thalidomide has been researched along with Peritoneal Carcinomatosis in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Excerpt | Relevance | Reference |
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"Grade 3/4 toxicities included neurological disorders (16%), nausea (12%), vomiting (8%), and thromboembolism (8%)." | 6.79 | Phase II trial of adjuvant oral thalidomide following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface disease from colorectal/appendiceal cancer. ( Aklilu, M; Fenstermaker, J; Levine, EA; McCoy, TP; Shen, P; Thomas, CR, 2014) |
"Celecoxib is a potent selective COX-2 inhibitor." | 5.32 | [A case report of disseminated malignant mesothelioma of peritoneum responding remarkably to thalidomide, celecoxib, vinorelbine and CDDP]. ( Hada, M; Kazuhiro, M, 2004) |
"Grade 3/4 toxicities included neurological disorders (16%), nausea (12%), vomiting (8%), and thromboembolism (8%)." | 2.79 | Phase II trial of adjuvant oral thalidomide following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface disease from colorectal/appendiceal cancer. ( Aklilu, M; Fenstermaker, J; Levine, EA; McCoy, TP; Shen, P; Thomas, CR, 2014) |
"Thalidomide was not more effective than tamoxifen in delaying recurrence or death but was more toxic." | 2.75 | Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian, fallopian tube or primary peritoneal carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation ( Benbrook, DM; Brady, MF; Darcy, KM; Edmonds, P; Hurteau, JA; Ivanov, I; Mannel, RS; McGuire, WP; Pearl, ML; Tewari, KS; Zanotti, K, 2010) |
" The majority of adverse events were grades 1-2, including fatigue (25/80 cycles), nausea/vomiting (23/80), constipation (13/80), abdominal pain (17/80), rash (12/80), neutropenia (12/80), and anemia (12/80)." | 2.73 | Safety and efficacy of lenalidomide (Revlimid) in recurrent ovarian and primary peritoneal carcinoma. ( Chan, JK; Guo, HY; Husain, A; Teng, NN; Zhang, MM, 2007) |
"Thalidomide is an anti-angiogenesis agent that has shown activity in some solid tumors." | 2.72 | Safety and efficacy of thalidomide in recurrent epithelial ovarian and peritoneal carcinoma. ( Chan, JK; Cheung, MK; Ciaravino, G; Husain, A; Manuel, MR; Teng, NN, 2006) |
"Celecoxib is a potent selective COX-2 inhibitor." | 1.33 | [A case report of unresectable gallbladder cancer that responded remarkably to the combination of thalidomide, celecoxib, and gemcitabine]. ( Hada, M; Horiuchi, T; Shinji, H, 2006) |
"Celecoxib is a potent selective COX-2 inhibitor." | 1.32 | [A case report of disseminated malignant mesothelioma of peritoneum responding remarkably to thalidomide, celecoxib, vinorelbine and CDDP]. ( Hada, M; Kazuhiro, M, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 7 (70.00) | 29.6817 |
2010's | 3 (30.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Shen, P | 1 |
Thomas, CR | 1 |
Fenstermaker, J | 1 |
Aklilu, M | 1 |
McCoy, TP | 1 |
Levine, EA | 1 |
Gurung, S | 1 |
Fu, H | 1 |
Zhang, WW | 1 |
Gu, YH | 1 |
Hurteau, JA | 1 |
Brady, MF | 1 |
Darcy, KM | 1 |
McGuire, WP | 1 |
Edmonds, P | 1 |
Pearl, ML | 1 |
Ivanov, I | 1 |
Tewari, KS | 1 |
Mannel, RS | 1 |
Zanotti, K | 1 |
Benbrook, DM | 1 |
Hada, M | 2 |
Kazuhiro, M | 1 |
Horiuchi, T | 1 |
Shinji, H | 1 |
Biswas, G | 1 |
Narayanan, P | 1 |
Bhagwat, R | 1 |
Khadwal, A | 1 |
Bakshi, AV | 1 |
Parikh, PM | 1 |
Chan, JK | 2 |
Manuel, MR | 1 |
Ciaravino, G | 1 |
Cheung, MK | 1 |
Husain, A | 2 |
Teng, NN | 2 |
Zhang, MM | 1 |
Guo, HY | 1 |
Calligaris, L | 1 |
Marchetti, F | 1 |
Ventura, A | 1 |
Abramson, N | 1 |
Stokes, PK | 1 |
Luke, M | 1 |
Marks, AR | 1 |
Harris, JM | 1 |
1 review available for thalidomide and Peritoneal Carcinomatosis
Article | Year |
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Hepatic epithelioid hemangioendothelioma metastasized to the peritoneum, omentum and mesentery: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; | 2015 |
5 trials available for thalidomide and Peritoneal Carcinomatosis
Article | Year |
---|---|
Phase II trial of adjuvant oral thalidomide following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface disease from colorectal/appendiceal cancer.
Topics: Adenocarcinoma; Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Appendiceal Neoplasms; | 2014 |
Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian, fallopian tube or primary peritoneal carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation
Topics: Administration, Oral; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents, Hormo | 2010 |
Safety and efficacy of thalidomide in recurrent epithelial ovarian and peritoneal carcinoma.
Topics: Administration, Oral; Adult; Aged; Angiogenesis Inhibitors; California; Drug Administration Schedule | 2006 |
Safety and efficacy of lenalidomide (Revlimid) in recurrent ovarian and primary peritoneal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Female; Humans; Lenalidomide; Middle Aged; Neoplasm Recurrence, | 2007 |
Ovarian and papillary-serous peritoneal carcinoma: pilot study with thalidomide.
Topics: Adult; Aged; Angiogenesis Inhibitors; CA-125 Antigen; Carcinoma, Papillary; Cystadenocarcinoma, Sero | 2002 |
4 other studies available for thalidomide and Peritoneal Carcinomatosis
Article | Year |
---|---|
[A case report of disseminated malignant mesothelioma of peritoneum responding remarkably to thalidomide, celecoxib, vinorelbine and CDDP].
Topics: Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cisplatin; Combined Modality Therapy; Dru | 2004 |
[A case report of unresectable gallbladder cancer that responded remarkably to the combination of thalidomide, celecoxib, and gemcitabine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Deoxycytidine; Drug Administration | 2006 |
Thalidomide in primary peritoneal mesothelioma.
Topics: Angiogenesis Inhibitors; Humans; Male; Mesothelioma; Middle Aged; Peritoneal Neoplasms; Thalidomide | 2006 |
Intestinal plexiform neurofibromas.
Topics: Angiogenesis Inhibitors; Child; Diagnosis, Differential; Female; Humans; Ileal Neoplasms; Mesentery; | 2008 |