thalidomide has been researched along with Polyneuropathies in 27 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide, the first clinically available immunomodulatory drug, reaches monotherapy treatment response in about 1/ 3 of significantly pretreated patients with multiple myeloma, and in combination with glucocorticoids approximately 50% response rate." | 8.89 | [Thalidomide in the treatment of multiple myeloma: focus on combination with bortezomib]. ( Gumulec, J; Hájek, R; Plonková, H, 2013) |
| "POEMS syndrome is associated with plasma cell dyscrasias and upregulation of vascular endothelial growth factor leading to systemic oedema, papilloedema and pulmonary hypertension." | 5.48 | POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation. ( Gilbert, L; Ordway, S; Wanko, S, 2018) |
| "Thalidomide, the first clinically available immunomodulatory drug, reaches monotherapy treatment response in about 1/ 3 of significantly pretreated patients with multiple myeloma, and in combination with glucocorticoids approximately 50% response rate." | 4.89 | [Thalidomide in the treatment of multiple myeloma: focus on combination with bortezomib]. ( Gumulec, J; Hájek, R; Plonková, H, 2013) |
| "Thalidomide is a promising therapy for multiple myeloma." | 3.72 | Thalidomide neuropathy: clinical, electrophysiological and neuroradiological features. ( Barbero, P; Bergamasco, B; Bergui, M; Bertola, A; Boccadoro, M; Ciaramitaro, P; Cocito, D; Durelli, L; Isoardo, G; Palumbo, A, 2004) |
| "POEMS syndrome is associated with plasma cell dyscrasias and upregulation of vascular endothelial growth factor leading to systemic oedema, papilloedema and pulmonary hypertension." | 1.48 | POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation. ( Gilbert, L; Ordway, S; Wanko, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Szudy-Szczyrek, A | 1 |
| Mlak, R | 1 |
| Bury-Kamińska, M | 1 |
| Mielnik, M | 1 |
| Podgajna, M | 1 |
| Kuśmierczuk, K | 1 |
| Mazurek, M | 1 |
| Homa-Mlak, I | 1 |
| Szczyrek, M | 1 |
| Krawczyk, J | 1 |
| Małecka-Massalska, T | 1 |
| Hus, M | 1 |
| Zaidi, S | 1 |
| Sattar, S | 1 |
| Asumal, KB | 1 |
| Ordway, S | 1 |
| Gilbert, L | 1 |
| Wanko, S | 1 |
| Briani, C | 1 |
| Torre, CD | 1 |
| Campagnolo, M | 1 |
| Lucchetta, M | 1 |
| Berno, T | 1 |
| Candiotto, L | 1 |
| Padua, L | 1 |
| Ermani, M | 1 |
| Cavaletti, G | 1 |
| Zambello, R | 1 |
| Hájek, R | 1 |
| Plonková, H | 1 |
| Gumulec, J | 1 |
| Lin, CL | 1 |
| Huang, P | 1 |
| Chen, GS | 1 |
| Lan, CC | 1 |
| Shahan, JL | 1 |
| Panu, LD | 1 |
| Hildebrandt, GC | 1 |
| COHEN, S | 1 |
| Isoardo, G | 1 |
| Bergui, M | 1 |
| Durelli, L | 1 |
| Barbero, P | 1 |
| Boccadoro, M | 1 |
| Bertola, A | 1 |
| Ciaramitaro, P | 1 |
| Palumbo, A | 1 |
| Bergamasco, B | 1 |
| Cocito, D | 1 |
| Laaksonen, S | 1 |
| Remes, K | 1 |
| Koskela, K | 1 |
| Voipio-Pulkki, LM | 1 |
| Falck, B | 1 |
| Mumenthaler, M | 1 |
| Schröder, JM | 1 |
| Gibbels, E | 4 |
| Liebaldt, GP | 1 |
| Broser, F | 2 |
| Amelung, W | 1 |
| Püntmann, E | 1 |
| Suchenwirth, R | 3 |
| Scheid, W | 1 |
| Wieck, HH | 1 |
| Kinzel, W | 1 |
| Herken, H | 1 |
| Merklen, FP | 1 |
| Cottenot, F | 1 |
| Pennec, J | 1 |
| Vernant, JC | 1 |
| Buzacoux, J | 1 |
| Hartlmaier, KM | 1 |
| Bochnik, HJ | 1 |
| Mainzer, G | 1 |
| Mannheim, W | 1 |
| Pittrich, W | 1 |
| Spehr, W | 1 |
| Hopf, HC | 1 |
| Hohl, J | 1 |
| Hafström, T | 1 |
| Seitelberger, F | 1 |
1 review available for thalidomide and Polyneuropathies
| Article | Year |
|---|---|
[Thalidomide in the treatment of multiple myeloma: focus on combination with bortezomib].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Hu | 2013 |
2 trials available for thalidomide and Polyneuropathies
| Article | Year |
|---|---|
Serum brain-derived neurotrophic factor (BDNF) concentration predicts polyneuropathy and overall survival in multiple myeloma patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bortezomib; Brain-Derived Neurotrophic Factor; Di | 2020 |
Thalidomide therapy and polyneuropathy in myeloma patients.
Topics: Action Potentials; Adult; Aged; Disease Progression; Female; Humans; Immunosuppressive Agents; Male; | 2005 |
24 other studies available for thalidomide and Polyneuropathies
| Article | Year |
|---|---|
An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome.
