thalidomide has been researched along with Polyneuropathy, Acquired in 27 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide, the first clinically available immunomodulatory drug, reaches monotherapy treatment response in about 1/ 3 of significantly pretreated patients with multiple myeloma, and in combination with glucocorticoids approximately 50% response rate." | 8.89 | [Thalidomide in the treatment of multiple myeloma: focus on combination with bortezomib]. ( Gumulec, J; Hájek, R; Plonková, H, 2013) |
| "POEMS syndrome is associated with plasma cell dyscrasias and upregulation of vascular endothelial growth factor leading to systemic oedema, papilloedema and pulmonary hypertension." | 5.48 | POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation. ( Gilbert, L; Ordway, S; Wanko, S, 2018) |
| "Thalidomide, the first clinically available immunomodulatory drug, reaches monotherapy treatment response in about 1/ 3 of significantly pretreated patients with multiple myeloma, and in combination with glucocorticoids approximately 50% response rate." | 4.89 | [Thalidomide in the treatment of multiple myeloma: focus on combination with bortezomib]. ( Gumulec, J; Hájek, R; Plonková, H, 2013) |
| "Thalidomide is a promising therapy for multiple myeloma." | 3.72 | Thalidomide neuropathy: clinical, electrophysiological and neuroradiological features. ( Barbero, P; Bergamasco, B; Bergui, M; Bertola, A; Boccadoro, M; Ciaramitaro, P; Cocito, D; Durelli, L; Isoardo, G; Palumbo, A, 2004) |
| "POEMS syndrome is associated with plasma cell dyscrasias and upregulation of vascular endothelial growth factor leading to systemic oedema, papilloedema and pulmonary hypertension." | 1.48 | POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation. ( Gilbert, L; Ordway, S; Wanko, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Szudy-Szczyrek, A | 1 |
| Mlak, R | 1 |
| Bury-Kamińska, M | 1 |
| Mielnik, M | 1 |
| Podgajna, M | 1 |
| Kuśmierczuk, K | 1 |
| Mazurek, M | 1 |
| Homa-Mlak, I | 1 |
| Szczyrek, M | 1 |
| Krawczyk, J | 1 |
| Małecka-Massalska, T | 1 |
| Hus, M | 1 |
| Zaidi, S | 1 |
| Sattar, S | 1 |
| Asumal, KB | 1 |
| Ordway, S | 1 |
| Gilbert, L | 1 |
| Wanko, S | 1 |
| Briani, C | 1 |
| Torre, CD | 1 |
| Campagnolo, M | 1 |
| Lucchetta, M | 1 |
| Berno, T | 1 |
| Candiotto, L | 1 |
| Padua, L | 1 |
| Ermani, M | 1 |
| Cavaletti, G | 1 |
| Zambello, R | 1 |
| Hájek, R | 1 |
| Plonková, H | 1 |
| Gumulec, J | 1 |
| Lin, CL | 1 |
| Huang, P | 1 |
| Chen, GS | 1 |
| Lan, CC | 1 |
| Shahan, JL | 1 |
| Panu, LD | 1 |
| Hildebrandt, GC | 1 |
| COHEN, S | 1 |
| Isoardo, G | 1 |
| Bergui, M | 1 |
| Durelli, L | 1 |
| Barbero, P | 1 |
| Boccadoro, M | 1 |
| Bertola, A | 1 |
| Ciaramitaro, P | 1 |
| Palumbo, A | 1 |
| Bergamasco, B | 1 |
| Cocito, D | 1 |
| Laaksonen, S | 1 |
| Remes, K | 1 |
| Koskela, K | 1 |
| Voipio-Pulkki, LM | 1 |
| Falck, B | 1 |
| Mumenthaler, M | 1 |
| Schröder, JM | 1 |
| Gibbels, E | 4 |
| Liebaldt, GP | 1 |
| Broser, F | 2 |
| Amelung, W | 1 |
| Püntmann, E | 1 |
| Suchenwirth, R | 3 |
| Scheid, W | 1 |
| Wieck, HH | 1 |
| Kinzel, W | 1 |
| Herken, H | 1 |
| Merklen, FP | 1 |
| Cottenot, F | 1 |
| Pennec, J | 1 |
| Vernant, JC | 1 |
| Buzacoux, J | 1 |
| Hartlmaier, KM | 1 |
| Bochnik, HJ | 1 |
| Mainzer, G | 1 |
| Mannheim, W | 1 |
| Pittrich, W | 1 |
| Spehr, W | 1 |
| Hopf, HC | 1 |
| Hohl, J | 1 |
| Hafström, T | 1 |
| Seitelberger, F | 1 |
1 review available for thalidomide and Polyneuropathy, Acquired
| Article | Year |
|---|---|
[Thalidomide in the treatment of multiple myeloma: focus on combination with bortezomib].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Hu | 2013 |
2 trials available for thalidomide and Polyneuropathy, Acquired
| Article | Year |
|---|---|
Serum brain-derived neurotrophic factor (BDNF) concentration predicts polyneuropathy and overall survival in multiple myeloma patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bortezomib; Brain-Derived Neurotrophic Factor; Di | 2020 |
Thalidomide therapy and polyneuropathy in myeloma patients.
Topics: Action Potentials; Adult; Aged; Disease Progression; Female; Humans; Immunosuppressive Agents; Male; | 2005 |
24 other studies available for thalidomide and Polyneuropathy, Acquired
| Article | Year |
|---|---|
An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome.
