregnancy; Pregnancy, Animal; Rats; Reproduction

1964
VIRAL AND DRUG HAZARDS IN PREGNANCY.
    Clinical pediatrics, 1964, Volume: 3

    Topics: Abnormalities, Drug-Induced; Androgens; Chickenpox; Congenital Abnormalities; Female; Hand Deformiti

1964
EFFECT OF ACETYLSALICYLIC ACID ON FOETAL RATS.
    The Journal of pharmacy and pharmacology, 1964, Volume: 16

    Topics: Abnormalities, Drug-Induced; Aspirin; Caseins; Fetus; Pharmacology; Pregnancy; Rats; Research; Reser

1964
HAZARDS OF OBSTETRICAL AND GYNECOLOGICAL DRUGS.
    The Ohio State medical journal, 1964, Volume: 60

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Androgens; Drug Therapy; Estrogens; Female; Gy

1964
[CHONDRODYSTROPHY AFTER THALIDOMIDE MEDICATION].
    Zentralblatt fur Gynakologie, 1964, Jun-27, Volume: 86

    Topics: Abnormalities, Drug-Induced; Bone Diseases, Developmental; Drug Therapy; Ectromelia; Enchondromatosi

1964
[EAR MALFORMATIONS IN THE FRAMEWORK OF THALIDOMIDE EMBRYOPATHY. (BASED ON A SURVEY OF 70 INFANTS BORN DURING 1959-1962)].
    Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1964, Volume: 43

    Topics: Abnormalities, Drug-Induced; Deafness; Ear Deformities, Acquired; Ear, External; Fetal Diseases; Hea

1964
THALIDOMIDE-INDUCED APLASIA OF THE INNER EAR.
    The Journal of laryngology and otology, 1964, Volume: 78

    Topics: Abnormalities, Drug-Induced; Ear Deformities, Acquired; Ear, External; Ear, Inner; Facial Paralysis;

1964
[THALIDOMIDE EMBRYOPATHY IN RABBITS FOLLOWING TRANSIENT LIVER DAMAGE IN THE MOTHER BY CARBON TETRACHLORIDE].
    Klinische Wochenschrift, 1964, Jun-15, Volume: 42

    Topics: Abnormalities, Drug-Induced; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical

1964
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists;

1964
MICROBIOLOGICALLY DETERMINED PANTOTHENIC ACID AND NICOTINIC ACID CONTENT OF CHICK EMBRYOS AFTER TREATMENT WITH THALIDOMIDE AND OF RAT FETUSES, NEWBORNS AND PLACENTAS FROM MOTHERS TREATED WITH THALIDOMIDE.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Biological Assay; Chick Embryo; Embryo, Mamm

1964
[DRUGS WHICH SHOULD NOT BE GIVEN TO A PREGNANT WOMAN].
    Nederlands tijdschrift voor geneeskunde, 1964, Nov-21, Volume: 108

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Antineoplastic Agents; Dihydrostreptomycin Sul

1964
[EAR DEFORMATIONS RELATED TO THALIDOMIDE].
    Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1964, Volume: 43

    Topics: Abnormalities, Drug-Induced; Ear Deformities, Acquired; Ear, External; Infant, Newborn; Pregnancy; T

1964
MORPHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THALIDOMIDE AND TRYPAN BLUE ON UTERI AND CONCEPTI OF GRAVID MICE.
    American journal of obstetrics and gynecology, 1965, Jan-15, Volume: 91

    Topics: Abnormalities, Drug-Induced; Amnion; Amniotic Fluid; Animals; Animals, Newborn; Ectromelia; Female;

1965
[OCULOMOTOR PARALYSIS IN THALIDOMIDE EMBRYOPATHY].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fetal Diseases; Ophthalmoplegia

1964
[CONTERGAN INJURY WITH EYE INVOLVEMENT].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena

1964
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena

1964
[INDUCTION OF FETAL MALFORMATIONS IN RABBITS WITH THALIDOMIDE].
    Pathologia et microbiologia, 1964, Volume: 27

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Lagomorpha; Pregnancy; Pregnancy, Animal; Rabb

1964
[THE PROCEDURES FOR THE TESTING OF TERATOGENIC EFFECTS TAKE SHAPE].
    Zeitschrift fur arztliche Fortbildung (Berlin), 1965, Volume: 54

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Haplorhini; Humans; Pregnancy; Sodium Chlori

1965
[EMBRYOTOXIC EFFECTS IN RATS].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1965, Mar-09, Volume: 250

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Ethionamide; Female; Fetal Death; Hu

1965
[FETAL MALFORMATIONS PRODUCED BY THALIDOMIDE IN THE MOUSE].
    Bollettino chimico farmaceutico, 1964, Volume: 103

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Infant, Newborn; Mice; Pregnancy; Research; Th

1964
RADIOGRAPHIC STUDIES OF THALIDOMIDE-INDUCED MALFORMATIONS IN MICE.
    Acta radiologica: diagnosis, 1965, Volume: 3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Ectromelia; Female; Humans; Kyphosis;

1965
THALIDOMIDE EMBRYOPATHY AND LIMB DEFECTS; ESPERIENCES IN HABILITATION OF CHILDREN WITH ECTROMELIAS.
    Archives of disease in childhood, 1965, Volume: 40

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Angiography; Artificial Limbs; Child; Ectromel

1965
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY, 1960-1961.
    American journal of public health and the nation's health, 1965, Volume: 55

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Industry; Female; Fetal Diseases; Germany

1965
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS.
    Toxicology and applied pharmacology, 1965, Volume: 7

    Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female;

1965
EFFECTS OF THALIDOMIDE ON FETAL DEVELOPMENT IN RABBITS AND ON ESTABLISHMENT OF PREGNANCY IN MONKEYS.
    Toxicology and applied pharmacology, 1965, Volume: 7

    Topics: Abnormalities, Drug-Induced; Animals; Arthrogryposis; Extremities; Fetal Death; Fetal Development; F

1965
TERATOGENIC EFFECTS OF THALIDOMIDE IN RABBITS, RATS, HAMSTERS, AND MICE.
    Toxicology and applied pharmacology, 1965, Volume: 7

    Topics: Abnormalities, Drug-Induced; Animals; Avitaminosis; Cricetinae; Female; Humans; Mice; Pharmacology;

1965
[ANATOMICAL FINDINGS OF THE SO-CALLED "THALIDOMIDE BABIES" WITH SPECIAL REFERENCE TO LIMBS].
    Nihon Seikeigeka Gakkai zasshi, 1965, Volume: 38

    Topics: Abnormalities, Drug-Induced; Ectromelia; Extremities; Female; Humans; Infant; Infant, Newborn; Mater

1965
[THALIDOMIDE AND CLEFT LIP, JAW AND PALATE].
    Deutsche Stomatologie, 1965, Volume: 15

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Female; Humans; Infant; Infant, Newborn; Pregn

1965
EFFECT OF THALIDOMIDE WARNING ON MEDICINE PRESCRIBED FOR PREGNANT WOMEN. ANALYSIS OF FREE MEDICINES DELIVERED TO EXPECTANT MOTHERS IN THE VAESTERBOTTEN COUNTY OF SWEDEN DURING 1961 AND 1962.
    British journal of preventive & social medicine, 1965, Volume: 19

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Medicine; Mothers; Pregnancy; Prenatal Care; S

1965
AN ATTEMPTED REVERSAL OF THALIDOMIDE EMBRYOPATHY IN THE RAT BY GLUTAMINE.
    Canadian journal of physiology and pharmacology, 1965, Volume: 43

    Topics: Abnormalities, Drug-Induced; Fetal Diseases; Glutamates; Glutamine; Pathology; Pharmacology; Pregnan

1965
STUDIES ON THE EFFECT OF TRYPAN BLUE IN THE PREGNANT ARMADILLO, DASYPUS NOVEMCINCTUS.
    The Anatomical record, 1965, Volume: 151

    Topics: Abnormalities, Drug-Induced; Animals; Armadillos; Blood Proteins; Female; Humans; Maternal-Fetal Exc

1965
BIOCHEMICAL EFFECTS OF DRUGS ON THE MAMMALIAN CONCEPTUS.
    Annals of the New York Academy of Sciences, 1965, Mar-12, Volume: 123

    Topics: Abnormalities, Drug-Induced; Animals; Blood; Electrophoresis; Embryology; Female; Glutamates; Humans

1965
SKELETAL MALFORMATIONS IN THE HOLTZMAN RAT EMBRYO FOLLOWING THE ADMINISTRATION OF THALIDOMIDE.
    Journal of embryology and experimental morphology, 1965, Volume: 13

    Topics: Abnormalities, Drug-Induced; Animals; Bone Diseases; Female; Humans; Injections; Injections, Intrape

1965
[THALIDOMIDE EMBRYOPATHY IN ANIMAL EXPERIMENT. REPRODUCTION OF THE THALIDOMIDE EMBRYOPATHY IN A TERATOLOGIC EXPERIMENT IN RABBITS WITH TRANSIENT LIVER DAMAGE].
    Zeitschrift fur Kinderheilkunde, 1964, Nov-17, Volume: 91

    Topics: Abnormalities, Drug-Induced; Animal Experimentation; Animals; Carbon Tetrachloride Poisoning; Female

1964
[FETAL DAMAGE CAUSED BY PHARMACEUTICAL AGENTS].
    Folia medica Neerlandica, 1965, Volume: 8

    Topics: Abnormalities, Drug-Induced; Endocrine System Diseases; Fetal Diseases; Humans; Morphine Dependence;

1965
Health of thalidomide victims and their progeny.
    Lancet (London, England), 2004, Jan-10, Volume: 363, Issue:9403

    Topics: Abnormalities, Drug-Induced; Cause of Death; Child of Impaired Parents; Congenital Abnormalities; Fe

2004
Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 81, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Body Weight; Dose-Resp

2004
Thalidomide: tragic past and promising future.
    Mayo Clinic proceedings, 2004, Volume: 79, Issue:7

    Topics: Angiogenesis Inhibitors; Female; Humans; Infant, Newborn; Multiple Myeloma; Pregnancy; Teratogens; T

2004
Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide.
    Birth defects research. Part A, Clinical and molecular teratology, 2004, Volume: 70, Issue:8

    Topics: Duane Retraction Syndrome; Fathers; Female; Hearing Loss; Humans; Male; Mutation; Pregnancy; Prenata

2004
Pre-20th century evidence for the placental passage of drugs.
    Drug news & perspectives, 2005, Volume: 18, Issue:3

    Topics: Coloring Agents; Female; History, 19th Century; History, 20th Century; Humans; Infant, Newborn; Inor

2005
[Surgical improvement of hearing in atresia auris congenita].
    Monatsschrift fur Ohrenheilkunde und Laryngo-Rhinologie, 1966, Volume: 100, Issue:4

    Topics: Abnormalities, Drug-Induced; Audiometry, Pure-Tone; Deafness; Ear, External; Female; Humans; Infant;

1966
Thalidomide embryopathy cases in Brazil after 1965.
    Reproductive toxicology (Elmsford, N.Y.), 2006, Volume: 22, Issue:1

    Topics: Adult; Brazil; Drug Utilization Review; Erythema Nodosum; Female; Fetal Diseases; Humans; Leprosy, L

2006
Thalidomide use in the US : experience with pregnancy testing in the S.T.E.P.S. programme.
    Drug safety, 2006, Volume: 29, Issue:4

    Topics: Drug and Narcotic Control; Drug Prescriptions; Female; Humans; Pregnancy; Pregnancy Tests; Retrospec

2006
Lenalidomide (Revlimid) for anemia of myelodysplastic syndrome.
    The Medical letter on drugs and therapeutics, 2006, Apr-10, Volume: 48, Issue:1232