Topics: Adult; Dexamethasone; Female; Humans; Hypogonadism; Melphalan; Paraproteinemias; POEMS Syndrome; Pol | 2017 |
POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation.
Topics: Adult; Combined Modality Therapy; Cyclophosphamide; Diagnosis, Differential; Drug Therapy, Combinati | 2018 |
Lenalidomide in patients with chemotherapy-induced polyneuropathy and relapsed or refractory multiple myeloma: results from a single-centre prospective study.
Topics: Adult; Aged; Angiogenesis Inhibitors; Female; Humans; Lenalidomide; Male; Middle Aged; Multiple Myel | 2013 |
Thalidomide-induced polyneuropathy: friend or foe for relief of itch?
Topics: Antipruritics; Humans; Male; Polyneuropathies; Pruritus; Thalidomide; Young Adult | 2009 |
Rhabdomyolysis in a multiple myeloma patient secondary to concurrent treatment with lenalidomide and pravastatin and to lenalidomide alone.
Topics: Amines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Boronic Acids; Bortezomib; Combi | 2012 |
Thalidomide polyneuropathy.
Topics: Humans; Neurologic Manifestations; Polyneuropathies; Thalidomide | 1962 |
Thalidomide neuropathy: clinical, electrophysiological and neuroradiological features.
Topics: Adult; Aged; Antineoplastic Agents; Axons; Evoked Potentials, Motor; Evoked Potentials, Somatosensor | 2004 |
[Exotoxin-induced polyneuropathies].
Topics: Acrylamides; Carbon Tetrachloride Poisoning; DDT; Disulfiram; Ethanol; Humans; Hydralazine; Isoniazi | 1975 |
[Unmyelinated nerve fibers in senile nerves and in late thalidomide neuropathy: a quantitative electron microscopic study (author's transl)].
Topics: Aged; Aging; Axons; Biopsy; Female; Humans; Male; Microscopy, Electron; Middle Aged; Nerve Degenerat | 1977 |
[What is the relevance of various previous lesions of the peripheral nervous system to a thalidomide polyneuropathy?].
Topics: Adult; Alcoholism; Autopsy; Diagnosis, Differential; Humans; Male; Muscles; Peripheral Nerves; Polyn | 1971 |
[Clinical aspects and therapy of the so-called Contergan-polyneuropathy].
Topics: Adult; Aged; Central Nervous System Diseases; Female; Humans; Male; Middle Aged; Nerve Degeneration; | 1966 |
[Polyneuritis and polyneuropathies due to drug therapy].
Topics: Anticonvulsants; Humans; Nitrofurantoin; Peripheral Nervous System Diseases; Polyneuropathies; Thali | 1968 |
[Thalidomide neuropathy in the late stage. A clinical documentation].
Topics: Aged; Female; Follow-Up Studies; Humans; Leprosy; Male; Middle Aged; Motor Neurons; Nerve Degenerati | 1973 |
[Evaluation of the therapeutical range of drugs].
Topics: Adolescent; Adult; Appetite Depressants; Child; Chloramphenicol; Drug and Narcotic Control; Drug Eva | 1974 |
[Quadriplegia, in lepromatous leprosy previously cleared-up, diffuse polyneuritis which appeared in spite of 6 years of follow-up consolidating treatment with Sultirene alone].
Topics: Adolescent; Adult; Child; Follow-Up Studies; Humans; Leprosy; Male; Polyneuropathies; Quadriplegia; | 1971 |
[Toxic injuries in thalidomide medication].
Topics: Adult; Depression; Female; Humans; Male; Middle Aged; Polyneuropathies; Pregnancy; Pregnancy Complic | 1967 |
[It's not only contergan. In May the big lawsuit begins. It touches on basic problems].
Topics: Abnormalities, Drug-Induced; Drug Industry; Female; Forensic Medicine; Germany, West; Humans; Infant | 1968 |
[Drug use within the scope of anamnesis and objective documentation].
Topics: Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Medical History Taking; Medic | 1971 |
[Problems of permanent damage in Contergan polyneuropathy and other polyneuropathies or polyneuritides. Results of clinical and electromyographic follow ups].
Topics: Aged; Electromyography; Female; Follow-Up Studies; Humans; Neural Conduction; Polyneuropathies; Thal | 1969 |
[Differential diagnosis of polyneuritides].
Topics: Arsenic Poisoning; Carbon Disulfide; Diabetic Neuropathies; Diagnosis, Differential; Diphtheria; Hum | 1969 |
Polyneuropathy after neurosedyn (thalidomide) and its prognosis.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Polyneuropathies; Prognosis; Thalidomide | 1967 |
[Thalidomide polyneuropathy. Clinical bioptical studies].
Topics: Electromyography; Female; Humans; Middle Aged; Muscular Atrophy; Polyneuropathies; Thalidomide | 1968 |
[Polyneuritis (polyneuropathy) of drug origin].
Topics: Anticonvulsants; Humans; Isoniazid; Nitrofurantoin; Polyneuropathies; Thalidomide | 1968 |
[Polyneurites and polyneuropathies of medicamentous origin].
Topics: Animals; Anticonvulsants; Humans; Nitrofurantoin; Polyneuropathies; Rats; Thalidomide | 1968 |