Topics: Adult; Dexamethasone; Female; Humans; Hypogonadism; Melphalan; Paraproteinemias; POEMS Syndrome; Pol | 2017 |
POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation.
Topics: Adult; Combined Modality Therapy; Cyclophosphamide; Diagnosis, Differential; Drug Therapy, Combinati | 2018 |
Lenalidomide in patients with chemotherapy-induced polyneuropathy and relapsed or refractory multiple myeloma: results from a single-centre prospective study.
Topics: Adult; Aged; Angiogenesis Inhibitors; Female; Humans; Lenalidomide; Male; Middle Aged; Multiple Myel | 2013 |
Thalidomide-induced polyneuropathy: friend or foe for relief of itch?
Topics: Antipruritics; Humans; Male; Polyneuropathies; Pruritus; Thalidomide; Young Adult | 2009 |
Rhabdomyolysis in a multiple myeloma patient secondary to concurrent treatment with lenalidomide and pravastatin and to lenalidomide alone.
Topics: Amines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Boronic Acids; Bortezomib; Combi | 2012 |
Thalidomide polyneuropathy.
Topics: Humans; Neurologic Manifestations; Polyneuropathies; Thalidomide | 1962 |
Thalidomide neuropathy: clinical, electrophysiological and neuroradiological features.
Topics: Adult; Aged; Antineoplastic Agents; Axons; Evoked Potentials, Motor; Evoked Potentials, Somatosensor | 2004 |
[Exotoxin-induced polyneuropathies].
Topics: Acrylamides; Carbon Tetrachloride Poisoning; DDT; Disulfiram; Ethanol; Humans; Hydralazine; Isoniazi | 1975 |
[Unmyelinated nerve fibers in senile nerves and in late thalidomide neuropathy: a quantitative electron microscopic study (author's transl)].
Topics: Aged; Aging; Axons; Biopsy; Female; Humans; Male; Microscopy, Electron; Middle Aged; Nerve Degenerat | 1977 |
[What is the relevance of various previous lesions of the peripheral nervous system to a thalidomide polyneuropathy?].
Topics: Adult; Alcoholism; Autopsy; Diagnosis, Differential; Humans; Male; Muscles; Peripheral Nerves; Polyn | 1971 |
[Clinical aspects and therapy of the so-called Contergan-polyneuropathy].
Topics: Adult; Aged; Central Nervous System Diseases; Female; Humans; Male; Middle Aged; Nerve Degeneration; | 1966 |
[Polyneuritis and polyneuropathies due to drug therapy].
Topics: Anticonvulsants; Humans; Nitrofurantoin; Peripheral Nervous System Diseases; Polyneuropathies; Thali | 1968 |
[Thalidomide neuropathy in the late stage. A clinical documentation].
Topics: Aged; Female; Follow-Up Studies; Humans; Leprosy; Male; Middle Aged; Motor Neurons; Nerve Degenerati | 1973 |
[Evaluation of the therapeutical range of drugs].
Topics: Adolescent; Adult; Appetite Depressants; Child; Chloramphenicol; Drug and Narcotic Control; Drug Eva | 1974 |
[Quadriplegia, in lepromatous leprosy previously cleared-up, diffuse polyneuritis which appeared in spite of 6 years of follow-up consolidating treatment with Sultirene alone].
Topics: Adolescent; Adult; Child; Follow-Up Studies; Humans; Leprosy; Male; Polyneuropathies; Quadriplegia; | 1971 |
[Toxic injuries in thalidomide medication].
Topics: Adult; Depression; Female; Humans; Male; Middle Aged; Polyneuropathies; Pregnancy; Pregnancy Complic | 1967 |
[It's not only contergan. In May the big lawsuit begins. It touches on basic problems].
Topics: Abnormalities, Drug-Induced; Drug Industry; Female; Forensic Medicine; Germany, West; Humans; Infant | 1968 |
[Drug use within the scope of anamnesis and objective documentation].
Topics: Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Medical History Taking; Medic | 1971 |
[Problems of permanent damage in Contergan polyneuropathy and other polyneuropathies or polyneuritides. Results of clinical and electromyographic follow ups].
Topics: Aged; Electromyography; Female; Follow-Up Studies; Humans; Neural Conduction; Polyneuropathies; Thal | 1969 |
[Differential diagnosis of polyneuritides].
Topics: Arsenic Poisoning; Carbon Disulfide; Diabetic Neuropathies; Diagnosis, Differential; Diphtheria; Hum | 1969 |
Polyneuropathy after neurosedyn (thalidomide) and its prognosis.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Polyneuropathies; Prognosis; Thalidomide | 1967 |
[Thalidomide polyneuropathy. Clinical bioptical studies].
Topics: Electromyography; Female; Humans; Middle Aged; Muscular Atrophy; Polyneuropathies; Thalidomide | 1968 |
[Polyneuritis (polyneuropathy) of drug origin].
Topics: Anticonvulsants; Humans; Isoniazid; Nitrofurantoin; Polyneuropathies; Thalidomide | 1968 |
[Polyneurites and polyneuropathies of medicamentous origin].
Topics: Animals; Anticonvulsants; Humans; Nitrofurantoin; Polyneuropathies; Rats; Thalidomide | 1968 |