    Topics: Anemia; Chromosome Deletion; Chromosomes, Human, Pair 5; Contraindications; Female; Humans; Lenalido

2006
Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations.
    Neuroscience, 2006, Sep-29, Volume: 142, Issue:1

    Topics: Action Potentials; Animals; Animals, Newborn; Aorta; Blotting, Western; Cattle; Central Nervous Syst

2006
45 years later...where do we stand?
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2007,Winter, Volume: 14, Issue:1

    Topics: Abnormalities, Drug-Induced; Canada; Drug-Related Side Effects and Adverse Reactions; Female; Foreca

2007
Evaluation of the developmental toxicity of lenalidomide in rabbits.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2007, Volume: 80, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Embryonic Development; Female; Fetal Death; Fetus; Lenalidomid

2007
New cases of thalidomide embryopathy in Brazil.
    Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:9

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Brazil; Contraindications;

2007
[The significance of group B vitamins and genetic factors on the reaction of the rat embryo to thalidomide].
    Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 51, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Diet; Drug Hypersensitivity; E

1966
[Thalidomide embryopathy in animal experiments. II. Thalidomide blood level in experimental animals with normal and damaged liver].
    Zeitschrift fur Kinderheilkunde, 1966, Volume: 96, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Live

1966
The embryotoxic effect on rabbits of monophenylbutazone (monazan) compared with phenylbutazone and thalidomide.
    Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetal Death; Male; Phenylbutazone; Pregnanc

1966
[Otoneurological studies of facial nerve paralysis in thalidomide dysplasia].
    Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1967, Volume: 189, Issue:1

    Topics: Abducens Nerve; Abnormalities, Drug-Induced; Child; Child, Preschool; Ear Deformities, Acquired; Ele

1967
Non-teratogenicity of antituberculous drugs.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1967, Aug-12, Volume: 41, Issue:30

    Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Antitubercular Agents; Drug Synergism; Ethionamid

1967
LSD: effects on offspring.
    Science (New York, N.Y.), 1967, Oct-27, Volume: 158, Issue:3800

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lysergic Acid Diethylamide; Pregnancy; Pregnanc

1967
The fate of[14C]thalidomide in the pregnant rabbit.
    The Biochemical journal, 1967, Volume: 104, Issue:2

    Topics: Adipose Tissue; Animals; Blood Chemical Analysis; Brain Chemistry; Carbon Isotopes; Embryo, Mammalia

1967
The fate of the hydrolysis products of thalidomide in the pregnant rabbit.
    The Biochemical journal, 1967, Volume: 104, Issue:2

    Topics: Adipose Tissue; Animals; Blood Chemical Analysis; Brain Chemistry; Carbon Isotopes; Digestive System

1967
Toxicity and teratogenicity of optical isomers of thalidomide.
    Nature, 1967, Jul-15, Volume: 215, Issue:5098

    Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry, Physical; Female; Fetus; Hexoba

1967
Chromosome changes in embryos treated with various teratogens.
    Journal of embryology and experimental morphology, 1967, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure

1967
[Cleft lip and palate in thalidomide-induced embryopathies].
    Acta geneticae medicae et gemellologiae, 1967, Volume: 16, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Arm; Child; Child, Preschool; Cleft Lip; Cleft Palate; Ear Defor

1967
The effect of thalidomide on the developing rat foetus.
    British journal of experimental pathology, 1967, Volume: 48, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Pregnancy; Pregnancy, Animal; Rats; Thali

1967
[The sensitivity period of thalidomide embryopathy in monkeys and humans].
    Deutsche medizinische Wochenschrift (1946), 1967, Nov-24, Volume: 92, Issue:47

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Pregnancy; Thalidomide; Time Factors

1967
Effects of maternal thalidomide treatment on pregnancy, fetal development, and mortality of the offspring in random-bred mice.
    American journal of veterinary research, 1967, Volume: 28, Issue:127

    Topics: Animals; Female; Fetal Death; Fetus; Mice; Pregnancy; Pregnancy, Animal; Thalidomide

1967
Effects of thalidomide treatment of inbred female mice on pregnancy, fetal development, and mortality of offspring.
    American journal of veterinary research, 1967, Volume: 28, Issue:127

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Mice; Pregnancy; Pre

1967
Another, late thalidomide abnormality.
    Lancet (London, England), 1981, Aug-15, Volume: 2, Issue:8242

    Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Thalidomide;

1981
Thalidomide: 20 years on.
    Lancet (London, England), 1981, Sep-05, Volume: 2, Issue:8245

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Europe; Female; History, 20th Century; Humans; Male;

1981
Studies on the hypothetical relationship of thalidomide-induced embryopathy and collagen biosynthesis.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Collagen; Female; Hydroxyproline; Pregnancy; Procollagen-Lysin

1981
Effect of thalidomide-derivatives on limb development in culture.
    Progress in clinical and biological research, 1983, Volume: 110 Pt A

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Extremities; Female; Limb Deformities, Cong

1983
Medical achievements this century--high technology or community health approach.
    Irish journal of medical science, 1983, Volume: 152, Issue:11

    Topics: Communicable Disease Control; Community Medicine; Female; Genetic Engineering; Hip Prosthesis; Histo

1983
Classic illustration. Figure showing the relationship between malformations of the thalidomide type and the sales of thalidomide.
    European journal of obstetrics, gynecology, and reproductive biology, 1984, Volume: 16, Issue:5

    Topics: Abnormalities, Drug-Induced; Female; History, 20th Century; Humans; Infant, Newborn; Pregnancy; Thal

1984
Embryotoxicity and teratogenicity of thalidomide in rats.
    Teratology, 1983, Volume: 27, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Dimethylformamide; Eye Abnormalities; Female; Fetal Death; Pre

1983
[Teratogenic action of Rifaximin in the rat and rabbit and its effect on perinatal development in the rat].
    Bollettino della Societa italiana di biologia sperimentale, 1984, May-30, Volume: 60, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Hydroxyurea; Pregnancy; Prenatal Exposure Delay

1984
[Maternal drug therapy as a risk factor for congenital heart disease].
    Duodecim; laaketieteellinen aikakauskirja, 1984, Volume: 100, Issue:11

    Topics: Anticonvulsants; Female; Heart Defects, Congenital; Hormones; Humans; Infant, Newborn; Lithium; Mate

1984
Bioactivation of thalidomide by a monkey liver fraction in a rat limb culture system.
    Progress in clinical and biological research, 1983, Volume: 110 Pt A

    Topics: Animals; Biotransformation; Extremities; Female; Liver; Macaca nemestrina; Male; Organ Culture Techn

1983
Another specific effect of prenatal acetazolamide exposure in the mouse.
    Teratology, 1983, Volume: 27, Issue:1

    Topics: 2,4,5-Trichlorophenoxyacetic Acid; Acetazolamide; Animals; Bromodeoxyuridine; Female; Mice; Pesticid

1983
Biographies of great American pediatricians--Helen Brooke Taussig: the mother of pediatric cardiology.
    Pediatric annals, 1982, Volume: 11, Issue:7

    Topics: Cardiology; Female; Heart Defects, Congenital; History of Medicine; Humans; Infant, Newborn; Pediatr

1982
Holt Oram syndrome mistaken for thalidomide embryopathy--embryological considerations.
    European journal of pediatrics, 1982, Volume: 138, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Diagnosis, Differential; Ectromelia; Female; Genetic Counseling;

1982
[Teratogenic effect of drugs].
    Der Gynakologe, 1982, Volume: 15, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; History, 16th Century; History, 17th Century; History,

1982
Dissimilar effects of thalidomide in dizygotic twins.
    Acta geneticae medicae et gemellologiae, 1980, Volume: 29, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Brazil; Diseases in Twins; Ectromelia; Female; Humans; Pregnancy

1980
Fetal ear malformations induced by maternal ingestion of thalidomide in the bonnet monkey (Macaca radiata).
    Teratology, 1981, Volume: 23, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Ear; Female; Gestational Age; Macaca radiata; Pregnancy; Thali

1981
[Consequences of unexpected drug effects, beginning with contergan studies by pediatrists].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1981, Sep-20, Volume: 57, Issue:26

    Topics: Abnormalities, Drug-Induced; Acrodynia; Bacterial Infections; Child; Child, Preschool; Chloramphenic

1981
Causal inference in teratology.
    Progress in clinical and biological research, 1980, Volume: 36

    Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Diazepam; Epidemiologic Methods; Female; Humans; I

1980
[Synthesis and teratogenic activity of some thalidomide analogous indane-1,3-diones (author's transl)].
    Archiv der Pharmazie, 1980, Volume: 313, Issue:6

    Topics: Animals; Female; Indans; Mice; Pregnancy; Teratogens; Thalidomide

1980
Nonteratogenicity of a structural analog of thalidomide in pregnant baboons (Papio cynocephalus).
    Teratology, 1980, Volume: 22, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Drug Evaluation, Preclinical; Female; P

1980
A metabolite of a structural analog of thalidomide lacks teratogenic effect in pregnant rhesus monkeys.
    Teratology, 1980, Volume: 22, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation, Preclinical; Female; Macaca; Macaca mulatta;

1980
The experimental approach to teratogenicity.
    Ecotoxicology and environmental safety, 1980, Volume: 4, Issue:4

    Topics: Animals; Embryo, Mammalian; Embryo, Nonmammalian; Environmental Pollutants; Female; Fetus; Polychlor

1980
Contraceptive efficacy.
    Archives of dermatology, 1995, Volume: 131, Issue:9

    Topics: Abnormalities, Drug-Induced; Contraception; Female; Humans; Isotretinoin; Pregnancy; Teratogens; Tha

1995
Amniotic band sequence in child of thalidomide victim.
    BMJ (Clinical research ed.), 1994, Nov-26, Volume: 309, Issue:6966

    Topics: Amniotic Band Syndrome; Female; Hand Deformities, Congenital; Humans; Infant, Newborn; Limb Deformit

1994
Evidence for teratogenicity of thalidomide using congenic and recombinant inbred rat strains.
    Folia biologica, 1994, Volume: 40, Issue:4

    Topics: Abnormalities, Drug-Induced; Alleles; Animals; Embryonic and Fetal Development; Female; Fetus; Genot

1994
Thalidomide in leprosy reaction.
    Lancet (London, England), 1994, Feb-19, Volume: 343, Issue:8895

    Topics: Erythema Nodosum; Female; Humans; Leprosy, Lepromatous; Pregnancy; Thalidomide

1994
Thalidomide: 35 years on and still deforming.
    Lancet (London, England), 1994, Apr-23, Volume: 343, Issue:8904

    Topics: Abnormalities, Drug-Induced; Brazil; Female; Humans; Infant, Newborn; Pregnancy; Thalidomide

1994
Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. 5. Lack of teratogenic effects of phthalimidophthalmide.
    Archives of toxicology, 1994, Volume: 68, Issue:3

    Topics: Animals; Callithrix; Female; Integrins; Male; Pregnancy; Teratogens; Thalidomide

1994
Autism in thalidomide embryopathy: a population study.
    Developmental medicine and child neurology, 1994, Volume: 36, Issue:4

    Topics: Adult; Autistic Disorder; Deafness; Female; Humans; Intellectual Disability; Male; Pregnancy; Prenat

1994
Representative and misrepresentative associations of birth defects in livebirths. Conditions under which relative risks greater than unity in livebirths necessarily imply relative risks greater than unity in all conceptuses.
    American journal of epidemiology, 1993, Mar-15, Volume: 137, Issue:6

    Topics: Congenital Abnormalities; Embryo, Mammalian; Female; Fetal Death; Fetus; Humans; Infant, Newborn; Mo

1993
Down-regulation of adhesion receptors on cells of primate embryos as a probable mechanism of the teratogenic action of thalidomide.
    Life sciences, 1996, Volume: 58, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Callithrix; Cells, Cultured; Down-Regulation; Embryo,

1996
Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:3

    Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Female; Pregnancy; Prostaglandins; Rabbits; Tera

1996
The place of thalidomide in the treatment of inflammatory disease.
    Lupus, 1996, Volume: 5, Issue:4

    Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cytokines;

1996
Stereoselective distribution of the teratogenic thalidomide analogue EM12 in the early embryo of marmoset monkey, Wistar rat and NMRI mouse.
    Archives of toxicology, 1996, Volume: 70, Issue:11

    Topics: Animals; Autoradiography; Callithrix; Embryonic and Fetal Development; Female; Maternal-Fetal Exchan

1996
A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data.
    Journal of the American Academy of Dermatology, 1997, Volume: 36, Issue:3 Pt 2

    Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Female; Humans; Isotretinoin; Keratol

1997
Thalidomide, a current teratogen in South America.
    Teratology, 1996, Volume: 54, Issue:6

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Leprostatic Agents; Leprosy; Male; Pre

1996
Therapeutic Teratology: the 1996 Teratology Society Public Affairs Symposium.
    Teratology, 1996, Volume: 54, Issue:6

    Topics: Abnormalities, Drug-Induced; Female; Humans; Isotretinoin; Patient Education as Topic; Pregnancy; Te

1996
Clinical appearance of spontaneous and induced first and second branchial arch syndromes.
    Scandinavian journal of plastic and reconstructive surgery and hand surgery, 1997, Volume: 31, Issue:2

    Topics: Adult; Animals; Branchial Region; Craniofacial Dysostosis; Disease Models, Animal; Facial Asymmetry;

1997
Interaction of [glutarimide-2-14C]-thalidomide with rat embryonic DNA in vivo.
    Teratogenesis, carcinogenesis, and mutagenesis, 1997, Volume: 17, Issue:1

    Topics: Animals; Carbon Radioisotopes; DNA; DNA Adducts; DNA Damage; Embryo, Mammalian; Female; Fetal Death;

1997
Jekyll and Hyde: a new license for thalidomide?
    Journal of the National Cancer Institute, 1997, Oct-15, Volume: 89, Issue:20

    Topics: Abnormalities, Drug-Induced; Acquired Immunodeficiency Syndrome; Antineoplastic Agents; Clinical Tri

1997
The return of thalidomide: are birth defects surveillance systems ready?
    American journal of medical genetics, 1997, Dec-19, Volume: 73, Issue:3

    Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Georgia; Humans; Infant; Infant, Newborn; Lim

1997
Thalidomide: lack of mutagenic activity across phyla and genetic endpoints.
    Mutation research, 1997, Dec-12, Volume: 396, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cells, Cultured; CHO Cells; Chromosome Aber

1997
Thalidomide: was the tragedy preventable?
    Lancet (London, England), 1998, Apr-18, Volume: 351, Issue:9110

    Topics: Congenital Abnormalities; Ectromelia; Female; History, 16th Century; History, 18th Century; History,

1998
Was tumour necrosis factor-alpha responsible for the fetal malformations associated with thalidomide in the early 1960s?
    Medical hypotheses, 1998, Volume: 50, Issue:4

    Topics: Abnormalities, Drug-Induced; Antigens, CD; Female; Humans; Models, Biological; Pregnancy; Receptors,

1998
Does thalidomide cause second generation birth defects?
    Drug safety, 1998, Volume: 19, Issue:5

    Topics: Abnormalities, Drug-Induced; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Thalidomi

1998
Thalidomide and the Titanic: reconstructing the technology tragedies of the twentieth century.
    American journal of public health, 1999, Volume: 89, Issue:1

    Topics: Drug Approval; Female; Government Regulation; History, 20th Century; Humans; Internationality; Lepro

1999
[Thalidomide once more in the spotlight].
    Nederlands tijdschrift voor geneeskunde, 1998, Nov-14, Volume: 142, Issue:46

    Topics: Adult; Bone Marrow Transplantation; Contraindications; Drug and Narcotic Control; Drug Approval; Fem

1998
Formed by thalidomide: mass torts as a false cure for toxic exposure.
    Columbia law review, 1997, Volume: 97, Issue:7

    Topics: Abnormalities, Drug-Induced; Canada; Europe; Female; Government Agencies; Humans; Japan; Legislation

1997
S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide.
    Clinical therapeutics, 1999, Volume: 21, Issue:2

    Topics: Dermatologic Agents; Drug and Narcotic Control; Drug Monitoring; Female; Humans; Immunosuppressive A

1999
Thalidomide on the comeback trail.
    Nature medicine, 1999, Volume: 5, Issue:5

    Topics: Adjuvants, Immunologic; Animals; DNA; Drug Approval; Erythema Nodosum; Female; Free Radicals; Matern

1999
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.
    Nature medicine, 1999, Volume: 5, Issue:5

    Topics: Animals; Cyclic N-Oxides; DNA Damage; Drug Resistance; Embryo Loss; Embryo, Mammalian; Female; Free

1999
Was the thalidomide tragedy preventable?
    Lancet (London, England), 1998, May-23, Volume: 351, Issue:9115

    Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; History, 20th Century; Humans;

1998
Oxidative DNA damage and embryo development.
    Nature medicine, 1999, Volume: 5, Issue:7

    Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; DNA Damage; Embryonic and Fetal Development; Fem

1999
The problem with Cytotec is that it has not been approved for obstetrical use.
    The Birth gazette, 1999,Spring, Volume: 15, Issue:2

    Topics: Diethylstilbestrol; Female; Humans; Labor, Induced; Misoprostol; Oxytocics; Pregnancy; Thalidomide;

1999
Interaction of thalidomide with DNA of rabbit embryos: a possible explanation for its immunosuppressant and teratogenic effects.
    Pharmacology & toxicology, 1999, Volume: 85, Issue:2

    Topics: Animals; Biotransformation; DNA; Embryo, Mammalian; Female; Immunosuppressive Agents; Pregnancy; Rab

1999
Tort liability and the availability of contraceptive drugs and devices in the United States.
    Review of law and social change. New York University, 1997, Volume: 23, Issue:3

    Topics: Antiemetics; Breast Implants; Contraceptive Agents; Delivery of Health Care; Doxylamine; Drug Indust

1997
Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone.
    Inflammation, 2000, Volume: 24, Issue:4

    Topics: Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Fema

2000
[The Contergan (Thalidomide) case. Catastrophic consequences].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2000, Volume: 19, Issue:9

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Infan

2000
The re-emergence of thalidomide: results of a scientific conference.
    Teratology, 2000, Volume: 62, Issue:6

    Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Adolescent; Adult; Anti-HIV Agents; Anti-Inflam

2000
Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.
    The Anatomical record, 2001, 03-01, Volume: 262, Issue:3

    Topics: Animals; Antigens, CD; Apoptosis; Cell Division; Culture Techniques; Female; Immunohistochemistry; M

2001
Thalidomide study.
    Project Inform perspective, 1997, Issue:22

    Topics: Clinical Trials as Topic; Drug Approval; HIV Wasting Syndrome; Humans; Oral Ulcer; Placebos; Pregnan

1997
The rehabilitation of thalidomide.
    Journal of the International Association of Physicians in AIDS Care, 1998, Volume: 4, Issue:1

    Topics: Abnormalities, Drug-Induced; CD4 Lymphocyte Count; Conflict of Interest; Contraception; Drug Approva

1998
Thalidomide's long and winding road.
    BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1998

    Topics: Abnormalities, Drug-Induced; Clinical Trials as Topic; Drug Approval; Female; Health Services Access

1998
[The thalidomide story: the Israeli chapter].
    Harefuah, 2001, Volume: 140, Issue:8

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Female; History, 20th Century; Humans; Israel; P

2001
[On the history of the Contergan (thalidomide) catastrophe in the light of drug legislation].
    Deutsche medizinische Wochenschrift (1946), 2001, Oct-19, Volume: 126, Issue:42

    Topics: Abnormalities, Drug-Induced; Animals; Drug Industry; Female; Fetus; France; Germany; History, 19th C

2001
AIDS, thalidomide and maternal-fetal rights in conflict.
    Princeton journal of bioethics, 1998,Spring, Volume: 1, Issue:1

    Topics: Abortion, Eugenic; Acquired Immunodeficiency Syndrome; Coercion; Contraception; Drug-Related Side Ef

1998
Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:3

    Topics: Animals; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Cysteine; Female; Fluo

2002
Is autism due to cerebral-cerebellum disconnection?
    Medical hypotheses, 2002, Volume: 58, Issue:4

    Topics: Animals; Autistic Disorder; Axons; Brain Stem; Cerebellum; Cerebral Cortex; Female; Gestational Age;

2002
Thalidomide disaster: old wine in new bottles?
    Korot (Jerusalem : 1952), 2001, Volume: 15

    Topics: Congenital Abnormalities; Disasters; Female; History, 20th Century; History, 21st Century; History,

2001
Editorial: Postscript to thalidomide.
    Lancet (London, England), 1975, Mar-08, Volume: 1, Issue:7906

    Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Child; Child, Preschool; Ectodermal Dysplasia; Fema

1975
Letter: Postscript to thalidomide.
    Lancet (London, England), 1975, Apr-26, Volume: 1, Issue:7913

    Topics: Abnormalities, Drug-Induced; Female; Fetus; Humans; Maternal-Fetal Exchange; Pregnancy; Thalidomide

1975
Letter: Neural crest, limb development, and thalidomide embryopathy.
    Lancet (London, England), 1976, Mar-20, Volume: 1, Issue:7960

    Topics: Abnormalities, Drug-Induced; Animals; Arm; Ectromelia; Female; Fetus; Gestational Age; Haplorhini; H

1976
Teratogenic action of thalidomide.
    Lancet (London, England), 1978, Jun-24, Volume: 1, Issue:8078

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Ectromelia; Embryo, Mammalian; Female; Forelimb;

1978
Agenesis of appendix: a further thalidomide anomaly.
    Lancet (London, England), 1978, Apr-15, Volume: 1, Issue:8068

    Topics: Abnormalities, Drug-Induced; Adolescent; Appendix; Female; Humans; Maternal-Fetal Exchange; Pregnanc

1978
Developmental staging and thalidomide teratogenicity in the green monkey (Cercopithecus aethiops).
    Teratology, 1978, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Chlorocebus aethiops; Female; Gestational Age; Haplorhini; Lim

1978
Unusual muscle abnormalities associated with thalidomide treatment in a rhesus monkey: a case report.
    Teratology, 1979, Volume: 19, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Forearm; Haplorhini; Macaca mulatta; Muscles; Pregnanc

1979
Fetal cardiovascular and other defects induced by thalidomide in cats.
    Teratology, 1975, Volume: 11, Issue:1

    Topics: Animals; Cardiomegaly; Cats; Coronary Vessels; Female; Fetal Heart; Heart Atria; Heart Defects, Cong

1975
Partial unilateral cryptophthalmos with syndactyly, brachycephaly, and renal anomalies.
    American journal of ophthalmology, 1975, Volume: 79, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Eye Abnormalities; Eyelids;

1975
A survey of thalidomide embryopathy in Taiwan.
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1977, Volume: 76, Issue:7

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Male; Pregnancy; Taiwan; Thalidomide

1977
Experimental aspects and clinical implications.
    Experimental pathology. Supplement, 1979, Volume: 4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Chick Embryo; Congenital Abn

1979
Necessary risks.
    The New England journal of medicine, 1979, Jun-07, Volume: 300, Issue:23

    Topics: Animals; Antiemetics; Dogs; Dronabinol; Drug Industry; Drug-Related Side Effects and Adverse Reactio

1979
Thalidomide and lack of teratogenesis in Long-Evans rats.
    Teratology, 1979, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Rats; Thalidomide

1979
The teratogenic activity of a thalidomide analogus EM12 in rats on a low-zinc diet.
    Teratology, 1979, Volume: 19, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Diet; Female; Forelimb; Gestational Age; Male; Pregnancy; Rats

1979
Teratologic evaluation of synthetic delta 9-tetrahydrocannabinol in rabbits.
    Teratology, 1979, Volume: 19, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dronabinol; Eating; Female; Fetal Viability; Gest

1979
[Scholastic and professional rehabilitation of patients with abnormalities of the upper extremities].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1979, Volume: 117, Issue:4

    Topics: Abnormalities, Drug-Induced; Arm; Ectromelia; Female; Humans; Learning Disabilities; Male; Pregnancy

1979
Drug and chemical effects on mother and child.
    Pediatric annals, 1979, Volume: 8, Issue:12

    Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Contraceptive Agents, Female; Environmental Pollut

1979
Teratogenicity of therapeutic agents.
    Current problems in pediatrics, 1979, Volume: 10, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Anima

1979
[The behavior of the facial nerve in vitamin A and thalidomide induced atresia auris congenita. A microsurgical and histological animal study (author's transl)].
    HNO, 1979, Volume: 27, Issue:9

    Topics: Animals; Ear, External; Ear, Middle; Facial Nerve; Female; Fetus; Microsurgery; Petrous Bone; Pregna

1979
[The development of the postural and motor apparatus in juveniles with thalidomide embryopathy].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1978, Volume: 116, Issue:4

    Topics: Ectromelia; Female; Fetal Diseases; Hip Joint; Humans; Musculoskeletal Development; Pregnancy; Shoul

1978
[Development of the extremities in the embryo].
    Chirurgie pediatrique, 1978, Volume: 19, Issue:5-6

    Topics: Abnormalities, Drug-Induced; Animals; Arm; Congenital Abnormalities; Female; Humans; Infant, Newborn

1978
[Teratogenic effect of N-phthaloyl-L-aspartic acid on the mouse (author's transl)].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:1

    Topics: Animals; Aspartic Acid; Female; Mice; Mice, Inbred Strains; Phthalimides; Pregnancy; Stereoisomerism

1977
[Teratologic-neurotoxicologic studies on biglumide (K-2004) and thalidomide].
    Archives of toxicology, 1977, Jun-18, Volume: 37, Issue:2

    Topics: Animals; Bone Marrow; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Central Nervous System; Cyc

1977
[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)].
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:10

    Topics: Animals; Chromatography; Embryo, Mammalian; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Pregnanc

1979
Non-confirmation of thalidomide induced teratogenesis in rats and mice.
    Teratology, 1977, Volume: 16, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Resorption; Mice; Pharmaceutical Vehicles; Polys

1977
The effect of thalidomide on a prosimian: the greater galago (Galago crassicaudatus).
    Journal of medical primatology, 1977, Volume: 6, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Female; Galago; Pregnancy; Thalidomide

1977
Thalidomide and neurological damage revisited.
    JAMA, 1978, Apr-21, Volume: 239, Issue:16

    Topics: Abnormalities, Drug-Induced; Central Nervous System Diseases; Female; Fetus; Humans; Infant, Newborn

1978
Poisoned people: psychotropic drugs in pregnancy: morphological and psychological adverse effects on offspring.
    Journal of biosocial science, 1978, Volume: 10, Issue:3

    Topics: Abnormalities, Drug-Induced; Alcoholism; Behavior; Female; Fetal Alcohol Spectrum Disorders; Fetus;

1978
[Thalidomide analogs. 10. Transplacental distribution kinetics of biglumide in the mouse].
    Archiv der Pharmazie, 1978, Volume: 311, Issue:9

    Topics: Animals; Bridged Bicyclo Compounds; Female; Kinetics; Maternal-Fetal Exchange; Mice; Pregnancy; Thal

1978
Hemorrhage in development of the face.
    Birth defects original article series, 1975, Volume: 11, Issue:7

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Arteries; Craniofacial Dysostosis; Di

1975
[Epidemiology of congenital abnormalities].
    Medizinische Klinik, 1977, May-27, Volume: 72, Issue:21

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Epidemiologic Method

1977
[Drug therapy during pregnancy and the lactation period].
    Zeitschrift fur arztliche Fortbildung, 1977, Apr-15, Volume: 71, Issue:8

    Topics: Androgens; Anti-Bacterial Agents; Barbiturates; Cortisone; Drug-Related Side Effects and Adverse Rea

1977
Early foetal thrombosis induced by thalidomide in mouse: possible explanation for teratogenicity.
    Experientia, 1977, Oct-15, Volume: 33, Issue:10

    Topics: Animals; Extremities; Female; Fetal Diseases; Hemorrhage; Mice; Mice, Inbred C57BL; Pregnancy; Thali

1977
Linear growth of children with limb deformities following exposure to thalidomide in utero.
    Acta paediatrica Scandinavica, 1977, Volume: 66, Issue:6

    Topics: Abnormalities, Drug-Induced; Adolescent; Body Height; Child; Female; Growth; Humans; Limb Deformitie

1977
Teratology study of two isoglutamine derivatives.
    Archives of toxicology, 1976, Jan-30, Volume: 35, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Chemical Ph

1976
[Effect of some preservatives on pregnancy and fetal development in experimental animals].
    Roczniki Panstwowego Zakladu Higieny, 1976, Volume: 27, Issue:5

    Topics: Animals; Benzhydryl Compounds; Chlorophenols; Female; Fetus; Maternal-Fetal Exchange; Methane; Pharm

1976
[Teratogenic effect and stereospecificity of a thalidomide metabolite].
    Die Pharmazie, 1976, Volume: 31, Issue:7

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Female; Fetus; Glutamates; Isomerism; Mi

1976
Responses of pre-implantation mouse embryos to thalidomide exposure in utero.
    Indian journal of experimental biology, 1976, Volume: 14, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic Development; Female; Mice; Mitosi

1976
Predictiveness and limitations of test methods in teratology: overview.
    Environmental health perspectives, 1976, Volume: 18

    Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation, Preclinical; Environmental Exposure; Female;

1976
Metabolic and toxic behavior of phthalimide derivates. I. Fate of imidan in the fetus.
    Archives of toxicology, 1976, Oct-28, Volume: 36, Issue:2

    Topics: Animals; Animals, Newborn; Biotransformation; Female; Fetus; Insecticides; Maternal-Fetal Exchange;

1976
[Pregnancy and drugs].
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1975, Volume: 74, Issue:4

    Topics: Anti-Bacterial Agents; Barbiturates; Chloramphenicol; Chlorothiazide; Female; Hormones; Humans; Preg

1975
Studies of embryo toxicity in rats and rabbits.
    Environmental quality and safety. Supplement, 1975, Volume: 4

    Topics: Animals; Biphenyl Compounds; Coloring Agents; Embryo, Mammalian; Female; Fetus; Male; Pregnancy; Rab

1975
Mutagenicity studies with captan, captofol, folpet and thalidomide.
    Food and cosmetics toxicology, 1975, Volume: 13, Issue:1

    Topics: Animals; Captan; Chlorine; Chloroform; Cyclohexenes; Embryo Implantation; Female; Fetal Death; Fungi

1975
A clinical look at the problem of drugs in pregnancy and their effect on the fetus.
    Canadian Medical Association journal, 1975, Mar-22, Volume: 112, Issue:6

    Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse

1975
Congenital fusion of bones: radiology, embryology and pathogenesis.
    Clinical radiology, 1975, Volume: 26, Issue:1

    Topics: Abnormalities, Drug-Induced; Bone and Bones; Bone Development; Carpal Bones; Cartilage; Child, Presc

1975
Reproductive, teratogenic, perinatal and postnatal studies with cyclazocine.
    Toxicology and applied pharmacology, 1975, Volume: 31, Issue:3

    Topics: Animals; Cyclazocine; Female; Fertility; Fetus; Gestational Age; Growth; Male; Pregnancy; Rabbits; R

1975
Teratogenesis.
    The Orthopedic clinics of North America, 1976, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Alcoholism; Aminopterin; Animals; Anticonvulsants; Dose-Response Relati

1976
Drug therapy and the developing human: who cares?
    Clinical toxicology, 1976, Volume: 9, Issue:1

    Topics: Anticonvulsants; Drug Industry; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; E

1976
Ultrastructural changes in the dorsal root ganglia evoked by thalidomide in rabbits.
    Experientia, 1976, May-15, Volume: 32, Issue:5

    Topics: Animals; Female; Fetus; Ganglia, Spinal; Gestational Age; Pregnancy; Rabbits; Schwann Cells; Thalido

1976
Epilepsy: a neurological complication of thalidomide embryopathy.
    Developmental medicine and child neurology, 1976, Volume: 18, Issue:2

    Topics: Adolescent; Ear; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Heart Defects, C

1976
The perception of teratogenic risk of cocaine.
    Teratology, 1992, Volume: 46, Issue:6

    Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Cocaine; Counseling; Education, Medical; Female;

1992
Thalidomide for systemic lupus erythematosus.
    Lancet (London, England), 1992, Apr-25, Volume: 339, Issue:8800

    Topics: Abnormalities, Drug-Induced; Female; Humans; Lupus Erythematosus, Systemic; Pregnancy; Thalidomide

1992
Comments on "Reply to 'Comments on "Moebius syndrome: animal model--human correlations and evidence for a brainstem vascular etiology"'".
    Teratology, 1992, Volume: 45, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain Stem; Female; Humans; Pregnancy; Syndrom

1992
Thalidomide retrospective: what did the clinical teratologist learn?
    Teratology, 1992, Volume: 46, Issue:5

    Topics: Abnormalities, Drug-Induced; Female; Germany; History, 20th Century; Humans; Infant, Newborn; Pregna

1992
The contributions of Widukind Lenz to teratology and science: comments on "Thalidomide retrospective: what did the clinical teratologist learn?".
    Teratology, 1992, Volume: 46, Issue:5

    Topics: Abnormalities, Drug-Induced; Female; Germany; History, 20th Century; Humans; Infant, Newborn; Pregna

1992
A personal perspective on the thalidomide tragedy.
    Teratology, 1992, Volume: 46, Issue:5

    Topics: Abnormalities, Drug-Induced; Female; Germany; History, 20th Century; Humans; Infant, Newborn; Pregna

1992
Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
    American journal of medical genetics, 1992, Dec-01, Volume: 44, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Alcoholism; Animals; British Columbia; Cocaine

1992
Scientific fraud: the McBride case.
    Medicine, science, and the law, 1992, Volume: 32, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Biomedical Research; Editorial Policies; Female; Humans; Infan

1992
Ocular teratology. Observations, speculations, questions, principles reaffirmed.
    Eye (London, England), 1992, Volume: 6 ( Pt 2)

    Topics: Ethanol; Eye; Eye Abnormalities; Female; Gestational Age; Humans; Pregnancy; Prenatal Exposure Delay

1992
Foetal life and a legal duty of care.
    Australian College of Midwives Incorporated journal, 1991, Volume: 4, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male

1991
Thalidomide induced alteration in secondary structure of rat embryonic DNA in vivo.
    Teratogenesis, carcinogenesis, and mutagenesis, 1990, Volume: 10, Issue:4

    Topics: Animals; Chromatography, DEAE-Cellulose; DNA; DNA Damage; DNA Repair; Female; Maternal-Fetal Exchang

1990
[Cocaine in pregnancy: a second Contergan?].
    Geburtshilfe und Frauenheilkunde, 1990, Volume: 50, Issue:11

    Topics: Abnormalities, Drug-Induced; Cocaine; Female; Humans; Infant, Newborn; Pregnancy; Risk Factors; Thal

1990
Thalidomide, pregnancy and renal failure.
    The Medical journal of Australia, 1990, Feb-05, Volume: 152, Issue:3

    Topics: Adult; Antihypertensive Agents; Combined Modality Therapy; Female; Humans; Hypertension; Kidney Fail

1990
The obstetric problems of the thalidomide children.
    BMJ (Clinical research ed.), 1989, Jan-07, Volume: 298, Issue:6665

    Topics: Cesarean Section; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Pregnanc

1989
Induction of neural-tube defects in nonhuman primates.
    Progress in clinical and biological research, 1985, Volume: 163B

    Topics: Abnormalities, Drug-Induced; alpha-Fetoproteins; Animals; Female; Macaca mulatta; Neural Tube Defect

1985
Clinical-epidemiologic assessment of pattern of birth defects associated with human teratogens: application to diabetic embryopathy.
    Pediatrics, 1989, Volume: 84, Issue:4

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Diabetes Mellitus, Type 1; Female; Georgia; H

1989
Thalidomide, orogenital ulcers, and risk of teratogenicity.
    Lancet (London, England), 1985, Mar-02, Volume: 1, Issue:8427

    Topics: Abnormalities, Drug-Induced; Female; Genital Diseases, Female; Humans; Pregnancy; Risk; Stomatitis,

1985
Thalidomide in dermatology and leprosy.
    Lancet (London, England), 1985, Jul-13, Volume: 2, Issue:8446

    Topics: Female; Humans; Leprosy; Male; Pregnancy; Skin Diseases; Thalidomide

1985
An indirect assessment of the Chernoff/Kavlock assay.
    Teratogenesis, carcinogenesis, and mutagenesis, 1987, Volume: 7, Issue:1

    Topics: Animals; Body Weight; Eating; Female; Fetus; Growth; Hemodynamics; Lethal Dose 50; Pregnancy; Rats;

1987
Anaesthesia and thalidomide-related abnormalities.
    Anaesthesia, 1989, Volume: 44, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section;

1989
After the tragedy: living with the consequences.
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Abnormalities, Drug-Induced; Attitude to Health; Disabled Persons; Female; Humans; Infant, Newborn;

1988
Embryotoxic effects of thalidomide derivatives on the non-human primate Callithrix jacchus; 3. Teratogenic potency of the EM 12 enantiomers.
    Archives of toxicology, 1988, Volume: 62, Issue:2-3

    Topics: Abnormalities, Drug-Induced; Animals; Callithrix; Female; Pregnancy; Stereoisomerism; Thalidomide

1988
Thalidomide retrospective: what did we learn?
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Pregnancy; Teratogens; Thalidomide

1988
Why I doubted that thalidomide was the cause of the epidemic of limb defects of 1959 to 1961.
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Animals; Arm; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Leg; Pregnancy; Teratog

1988
Thalidomide update: regulatory aspects.
    Teratology, 1988, Volume: 38, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Legislation, Drug; Pregnancy; Teratoge

1988
Prenatal diagnosis of thalidomide syndrome.
    Prenatal diagnosis, 1987, Volume: 7, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Ectromelia; Female; Fetal Diseases; Humans; Pregnancy; Prenatal

1987
Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development.
    Archives of toxicology, 1988, Volume: 61, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Callithrix; Dose-Response Relationship, Drug;

1988
Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. II. Elucidation of the susceptible period and of the variability of embryonic stages.
    Archives of toxicology, 1988, Volume: 61, Issue:3

    Topics: Animals; Callithrix; Embryo, Mammalian; Embryonic and Fetal Development; Female; Gestational Age; Ma

1988
Pregnancy in women with thalidomide-induced disabilities. Case report and a questionnaire study.
    British journal of obstetrics and gynaecology, 1988, Volume: 95, Issue:7

    Topics: Abnormalities, Drug-Induced; Adult; Cesarean Section; Ectromelia; Female; Humans; Infant, Newborn; P

1988
Monitoring for multiple malformations in the detection of epidemics of birth defects.
    Teratology, 1987, Volume: 36, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Biometry; Female; Humans; Pregnancy; Rubella;

1987
Electroencephalographic study of 137 patients with thalidomide embryopathy.
    The Japanese journal of psychiatry and neurology, 1987, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Brain; Child; Electroencephalography; Epilepsy; Female; Fetal Diseases; Hearing D

1987
The value of case reports in human teratology.
    American journal of obstetrics and gynecology, 1986, Volume: 154, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth

1986
Acetylcholine and choline levels in rabbit fetuses exposed to anticholinergics.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1987, Volume: 5, Issue:2

    Topics: Acetylcholine; Animals; Choline; Female; Fetal Diseases; Fetus; Gestational Age; Maternal-Fetal Exch

1987
Progressive non-infectious anterior vertebral fusion.
    Skeletal radiology, 1986, Volume: 15, Issue:8

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Fetal Diseases; Humans; Kyphosis; Lumbar V

1986
Preventive surgery for congenital deformities of the hand.
    Hand clinics, 1985, Volume: 1, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Fetus; Genetic Engineering;

1985
[Detection and quantification of adverse reactions on the embryo and the fetus: studies and registries of congenital malformations].
    Medicina clinica, 1986, Jan-11, Volume: 86, Issue:1

    Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Pregnancy; Registries; Research Design; Spa

1986
The role of cholinergic nerves in development.
    Progress in clinical and biological research, 1985, Volume: 163C

    Topics: Abnormalities, Drug-Induced; Animals; Extremities; Female; Humans; Limb Deformities, Congenital; Par

1985
Thalidomide embryopathy in Germany, 1959-1961.
    Progress in clinical and biological research, 1985, Volume: 163C

    Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Germany, West; Humans; Infant, Newborn; Male; Pregn

1985
Temporomandibular malformations in the bonnet monkey (Macaca radiata) fetus following maternal ingestion of thalidomide.
    Journal of craniofacial genetics and developmental biology, 1985, Volume: 5, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetus; Gestational A

1985
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
    Teratology, 1985, Volume: 32, Issue:1

    Topics: Abdomen; Abnormalities, Multiple; Cardiovascular Abnormalities; Cranial Nerves; Dentition; Embryo, M

1985
On predicting environmentally-induced human reproductive hazards: an overview and historical perspective.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:4

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dose-Response Relationship, Drug; Female; Humans;

1985
[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits].
    Jikken dobutsu. Experimental animals, 1985, Volume: 34, Issue:3

    Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Female; Heart Defects, Congenital; Hydroce

1985
Blame, compensation and birth defects.
    The Medical journal of Australia, 1985, Nov-11, Volume: 143, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation; Drug Industry; Female; Humans; Infant, Newbor

1985
Thalidomide and congenital Charcot's joints.
    Lancet (London, England), 1973, Nov-10, Volume: 2, Issue:7837

    Topics: Abnormalities, Drug-Induced; Ankle; Arthrography; Arthropathy, Neurogenic; Bone and Bones; Child; Em

1973
Letter: Thalidomide and embryonic neuropathy.
    Lancet (London, England), 1974, Jun-01, Volume: 1, Issue:7866

    Topics: Abnormalities, Drug-Induced; Animals; Cervical Plexus; Female; Ganglia, Spinal; Pregnancy; Rabbits;

1974
The susceptibility of the fetus and child to chemical pollutants. Chemicals in human teratogenesis and transplacental carcinogenesis.
    Pediatrics, 1974, Volume: 53, Issue:5

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Amphetamine; Androgens; Anticonvulsants; Antithyroid

1974
Human experiences related to adverse drug reactions to the fetus or neonate from some maternally administered drugs.
    Advances in experimental medicine and biology, 1972, Volume: 27

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Antithyroid Agents; Contraceptives, Oral; Diethy

1972
Another chance for thalidomide?
    Lancet (London, England), 1966, Jan-08, Volume: 1, Issue:7428

    Topics: Abnormalities, Drug-Induced; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Culture

1966
Thalidomide.
    Lancet (London, England), 1965, Nov-20, Volume: 2, Issue:7421

    Topics: Abnormalities, Drug-Induced; Anodontia; Child, Preschool; Female; Humans; Pregnancy; Thalidomide; To

1965
Minor ocular abnormalities associated with thalidomide.
    Lancet (London, England), 1966, May-21, Volume: 1, Issue:7447

    Topics: Abnormalities, Drug-Induced; Child, Preschool; Choroid; Eye Abnormalities; Female; Humans; Infant; I

1966
Immunosuppression by thalidomide: implications for teratology.
    Lancet (London, England), 1966, May-21, Volume: 1, Issue:7447

    Topics: Abnormalities, Drug-Induced; Abortion, Habitual; Female; Humans; Immunosuppressive Agents; Pregnancy

1966
Effect of thalidomide on survival of skin homografts in rabbits.
    Lancet (London, England), 1966, Jun-04, Volume: 1, Issue:7449

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Female; Immunosuppressive Agents; Pregn

1966
Congenital deformities and insulin antagonism.
    Lancet (London, England), 1966, Oct-29, Volume: 2, Issue:7470

    Topics: Carbohydrate Metabolism; Consanguinity; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases;

1966
Influence of thalidomide on fertility and on reproductive organs in rats. Preliminary communication.
    American journal of obstetrics and gynecology, 1968, Feb-15, Volume: 100, Issue:4

    Topics: Animals; Endometrium; Estrus; Female; Fertility; Ovary; Ovulation; Pregnancy; Rats; Staining and Lab

1968
Is lysergide a teratogen?
    Lancet (London, England), 1968, Mar-23, Volume: 1, Issue:7543

    Topics: Abnormalities, Drug-Induced; Animals; Female; Lysergic Acid Diethylamide; Pregnancy; Rabbits; Specie

1968
Teratology.
    Lancet (London, England), 1969, Sep-06, Volume: 2, Issue:7619

    Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Chick Embryo; Congenital Abnormalities; Embryo, Ma

1969
[Problems posed by the effects of medication on offspring].
    Pure and applied chemistry. Chimie pure et appliquee, 1969, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Dactinomycin; Female; Fetus; Glutethimide; Humans; Hypoglycemi

1969
Normal child after maternal thalidomide ingestion in critical period of pregnancy.
    Lancet (London, England), 1970, Feb-07, Volume: 1, Issue:7641

    Topics: Child; Female; Gestational Age; Humans; Male; Pregnancy; Thalidomide

1970
Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys.
    Teratology, 1973, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Arm; Bone and Bones; Brain; Dose-Response Relationship, Drug;

1973
The sensitive period and malformation syndrome produced by thalidomide in crab-eating monkey (Macaca fascicularis).
    Journal of medical primatology, 1973, Volume: 2, Issue:5

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Coccyx; Female; Femur; Fingers; Gestatio

1973
The relation of vitamin-B complex to the effect of thalidomide on the sensitivity of intracellular haemoglobin to oxidation.
    Developmental medicine and child neurology, 1967, Volume: 9, Issue:1

    Topics: Animals; Erythrocytes; Female; Glutethimide; Hemoglobins; Male; Niacinamide; Oxidation-Reduction; Ph

1967
Effect of transplanted tumor and various agents on liver regeneration during pregnancy.
    Rivista di patologia nervosa e mentale, 1966, Volume: 87, Issue:4

    Topics: Animals; Benzofurans; Carcinoma 256, Walker; Female; Fetal Death; Hepatectomy; Liver Regeneration; N

1966
[On the penetration of foreign body materials into the young vertebrate embryo].
    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1966, Volume: 22, Issue:1

    Topics: Animals; Deferoxamine; Embryo Implantation; Embryo, Mammalian; Female; Glycosaminoglycans; Lipids; P

1966
[Comparative studies on the problem of the further development disorders of the vertebral column in children with dysmelia syndrome and children with peromelia].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1967, Volume: 103, Issue:3

    Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Diagnosis, Differential; Ectromelia; Female; H

1967
[Teratologic study of a new, structurally related to thalidomide, sedative-hypnotic effective compound (K-2004)].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:2

    Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Her

1969
Hypothetical explanation of the embryotoxic action of thalidomide.
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4

    Topics: Animals; Ascorbic Acid; Collagen; Embryo, Mammalian; Embryo, Nonmammalian; Female; Isoenzymes; Ketog

1970
A morphological and histochemical study of thalidomide-induced upper limb malformations in rabbit fetuses.
    Teratology, 1971, Volume: 4, Issue:4

    Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Bone and Bones; Calcium; Cartilage; Embr

1971
[Abnormalities in the field of otorhinolaryngology. Genetic report].
    Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1972, Volume: 202, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Chromosome Aberrations

1972
Tumour-incidence in progeny of thalidomide-treated mice.
    British journal of cancer, 1967, Volume: 21, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Female; Hodgkin D

1967
Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats.
    Laboratory animal care, 1969, Volume: 19, Issue:5

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animal Feed; Animals; Birth Weight; Chlorproma

1969
A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
    Teratology, 1968, Volume: 1, Issue:3

    Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Car

1968
[Drug-induced polyneuropathy].
    Therapeutische Umschau. Revue therapeutique, 1970, Volume: 27, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Drug-Related Side Effects and Adverse Reactions; Female

1970
Disorders of the auditory apparatus caused by embryopathy or foetopathy: prophylaxis and treatment (a) deafness as a result of congenital malformations occurring during the first three months (b) deafness resulting from diseases of the foetus occurring af
    Acta oto-laryngologica. Supplementum, 1971, Volume: 291

    Topics: Child, Preschool; Deafness; Ear; Ear, Inner; Female; Humans; Pregnancy; Pregnancy Complications; Rad

1971
[Genetic analysis of skeletal diseases. Genetic report].
    Der Radiologe, 1973, Volume: 13, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Bone Diseases; Child; Chromoso

1973
Editorial: The pathogenesis of congenital malformations.
    The Medical journal of Australia, 1974, Feb-09, Volume: 1, Issue:6

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Female; Humans; Infant, Newborn; Pregnancy; P

1974
A note on the absorption and excretion of 14C-labelled thalidomide in pregnant mice.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:1

    Topics: Animals; Carbon Isotopes; Digestive System; Feces; Female; Fetus; Maternal-Fetal Exchange; Mice; Pla

1966
Congenital malformations in nonhuman primates: spontaneous and experimentally induced.
    The Anatomical record, 1967, Volume: 158, Issue:1

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Congenital Abnormalities; Female; Haplor

1967
The fate of [14C] thalidomide in the pregnant hamster.
    The Journal of pharmacy and pharmacology, 1967, Volume: 19, Issue:9

    Topics: Animals; Carbon Isotopes; Cricetinae; Embryo, Mammalian; Female; Maternal-Fetal Exchange; Pregnancy;

1967
Effects of thalidomide and chlorcyclizine on the biosynthesis of nucleic acids and proteins in fetal and maternal tissues of the rat.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 171, Issue:1

    Topics: Amino Acids; Animals; Carbon Isotopes; Chromatography, Thin Layer; Dactinomycin; DNA; Female; Fetus;

1970
[Embryotoxicity of N-phthaloyl-DL-glutamine].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1971, Volume: 26, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Glutamine; Mice; Phthalic Acids; Pr

1971
[Embryotoxic acitivity of N-phthaloyl-DL-isoglutamine].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1971, Volume: 26, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Glutamine; Mice; Mice, Inbred Strains;

1971
Fetal nerve cell degeneration produced by thalidomide in rabbits.
    Teratology, 1974, Volume: 10, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Cell Nucleolus; Cell Nucleus; Dose-Response Relationship, Drug

1974
Teratogenicity and embryotoxicity of thalidomide and 3-aza-thalidomide in mice.
    Pharmacology, 1974, Volume: 11, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Aza Compounds; Body Weight; Bone and Bones; Depression, Chemic

1974
Problems associated with the screening of drugs for possible teratogenic activity.
    Experimental embryology and teratology, 1974, Volume: 1, Issue:0

    Topics: 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Rela

1974
The missing umbilical artery. I. Prospective study based on a maternity unit.
    Archives of disease in childhood, 1974, Volume: 49, Issue:11

    Topics: Adult; Anencephaly; Birth Weight; Congenital Abnormalities; Female; Gestational Age; Humans; Hydroce

1974
[Teratological study on the thalidomide-like compounds K-2004 and K-2604 in the mouse and rat].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Drug Evalua

1974
Teratogenicity from drugs--an increasing problem.
    Disease-a-month : DM, 1974

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Amniocentesis; Animals; Anti-Bact

1974
Drugs and the unborn child.
    Dental anaesthesia and sedation, 1972, Volume: 1, Issue:1

    Topics: Female; Fetus; Maternal-Fetal Exchange; Morphine; Phenothiazines; Pregnancy; Reserpine; Scopolamine;

1972
[The doctor's responsibility and risk in the prescribing of drugs].
    Munchener medizinische Wochenschrift (1950), 1973, Apr-27, Volume: 115, Issue:17

    Topics: Adult; Amphetamine; Appetite Depressants; Drug and Narcotic Control; Drug Industry; Drug Packaging;

1973
The significance of dermatoglyphics in medicine. A short survey and summary.
    Clinical pediatrics, 1973, Volume: 12, Issue:8

    Topics: Abnormalities, Drug-Induced; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 13-15

1973
[Drugs as cause of diseases].
    Der Internist, 1974, Volume: 15, Issue:1

    Topics: Abnormalities, Drug-Induced; Berlin; Contraceptives, Oral; Cortisone; Drug-Related Side Effects and

1974
The teratogenic activity of a thalidomide analogue, EM 12 in rabbits, rats, and monkeys.
    Teratology, 1972, Volume: 5, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Bone Diseases, Developmental; Female; Fetal De

1972
The marmoset as a model for teratological research.
    Journal of anatomy, 1972, Volume: 111, Issue:Pt 3

    Topics: Abnormalities, Drug-Induced; Animals; Estrus; Female; Haplorhini; Pregnancy; Thalidomide; Twins; Vit

1972
Limb reduction anomalies induced in the marmoset by thalidomide.
    Journal of anatomy, 1972, Volume: 111, Issue:Pt 3

    Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Female; Haplorhini; Limb Deformities, Congenital;

1972
Effects on macaque embryos of drugs reported or suspected to be teratogenic to humans.
    Acta endocrinologica. Supplementum, 1972, Volume: 166

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Cesarean Section; Embryo, Mammalian; Fem

1972
The marmoset as an animal model for teratological research.
    Nature, 1972, Oct-20, Volume: 239, Issue:5373

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Disease Models, Animal; Female; Fetu

1972
Pharmacodynamic principles in chemical teratology: dose-effect relationships.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 183, Issue:3

    Topics: Abnormalities, Drug-Induced; Adsorption; Cyclophosphamide; Dose-Response Relationship, Drug; Drug-Re

1972
Television programme no contempt.
    British medical journal, 1972, Dec-02, Volume: 4, Issue:5839

    Topics: Abnormalities, Drug-Induced; Child; Female; Humans; Jurisprudence; Pregnancy; Television; Thalidomid

1972
Thalidomide injunction granted.
    British medical journal, 1972, Dec-02, Volume: 4, Issue:5839

    Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Humans; Jurisprudence; Newspapers as Topic; P

1972
[Drug therapy in females of the reproductive age with reference to teratologic aspects].
    Munchener medizinische Wochenschrift (1950), 1972, Sep-08, Volume: 114, Issue:36

    Topics: Abnormalities, Drug-Induced; Age Factors; Aminopterin; Drug-Related Side Effects and Adverse Reactio

1972
The use of an incubator in detecting drug-induced congenital malformations.
    Advances in experimental medicine and biology, 1972, Volume: 27

    Topics: Abnormalities, Drug-Induced; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotra

1972
Drug testing for teratogenicity: its implications, limitations and application to man.
    Advances in experimental medicine and biology, 1972, Volume: 27

    Topics: Abnormalities, Drug-Induced; Abortion, Induced; Animals; Animals, Laboratory; Communication; Compute

1972
Disabled children--free contraception for all? More liberal liquor laws?
    The New England journal of medicine, 1973, Feb-22, Volume: 288, Issue:8

    Topics: Abnormalities, Drug-Induced; Adult; Alcoholism; Child; Contraception; Family Planning Services; Fema

1973
Congenital malformations and their control.
    British medical journal, 1973, Jan-27, Volume: 1, Issue:5847

    Topics: Abnormalities, Drug-Induced; Animals; Dogs; Female; Humans; Mice; Pregnancy; Rats; Thalidomide

1973
Moebius syndrome associated with the mother taking thalidomide during gestation. Case report.
    Plastic and reconstructive surgery, 1973, Volume: 51, Issue:1

    Topics: Abducens Nerve; Abnormalities, Drug-Induced; Abnormalities, Multiple; Anxiety; Facial Expression; Fa

1973
The fetus: medicine's newest patient.
    Journal of the Irish Medical Association, 1973, Apr-28, Volume: 66, Issue:8

    Topics: Abnormalities, Drug-Induced; Embryonic and Fetal Development; Female; Fetal Diseases; Fetus; Humans;

1973
[Teratological tests of the hydrolysis products of thalidomide].
    Experientia, 1973, Apr-15, Volume: 29, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Gestational Age; Glutamates; Hydrolysis; Matern

1973
The effect of thalidomide intake during 113 human pregnancies.
    Teratology, 1973, Volume: 8, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Gestational Age; Humans; Japan; Pregnanc

1973
[Action of psychopharmacological agents on the product of conception].
    Minerva ginecologica, 1973, Volume: 25, Issue:9

    Topics: Abnormalities, Drug-Induced; Amphetamine; Animals; Anticonvulsants; Embryo, Mammalian; Female; Fetal

1973
Thalidomide and critical period. Prescription for 113 pregnant women in a maternity.
    Acta Universitatis Carolinae. Medica. Monographia, 1973, Volume: 56

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Child; Female; Fetal Death; Fetus; Follow-Up Stu

1973
Prospects and limitations of epidemiology in human teratology.
    Acta Universitatis Carolinae. Medica. Monographia, 1973, Volume: 56

    Topics: Abnormalities, Drug-Induced; Carcinogens; Chromosome Aberrations; Chromosome Disorders; Congenital A

1973
Orofacial malformations.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:5

    Topics: Animals; Antimetabolites; Cell Differentiation; Cleft Lip; Cleft Palate; Dermoid Cyst; Eye Neoplasms

1974
Teratologic studies with FD and C red no. 2 in rats and rabbits.
    Toxicology and applied pharmacology, 1974, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Autopsy; Body Weight; Cleft Palate; Coloring Agents; Female; F

1974
[The teratogenic risk].
    Archives d'anatomie, d'histologie et d'embryologie normales et experimentales, 1968, Volume: 51, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Busulfan; Carbutamide; Congenital Abnormalities;

1968
[Congenital transmission of Trypanosoma cruzi. I. Effect of thalidomide on T. cruzi infection in rats].
    Biologica (Santiago, Chile), 1965, Volume: 37

    Topics: Animals; Animals, Newborn; Chagas Disease; Female; Mice; Placenta; Pregnancy; Pregnancy, Animal; Tha

1965
The teratogenic activity of thalidomide in the rabbit.
    The Journal of pathology and bacteriology, 1966, Volume: 91, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Eye Abnormalities; Female; Limb Deformities, Congenital; Nervo

1966
Ocular findings in thalidomide children.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1967, Volume: 2, Issue:3

    Topics: Abnormalities, Drug-Induced; Blepharoptosis; Canada; Coloboma; Eye Abnormalities; Female; Humans; In

1967
Drug toxicity in the animal fetus.
    Applied therapeutics, 1967, Volume: 9, Issue:11

    Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cats; Cricetinae; Dogs; Embryo, Mammalian; Female; Fe

1967
[A case of thalidomide anotia].
    Minerva pediatrica, 1967, Nov-17, Volume: 19, Issue:46

    Topics: Abnormalities, Drug-Induced; Ataxia; Blepharoptosis; Child; Ear; Eye Abnormalities; Female; Humans;

1967
[A comparison of the sensitive phase for thalidomide in animal experiment and in man].
    Archiv fur Kinderheilkunde, 1968, Volume: 177, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Arm; Ear; Female; Fetal Diseases; Haplorhini; Humans; Infant,

1968
Thalidomide: disposition in rhesus monkey and studies of its hydrolysis in tissues of this and other species.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 173, Issue:2

    Topics: Absorption; Animals; Brain; Brain Chemistry; Cricetinae; Dogs; Feces; Female; Haplorhini; In Vitro T

1970
An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates.
    Toxicology and applied pharmacology, 1971, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Female; Fetus; Haplorhini; Humerus; Indoles

1971
Motor skills of infant rhesus monkeys with thalidomide-induced forelimb malformations.
    Developmental psychobiology, 1969, Volume: 2, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Disease Models, Animal; Exploratory Behavior

1969
[Thalidomide analogues. IV].
    Justus Liebigs Annalen der Chemie, 1972, Volume: 755

    Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Culture Techniques; Embryo, Mamm

1972
Teratological studies on thalidomide in rats.
    Acta pharmacologica et toxicologica, 1972, Volume: 31, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Bone and Bones; Cesarean Section; F

1972
Teratological studies on thalidomide in rabbits.
    Acta pharmacologica et toxicologica, 1972, Volume: 31, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Autolysis; Birth Weight; Body Weight; Bone and Bones; Cesarean

1972
Thalidomide teratology in swine: a preparatory study.
    Acta pharmacologica et toxicologica, 1972, Volume: 31, Issue:1

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Bone and Bones; Female; Fetus; Gestation

1972
Michel's deafness.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1972, Volume: 96, Issue:3

    Topics: Abnormalities, Drug-Induced; Child; Deafness; Ear Canal; Ear, Inner; Female; Humans; Pregnancy; Thal

1972
[Synthesis and teratologic examination of various thalidomide metabolites].
    Die Pharmazie, 1972, Volume: 27, Issue:6

    Topics: Animals; Benzoates; Embryo, Mammalian; Female; Glutamates; Glutamine; Hydrolysis; Imides; Mice; Phth

1972
[Drugs during pregnancy].
    Therapeutische Umschau. Revue therapeutique, 1971, Volume: 28, Issue:7

    Topics: Antineoplastic Agents; Calcium; Coumarins; Ergot Alkaloids; Female; Hormones; Humans; Iron; Pregnanc

1971
[Compensation of the teratogenic effect of a thalidomide metabolite using L-glutamic acid].
    Experientia, 1971, Apr-15, Volume: 27, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Drug Antagonism; Female; Glutamates; Injections, Intraperitone

1971
[Teratological determination of some thalidomide metabolites].
    Experientia, 1971, Oct-15, Volume: 27, Issue:10

    Topics: Abnormalities, Drug-Induced; Amides; Animals; Benzoates; Drug Interactions; Female; Fetus; Glutamate

1971
[Cardiovascular findings in children with the thalidomide-dysmelia-syndrome].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1971, Volume: 37

    Topics: Abnormalities, Drug-Induced; Child; Ectromelia; Female; Germany, West; Heart Defects, Congenital; Hu

1971
Congenital aural atresia: anatomy and surgical management.
    Birth defects original article series, 1971, Volume: 07, Issue:4

    Topics: Abnormalities, Drug-Induced; Chromosome Aberrations; Congenital Abnormalities; Ear; Female; Follow-U

1971
[Toxic injuries in thalidomide medication].
    Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1967, Volume: 35, Issue:8

    Topics: Adult; Depression; Female; Humans; Male; Middle Aged; Polyneuropathies; Pregnancy; Pregnancy Complic

1967
[Thalidomide-embryopathies and their effect on dentition].
    Deutsche zahnarztliche Zeitschrift, 1965, Dec-01, Volume: 20, Issue:12

    Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Infant, Newborn; Jaw Abnormalities; Pregnan

1965
[Dysplasia in the mouth, jaw and teeth in dysmelia. Contribution to the thalidomide-embryopathies].
    Deutsche zahnarztliche Zeitschrift, 1967, Volume: 22, Issue:2

    Topics: Abnormalities, Drug-Induced; Dental Caries; Ectromelia; Female; Humans; Infant, Newborn; Male; Pregn

1967
[Dysgnathias in the deciduous dentition in dysmelia: contribution to thalidomide embryopathy].
    Fortschritte der Kieferorthopadie, 1966, Volume: 27, Issue:4

    Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Dentition; Diastema; Ectromelia; Female; Human

1966
[Cephalometric findings in dysmelic children with symptoms of thalidomide embryopathy].
    Deutsche zahnarztliche Zeitschrift, 1968, Volume: 23, Issue:4

    Topics: Abnormalities, Drug-Induced; Cephalometry; Child; Child, Preschool; Female; Humans; Infant; Male; Mo

1968
[It's not only contergan. In May the big lawsuit begins. It touches on basic problems].
    Zahnarztliche Mitteilungen, 1968, May-01, Volume: 58, Issue:9

    Topics: Abnormalities, Drug-Induced; Drug Industry; Female; Forensic Medicine; Germany, West; Humans; Infant

1968
Clinical, orthodontic and radiological findings in the jaws and face of children with dysmelia associated with thalidomide-embryopathy.
    International dental journal, 1968, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Ankylosis; Cephalometry; Child, Preschool; Cleft Lip; Cleft Palate; Fem

1968
Anomalies of the teeth in a child with upper phocomelia. Report of a case.
    Oral surgery, oral medicine, and oral pathology, 1970, Volume: 29, Issue:2

    Topics: Abnormalities, Drug-Induced; Arm; Child; Ectromelia; Face; Female; Humans; Male; Pregnancy; Pregnanc

1970
[The contergan tragedy--a brutal lesson].
    Zahnarztliche Mitteilungen, 1971, Jan-16, Volume: 61, Issue:2

    Topics: Female; Humans; Legislation, Pharmacy; Pregnancy; Thalidomide

1971
Failure of gestation of goat x sheep hybrids in goats and sheep.
    Journal of reproduction and fertility. Supplement, 1968, Volume: 3

    Topics: Animals; Azathioprine; Embryo, Mammalian; Female; Fetal Death; Fetus; Gestational Age; Goats; Hybrid

1968
[Characteristics of the action of medicinal substances on the fetus at various periods of intrauterine development].
    Vestnik Akademii meditsinskikh nauk SSSR, 1969, Volume: 24, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antine

1969
Developmental biology.
    American journal of diseases of children (1960), 1969, Volume: 118, Issue:6

    Topics: Abnormalities, Drug-Induced; Biology; Cell Differentiation; Cortisone; DNA; Embryonic and Fetal Deve

1969
[Congenital gustolacrimal syndrome complicated with bilateral Duane's syndrome and gustolacrimal reflex, with special emphasis on the etiology].
    Ganka. Ophthalmology, 1969, Volume: 11, Issue:9

    Topics: Child; Child, Preschool; Female; Humans; Male; Ophthalmoplegia; Pregnancy; Reflex, Abnormal; Taste;

1969
[Teratologic studies with imipramine in rats and rabbits. Planning and interpretation of teratologic studies under consideration of the biochemistry and toxicology of test substance].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:10

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Body Weight; Desipramine; Drug Toleranc

1969
Teratogenic activity of several phthalimide derivatives in the golden hamster.
    Toxicology and applied pharmacology, 1970, Volume: 16, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Cricetinae; Embryo, Mammalian;

1970
The alimentary tract malformations in the rabbit thalidomide embryopathy.
    British journal of experimental pathology, 1970, Volume: 51, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Colon; Digestive System Abnormalities; Diverticulum, Colon; Es

1970
Investigations on the possible teratogenic effects of trazodone in rats and rabbits.
    Bollettino chimico farmaceutico, 1970, Volume: 109, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Cyclizine; Female; Maternal-Fetal Exchange; Piperazines; Pregn

1970
Phenocopy.
    Humangenetik, 1970, Volume: 9, Issue:3

    Topics: Abnormalities, Multiple; Anemia, Aplastic; Arm; Congenital Hypothyroidism; Deafness; Female; Feminiz

1970
Teratological studies of p-butoxyphenylacethydroxamic acid (CP 1044 J3) in rats and rabbits.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Hydroxamic Acids; Hydr

1970
[The L-isomer as teratogenic principle of N-phthalyl-DL-glutamic acid].
    Experientia, 1970, Nov-15, Volume: 26, Issue:11

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Glutamates; Isotonic S

1970
Congenital symmetric limb deformities.
    American journal of diseases of children (1960), 1970, Volume: 120, Issue:4

    Topics: Abnormalities, Drug-Induced; Arm; Black People; Congenital Abnormalities; Female; Humans; Infant, Ne

1970
[Surgery in middle ear abnormalities].
    Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1970, Volume: 196, Issue:2

    Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Ear Ossicles; Ear, Middle; Ectromelia; Female;

1970
[Lesions of the auditory apparatus during pregnancy].
    Journal de medecine de Lyon, 1970, Nov-20, Volume: 51, Issue:197

    Topics: Abnormalities, Drug-Induced; Animals; Bacterial Infections; Deafness; Drug-Related Side Effects and

1970
Report of Inter-Society Commission for Heart Disease Resources. Prevention of Cardiovascular Disease. Primary prevention of congenital heart disease.
    Circulation, 1970, Volume: 41, Issue:6

    Topics: Child; Chromosome Aberrations; Female; Fetal Death; Heart Defects, Congenital; Humans; Infant; Infan

1970
[Teratogenic effect of N-phthalyl-DL-glutamic acid following intraperitoneal application in mice].
    Experientia, 1970, Oct-15, Volume: 26, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetus; Glutamates; Mice; Phthalic Acids;

1970
[Study of the thalidomide effect on chick embryo].
    Experimentelle Pathologie, 1970, Volume: 4, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Eggs; Extremities; Female; Fetal Death; Pregnanc

1970
Chromosomal breakage and teratogenesis.
    Teratology, 1971, Volume: 4, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Chromosome Aberrations; Chromosom

1971
[Drugs and pregnancy].
    Nordisk medicin, 1967, Oct-19, Volume: 78, Issue:42

    Topics: Drug-Related Side Effects and Adverse Reactions; Female; Fetus; Humans; Pregnancy; Thalidomide

1967
[The front line in research in experimental teratology].
    Nordisk medicin, 1967, Oct-19, Volume: 78, Issue:42

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Hominidae; Humans; Pregnancy

1967
[Species differences in the metabolism of drugs].
    Nordisk medicin, 1967, Oct-19, Volume: 78, Issue:42

    Topics: Abnormalities, Drug-Induced; Animals; Dogs; Female; Mice; Pharmaceutical Preparations; Pregnancy; Ra

1967
[Teratogenesis and drug control].
    Lijecnicki vjesnik, 1967, Volume: 89, Issue:8

    Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Androgens; Animals; Chlordiazepoxide; Drug and Na

1967
[Significance of exogenous influences for the development of human abnormalities].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1967, Mar-15, Volume: 22, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Fetal Diseases; Humans; Infa

1967
[Symposium on congential malformations. Introduction].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Humans; Infa

1967
[Dysmelia from the view-point of the obstetrician].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ectromelia; Female; Germany, East; Germany, We

1967
[Malformation and liver damage. On the necessary 2nd noxa in experimental thalidomide embryopathies].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbon Tetrachloride; Chemical and Dr

1967
[On methods and statistics in dysmelia research].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Ectromelia; Factor Analysis, Statistical; Female; Health Surveys; Human

1967
[Concluding remarks on the preceding comment by W. Lenz].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Austria; Ectromelia; Female; Humans; Pregnancy; Thalidomide

1967
[Remarks on the work of A. Rett: "The Thalidomide Problem in Austria" Wien. med. Wschr. (1965):21].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Austria; Ectromelia; Female; Humans; Pregnancy; Thalidomide

1967
[Abnormalities of internal organs in thalidomide embryopathy. A contribution to the determination of the sensitivity phase in thalidomide administration during early pregnancy].
    Archiv fur Kinderheilkunde, 1967, Volume: 176, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Digestive System Abnormalities; Ear Deformities, Acquired; Femal

1967
[The genesis of congenital malformations].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Antineoplastic Agents; Cell Division; C

1967
Drug testing in animals for fetal toxicity.
    Bollettino chimico farmaceutico, 1967, Volume: 106, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetus; Male; Pregnancy; Propylene Glycols;

1967
Concerning the morphogeneis of thalidomide dysmelia in rabbits.
    British journal of experimental pathology, 1967, Volume: 48, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Bone and Bones; Cell Differentiation; Ectromeli

1967
[The so-called dysmelia syndrome (Thalidomide embryopathy) and its differential diagnosis].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnosis, Differential; Ectromelia; Facial Ex

1967
[The importance of psychology in the research on the etiology of dysmelia].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Anxiety; Ectromelia; Female; Health Surveys; Humans; Maternal-Fetal Exc

1967
[Inhibition of the immune reaction by thalidomide and the results of this process on the theory of the teratogenous effect of this substance].
    Wiener medizinische Wochenschrift (1946), 1967, Apr-15, Volume: 117, Issue:15

    Topics: Abnormalities, Drug-Induced; Animals; Female; Genes; Immunosuppressive Agents; Mice; Pregnancy; Thal

1967
[Further studies on the growth inhibitory effect of hypnotics in embryos of Sinapis alba].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:12

    Topics: Caffeine; Chloral Hydrate; Chlorophyll; Depression, Chemical; Embryo, Mammalian; Embryo, Nonmammalia

1967
A comparison of the teratogenic activity of thalidomide in rabbits and rats.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 160, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Dimethyl Sulfoxide; Embryo Implantation; Femal

1968
Binding of thalidomide by macromolecules in the fetal and maternal rat.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:2

    Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema

1968
Binding of thalidomide by macromolecules in the fetal and maternal rat.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:2

    Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema

1968
Binding of thalidomide by macromolecules in the fetal and maternal rat.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:2

    Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema

1968
Binding of thalidomide by macromolecules in the fetal and maternal rat.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:2

    Topics: Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Gel; DNA; Electrophoresis; Fema

1968
A Swedish register of congenital malformations. Experience with continuous registration during 2 years with special reference to multiple malformations.
    Pediatrics, 1968, Volume: 41, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Fetal Death;

1968
Effect of thalidomide on the antibody response.
    American journal of obstetrics and gynecology, 1968, Volume: 100, Issue:7

    Topics: Animals; Antibody Formation; Culture Techniques; Female; Hemagglutination Tests; Immunosuppressive A

1968
The cardiovascular malformations in the rabbit thalidomide embryopathy.
    British journal of experimental pathology, 1968, Volume: 49, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Aorta; Bronchial Arteries; Cardiovascular Abnormalities; Cardi

1968
Thalidomide. A study of biochemical teratology.
    Archives of environmental health, 1968, Volume: 16, Issue:4

    Topics: Abnormalities, Drug-Induced; Amines; Animals; Chemistry, Pharmaceutical; Ectromelia; Embryo, Mammali

1968
The susceptible period for thalidomide malformations in man and monkey.
    German medical monthly, 1968, Volume: 13, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Humans; Monkey Diseases; Pregnancy;

1968
[Action of thalidomide on the rate of malformations in rats with preformed genetic damage caused by malachite green].
    Archiv fur Toxikologie, 1968, Volume: 23, Issue:2

    Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Coloring Agents; Dwarfism; Female; Fetal De

1968
Genetical, social, and medical aspects of abortion.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1968, Jul-20, Volume: 42, Issue:28

    Topics: Abnormalities, Drug-Induced; Abortion, Criminal; Abortion, Legal; Abortion, Therapeutic; Adolescent;

1968
[Prenatal and neonatal drug-induced lesions].
    Wiener klinische Wochenschrift, 1968, Jun-21, Volume: 80, Issue:25

    Topics: Abnormalities, Drug-Induced; Adult; Androgens; Drug-Related Side Effects and Adverse Reactions; Eryt

1968
[Treatment of leprous reaction of the erythema nodosum type with thalidomide (N-phthalimidoglutarimide)].
    Bulletin de la Societe medicale d'Afrique noire de langue francaise, 1968, Volume: 13, Issue:1

    Topics: Ectromelia; Erythema Nodosum; Female; Humans; Leprosy; Male; Pregnancy; Sex Factors; Thalidomide

1968
[Thalidomide embryopathy in Japan].
    Archiv fur Kinderheilkunde, 1968, Volume: 177, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ear; Ectromelia; Female; Fetal Diseases; Finge

1968
[Malformations].
    Beitrage zur Orthopadie und Traumatologie, 1968, Volume: 15, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Embryology; Female; Fetal Diseases;

1968
[Chemotherapeutic fetopathy].
    L'union medicale du Canada, 1968, Volume: 97, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Hypnotics and Sedatives; Maternal-Fetal Exchan

1968
Relationship between teratogeny and structure in the thalidomide field.
    Experientia, 1968, Oct-15, Volume: 24, Issue:10

    Topics: Abnormalities, Drug-Induced; Amides; Animals; Aortic Valve Stenosis; Chemical Phenomena; Chemistry;

1968
Thalidomide syndrome in rhesus monkeys (Macaca mulatta).
    Folia primatologica; international journal of primatology, 1969, Volume: 10, Issue:3

    Topics: Animals; Female; Fetal Diseases; Monkey Diseases; Pregnancy; Thalidomide

1969
[Thalidomide embryopathy. V. Kidney malformations].
    Deutsche medizinische Wochenschrift (1946), 1965, Dec-03, Volume: 90, Issue:49

    Topics: Abnormalities, Drug-Induced; Female; Humans; Kidney; Pregnancy; Thalidomide

1965
Persistent stapedial artery.
    The Journal of laryngology and otology, 1965, Volume: 79, Issue:11

    Topics: Abnormalities, Drug-Induced; Child, Preschool; Deafness; Ear Ossicles; Ear, Middle; Female; Humans;

1965
The metabolism of thalidomide: some biological effects of thalidomide and its metabolites.
    British journal of pharmacology and chemotherapy, 1965, Volume: 25, Issue:2

    Topics: Animals; Carboxy-Lyases; Chemical Phenomena; Chemistry; Female; Glutamate Dehydrogenase; Glutamates;

1965
Susceptibility of certain inbred strains of hamsters to teratogenic effects of thalidomide.
    Toxicology and applied pharmacology, 1965, Volume: 7, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Breeding; Cricetinae; Female; Fetus; In Vitro Techniques; Preg

1965
Embryotoxic activity of some pesticides and drugs related to phthalimide.
    Food and cosmetics toxicology, 1965, Volume: 3, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Chemical Phenomena; Chemistry; Female; Imid

1965
Thalidomide malformations and genetic background in the rabbit.
    Experientia, 1965, Nov-15, Volume: 21, Issue:11

    Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Rabbits; Thalidomide

1965
[The sensitive phase in thalidomide embryopathy].
    Humangenetik, 1965, Volume: 1, Issue:6

    Topics: Female; Fetus; Humans; Pregnancy; Thalidomide

1965
Transplacental effects of drugs in mice.
    Texas reports on biology and medicine, 1965,Winter, Volume: 23, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell

1965
Teratogenetic properties of thalidomide.
    British medical journal, 1965, Oct-30, Volume: 2, Issue:5469

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Humans; Pregnancy; Thalidomide

1965
Thalidomide injury to the myocardium of armadillo embryos.
    Journal of embryology and experimental morphology, 1965, Volume: 13, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Heart; Myocardium; Necrosis; Pregna

1965
Thalidomide experience in Japan.
    Annales paediatrici. International review of pediatrics, 1965, Volume: 205, Issue:5

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Ectromelia; Female; Humans; Infant, Newborn; J

1965
[Disorders of induction and morphogenesis caused by drugs].
    Arzneimittel-Forschung, 1965, Volume: 15, Issue:8

    Topics: Abnormalities, Drug-Induced; Cell Differentiation; DNA; Embryo, Mammalian; Enzymes; Female; Genetic

1965
Medical and psychosocial aspects of the habilitation of thalidomide children.
    Canadian Medical Association journal, 1966, Aug-27, Volume: 95, Issue:9

    Topics: Abnormalities, Drug-Induced; Adult; Artificial Limbs; Child, Preschool; Deafness; Ear Deformities, A

1966
Thalidomide solutions.
    Science (New York, N.Y.), 1966, Dec-09, Volume: 154, Issue:3754

    Topics: Animals; Chemical Phenomena; Chemistry; Female; Methylcellulose; Pregnancy; Rabbits; Solutions; Thal

1966
Thalidomide solutions.
    Science (New York, N.Y.), 1966, Dec-09, Volume: 154, Issue:3754

    Topics: Animals; Female; Methylcellulose; Pregnancy; Rabbits; Solutions; Thalidomide

1966
Thalidomide: the case for legal action.
    The Medical journal of Australia, 1966, May-14, Volume: 1, Issue:20

    Topics: Abnormalities, Drug-Induced; Australia; Drug Industry; Female; Humans; Jurisprudence; Pregnancy; Tha

1966
[Thalidomide-damaged children with multiple handicaps. The problem of diagnosis and rehabilitation].
    Lakartidningen, 1966, Jan-26, Volume: 63, Issue:4

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Pregnancy; Sweden; Thalidomide

1966
Hazards to the newlyborn infant from thalidomide-containing drugs administered to pregnant mothers. (Report on three cases).
    The Journal of the Egyptian Medical Association, 1966, Volume: 49, Issue:1

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Limb Deformities, Congenital; Male; Pregnancy;

1966
Teratological studies in the thalidomide field.
    Life sciences, 1966, Volume: 5, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Fetal Death; Hexobarbital; Mice; Pregn

1966
[Considerations on the occurrence of human abnormalities].
    Folia medica Cracoviensia, 1966, Volume: 8, Issue:4

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Environment; Environmental Exposure; Female;

1966
[Thalidomide embryopathy in animal experiments. 3. Teratologic tests of thalidomide catabolic products].
    Zeitschrift fur Kinderheilkunde, 1966, Volume: 96, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Encephalocele; Female; Glutamates; Glutamine; Phthalic Acids;

1966
[Embryopathies and fetal diseases of therapeutic origin].
    Semaine therapeutique, 1966, Volume: 42, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Anticoagulants; Antimalarials; Antineop

1966